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Translational Molecular Pathology

Our group aims to unravel the molecular mechanisms of cancer progression and metastasis to identify new diagnostic, prognostic and therapeutic targets in cancer. By combining the knowledge and availability of human tumors in the Pathology department with the expertise of the basic molecular cell biology research group, we focus on:

  • Understanding: the molecular mechanisms underlying clonal cooperation and intercellular communication in heterogeneous tumors.
  • The role of MNK kinases in cellular stress resistance.
  • The role of ITGB3 in intercellular communication via extracellular vesicles in cancer metastasis (Santiago Ramon y Cajal).
  • The role of direct cell-cell communication via gap junctions and intercellular protrusions in cancer (Trond Aasen)
  • The malignant transition of Plexiform Neurofibromas (Cleofe Romagosa).

Team

Jordi Temprana Salvador

Jordi Temprana Salvador

Research technician
Translational Molecular Pathology
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Maria Rosa Somoza Lopez de Haro

Maria Rosa Somoza Lopez de Haro

Research technician
Translational Molecular Pathology
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Stefania Landolfi

Stefania Landolfi

Translational Molecular Pathology
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Luisa Sofia Silva Alcoser

Luisa Sofia Silva Alcoser

Predoctoral researcher
Translational Molecular Pathology
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Elena Muro Blanc

Elena Muro Blanc

Predoctoral researcher
Translational Molecular Pathology
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Sara Garcia Ortega

Sara Garcia Ortega

Predoctoral researcher
Translational Molecular Pathology
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Jordi Temprana Salvador

Jordi Temprana Salvador

Research technician
Translational Molecular Pathology
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Maria Rosa Somoza Lopez de Haro

Maria Rosa Somoza Lopez de Haro

Research technician
Translational Molecular Pathology
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Stefania Landolfi

Stefania Landolfi

Translational Molecular Pathology
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Luisa Sofia Silva Alcoser

Luisa Sofia Silva Alcoser

Predoctoral researcher
Translational Molecular Pathology
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Elena Muro Blanc

Elena Muro Blanc

Predoctoral researcher
Translational Molecular Pathology
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Sara Garcia Ortega

Sara Garcia Ortega

Predoctoral researcher
Translational Molecular Pathology
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Research lines

Involvement of the human Hepatitis A Viral Receptor (hHAVcr-1) in renal cancer development and progression. Value as a diagnostic and prognostic biomarker in renal carcinomas

We have postulated that hHAVcr-1 might constitute an important biomarker for early detection of ccRCC and could also be used as a target for therapy of kidney carcinomas, since immunotoxins directed against the monkey homologue of hHAVcr-1 could kill kidney cells.


Specific aims are focused to: i) determine the diagnostic and prognostic potential of hHAVcr-1 expression in renal cell carcinomas, by correlating hHAVcr-1 levels in archive, fresh surgical and TMA tissues  with tumor anatomo-pathological characteristics and patients outcome and, ii) determine the function of hHAVcr-1, which remains elusive, in development and progression of kidney carcinomas, using ccRCC derived cell lines with silenced or overexpressed hHAVcr-1. Tumors overexpressing or defective in hHAVcr-1 will be compared with controls, in relation to their behavior and anatomo-pathological characteristics. Differences are being correlated with proteomic and gene expression profiles obtained on each case. Differential expression pathways and target molecules correlating with absence/presence of hHAVcr-1 shall be identified. New strategies for diagnosis, prognosis and treatment of ccRCC must be further developed.

(Programa de Recerca en Cancer Renal CIBBIM-IRHUVH. )


IP: Inés de Torres Ramirez

Long-term mast cell stabilization downregulates mucosal microinflammation in the jejunum of diarrhea-prone irritable bowel syndrome (IBS)

Study of the effect of mast-cell stabilization on mucosal inflammation and the clinical response. Inmunohistochemistry analysis of microinflammation (mast cells, intraepithelial lymphocytes and eosinophils) in Irritable Bowel Syndome (IBS) Biological inflammation was evaluated in pooled biopsies by quantitative real time PCR to analyze the expression of preselected genes implicated in innate inmunity (Toll-like receptors (TLR) and defensins (DEF)), mast cell activation and growth and neuronal regulation.. Mucosal eosinophils show restrained activation in the yeyunum od diarrhea –prone irritable bowel sindrome patiens

Pharmacological stabilization of mucosal mast cells effectively reduces pro-inflammatory gene expression profiles in the jejunal mucosa of D-IBS patients and concomitantly improves clinical manifestations.

