About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The main objectives are to improve the diagnosis of immunodeficiencies and autoimmune diseases, addressing also their heterogeneity and mechanisms in close collaboration with the pediatrics, thyroid and systemic disease groups, being internationally recognized in both areas. The group participates in numerous research projects at the Vall d'Hebron Barcelona Hospital Campus that use immunological tests developed for specific projects led by the kidney transplantation, intensive care medicine, internal medicine, allergy and rheumatology groups. During the COVID pandemic the group made contributions in improving the immunogenetic and immunological risk profiles and in the evaluation of the immune response to vaccination and natural infection, collaborating with national and international networks. The group has also generated a biobank of more than 8.000 samples from patients with COVID-19 that have been incorporated into the VHIR biobank.
The group works as a coordinator of the "Focis" Center of Excellence (Federation of Clinical Immunology Societies) of Barcelona.
IP: Antoni Soriano Arandes Collaborators: Jorgina Vila Soler, Joan Balcells Ramirez, Núria Worner Tomasa, Clara Franco Jarava, Cristina Andrés Vergés Funding agency: Fundació La Marató de TV3 Funding: 161075 Reference: 202134 Duration: 23/09/2021 - 22/09/2024
IP: Juan Jose Gonzalez Lopez Collaborators: Manuel Hernández González, Jose Angel Rodrigo Pendás, Aina Aguiló Cucurull, Alba Mir Cros, Albert Moreno Mingorance, Andrea Martín Nalda, Nuria Serre Delcor, Josep Roca Grande, Laura Batlle Masó Funding agency: Instituto de Salud Carlos III Funding: 123420 Reference: PI21/00132 Duration: 01/01/2022 - 31/12/2024
IP: Marta Miarons Font Collaborators: Javier Varela Gonzalez-aller, Gloria Inés Iacoboni García-Calvo, Maria Queralt Gorgas Torner, Lucas Rivera Sánchez, Anna Maria Farriols Danes, Pere Barba Suñol, Carla Alonso Martinez, Janire Perurena Prieto, Maria Josep Carreras Soler, Cecilia Carmen Carpio Segura Funding agency: Instituto de Salud Carlos III Funding: 111320 Reference: PI21/00197 Duration: 01/01/2022 - 31/12/2024
PMID: 37879817 Journal: Revista espanola de patologia Year: 2023 Reference: Rev Esp Patol. 2023 Oct-Dec;56(4):217-218. doi: 10.1016/j.patol.2023.09.001. Impact factor: Publication type: Editorial in national publication Authors: Acuna Perez, Maria Jose; Agueras, Cajal; Calavia, Olga; Colobran, Roger; Garcia Ramos, Maite; Garcia-Aznar, Jose Maria; Maneiro Pampin, Emilia; Minguell Domingo, Laura; Novoa Bolivar, Erika M; Ocejo Vinyals, Javier Gonzalo et al. DOI: 10.1016/j.patol.2023.09.001
PMID: 37879823 Journal: Revista espanola de patologia Year: 2023 Reference: Rev Esp Patol. 2023 Oct-Dec;56(4):261-270. doi: 10.1016/j.patol.2023.05.001. Epub 2023 Sep 1. Impact factor: Publication type: Paper in international publication Authors: Algaba, Ferran; Baptista, Joao Pedro; Bruggemann, Roger J; Darvall, Jai; De Waele, Jan J; Dimopoulos, George; Gonzalez-Peramato, Pilar; Hernandez-Mitre, Maria Patricia; Lefrant, Jean-Yves; Lipman, Jeffrey et al. DOI: 10.1016/j.patol.2023.05.001
PMID: 38039432 Journal: JCO Precision Oncology Year: 2023 Reference: JCO Precis Oncol. 2023 Sep;7:e2300338. doi: 10.1200/PO.23.00338. Impact factor: Publication type: Paper in international publication Authors: Aas, Turid; Aase, Hildegunn S; Alvarez-Escola, Cristina; Araujo-Castro, Marta; Aulinas, Anna; Bernabeu, Ignacio; Biagetti, Betina; Blanco, Concepcion; Blix, Egil S; Calatayud, Maria et al. DOI: 10.1200/PO.23.00338
