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Transfusional Medicine

We are dedicated to investigate transfusional activity, the alteration of erythrocytes during the conservation period and extracorporeal photoapheresis. We work on the molecular and serological characterization of blood group variants. In non-invasive fetal genotyping strategies due to blood group incompatibilities. We develop iPSC lines and produce in vitro erythrocytes with rare phenotypes.

We deepen in the knowledge of epidemiology and the detection of infectious agents relevant for safety of the products supplied by the Blood and Tissue Bank.

We investigate in clinical immunology and develop our own HLA and KIR typing protocols. We develop and incorporate new therapeutic applications in cell therapy including hematopoietic transplantation, cellular immunology and regenerative medicine.

We investigate the molecular mechanisms and genotype-phenotype correlation of coagulopathies, haemorrhagic diathesis and other associated congenital pathologies. We develop tools based on the new technologies of parallel massive sequencing with application to the molecular study, genetic counselling and prenatal diagnosis.

Team

Sara Morini

Sara Morini

Postdoctoral researcher
Transfusional Medicine
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Jesus  Fernandez Sojo

Jesus Fernandez Sojo

Predoctoral researcher
Transfusional Medicine
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Boto Ruiz, Neus

Boto Ruiz, Neus

Transfusional Medicine
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Caro Pauon, Carles

Caro Pauon, Carles

Transfusional Medicine
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Cecilia González Santesteban

Cecilia González Santesteban

Research technician
Transfusional Medicine
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Dinara Samarkanova

Dinara Samarkanova

Postdoctoral researcher
Transfusional Medicine
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Sara Morini

Sara Morini

Postdoctoral researcher
Transfusional Medicine
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Jesus  Fernandez Sojo

Jesus Fernandez Sojo

Predoctoral researcher
Transfusional Medicine
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Boto Ruiz, Neus

Boto Ruiz, Neus

Transfusional Medicine
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Caro Pauon, Carles

Caro Pauon, Carles

Transfusional Medicine
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Cecilia González Santesteban

Cecilia González Santesteban

Research technician
Transfusional Medicine
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Dinara Samarkanova

Dinara Samarkanova

Postdoctoral researcher
Transfusional Medicine
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Research lines

Biological safety

Epidemiology and detection of infectious agents relevant for the safety of the products supplied by the Blood and Tissue Bank.


PI: Piron, Maria


Researchers:

Casamitjana Ponces, Natàlia


Researchers in training:

De la Torre Rial, Carmen

IP: -

Cell therapy

Development and incorporation of new therapeutic applications in the area of ??cell therapy including hematopoietic transplantation, cellular immunology and regenerative medicine.


PI: Querol Giner, Sergi


Researchers:

García Gómez, Susana

Rodríguez Gómez, Luciano


Researchers in training:

Samarkanova, Dinara

Enrich Randés, Emma

Lopez Montañes, Maria


Nursing, technical and administrative staff:

Lopez Montañes, Maria

Ribo, Nuria

IP: -

Congenital coagulopathies

Investigation in the molecular mechanisms and the genotype-phenotype correlation of coagulopathies, hemorrhagic diathesis and other associated congenital pathologies. Development of tools based on the new technologies of parallel massive sequencing with application to the molecular study, genetic counselling and prenatal diagnosis.


PI: Parra López, Rafael and Vidal Pérez, Francisco


Researchers:

Corrales Insa, Irene

Altisent Roca, Carme


Researcher in training:

Borrás Agustí, Nina


Nursing, technical and administrative staff:

Ramírez Orihuela, Lorena

Comes Fernández, Natalia

Garcia, Iris

IP: Parra López, Rafael, Vidal Pérez, Francisco

Histocompatibility and immunogenetics

Clinical immunology and development of our own HLA and KIR typing protocols.


PI: Herrero Mata, María José


Researchers:

Caro Oleas, José Luís

Rudilla Salvador, Francesc


Researchers in training:

Enrich Randé, Emma

Grau Vorster, Marta

Closa Gil, Laia

IP: Herrero Mata, Maria Jose

Projects

Evaluación clínica de los hematíes procedentes de la sangre de cordón para la transfusión en prematuros extremos

IP: Querol Giner, Sergi
Collaborators: Codinach Creus, Margarita
Funding agency: Instituto de Salud Carlos III
Funding: 61105
Reference: PI22/00290
Duration: 01/01/2023 - 31/12/2025

Traslación de un producto alogénico de ingeniería tisular para el tratamiento de lesiones focales del cartílago articular

IP: Vélez Villa, Roberto
Collaborators: Traslación de un producto alogénico de ingeniería tisular para el tratamiento de lesiones focales del cartílago articular, Joshi Jubert, Nayana, Server Salvà, Anna, Pacha Vicente, Daniel Alejandro, Prat Matifoll, Joan Albert, Cabrera Perez, Raquel, Morini , Sara
Funding agency: AGAUR no fer servir-correcte 4301-37
Funding: 0.01
Reference: 2021 SGR 00877
Duration: 01/01/2022 - 31/12/2024

Ensayo clínico fase I-Ib de seguridad e immunobiologia de la Infusión Profilactica de Linfocitos Gammadelta y Células NK de donante HLA idéntido post Alo-TPH con deplección T.

