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Stroke Research

The search for quality and innovation has always been an inherent part of the activity of the Stroke Research Group and represents the common thread that leads us to excellence and continuous improvement.

In recent years, the Stroke Research Group has established itself as a leader in the management, recruitment and international coordination of multicenter clinical trials, as well as in the development of patents for new thrombectomy devices and the creation of new technological solutions and digital platforms to improve the diagnosis, treatment and follow-up of stroke patients. Robust strategic alliances have also been consolidated with public and private entities that ensure the viability and scalability of the research projects initiated in our group.

The Stroke Research Group is made up of a transversal and multidisciplinary team that shares a common idea: to contribute from its area of knowledge to the care and management of stroke through the effective transfer of knowledge and the complementarity of the processes of clinical research.

Publications

Intravenous Thrombolysis in Patients With Cervical Artery Dissection: A Secondary Analysis of the STOP-CAD Study.

PMID: 39298709
Journal: NEUROLOGY
Year: 2024
Reference: Neurology. 2024 Oct 8;103(7):e209843. doi: 10.1212/WNL.0000000000209843. Epub 2024 Sep 19.
Impact factor:
Publication type: Paper in international publication
Authors: Adams, Latasha; Affan, Muhammad; Aguiar de Sousa, Diana; Akpokiere, Favour; Al Kasab, Sami; Ali, Farman; Almajali, Mohammad; Alvarado, Alonso; Alvi, Muhammad M; Amar, Jordan Y et al.
DOI: 10.1212/WNL.0000000000209843

Optimizing the hemodynamics of hand injections in neuroangiography.

PMID: 39311020
Journal: INTERVENTIONAL NEURORADIOLOGY
Year: 2024
Reference: Interv Neuroradiol. 2024 Sep 23:15910199241285944. doi: 10.1177/15910199241285944.
Impact factor:
Publication type: Paper in international publication
Authors: Bayraktar, Esref Alperen; Bilgin, Cem; Brinjikji, Waleed; Cloft, Harry J; Cortese, Jonathan; Kadirvel, Ramanathan; Kallmes, David F; Li, Jiahui; Ueki, Yasuhito et al.
DOI: 10.1177/15910199241285944

Triple Aspiration versus Conventional Aspiration Techniques: A Randomized In Vitro Evaluation.

PMID: 38991770
Journal: AMERICAN JOURNAL OF NEURORADIOLOGY
Year: 2024
Reference: AJNR Am J Neuroradiol. 2024 Oct 3. doi: 10.3174/ajnr.A8409.
Impact factor:
Publication type: Paper in international publication
Authors: Bayraktar, Esref Alperen; Bilgin, Cem; Brinjikji, Waleed; Cloft, Harry J; Cortese, Jonathan R; Kadirvel, Ramanathan; Kallmes, David F; Li, Jiahui; Naylor, Ryan M; Oliver, Alexander A et al.
DOI: 10.3174/ajnr.A8409

The doctor-patient perception mismatch: Improving approaches to assessing outcomes after ischemic stroke treated with reperfusion therapy.

PMID: 39657503
Journal: JOURNAL OF CLINICAL NEUROSCIENCE
Year: 2024
Reference: J Clin Neurosci. 2024 Dec 9;132:110981. doi: 10.1016/j.jocn.2024.110981.
Impact factor:
Publication type: Paper in international publication
Authors: Brown, Danielle C; Dubinski, Michael J; Gadea, Marta Olive; Hanafy, Khalid A; Hester, Taryn; Jovin, Tudor G; Khalife, Jane; Koneru, Manisha; Penckofer, Mary; Ribo, Marc et al.
DOI: 10.1016/j.jocn.2024.110981

APRIL: A double-blind, placebo-controlled, randomized, Phase Ib/IIa clinical study of ApTOLL for the treatment of acute ischemic stroke.