PMID: 38057242 Journal: Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia H Year: 2023 Reference: Farm Hosp. 2023 Dec 5:S1130-6343(23)00890-5. doi: 10.1016/j.farma.2023.09.009. Impact factor: Publication type: Paper in international publication Authors: Climente, Monica; Escolano, Angel; Manrique-Rodriguez, Silvia; Miarons, Marta; Parra, Alba Pau; Perurena-Prieto, Janire; Quintanilla, Laura Garcia; Ramos, Natalia et al. DOI: 10.1016/j.farma.2023.09.009
PMID: 35464398 Journal: Frontiers in Immunology Year: 2022 Reference: Front Immunol. 2022 Apr 8;13:881206. doi: 10.3389/fimmu.2022.881206. eCollection 2022. Impact factor: 7.561 Publication type: Paper in international publication Authors: Labrador-Horrillo, Moises, Franco-Jarava, Clara, Parra-Martinez, Alba, Antolin, Maria, Salgado-Perandres, Sandra, Aguilo-Cucurull, Aina, Martinez-Gallo, Monica, Colobran, Roger, Garcia-Prat, Marina et al. DOI: 10.3389/fimmu.2022.881206
PMID: 35453934 Journal: Diagnostics Year: 2022 Reference: Diagnostics (Basel). 2022 Apr 1;12(4). pii: diagnostics12040886. doi: 10.3390/diagnostics12040886. Impact factor: 3.706 Publication type: Paper in international publication Authors: Gabriel-Medina, Pablo, Diaz-Troyano, Noelia, Barquin-DelPino, Raquel, Castillo-Ribelles, Laura, Esteban, Angels, Hernandez-Gonzalez, Manuel, Ferrer-Costa, Roser, Pumarola, Tomas, Rodriguez-Frias, Francisco, Klammer, Martin et al. DOI: 10.3390/diagnostics12040886
PMID: 35460231 Journal: RHEUMATOLOGY Year: 2022 Reference: Rheumatology (Oxford). 2022 Apr 23. pii: 6572805. doi: 10.1093/rheumatology/keac252. Impact factor: 7.58 Publication type: Paper in international publication Authors: Selva-O'Callaghan, Albert, Trallero-Araguas, Ernesto, Sanz-Martinez, Maria Teresa et al. DOI: 10.1093/rheumatology/keac252
PMID: 35433311 Journal: World journal of critical care medicine Year: 2022 Reference: World J Crit Care Med. 2022 Jan 9;11(1):1-21. doi: 10.5492/wjccm.v11.i1.1. eCollection 2022 Jan 9. Impact factor: 0 Publication type: Review in international publication Authors: Ruiz-Rodriguez, Juan Carlos, Ruiz-Sanmartin, Adolfo, Perez-Carrasco, Marcos, Palmada, Clara, Ribas, Vicent, Martinez-Gallo, Monica, Hernandez-Gonzalez, Manuel, Gonzalez-Lopez, Juan J, Larrosa, Nieves, Ferrer, Ricard et al. DOI: 10.5492/wjccm.v11.i1.1
PMID: 33868243 Journal: Frontiers in Immunology Year: 2021 Reference: Front Immunol. 2021 Mar 31;12:625591. doi: 10.3389/fimmu.2021.625591. eCollection 2021. Impact factor: 7.561 Publication type: Letter whit IF Authors: Cervera, Jose Vicente, Ibanez, Mariam, Liquori, Alessandro, Franco-Jarava, Clara, Martinez-Gallo, Monica, Rodriguez-Vega, Hector, Teresa, Jaijo, Carreras, Carmen, Such, Esperanza, Zuniga, Angel et al. DOI: 10.3389/fimmu.2021.625591
PMID: 33742673 Journal: RHEUMATOLOGY Year: 2021 Reference: Rheumatology (Oxford). 2021 Dec 24;61(1):154-162. doi: 10.1093/rheumatology/keab279. Impact factor: 7.58 Publication type: Paper in international publication Authors: Bellocchi, Chiara, Callejas-Moraga, Authors' Names Eduardo Luis, Del-Castillo, Alfredo Guillen-, Perurena-Prieto, Janire, Sanz-Martinez, Maria Teresa, Fonollosa-Pla, Vicente, Lorite-Gomez, Karen, Severino, Adriana, Simeon-Aznar, Carmen P, Mahler, Michael et al. DOI: 10.1093/rheumatology/keab279
PMID: 33422078 Journal: MALARIA JOURNAL Year: 2021 Reference: Malar J. 2021 Jan 9;20(1):35. doi: 10.1186/s12936-021-03580-x. Impact factor: 2.979 Publication type: Paper in international publication Authors: Omer, Samia, Franco-Jarava, Clara, Noureldien, Ali, Omer, Mona, Abdelrahim, Mutasim, Molina, Israel, Adam, Ishag et al. DOI: 10.1186/s12936-021-03580-x