IP: -
Collaborators: Ana Pérez González, Azqueta Molluna, Carmen , Rudilla Salvador, Francesc, Fernandez Sojo, Jesus , Fox , Maria Laura
Funding agency: Instituto de Salud Carlos III
Funding: 217800
Reference: PI22/00710
Duration: 01/01/2023 - 31/12/2025

RICORS TERAV - Teràpies avançades

IP: Joan García López
Collaborators: Querol Giner, Sergi, RICORS TERAV - Teràpies avançades, Vives Armengol, Joaquim, Rodríguez Gómez, Luciano, Rudilla Salvador, Francesc, Vives Armengol, Joaquim, Vives Armengol, Joaquim, Vives Armengol, Joaquim, Vives Armengol, Joaquim, Vives Armengol, Joaquim, Vives Armengol, Joaquim, Vives Armengol, Joaquim, Vives Armengol, Joaquim, Vives Armengol, Joaquim, Vives Armengol, Joaquim, Vives Armengol, Joaquim
Funding agency: Instituto de Salud Carlos III
Funding: 338472.2
Reference: RD21/0017/0022
Duration: 01/01/2022 - 31/12/2024

Publications

Recommendations for the future management of thrombocytopenia in patients with liver cirrhosis: A modified RAND/UCLA appropriateness method.

PMID: 37028757
Journal: Gastroenterologia y Hepatologia
Year: 2024
Reference: Gastroenterol Hepatol. 2024 Jan;47(1):32-50. doi: 10.1016/j.gastrohep.2023.03.008. Epub 2023 Apr 5.
Impact factor:
Publication type: Paper in national publication
Authors: Llop, Elba; Lozano, Maria Luisa; Luis Calleja, Jose; Parra, Rafael; Pradera, Maria Angeles Fuentes; Sanchez, Olga Delgado; Vazquez, Juan Turnes; Zarraga, Fernando Lopez et al.
DOI: 10.1016/j.gastrohep.2023.03.008

Impact of genetic structural variants in factor XI deficiency: identification, accurate characterization, and inferred mechanism by long-read sequencing.

PMID: 36940803
Journal: JOURNAL OF THROMBOSIS AND HAEMOSTASIS
Year: 2023
Reference: J Thromb Haemost. 2023 Jul;21(7):1779-1788. doi: 10.1016/j.jtha.2023.03.009. Epub 2023 Mar 20.
Impact factor:
Publication type: Paper in international publication
Authors: Bravo-Perez, Carlos; Cifuentes, Rosa; Corral, Javier; Garrido-Rodriguez, Pedro; Llamas, Maria; Lozano, Maria Luisa; Martin-Fernandez, Laura; Minano, Antonia; Morena-Barrio, Belen de la; Morena-Barrio, Maria Eugenia de la et al.
DOI: 10.1016/j.jtha.2023.03.009

The slowdown of new infections by human retroviruses has reached a plateau in Spain.

PMID: 37212269
Journal: JOURNAL OF MEDICAL VIROLOGY
Year: 2023
Reference: J Med Virol. 2023 May;95(5):e28779. doi: 10.1002/jmv.28779.
Impact factor:
Publication type: Review in international publication
Authors: Aguilera, Antonio; Ayerdi, Oscar; Benito, Rafael; Carrizo, Paula; de Mendoza, Carmen; Encinas, Begona; Fernandez-Ruiz, Mario; Gonzalez, Rocio; Liendo, Paloma; Miro, Elisenda et al.
DOI: 10.1002/jmv.28779

Quality by Design: Development of Safe and Efficacious Full-Thickness Acellular Dermal Matrix Based on EuroGTPII Methodologies.

PMID: 37425344
Journal: Therapeutics and Clinical Risk Management
Year: 2023
Reference: Ther Clin Risk Manag. 2023 Jul 4;19:567-578. doi: 10.2147/TCRM.S410574. eCollection 2023.
Impact factor:
Publication type: Paper in international publication
Authors: Castells-Sala, Cristina; Farinas, Oscar; Lopez-Chicon, Patricia; Perez, Maria Luisa; Piteira, Ana Rita; Tabera, Jaime; Vilarrodona, Anna et al.
DOI: 10.2147/TCRM.S410574

Development of an in-house bone marrow collection kit: The Catalan bone marrow transplantation group experience.

PMID: 37533171
Journal: VOX SANGUINIS
Year: 2023
Reference: Vox Sang. 2023 Aug 2. doi: 10.1111/vox.13499.
Impact factor:
Publication type: Paper in international publication
Authors: Azqueta, Carmen; Badell, Isabel; Carreras, Enric; Diaz-de-Heredia, Cristina; Esquirol, Albert; Fernandez-Sojo, Jesus; Ferra, Christelle; Garcia-Buendia, Ana; Gomez, David; Lozano, Miquel et al.
DOI: 10.1111/vox.13499

Long-Read Sequencing Identifies the First Retrotransposon Insertion and Resolves Structural Variants Causing Antithrombin Deficiency.