PMID: 36908619
Journal: Frontiers in Neurology
Year: 2023
Reference: Front Neurol. 2023 Feb 24;14:1127585. doi: 10.3389/fneur.2023.1127585. eCollection 2023.
Impact factor:
Publication type: Paper in international publication
Authors: Abad-Santos, Francisco; Casariego, Joaquin; Cobo, Erik; Cotgreave, Ian; Dalsgaard, Mads; Flores, Alan; Gallego, Jaime; Hernandez-Jimenez, Macarena; Hernandez-Perez, Maria; Jilma, Bernd et al.
DOI: 10.3389/fneur.2023.1127585

Effect of atherosclerosis on 5-year risk of major vascular events in patients with transient ischaemic attack or minor ischaemic stroke: an international prospective cohort study.

PMID: 36931807
Journal: LANCET NEUROLOGY
Year: 2023
Reference: Lancet Neurol. 2023 Apr;22(4):320-329. doi: 10.1016/S1474-4422(23)00067-4.
Impact factor:
Publication type: Paper in international publication
Authors: Albers, Gregory W; Amarenco, Pierre; Caplan, Louis R; Charles, Hugo; Donnan, Geoffrey A; Ferro, Jose M; Hennerici, Michael G; Labreuche, Julien; Lavallee, Philippa C; Molina, Carlos et al.
DOI: 10.1016/S1474-4422(23)00067-4

Clinical Reasoning: An 82-Year-Old Woman With Subacute Ophthalmoparesis and Ataxia.

PMID: 36990717
Journal: NEUROLOGY
Year: 2023
Reference: Neurology. 2023 Aug 1;101(5):e570-e575. doi: 10.1212/WNL.0000000000207246. Epub 2023 Mar 29.
Impact factor:
Publication type: Letter or abstract
Authors: Auger, Cristina; Baucells, Andres; Gonzalez, Victoria; Llaurado, Arnau; Rodrigo-Gisbert, Marc et al.
DOI: 10.1212/WNL.0000000000207246

Translation of nurse-initiated protocols to manage fever, hyperglycaemia and swallowing following stroke across Europe (QASC Europe): A pre-test/post-test implementation study.

PMID: 37021183
Journal: European Stroke Journal
Year: 2023
Reference: Eur Stroke J. 2023 Mar;8(1):132-147. doi: 10.1177/23969873221126027. Epub 2022 Oct 24.
Impact factor:
Publication type: Paper in international publication
Authors: Antonella, Urso; Cadilhac, Dominique; Cassier-Woidasky, Anne-Kathrin; Cheung, Ngai Wah; Coughlan, Kelly; D'Este, Catherine; Dale, Simeon; Fischer, Thomas; Grecu, Andreea; Grimshaw, Jeremy M et al.
DOI: 10.1177/23969873221126027

Distal Transradial Artery Access for Neuroangiography and Neurointerventions : Pitfalls and Exploring the Boundaries.

PMID: 34258635
Journal: Clinical Neuroradiology
Year: 2022
Reference: Clin Neuroradiol. 2022 Jun;32(2):427-434. doi: 10.1007/s00062-021-01039-9. Epub 2021 Jul 13.
Impact factor:
Publication type: Paper in international publication
Authors: Aixut, Sonia; Barranco-Pons, Roger; Chirife, Oscar Sabino; de Dios Las Cuevas, Marta; Klass, Darren; Rodriguez Caamano, Isabel et al.
DOI: 10.1007/s00062-021-01039-9

Predictors of Recurrent Stroke After Embolic Stroke of Undetermined Source in the RE-SPECT ESUS Trial.