PMID: 32256498 Journal: Frontiers in Immunology Year: 2020 Reference: Front Immunol. 2020 Mar 17;11:455. doi: 10.3389/fimmu.2020.00455. eCollection 2020. Impact factor: 5.085 Publication type: Paper in international publication Authors: Truedsson, Lennart, Hara, Toshiro, Nonoyama, Shigeaki, Schwenk, Jochen M, Nilsson, Peter, Hammarstrom, Lennart, von Dobeln, Ulrika, Hernandez-Gonzalez, Manuel, Rezaei, Nima, Aghamohammadi, Asghar et al. DOI: 10.3389/fimmu.2020.00455
PMID: 32206630 Journal: Pediatric gastroenterology, hepatology & nutrition Year: 2020 Reference: Pediatr Gastroenterol Hepatol Nutr. 2020 Mar;23(2):174-179. doi: 10.5223/pghn.2020.23.2.174. Epub 2020 Mar 4. Impact factor: 0 Publication type: Letter or abstract Authors: Quintero, Jesus, Juamperez, Javier, Gonzales, Emmanuel, Julio, Ecaterina, Mercadal-Hally, Maria, Collado-Hilly, Mauricette, Marin-Sanchez, Ana, Charco, Ramon et al. DOI: 10.5223/pghn.2020.23.2.174
PMID: 32117230 Journal: Frontiers in Immunology Year: 2020 Reference: Front Immunol. 2020 Feb 12;11:46. doi: 10.3389/fimmu.2020.00046. eCollection 2020. Impact factor: 5.085 Publication type: Paper in international publication Authors: Riviere, Jacques G, Franco-Jarava, Clara, Martinez-Gallo, Monica, Aguilo-Cucurull, Aina, Blasco-Perez, Laura, Paramonov, Ida, Antolin, Maria, Martin-Nalda, Andrea, Soler-Palacin, Pere, Colobran, Roger et al. DOI: 10.3389/fimmu.2020.00046
PMID: 32076423 Journal: Frontiers in Immunology Year: 2020 Reference: Front Immunol. 2020 Jan 31;11:107. doi: 10.3389/fimmu.2020.00107. eCollection 2020. Impact factor: 5.085 Publication type: Paper in international publication Authors: Vinas-Gimenez, Laura, Padilla, Natalia, Batlle-Maso, Laura, Casals, Ferran, Riviere, Jacques G, Martinez-Gallo, Monica, de la Cruz, Xavier, Colobran, Roger et al. DOI: 10.3389/fimmu.2020.00107
PMID: 30682461 Journal: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY Year: 2019 Reference: J Allergy Clin Immunol. 2019 May;143(5):1952-1956.e6. doi: 10.1016/j.jaci.2018.12.1013. Epub 2019 Jan 22. Impact factor: 14.11 Publication type: Paper in international publication Authors: Bucciol, Giorgia, Nicholas, Sarah K, Calvo, Pier Luigi, Cant, Andrew, Edgar, J David M, Espanol, Teresa, Ferrua, Francesca, Galicchio, Miguel, Gennery, Andrew R, Hadzic, Nedim et al. DOI: 10.1016/j.jaci.2018.12.1013
PMID: 30273710 Journal: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY Year: 2019 Reference: J Allergy Clin Immunol. 2019 Jan;143(1):359-368. doi: 10.1016/j.jaci.2018.09.009. Epub 2018 Sep 29. Impact factor: 14.11 Publication type: Paper in international publication Authors: Balderrama-Rodriguez, Angelica, Ramos, Eduardo, Modesto, Consuelo, Mesa-Del-Castillo, Pablo, Ortego-Centeno, Norberto, Clemente, Daniel, Souto, Alejandro, Palmou, Natalia, Remesal, Agustin, Leslie, Kieron S et al. DOI: 10.1016/j.jaci.2018.09.009
The results show that, in some patients with mutations in the X chromosome, the healthy gene is inactivated and the mutated gene manifests itself, which favors the onset of the disease.
Researchers have used an innovative protocol to identify people with this autoimmune disease who have a higher risk of cancer.
As age increases in men, the concentration of the hormone in the blood drops and this increases the likelihood of severe progression of the infection in COVID-19 patients