PMID: 35764313
Journal: THROMBOSIS AND HAEMOSTASIS
Year: 2022
Reference: Thromb Haemost. 2022 Jun 28. doi: 10.1055/s-0042-1749345.
Impact factor: 5.723
Publication type: Paper in international publication
Authors: Sanchis-Juan, Alba; Corral, Javier; Ouwehand, Willem H; Vicente, Vicente; Raymond, Frances Lucy; Vidal, Francisco; Undas, Anetta; Puurunen, Marja; Morange, Pierre-Emmanuel; Lopez-Fernandez, Maria Fernanda et al.
DOI: 10.1055/s-0042-1749345

Leukocytapheresis variables and transit time for allogeneic cryopreserved hpc: better safe than sorry.

PMID: 35804055
Journal: BONE MARROW TRANSPLANTATION
Year: 2022
Reference: Bone Marrow Transplant. 2022 Jul 8. pii: 10.1038/s41409-022-01750-2. doi: 10.1038/s41409-022-01750-2.
Impact factor: 5.483
Publication type: Paper in international publication
Authors: Martino, Rodrigo, Fernandez-Sojo, Jesus, Horton, Roger, Cid, Joan, Azqueta, Carmen, Garcia-Buendia, Ana, Valdivia, Elena, Martorell, Lluis, Rubio-Lopez, Nuria, Codinach, Margarita et al.
DOI: 10.1038/s41409-022-01750-2

Post thawing viable CD34+ Cells dose is a better predictor of clinical outcome in lymphoma patients undergoing autologous stem cell transplantation.

PMID: 35614316
Journal: BONE MARROW TRANSPLANTATION
Year: 2022
Reference: Bone Marrow Transplant. 2022 May 25. pii: 10.1038/s41409-022-01722-6. doi: 10.1038/s41409-022-01722-6.
Impact factor: 5.483
Publication type: Letter whit IF
Authors: Talarn, Carme, Cid, Joan, Azqueta, Carmen, Valdivia, Elena, Martorell, Lluis, Codinach, Margarita, Marsal, Julia, Mussetti, Alberto, Esquirol, Albert, Trabazo, Maria et al.
DOI: 10.1038/s41409-022-01722-6

Integrated GWAS and Gene Expression Suggest ORM1 as a Potential Regulator of Plasma Levels of Cell-Free DNA and Thrombosis Risk.

PMID: 35272364
Journal: THROMBOSIS AND HAEMOSTASIS
Year: 2022
Reference: Thromb Haemost. 2022 Mar 10. doi: 10.1055/s-0041-1742169.
Impact factor: 5.723
Publication type: Paper in international publication
Authors: Lopez, Sonia, Martinez-Perez, Angel, Rodriguez-Rius, Alba, Vinuela, Ana, Brown, Andrew A, Martin-Fernandez, Laura, Vilalta, Noelia, Arus, Marc, Panousis, Nikolaos I, Buil, Alfonso et al.
DOI: 10.1055/s-0041-1742169

Fast protocol for the processing of split-thickness skin into decellularized human dermal matrix.

PMID: 34119882
Journal: TISSUE & CELL
Year: 2021
Reference: Tissue Cell. 2021 Oct;72:101572. doi: 10.1016/j.tice.2021.101572. Epub 2021 Jun 4.
Impact factor: 2.466
Publication type: Paper in international publication
Authors: Perez, M L, Castells-Sala, C, Lopez-Chicon, P, Nieto-Nicolau, N, Aiti, A, Farinas, O, Casaroli-Marano, R P, Porta, O, Vilarrodona, A et al.
DOI: 10.1016/j.tice.2021.101572

Cryopreservation of unrelated donor hematopoietic stem cells: the right answer for transplantations during the COVID-19 pandemic?

PMID: 34127808
Journal: BONE MARROW TRANSPLANTATION
Year: 2021
Reference: Bone Marrow Transplant. 2021 Oct;56(10):2489-2496. doi: 10.1038/s41409-021-01367-x. Epub 2021 Jun 14.
Impact factor: 5.483
Publication type: Paper in international publication
Authors: Linares, Monica, Ancochea, Agueda, Garcia-Rey, Enric, Garcia-Munoz, Nadia, Medina, Laura, Castillo, Nerea, Carreras, Enric, Villa, Juliana, Querol, Sergio, Valcarcel, David et al.
DOI: 10.1038/s41409-021-01367-x

Putting the spotlight on donation-related risks and donor safety - are we succeeding in protecting donors?

PMID: 33103801
Journal: VOX SANGUINIS
Year: 2021
Reference: Vox Sang. 2021 Mar;116(3):313-323. doi: 10.1111/vox.13014. Epub 2020 Oct 26.
Impact factor: 2.144
Publication type: Paper in international publication
Authors: Korkalainen, Piia, Wulff, Birgit, Fernandez-Sojo, Jesus, Eguizabal, Cristina, Urbano, Fernando, Vesga, Miguel Angel, Pozenel, Primoz, van Kraaij, Marian, Hansen, Morten Bagge, Slot, Ed et al.
DOI: 10.1111/vox.13014

Diagnostic challenges in von Willebrand disease. Report of two cases with emphasis on multimeric and molecular analysis.