PMID: 35656979
Journal: Journal of the American Heart Association
Year: 2022
Reference: J Am Heart Assoc. 2022 Jun 7;11(11):e023545. doi: 10.1161/JAHA.121.023545. Epub 2022 Jun 3.
Impact factor:
Publication type: Paper in international publication
Authors: Bladin, Christopher F; Brueckmann, Martina; Chutinet, Aurauma; Cronin, Lisa; Del Brutto, Victor J; Diener, Han-Christoph; Easton, J Donald; Estol, Conrado J; Granger, Christopher B; Grauer, Claudia et al.
DOI: 10.1161/JAHA.121.023545

Thrombectomy vs Medical Management in Mild Strokes due to Large Vessel Occlusion: Exploratory Analysis from the EXTEND-IA Trials and a Pooled International Cohort.

PMID: 35599458
Journal: ANNALS OF NEUROLOGY
Year: 2022
Reference: Ann Neurol. 2022 Sep;92(3):364-378. doi: 10.1002/ana.26418. Epub 2022 Jul 25.
Impact factor:
Publication type: Paper in international publication
Authors: Abraham, Michael G; Albers, Gregory W; Almaghrabi, Tareq; Arenillas, Juan F; Beharry, James; Blackburn, Spiros L; Blasco, Jordi; Campbell, Bruce Cv; Cappelen-Smith, Cecilia; Cardona Portela, Pere et al.
DOI: 10.1002/ana.26418

Endovascular Therapy versus No Endovascular Therapy in Patients receiving Best Medical Management for Acute Isolated Occlusion of the Posterior Cerebral Artery: Systematic Review and Meta-Analysis.

PMID: 35587104
Journal: EUROPEAN JOURNAL OF NEUROLOGY
Year: 2022
Reference: Eur J Neurol. 2022 Sep;29(9):2664-2673. doi: 10.1111/ene.15410. Epub 2022 Jun 17.
Impact factor:
Publication type: Review in international publication
Authors: Abdalkader, Mohamad; Berberich, Anne; Finitsis, Stephanos; Fragata, Isabel; Hanning, Uta; Herweh, Christian; Kaiser, Daniel P O; Marto, Joao Pedro; Meyer, Lukas; Michel, Patrik et al.
DOI: 10.1111/ene.15410

Circulating AQP4 Levels in Patients with Cerebral Amyloid Angiopathy-Associated Intracerebral Hemorrhage.

PMID: 33801197
Journal: Journal of Clinical Medicine
Year: 2021
Reference: J Clin Med. 2021 Mar 2;10(5). pii: jcm10050989. doi: 10.3390/jcm10050989.
Impact factor:
Publication type: Paper in international publication
Authors: Arenillas, Juan F; Bonaterra-Pastra, Anna; Cardona Portela, Pere; Delgado, Pilar; Faura, Julia; Freijo, M Mar; Hernandez-Guillamon, Mar; Lebrato-Hernandez, Lucia; Marazuela, Paula; Martinez-Zabaleta, Maite et al.
DOI: 10.3390/jcm10050989

Single nucleotide variations in ZBTB46 are associated with post-thrombolytic parenchymal haematoma.

PMID: 33723576
Journal: BRAIN
Year: 2021
Reference: Brain. 2021 Sep 4;144(8):2416-2426. doi: 10.1093/brain/awab090.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez-Sabin, Jose; Arenillas, Juan Francisco; Bustamante, Alejandro; Cabezas, Juan Antonio; Campos, Francisco; Carcel-Marquez, Jara; Carrera, Caty; Castellanos, Mar; Castillo, Jose; Cole, John et al.
DOI: 10.1093/brain/awab090

Ischemic Core Overestimation on Computed Tomography Perfusion.

PMID: 33682453
Journal: STROKE
Year: 2021
Reference: Stroke. 2021 May;52(5):1751-1760. doi: 10.1161/STROKEAHA.120.031800. Epub 2021 Mar 8.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez-Sabin, Jose; Boned, Sandra; Campos, Daniel; Ciolli, Ludovico; Deck, Matias; Garcia-Tornel, Alvaro; Hernandez, David; Juega, Jesus; Molina, Carlos A; Muchada, Marian et al.
DOI: 10.1161/STROKEAHA.120.031800

Blood Biomarkers to Differentiate Ischemic and Hemorrhagic Strokes Might Allow Prehospital Thrombolysis.