( Digestive Disease Research Unit)


IP: Inés de Torres Ramirez

Mechanisms of cerebral aging: role of GSK3ß/cdk5 and sirtuins.

Aging may be considered as an accumulation of changes in cells and tissues that increases the risk of disease and death. The senescence-accelerated prone mice SAMP8 is an aging model with brain histopathological signs and other aging-related disorders, such as ß-amyloid and tau protein aggregates and increased oxidative stress. If hyperphosphorylated, tau protein contributes to the development of a tauopathy, process linked to neurodegenerative diseases of the aging brain such as Alzheimer disease. Several kinases (PKC, ERK, CDK5 or GSK3ß) perform this tau protein post-transcriptional modification. We plan to determine the effect that inhibitors of these kinases such as lithium, in vivo and in vitro, could have in slowing down the brain neurodegenerative processes. Besides, we will study the role of a newly described protein family, sirtuins.


Sirtuins are ontogenically preserved proteins related to longevity. We will evaluate the gene and protein expression of Sirt 1, 2 and 3 in cultured neurons and in the brain of this mouse strain. We seek to elucidate the participation of sirtuins in cerebral ageing using as a tools resveratrol, a flavonoid described as activator of these proteins, and caloric restriction, two paradigms that lead to an elongation of lifespan and neuroprotection in several animal models. In the in vitro studies, the role of GDNF in maintaining neuronal functionality and its correlation with sirtuins will be investigated because this trophic factor decreases with aging and shows a lesser expression in SAMP8 mice. These studies will contribute to the development of new therapeutic strategies to prevent age-related neurodegeneratives diseases.

IP: -

Role of HER3 expression in carcinogenesis of endometrial and breast tumors. Search for new predictive markers to anti-HER treatments.

The cell signaling pathways downstream of epidermal growth factor receptor family members is tightly regulated in normal epithelial cells, and its alteration induce different cell processes (cell proliferation, cell growth, etc...) which triggers in cellular transformation. Within this family receptors, HER1/EGFR and HER2/neu are the best known, being subject to interest other family members like HER3. The aim of the study is establish de role of HER3 protein expression by Immunohistochemistry in endometrial and breast tumors, and establish any association with clinic-pathological parameters. Furthermore, we would like to know the implication of HER3 in the resistance mechanisms to anti-HER treatment agents.

IP: Javier Hernandez Losa

Projects

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IP: Eva Colas Ortega
Collaborators: Vicente Bebia Conesa, Carina Masferrer Ferragutcasas, Fco Javier De la Torre Fdez de Vega, Silvia Cabrera Diaz, Ana Luzarraga Aznar, Lourdes Elena Salazar Huayna
Funding agency: Instituto de Salud Carlos III
Funding: 177500
Reference: PI23/01470
Duration: 01/01/2024 - 31/12/2026

Papel de la proteína MFGE8 como potencial biomarcador y diana terapéutica en la angiopatía amiloide cerebral

IP: Maria Mar Hernandez Guillamon
Collaborators: Berta Paez Montserrat, Kerrie Adrián Campbell, Anna Bonaterra Pastra, Jessica Camacho Soriano, Olalla Pancorbo Rosal
Funding agency: Instituto de Salud Carlos III
Funding: 208750
Reference: PI23/00082
Duration: 01/01/2024 - 31/12/2026

Targeting extracelluar vesicel mediated intercellular communication as a novel approach to combat cancer metastasis.

IP: Stefan Hummer
Collaborators: Santiago Ramon y Cajal Agüeras, Elena Muro Blanc, Vicente Peg Camara, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras
Funding agency: Fundación Ramón Areces
Funding: 127486
Reference: CIVP21S13325
Duration: 06/07/2023 - 05/07/2026

INtegrative GENomic, digital Imaging and clinical information towars Precision Oncology Optimization – INGENIO

IP: Santiago Ramon y Cajal Agüeras
Collaborators: Jordi Temprana Salvador, Josep Castellví Vives, Joaquim Mateo Valderrama, Javier Hernandez Losa, Vicente Peg Camara, Irene Sansano Valero
Funding agency: Instituto de Salud Carlos III
Funding: 80400
Reference: PMP21/00107
Duration: 01/01/2022 - 31/12/2025

Publications

Nutritional status associates with immunotherapy clinical outcomes in recurrent or metastatic head and neck squamous cell carcinoma patients.