PMID: 32664776
Journal: PLATELETS
Year: 2021
Reference: Platelets. 2021 Jul 4;32(5):697-700. doi: 10.1080/09537104.2020.1784403. Epub 2020 Jul 14.
Impact factor: 3.862
Publication type: Paper in international publication
Authors: Vidal, F, Corrales, I, Borras, N, Torramade-Moix, S, Palomo, M, Escolar, G, Diaz-Ricart, M, Altisent, C, Parra, R, Pino, M et al.
DOI: 10.1080/09537104.2020.1784403

Multicenter Study on Differential Human Neutrophil Antigen 2 Expression and Underlying Molecular Mechanisms.

PMID: 33173457
Journal: TRANSFUSION MEDICINE AND HEMOTHERAPY
Year: 2020
Reference: Transfus Med Hemother. 2020 Oct;47(5):385-395. doi: 10.1159/000505523. Epub 2020 Jan 22.
Impact factor: 1.937
Publication type: Paper in international publication
Authors: Kellershohn, Josina, Flesch, Brigitte K, Reil, Angelika, Nogues, Nuria, Canals, Carme, Bugert, Peter, Schulze, Torsten J, Huiskes, Elly, Porcelijn, Leendert, Hoglund, Petter et al.
DOI: 10.1159/000505523

Extrinsic modulation of integrin alpha6 and progenitor cell behavior in mesenchymal stem cells.

PMID: 32659733
Journal: Stem Cell Research
Year: 2020
Reference: Stem Cell Res. 2020 Jun 30;47:101899. doi: 10.1016/j.scr.2020.101899.
Impact factor: 4.489
Publication type: Paper in international publication
Authors: Farinas, Oscar, Savio, Andres, Vilarrodona, Anna, Casaroli-Marano, Ricardo P, de la Torre, Raquel M, Nieto-Nicolau, Nuria et al.
DOI: 10.1016/j.scr.2020.101899

Neonatal alloimmune thrombocytopenia due to anti-HPA 5a in a HPA-5a homozygous neonate.

PMID: 32763115
Journal: TRANSFUSION AND APHERESIS SCIENCE
Year: 2020
Reference: Transfus Apher Sci. 2020 Dec;59(6):102880. doi: 10.1016/j.transci.2020.102880. Epub 2020 Jul 22.
Impact factor: 1.285
Publication type: Letter or abstract
Authors: Porta, R, Serrano, P, Paltrinieri, A, Ristic, G, Canals, C, Lozano, M et al.
DOI: 10.1016/j.transci.2020.102880

Induced pluripotent stem cell-derived lung alveolar epithelial type II cells reduce damage in bleomycin-induced lung fibrosis.

PMID: 32493487
Journal: Stem Cell Research & Therapy
Year: 2020
Reference: Stem Cell Res Ther. 2020 Jun 3;11(1):213. doi: 10.1186/s13287-020-01726-3.
Impact factor: 5.116
Publication type: Paper in international publication
Authors: Alvarez-Palomo, Belen, Sanchez-Lopez, Luis Ignacio, Moodley, Yuben, Edel, Michael J, Serrano-Mollar, Anna et al.
DOI: 10.1186/s13287-020-01726-3

Latency Reversal Agents Affect Differently the Latent Reservoir Present in Distinct CD4+ T Subpopulations.

PMID: 31425551
Journal: PLoS Pathogens
Year: 2019
Reference: PLoS Pathog. 2019 Aug 19;15(8):e1007991. doi: 10.1371/journal.ppat.1007991. eCollection 2019 Aug.
Impact factor: 6.463
Publication type: Paper in international publication
Authors: Grau-Exposito, Judith, Luque-Ballesteros, Laura, Navarro, Jordi, Curran, Adrian, Burgos, Joaquin, Ribera, Esteban, Torrella, Ariadna, Planas, Bibiana, Badia, Rosa, Martin-Castillo, Mario et al.
DOI: 10.1371/journal.ppat.1007991

HLA-A, -B, -C, -DRB1 and -DQB1 allele and haplotype frequencies: An analysis of umbilical cord blood units at the Barcelona Cord Blood Bank.

PMID: 31353832
Journal: HLA
Year: 2019
Reference: HLA. 2019 Oct;94(4):347-359. doi: 10.1111/tan.13644. Epub 2019 Aug 6.
Impact factor: 2.785
Publication type: Paper in international publication
Authors: Enrich, Emma, Campos, Eva, Martorell, Lluis, Herrero, Maria Jose, Vidal, Francisco, Querol, Sergi, Rudilla, Francesc et al.
DOI: 10.1111/tan.13644

Impact of prophylaxis on health-related quality of life of boys with hemophilia: An analysis of pooled data from 9 countries.

PMID: 31294327
Journal: Research and practice in thrombosis and haemostasi
Year: 2019
Reference: Res Pract Thromb Haemost. 2019 Apr 23;3(3):397-404. doi: 10.1002/rth2.12202. eCollection 2019 Jul.
Impact factor: 0
Publication type: Paper in international publication
Authors: Antunes, Sandra V, Usuba, Koyo, Price, Victoria E, Blanchette, Victor, Abad, Audrey, Altisent, Carmen, Buchner-Daley, Loretta, Carneiro, Jorge D A, Feldman, Brian M, Fischer, Kathelijn et al.
DOI: 10.1002/rth2.12202

Compliance with Good Manufacturing Practice in the Assessment of Immunomodulation Potential of Clinical Grade Multipotent Mesenchymal Stromal Cells Derived from Wharton's Jelly.