PMID: 33674361
Journal: NEUROLOGY
Year: 2021
Reference: Neurology. 2021 Apr 13;96(15):e1928-e1939. doi: 10.1212/WNL.0000000000011742. Epub 2021 Mar 5.
Impact factor:
Publication type: Paper in international publication
Authors: Azurmendi, Leire; Bustamante, Alejandro; Llombart, Victor; Montaner, Joan; Orset, Cyrille; Pecharroman, Emili; Penalba, Anna; Ribo, Marc; Sanchez, Jean Charles; Simats, Alba et al.
DOI: 10.1212/WNL.0000000000011742

Mechanical thrombectomy with a novel stent retriever with multifunctional zones: Initial Clinical Experience with the NeVa thrombectomy device.

PMID: 30951765
Journal: JOURNAL OF NEURORADIOLOGY
Year: 2020
Reference: J Neuroradiol. 2020 Jun;47(4):301-305. doi: 10.1016/j.neurad.2019.03.007. Epub 2019 Apr 2.
Impact factor:
Publication type: Paper in international publication
Authors: Blasco, J; Hernandez, D; Machi, P; Macho, J; Requena, M; Ribo, M; Tomasello, A; Zamarro, J et al.
DOI: 10.1016/j.neurad.2019.03.007

Management of acute ischemic stroke in patients with COVID-19 infection: Insights from an international panel.

PMID: 32444298
Journal: AMERICAN JOURNAL OF EMERGENCY MEDICINE
Year: 2020
Reference: Am J Emerg Med. 2020 Jul;38(7):1548.e5-1548.e7. doi: 10.1016/j.ajem.2020.05.018. Epub 2020 May 11.
Impact factor:
Publication type: Letter or abstract
Authors: Abd-Allah, Foad; Al-Senani, Fahmi; Aytac, Emrah; Borhani-Haghighi, Afshin; Ciccone, Alfonso; Gomez, Camilo R; Gongora-Rivera, Fernando; Gurkas, Erdem; Hsu, Chung Y; Jani, Vishal et al.
DOI: 10.1016/j.ajem.2020.05.018

Cardioembolic Ischemic Stroke Gene Expression Fingerprint in Blood: a Systematic Review and Verification Analysis.

PMID: 31475302
Journal: Translational Stroke Research
Year: 2020
Reference: Transl Stroke Res. 2020 Jun;11(3):326-336. doi: 10.1007/s12975-019-00730-x. Epub 2019 Sep 2.
Impact factor:
Publication type: Review in international publication
Authors: Bustamante, Alejandro; Clua-Espuny, Josep Lluis; Consegal, Marta; Fernandez-Cadenas, Israel; Garcia-Berrocoso, Teresa; Gill, Natalia; Huerga Encabo, Hector; Jickling, Glen C; Juega, Jesus; Meisel, Andreas et al.
DOI: 10.1007/s12975-019-00730-x

Computed Tomography Perfusion After Thrombectomy: An Immediate Surrogate Marker of Outcome After Recanalization in Acute Stroke.

PMID: 32404034
Journal: STROKE
Year: 2020
Reference: Stroke. 2020 Jun;51(6):1736-1742. doi: 10.1161/STROKEAHA.120.029212. Epub 2020 May 14.
Impact factor:
Publication type: Paper in international publication
Authors: Boned, Sandra; Campos, Daniel; Deck, Matias; Garcia-Tornel, Alvaro; Hernandez, David; Juega, Jesus; Molina, Carlos A; Muchada, Marian; Olive-Gadea, Marta; Pagola, Jorge et al.
DOI: 10.1161/STROKEAHA.120.029212

An injectable implant to stimulate the sphenopalatine ganglion for treatment of acute ischaemic stroke up to 24 h from onset (ImpACT-24B): an international, randomised, double-blind, sham-controlled, pivotal trial.