PMID: 36989964
Journal: ORAL ONCOLOGY
Year: 2023
Reference: Oral Oncol. 2023 May;140:106364. doi: 10.1016/j.oraloncology.2023.106364. Epub 2023 Mar 28.
Impact factor:
Publication type: Paper in international publication
Authors: Aguilar, Susana; Aguilar, Susana; Alberola, Margarita; Alberola, Margarita; Assaf Pastrana, Juan David; Assaf Pastrana, Juan David; Benavente, Sergi; Bescos, Coro; Brana, Irene; Dienstmann, Rodrigo et al.
DOI: 10.1016/j.oraloncology.2023.106364

Impact of the COVID-19 pandemic in the early-onset colorectal cancer.

PMID: 37031602
Journal: Translational Oncology
Year: 2023
Reference: Transl Oncol. 2023 Jun;32:101668. doi: 10.1016/j.tranon.2023.101668. Epub 2023 Apr 5.
Impact factor:
Publication type: Paper in international publication
Authors: Baraibar, Iosune; Capdevila, Jaume; Castells, Marta R; Castillo, Gloria; Comas, Raquel; Comas, Raquel; Dopazo, Cristina; Elez, Elena; Espin, Eloy; Garcia, Ariadna et al.
DOI: 10.1016/j.tranon.2023.101668

[Rapidly progressive intracranial large artery aterosclerosis, a rare stroke etiology].

PMID: 37046396
Journal: REVISTA DE NEUROLOGIA
Year: 2023
Reference: Rev Neurol. 2023 Apr 16;76(8):273-275. doi: 10.33588/rn.7608.2022328.
Impact factor:
Publication type: Letter or abstract
Authors: Anton-Jimenez, A; Martinez-Saez, E; Rovira, A; Sarria-Estrada, S; Tortajada-Bustelo, J C et al.
DOI: 10.33588/rn.7608.2022328

Hybrid neurofibroma/schwannoma of the orbit.

PMID: 37061243
Journal: Revista espanola de patologia
Year: 2023
Reference: Rev Esp Patol. 2023 Apr-Jun;56(2):140-143. doi: 10.1016/j.patol.2022.03.002. Epub 2022 Jun 15.
Impact factor:
Publication type: Letter or abstract
Authors: Arcediano, Miguel Angel; Dinares, Carme; Dinares, Carme; Naranjo, Lourdes; Ramon Y Cajal, Santiago; Ramon Y Cajal, Santiago; Romagosa, Cleofe; Romagosa, Cleofe; Salazar-Huayna, Lourdes; Siurana, Sahyly et al.
DOI: 10.1016/j.patol.2022.03.002

Variant t(11;22)(q13;q11.2) with IGL involvement in mantle cell lymphoma.

PMID: 35129412
Journal: LEUKEMIA & LYMPHOMA
Year: 2022
Reference: Leuk Lymphoma. 2022 Jul;63(7):1746-1749. doi: 10.1080/10428194.2022.2034158. Epub 2022 Feb 7.
Impact factor: 3.28
Publication type: Letter or abstract
Authors: Cabirta, Alba; Hidalgo-Gomez, Gloria; Marin-Niebla, Ana; Gallur, Laura; Saumell, Silvia; Castellvi, Josep; Blanco, Adoracion; Lopez-Andreoni, Laura; Montoro, Maria Julia; Navarrete, Mayda et al.
DOI: 10.1080/10428194.2022.2034158

Is Tumor Budding a New Predictor for Early Cystectomy in pT1 High-Grade Bladder Cancer?

PMID: 34352790
Journal: UROLOGIA INTERNATIONALIS
Year: 2022
Reference: Urol Int. 2022;106(2):154-162. doi: 10.1159/000517543. Epub 2021 Aug 5.
Impact factor: 2.089
Publication type: Paper in international publication
Authors: Raventos Busquets, Carles X; Semidey, M Eugenia; Lozano Palacio, Fernando; Carrion Puig, Albert; Aula Olivar, Ana; De Torres Ramirez, Ines M; Trilla Herrera, Enrique et al.
DOI: 10.1159/000517543

Placental Tissue Destruction and Insufficiency from COVID-19 Causes Stillbirth and Neonatal Death from Hypoxic-Ischemic Injury: A Study of 68 Cases with SARS-CoV-2 Placentitis from 12 Countries.