PMID: 31117301
Journal: Cells
Year: 2019
Reference: Cells. 2019 May 21;8(5). pii: cells8050484. doi: 10.3390/cells8050484.
Impact factor: 5.656
Publication type: Paper in international publication
Authors: Grau-Vorster, Marta, Rodriguez, Luciano, Del Mazo-Barbara, Anna, Mirabel, Clementine, Blanco, Margarita, Codinach, Margarita, Gomez, Susana G, Querol, Sergi, Garcia-Lopez, Joan, Vives, Joaquim et al.
DOI: 10.3390/cells8050484

Factors Leading to the Loss of Natural Elite Control of HIV-1 Infection.

PMID: 29212942
Journal: JOURNAL OF VIROLOGY
Year: 2018
Reference: J Virol. 2018 Feb 12;92(5):e01805-17. doi: 10.1128/JVI.01805-17. Print 2018 Mar 1.
Impact factor:
Publication type: Paper in international publication
Authors: Alcami, Jose; Benito, Jose Miguel; Casado, Concepcion; Coiras, Maite; Dapena, Marta; Del Romero, Jorge; Dominguez-Molina, Beatriz; Garcia, Felipe; Gomez, Josep; Iribarren, Jose Antonio et al.
DOI: 10.1128/JVI.01805-17

Estimated fetal weight percentile as a tool to predict collection of cord blood units with higher cellular content: implications for prenatal selection of cord blood donors.

PMID: 29732577
Journal: TRANSFUSION
Year: 2018
Reference: Transfusion. 2018 Jul;58(7):1732-1738. doi: 10.1111/trf.14651. Epub 2018 May 6.
Impact factor:
Publication type: Paper in international publication
Authors: Amat, Lluis; Arroyo, JoseLuis; Azqueta, Carmen; Brull, Jose Maria; Cemborain, Arantxa; Cuadras, Daniel; Gaya, Antoni; Gomez Roig, Maria Dolores; Gomez, Susana; Lin, Xinxin et al.
DOI: 10.1111/trf.14651

Immunogenicity, efficacy and safety of Nuwiq((R)) (human-cl rhFVIII) in previously untreated patients with severe haemophilia A-Interim results from the NuProtect Study.

PMID: 28815880
Journal: HAEMOPHILIA
Year: 2018
Reference: Haemophilia. 2018 Mar;24(2):211-220. doi: 10.1111/hae.13320. Epub 2017 Aug 16.
Impact factor: 2.768
Publication type: Paper in international publication
Authors: Liesner, R J, Knaub, S, Neufeld, E J, Walter, O, Belyanskaya, L, Pavlova, A, Altisent, C, Belletrutti, M J, Borel-Derlon, A, Carcao, M et al.
DOI: 10.1111/hae.13320

Role of multimeric analysis of von Willebrand factor (VWF) in von Willebrand disease (VWD) diagnosis: Lessons from the PCM-EVW-ES Spanish project.

PMID: 29924855
Journal: PLoS One
Year: 2018
Reference: PLoS One. 2018 Jun 20;13(6):e0197876. doi: 10.1371/journal.pone.0197876. eCollection 2018.
Impact factor: 2.766
Publication type: Paper in international publication
Authors: Perez-Rodriguez, Almudena, Batlle, Javier, Corrales, Irene, Borras, Nina, Rodriguez-Trillo, Angela, Loures, Esther, Cid, Ana Rosa, Bonanad, Santiago, Cabrera, Noelia, Moret, Andres et al.
DOI: 10.1371/journal.pone.0197876

Thymic Function Failure Is Associated With Human Immunodeficiency Virus Disease Progression.

PMID: 28158588
Journal: CLINICAL INFECTIOUS DISEASES
Year: 2017
Reference: Clin Infect Dis. 2017 May 1;64(9):1191-1197. doi: 10.1093/cid/cix095.
Impact factor:
Publication type: Paper in international publication
Authors: Blanco, Jose Ramon; De Luna-Romero, Marta; De Ory, Santiago J; De Pablo-Bernal, Rebeca S; Ferrando-Martinez, Sara; Genebat, Miguel; Gutierrez, Felix; Koup, Richard A; Leal, Manuel; Montero, Marta et al.
DOI: 10.1093/cid/cix095

Post-Transplantation Cyclophosphamide-Based Haploidentical Transplantation as Alternative to Matched Sibling or Unrelated Donor Transplantation for Hodgkin Lymphoma: A Registry Study of the Lymphoma Working Party of the European Society for Blood and Marrow Transplantation.

PMID: 28846465
Journal: JOURNAL OF CLINICAL ONCOLOGY
Year: 2017
Reference: J Clin Oncol. 2017 Oct 20;35(30):3425-3432. doi: 10.1200/JCO.2017.72.6869. Epub 2017 Aug 28.
Impact factor: 24.008
Publication type: Paper in international publication
Authors: Dominietto, Alida, Castagna, Luca, Afanasyev, Boris, Robinson, Stephen, Blaise, Didier, Corradini, Paolo, Itala-Remes, Maija, Bermudez, Arancha, Forcade, Edouard, Russo, Domenico et al.
DOI: 10.1200/JCO.2017.72.6869

Risk Factors for the Progression from Low to High Titres in 260 Children with Severe Haemophilia A and Newly Developed Inhibitors.