PMID: 31133406
Journal: LANCET
Year: 2019
Reference: Lancet. 2019 Jul 20;394(10194):219-229. doi: 10.1016/S0140-6736(19)31192-4. Epub 2019 May 24.
Impact factor:
Publication type: Paper in international publication
Authors: Agnelli, Giancarlo; Alonso, Maria; Andersen, Grethe; Anzhelika, Payenok; Arenillas, Juan; Auriel, Eitan; Azevedo, Elsa; Beridze, Maya; Beridze, Mzia; Berrouschot, Joerg et al.
DOI: 10.1016/S0140-6736(19)31192-4

Sphenopalatine Ganglion Stimulation to Augment Cerebral Blood Flow.

PMID: 31117920
Journal: STROKE
Year: 2019
Reference: Stroke. 2019 Aug;50(8):2108-17. doi: 10.1161/STROKEAHA.118.024582.
Impact factor:
Publication type: Paper in international publication
Authors: Abbushi, Alexander; Akhtar, Naveed; Albers, Johannes; Allendorfer, Jens; Alonso, Maria; Andersen, Grethe; Angel, Ois; Anthofer, Birgit; Aparicio Caballero, Marco Alberto; Arenillas, Joaquin et al.
DOI: 10.1161/STROKEAHA.118.024582

Estimated treatment effect of ticagrelor versus aspirin by investigator-assessed events compared with judgement by an independent event adjudication committee in the SOCRATES trial.

PMID: 31092152
Journal: International Journal of Stroke
Year: 2019
Reference: Int J Stroke. 2019 Dec;14(9):908-914. doi: 10.1177/1747493019851282. Epub 2019 May 15.
Impact factor:
Publication type: Paper in international publication
Authors: Albers, Gregory W; Amarenco, Pierre; Denison, Hans; Easton, J Donald; Evans, Scott R; Johnston, S Claiborne; Knutsson, Mikael; Ladenvall, Per; Minematsu, Kazuo; Molina, Carlos A et al.
DOI: 10.1177/1747493019851282

Procedural approaches and angiographic signs predicting first-pass recanalization in patients treated with mechanical thrombectomy for acute ischaemic stroke.

PMID: 31072248
Journal: INTERVENTIONAL NEURORADIOLOGY
Year: 2019
Reference: Interv Neuroradiol. 2019 Oct;25(5):491-496. doi: 10.1177/1591019919847623. Epub 2019 May 9.
Impact factor:
Publication type: Paper in international publication
Authors: Aixut, Sonia; Coscojuela, Pilar; Dinia, Lavinia; Gramegna, Laura Ludovica; Hernandez, David; Lopez-Rueda, Antonio; Luttich, Alexandre; Melendez, Fernando; Moreu, Manuel; Quintana, Manuel et al.
DOI: 10.1177/1591019919847623

Long-term retention rates of antiepileptic drugs used in acute seizures.

PMID: 30118928
Journal: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
Year: 2018
Reference: Seizure. 2018 Oct;61:78-82. doi: 10.1016/j.seizure.2018.08.007. Epub 2018 Aug 11.
Impact factor: 2.839
Publication type: Paper in international publication
Authors: Toledo, Manuel, Fonseca, Elena, Olive, Marta, Requena, Manuel, Quintana, Manuel, Abraira-Del-Fresno, Laura, Salas-Puig, Xavier, Santamarina, Estevo et al.
DOI: 10.1016/j.seizure.2018.08.007

Blog

News

This project seeks to promote the use of artificial intelligence in stroke treatment, improving data management, transparency and clinical monitoring of patients.

A new consortium of leading organizations embarks on a groundbreaking project to enhance patient triage and healthcare delivery.

UMBRELLA, a consortium of over 20 public and private partners, kicks off this week with the aim of revolutionising the entire stroke care pathway in Europe by adopting a holistic approach that covers stroke diagnosis, prevention and care.