PMID: 35142798
Journal: ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
Year: 2022
Reference: Arch Pathol Lab Med. 2022 Jun 1;146(6):660-676. doi: 10.5858/arpa.2022-0029-SA.
Impact factor: 5.534
Publication type: Paper in international publication
Authors: Schwartz, David A; Avvad-Portari, Elyzabeth; Babal, Pavel; Baldewijns, Marcella; Blomberg, Marie; Bouachba, Amine; Saad, Ali G; Sand, Anna; Schoenmakers, Sam; Sehn, Jennifer K et al.
DOI: 10.5858/arpa.2022-0029-SA

Mesenchymal Stem Cells Delivery in Individuals with Different Pathologies: Multimodal Tracking, Safety and Future Applications.

PMID: 35163605
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2022
Reference: Int J Mol Sci. 2022 Jan 31;23(3). pii: ijms23031682. doi: 10.3390/ijms23031682.
Impact factor: 5.924
Publication type: Paper in international publication
Authors: Vassaux, Georges; Medel-Martinez, Ana; Burnet, Jerome; Quintanilla, Miguel; Ramon Y Cajal, Santiago; Hernandez-Losa, Javier; De la Vieja, Antonio; Martin-Duque, Pilar; Belmar-Lopez, Carolina et al.
DOI: 10.3390/ijms23031682

Evolution of the Early Spliceosomal Complex-From Constitutive to Regulated Splicing.

PMID: 34830325
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2021
Reference: Int J Mol Sci. 2021 Nov 18;22(22). pii: ijms222212444. doi: 10.3390/ijms222212444.
Impact factor: 5.924
Publication type: Review in international publication
Authors: Ayte, Jose, Hummer, Stefan, Borao, Sonia et al.
DOI: 10.3390/ijms222212444

Targeting Sphingolipids for Cancer Therapy.

PMID: 34737957
Journal: Frontiers in Oncology
Year: 2021
Reference: Front Oncol. 2021 Oct 19;11:745092. doi: 10.3389/fonc.2021.745092. eCollection 2021.
Impact factor: 6.244
Publication type: Review in international publication
Authors: Companioni, Osmel, Mir, Cristina, Garcia-Mayea, Yoelsis, LLeonart, Matilde E et al.
DOI: 10.3389/fonc.2021.745092

Case Report: A Case Study Documenting the Activity of Atezolizumab in a PD-L1-Negative Triple-Negative Breast Cancer.

PMID: 34616675
Journal: Frontiers in Oncology
Year: 2021
Reference: Front Oncol. 2021 Sep 20;11:710596. doi: 10.3389/fonc.2021.710596. eCollection 2021.
Impact factor: 6.244
Publication type: Letter whit IF
Authors: Sanso, Miriam, Chic, Nuria, Martinez, Debora, Gonzalez-Farre, Blanca, Sanfeliu, Esther, Ghiglione, Lucio, Carcelero, Esther, Garcia-Corbacho, Javier, Sanchez, Marcelo, Soy, Dolors et al.
DOI: 10.3389/fonc.2021.710596

Genetic evolution to tyrosine kinase inhibitory therapy in patients with EGFR-mutated non-small-cell lung cancer.

PMID: 34599295
Journal: BRITISH JOURNAL OF CANCER
Year: 2021
Reference: Br J Cancer. 2021 Nov;125(11):1561-1569. doi: 10.1038/s41416-021-01558-9. Epub 2021 Oct 1.
Impact factor: 7.64
Publication type: Paper in international publication
Authors: Martinez-Marti, Alex, Felip, Enriqueta, Mancuso, Francesco Mattia, Caratu, Ginevra, Matito, Judit, Nuciforo, Paolo, Sansano, Irene, Diaz-Mejia, Nely, Cedres, Susana, Callejo, Ana et al.
DOI: 10.1038/s41416-021-01558-9

Circulating tumour DNA from the cerebrospinal fluid allows the characterisation and monitoring of medulloblastoma.