PMID: 29212115
Journal: THROMBOSIS AND HAEMOSTASIS
Year: 2017
Reference: Thromb Haemost. 2017 Dec;117(12):2274-2282. doi: 10.1160/TH17-01-0059. Epub 2017 Dec 6.
Impact factor: 5.627
Publication type: Paper in international publication
Authors: Escuriola-Ettingshausen, Carmen, Mancuso, Maria Elisa, Fischer, Kathelijn, Santagostino, Elena, Oldenburg, Johannes, Platokouki, Helen, Konigs, Cristoph, Carcao, Manuel, Ljung, Rolf, Petrini, Pia et al.
DOI: 10.1160/TH17-01-0059

Advanced cell-based modeling of the royal disease: characterization of the mutated F9 mRNA.

PMID: 28834196
Journal: JOURNAL OF THROMBOSIS AND HAEMOSTASIS
Year: 2017
Reference: J Thromb Haemost. 2017 Nov;15(11):2188-2197. doi: 10.1111/jth.13808. Epub 2017 Sep 25.
Impact factor: 5.287
Publication type: Paper in international publication
Authors: Martorell, L, Luce, E, Vazquez, J L, Richaud-Patin, Y, Jimenez-Delgado, S, Corrales, I, Borras, N, Casacuberta-Serra, S, Weber, A, Parra, R et al.
DOI: 10.1111/jth.13808

Final results of a phase I-II trial using ex vivo expanded autologous Mesenchymal Stromal Cells for the treatment of osteoarthritis of the knee confirming safety and suggesting cartilage regeneration.

PMID: 26783191
Journal: KNEE
Year: 2016
Reference: Knee. 2016 Aug;23(4):647-54. doi: 10.1016/j.knee.2015.08.013. Epub 2016 Jan 11.
Impact factor:
Publication type: Paper in international publication
Authors: Codinach, Margarita; Coll, Ruth; Garcia-Lopez, Joan; Huguet, Marina; Lopez, Ramon; Munar, Ana; Orozco, Lluis; Soler, Robert; Vives, Joaquim et al.
DOI: 10.1016/j.knee.2015.08.013

The nuclear receptor NOR-1 regulates the small muscle protein, X-linked (SMPX) and myotube differentiation.

PMID: 27181368
Journal: Scientific Reports
Year: 2016
Reference: Sci Rep. 2016 May 16;6:25944. doi: 10.1038/srep25944.
Impact factor:
Publication type: Paper in international publication
Authors: Aguilo, Silvia; Alonso, Judith; Ferran, Beatriz; Marti-Pamies, Ingrid; Martinez-Gonzalez, Jose; Rodriguez, Cristina; Rodriguez-Calvo, Ricardo; Vidal, Francisco et al.
DOI: 10.1038/srep25944

Spanish consensus guidelines on prophylaxis with bypassing agents for surgery in patients with haemophilia and inhibitors.

PMID: 26714021
Journal: EUROPEAN JOURNAL OF HAEMATOLOGY
Year: 2016
Reference: Eur J Haematol. 2016 May;96(5):461-74. doi: 10.1111/ejh.12730. Epub 2016 Feb 4.
Impact factor: 2.544
Publication type: Review in international publication
Authors: Mingot-Castellano, Maria Eva, Alvarez-Roman, Maria Teresa, Lopez-Fernandez, Maria Fernanda, Altisent-Roca, Carmen, Canaro-Hirnyk, Mariana Isabel, Jimenez-Yuste, Victor, Cid-Haro, Ana Rosa, Perez-Garrido, Rosario, Sedano-Balbas, Carmen et al.
DOI: 10.1111/ejh.12730

Long-acting recombinant coagulation factor IX albumin fusion protein (rIX-FP) in hemophilia B: results of a phase 3 trial.

PMID: 26755710
Journal: BLOOD
Year: 2016
Reference: Blood. 2016 Apr 7;127(14):1761-9. doi: 10.1182/blood-2015-09-669234. Epub 2016 Jan 11.
Impact factor: 11.841
Publication type: Paper in international publication
Authors: Santagostino, Elena, Martinowitz, Uri, Lissitchkov, Toshko, Pan-Petesch, Brigitte, Hanabusa, Hideji, Oldenburg, Johannes, Boggio, Lisa, Negrier, Claude, Pabinger, Ingrid, von Depka Prondzinski, Mario et al.
DOI: 10.1182/blood-2015-09-669234

miR-146a targets Fos expression in human cardiac cells.

PMID: 26112171
Journal: Disease Models & Mechanisms
Year: 2015
Reference: Dis Model Mech. 2015 Sep;8(9):1081-91. doi: 10.1242/dmm.020768. Epub 2015 Jun 25.
Impact factor:
Publication type: Paper in international publication
Authors: Barroso, Emma; Botteri, Gaia; Capdevila-Busquets, Eva; Chan, Tung O; Davidson, Mercy M; Feldman, Arthur M; Martinez-Gonzalez, Jose; Palomer, Xavier; Rodriguez, Cristina; Vazquez-Carrera, Manuel et al.
DOI: 10.1242/dmm.020768

Adherence to prophylaxis and quality of life in children and adolescents with severe haemophilia A.

PMID: 25649244
Journal: HAEMOPHILIA
Year: 2015
Reference: Haemophilia. 2015 Jul;21(4):458-64. doi: 10.1111/hae.12618. Epub 2015 Feb 4.
Impact factor: 2.603
Publication type: Paper in international publication
Authors: Garcia-Dasi, M, Aznar, J A, Jimenez-Yuste, V, Altisent, C, Bonanad, S, Mingot, E, Lucia, F, Gimenez, F, Lopez, M Fernanda, Marco, P et al.
DOI: 10.1111/hae.12618

Bleeding before prophylaxis in severe hemophilia: paradigm shift over two decades.

PMID: 25527565
Journal: HAEMATOLOGICA
Year: 2015
Reference: Haematologica. 2015 Mar;100(3):e84-6. doi: 10.3324/haematol.2014.115709. Epub 2014 Dec 19.
Impact factor: 5.814
Publication type: Letter whit IF
Authors: Nijdam, Annelies, Altisent, Carmen, Carcao, Manuel D, Cid, Ana R, Claeyssens-Donadel, Segolene, Kurnik, Karin, Ljung, Rolf, Nolan, Beatrice, Petrini, Pia, Platokouki, Helen et al.
DOI: 10.3324/haematol.2014.115709

Similar bleeding phenotype in young children with haemophilia A or B: a cohort study.

PMID: 24893572
Journal: HAEMOPHILIA
Year: 2014
Reference: Haemophilia. 2014 Nov;20(6):747-55. doi: 10.1111/hae.12470. Epub 2014 Jun 3.
Impact factor: 2.468
Publication type: Paper in international publication
Authors: Chalmers, E, Clausen, N, Petrini, P, Claeyssens-Donadel, S, Gouw, S C, Liesner, R, Altisent, C, Auerswald, G, Carcao, M, Cid, A et al.
DOI: 10.1111/hae.12470

Proteomic analysis of platelet N-glycoproteins in PMM2-CDG patients.

PMID: 24388574
Journal: THROMB RES
Year: 2014
Reference: Thromb Res. 2014 Mar;133(3):412-7. doi: 10.1016/j.thromres.2013.12.024. Epub 2013 Dec 21.
Impact factor: 2.427
Publication type: Paper in international publication
Authors: Sevivas, T, Vicente, V, Jaeken, J, Freson, K, Corral, J, Altisent, C, Perez-Duenas, B, Rivera, J, Lozano, M L, de la Morena-Barrio, M E et al.
DOI: 10.1016/j.thromres.2013.12.024

Intensity of factor VIII treatment and inhibitor development in children with severe hemophilia A: the RODIN study.

PMID: 23553768
Journal: BLOOD
Year: 2013
Reference: Blood. 2013 May 16;121(20):4046-55. doi: 10.1182/blood-2012-09-457036. Epub 2013 Apr 3.
Impact factor: 9.06
Publication type: Paper in international publication
Authors: Chambost, Herve, Kurnik, Karin, Liesner, Ri, Petrini, Pia, Platokouki, Helen, Altisent, Carmen, Oldenburg, Johannes, Nolan, Beatrice, Garrido, Rosario Perez, Mancuso, M Elisa et al.
DOI: 10.1182/blood-2012-09-457036

GPI-anchor and GPI-anchored protein expression in PMM2-CDG patients.

PMID: 24139637
Journal: Orphanet Journal of Rare Diseases
Year: 2013
Reference: Orphanet J Rare Dis. 2013 Oct 20;8:170. doi: 10.1186/1750-1172-8-170.
Impact factor: 4.315
Publication type: Paper in international publication
Authors: de la Morena-Barrio, Maria E, Hernandez-Caselles, Trinidad, Corral, Javier, Garcia-Lopez, Roberto, Martinez-Martinez, Irene, Perez-Duenas, Belen, Altisent, Carmen, Sevivas, Teresa, Kristensen, Soren R, Guillen-Navarro, Encarna et al.
DOI: 10.1186/1750-1172-8-170

High-throughput molecular diagnosis of von Willebrand disease by next generation sequencing methods.

PMID: 22315491
Journal: Haematologica-The Hematology Journal
Year: 2012
Reference: Haematologica. 2012 Jul;97(7):1003-7. doi: 10.3324/haematol.2011.055285. Epub 2012 Feb 7.
Impact factor: 6.424
Publication type: Paper in international publication
Authors: Corrales, Irene, Catarino, Susana, Ayats, Julia, Arteta, David, Altisent, Carmen, Parra, Rafael, Vidal, Francisco et al.
DOI: 10.3324/haematol.2011.055285

Acquired haemophilia A. First line treatment with calcineurin inhibitors and steroid pulses: a 10-year follow-up study.

PMID: 22429259
Journal: HAEMOPHILIA
Year: 2012
Reference: Haemophilia. 2012 Sep;18(5):789-93. doi: 10.1111/j.1365-2516.2012.02772.x. Epub 2012 Mar 19.
Impact factor: 2.597
Publication type: Paper in international publication
Authors: , , , , et al.
DOI: 10.1111/j.1365-2516.2012.02772.x

The optimal mode of delivery for the haemophilia carrier expecting an affected infant: further considerations.