PMID: 33110059
Journal: Nature Communications
Year: 2020
Reference: Nat Commun. 2020 Oct 27;11(1):5376. doi: 10.1038/s41467-020-19175-0.
Impact factor: 12.121
Publication type: Paper in international publication
Authors: Gros, Luis, Ramon Y Cajal, Santiago, Poca, Maria A, Puente, Xose S, Sahuquillo, Juan, Gallego, Soledad, Seoane, Joan, Hladun, Raquel, Lesende-Rodriguez, Ivan, Vazquez-Mendez, Elida et al.
DOI: 10.1038/s41467-020-19175-0

External validation of putative biomarkers in eutopic endometrium of women with endometriosis using NanoString technology.

PMID: 33033989
Journal: JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
Year: 2020
Reference: J Assist Reprod Genet. 2020 Dec;37(12):2981-2987. doi: 10.1007/s10815-020-01965-6. Epub 2020 Oct 9.
Impact factor: 2.829
Publication type: Paper in international publication
Authors: Vallve-Juanico, Julia, Lopez-Gil, Carlos, Ponomarenko, Julia, Melnychuk, Taisiia, Castellvi, Josep, Ballesteros, Agustin, Colas, Eva, Santamaria Costa, Xavier, Gil-Moreno, Antonio et al.
DOI: 10.1007/s10815-020-01965-6

Cx43 and Associated Cell Signaling Pathways Regulate Tunneling Nanotubes in Breast Cancer Cells.

PMID: 33003486
Journal: Cancers
Year: 2020
Reference: Cancers (Basel). 2020 Sep 29;12(10). pii: cancers12102798. doi: 10.3390/cancers12102798.
Impact factor: 6.126
Publication type: Paper in international publication
Authors: Aasen, Trond, Ramon Y Cajal, Santiago, Girao, Henrique, Pearce, Christopher, Tishchenko, Alexander, Azorin, Daniel D, Vidal-Brime, Laia, Munoz, Maria Jose, Arenas, Pol Jimenez et al.
DOI: 10.3390/cancers12102798

Publisher Correction: ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells.

PMID: 32934237
Journal: Nature Communications
Year: 2020
Reference: Nat Commun. 2020 Sep 15;11(1):4730. doi: 10.1038/s41467-020-18674-4.
Impact factor: 12.121
Publication type: Letter or abstract
Authors: Fuentes, Pedro, Sese, Marta, Guijarro, Pedro J, Emperador, Marta, Sanchez-Redondo, Sara, Peinado, Hector, Hummer, Stefan, Cajal, Santiago Ramon Y et al.
DOI: 10.1038/s41467-020-18674-4

Significant Improvement in Diagnosis of Hepatitis C Virus Infection by One Step Strategy in a Central Laboratory: An Optimal Tool for Hepatitis C Elimination?

PMID: 31694971
Journal: JOURNAL OF CLINICAL MICROBIOLOGY
Year: 2019
Reference: J Clin Microbiol. 2019 Dec 23;58(1). pii: JCM.01815-19. doi: 10.1128/JCM.01815-19. Print 2019 Dec 23.
Impact factor: 4.959
Publication type: Paper in international publication
Authors: Quer, Josep, Casis-Saez, Ernesto, Rodriguez-Frias, Francisco, Esteban-Mur, Rafael, Buti-Ferret, Maria, Ferrer-Costa, Roser, Lopez-Martinez, Rosa, Arias-Garcia, Andrea, Rodriguez-Algarra, Francisco, Castellote-Belles, Laura et al.
DOI: 10.1128/JCM.01815-19

Resident memory T cells are a cellular reservoir for HIV in the cervical mucosa.

PMID: 31628331
Journal: Nature Communications
Year: 2019
Reference: Nat Commun. 2019 Oct 18;10(1):4739. doi: 10.1038/s41467-019-12732-2.
Impact factor: 11.878
Publication type: Paper in international publication
Authors: Sanhueza, Tamara, Tapia, Gustavo, Lloveras, Belen, Fernandez, Marco A, Prado, Julia G, Sole-Sedeno, Josep M, Tarrats, Antoni, Lecumberri, Carla, Manalich-Barrachina, Laura, Centeno-Mediavilla, Cristina et al.
DOI: 10.1038/s41467-019-12732-2

Characterization of Kelch domain-containing protein 7B in breast tumours and breast cancer cell lines.