PMID: 21371199
Journal: HAEMOPHILIA
Year: 2011
Reference: Haemophilia. 2011 Sep;17(5):818-9. doi: 10.1111/j.1365-2516.2011.02505.x. Epub 2011 Mar 4.
Impact factor: 2.364
Publication type: Letter or abstract
Authors: , , , , et al.
DOI: 10.1111/j.1365-2516.2011.02505.x

The study of the effect of splicing mutations in von Willebrand factor using RNA isolated from patients' platelets and leukocytes.

PMID: 21251206
Journal: JOURNAL OF THROMBOSIS AND HAEMOSTASIS
Year: 2011
Reference: J Thromb Haemost. 2011 Apr;9(4):679-88. doi: 10.1111/j.1538-7836.2011.04204.x.
Impact factor: 5.439
Publication type: Paper in international publication
Authors: , , , , et al.
DOI: 10.1111/j.1538-7836.2011.04204.x

The 'royal disease' mutation in a Spanish patient.

PMID: 20626617
Journal: JOURNAL OF THROMBOSIS AND HAEMOSTASIS
Year: 2010
Reference: J Thromb Haemost. 2010 Oct;8(10):2316-7. doi: 10.1111/j.1538-7836.2010.03977.x.
Impact factor: 6.069
Publication type: Letter or abstract
Authors: Ramirez, L, Altisent, C, Parra, R, Vidal, F et al.
DOI: 10.1111/j.1538-7836.2010.03977.x

Integration of molecular and clinical data of 40 unrelated VWD families in a Spanish locus-specific mutation database. First release including 58 mutations.

PMID: 20801902
Journal: Haematologica-The Hematology Journal
Year: 2010
Reference: Haematologica. 2010 Nov;95(11):1982-4. Epub 2010 Aug 26.
Impact factor: 6.416
Publication type: Letter or abstract
Authors: , , , , , et al.
DOI: 10.3324/haematol.2010.028977

Rapid molecular diagnosis of von Willebrand disease by direct sequencing. Detection of 12 novel putative mutations in VWF gene.

PMID: 19277422
Journal: THROMBOSIS AND HAEMOSTASIS
Year: 2009
Reference: Thromb Haemost. 2009 Mar;101(3):570-6.
Impact factor: 3.803
Publication type: Paper in international publication
Authors: Corrales, Irene, Ramirez, Lorena, Altisent, Carme, Parra, Rafael, Vidal, Francisco et al.
DOI:

Thesis

Umbilical cord blood platelet rich plasma derivatives for therapeutic applications and development of clinical trials fr treatment of skin and ocular ulcers

PhD student: Dinara Samarkanova , Dinara Samarkanova
Director/s: Sergi Querol Giner
University: Universidad Autònoma de Barcelona
Year: 2020

TGF-B1 y otras moléculas como biomarcadores de consolidación ósea en pseudoartrosis hipertrófica de huesos largos

PhD student: Daniel Chaverri Fierro, Daniel Chaverri Fierro
Director/s: Juan Minguell Moñart, Joaquim Vives Armengol
University: Universidad Autònoma de Barcelona
Year: 2019

TGF-B1 y otras moléculas como biomarcadores de consolidación ósea en pseudoartrosis hipertrófica de huesos largos

PhD student: Daniel Chaverri Fierro, Daniel Chaverri Fierro
Director/s: Juan Minguell Moñart, Joaquim Vives Armengol
University: Universidad Autònoma de Barcelona
Year: 2019

Cinética y factores predictivos de estudio de la cinética de la reconstitución inmune y sus factores predictivos en el trasplante de sangre de cordón umbilical

PhD student: Nerea Castillo Flores, Nerea Castillo Flores
Director/s: Sergi Querol Giner
University: Universidad Autònoma de Barcelona
Year: 2017

Reparació prenatal del mielomeningocele mitjançant cèl·lules mesenquimals estromals de líquid amniòtic en model oví

PhD student: Margarita Codinach Creus
Director/s: César Galo García Fontecha, Joaquim Vives Armengol
University: Universidad Autònoma de Barcelona
Year: 2015

Búsqueda de Biomarcadores asociados a la conversión a esclerosis múltiple en pacientes con síndromes clínicos aislados

PhD student: Ester Canto Puig
Director/s: Manuel Comabella Lopez, Xavier Montalban Gairín
University: Universidad Autònoma de Barcelona
Year: 2014

Aplicació de tecnologies optimitzades al diagnòstic molecular de la malaltia de von Willebrand per l’estudi de la relació genotip-fenotip

PhD student: Irene Corrales Insa
Director/s: Francisco Vidal Pérez
University: Universitat de Barcelona
Year: 2011

Caracteritzación de la glicoproteína CD8 mutante responsable de la Deficiencia Familiar de CD8. Estudios de otras inmunodeficiencias que afectan a la función de los linfocitos T citotóxicos

PhD student: Cecilia González Santesteban, Cecilia González Santesteban
Director/s:
University: Universidad Autònoma de Barcelona
Year: 2009

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