PMID: 31452764
Journal: Oncology Letters
Year: 2019
Reference: Oncol Lett. 2019 Sep;18(3):2853-2860. doi: 10.3892/ol.2019.10672. Epub 2019 Jul 26.
Impact factor: 1.871
Publication type: Paper in international publication
Authors: Martin-Pardillos, Ana, Cajal, Santiago Ramon Y et al.
DOI: 10.3892/ol.2019.10672

Expression of CD20 after viral reactivation renders HIV-reservoir cells susceptible to Rituximab.

PMID: 31420544
Journal: Nature Communications
Year: 2019
Reference: Nat Commun. 2019 Aug 16;10(1):3705. doi: 10.1038/s41467-019-11556-4.
Impact factor: 11.878
Publication type: Paper in international publication
Authors: Ribera, Esteban, Raventos, Berta, Willekens, Rein, Torrella, Ariadna, Planas, Bibiana, Badia, Rosa, Garcia, Felipe, Castellvi, Josep, Genesca, Meritxell, Falco, Vicenc et al.
DOI: 10.1038/s41467-019-11556-4

The umbilical cord, preeclampsia and the VEGF family.

PMID: 30568515
Journal: International journal of women's health
Year: 2018
Reference: Int J Womens Health. 2018 Nov 28;10:783-795. doi: 10.2147/IJWH.S174734. eCollection 2018.
Impact factor: 0
Publication type: Paper in international publication
Authors: Olaya-C, Mercedes, Garrido, Marta, Hernandez-Losa, Javier, Sese, Marta, Ayala-Ramirez, Paola, Somoza, Rosa, Vargas, Magda Jimena, Cajal, Santiago Ramon Y et al.
DOI: 10.2147/IJWH.S174734

Lgr5 Does Not Vary Throughout the Menstrual Cycle in Endometriotic Human Eutopic Endometrium.

PMID: 30577586
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2018
Reference: Int J Mol Sci. 2018 Dec 21;20(1). pii: ijms20010022. doi: 10.3390/ijms20010022.
Impact factor: 3.687
Publication type: Paper in international publication
Authors: Gil-Moreno, Antonio, Vallve-Juanico, Julia, Baron, Cristian, Suarez-Salvador, Elena, Castellvi, Josep, Ballesteros, Agustin, Santamaria, Xavier et al.
DOI: 10.3390/ijms20010022

Otologic, audiometric and speech findings in patients undergoing surgery for cleft palate.

PMID: 30409226
Journal: BMC Pediatrics
Year: 2018
Reference: BMC Pediatr. 2018 Nov 8;18(1):350. doi: 10.1186/s12887-018-1312-7.
Impact factor: 2.042
Publication type: Paper in international publication
Authors: Lorente, Juan, LLeonart, Matilde E, Rochera-Villach, Maria Isabel, Ortiz, Nuria, Garcia-Vaquero, Cristina, Mir, Cristina, Graterol, Domingo et al.
DOI: 10.1186/s12887-018-1312-7

A RAD51 assay feasible in routine tumor samples calls PARP inhibitor response beyond BRCA mutation.

PMID: 30377213
Journal: EMBO Molecular Medicine
Year: 2018
Reference: EMBO Mol Med. 2018 Dec;10(12). pii: emmm.201809172. doi: 10.15252/emmm.201809172.
Impact factor: 10.293
Publication type: Paper in international publication
Authors: Vidal, Marc, Peg, Vicente, Serres-Creixams, Xavier, Dellaire, Graham, Simard, Jacques, Nuciforo, Paolo, Rubio, Isabel T, Dientsmann, Rodrigo, Barrett, J Carl, Caldas, Carlos et al.
DOI: 10.15252/emmm.201809172

Hypoxia-mediated translational activation of ITGB3 in breast cancer cells enhances TGF-beta signaling and malignant features in vitro and in vivo.

PMID: 29383126
Journal: Oncotarget
Year: 2017
Reference: Oncotarget. 2017 Dec 12;8(70):114856-114876. doi: 10.18632/oncotarget.23145. eCollection 2017 Dec 29.
Impact factor: 5.168
Publication type: Paper in international publication
Authors: Esteve-Codina, Anna, Bejar, Eva, McGrail, Kimberley, Thomas, George, Aasen, Trond, Ramon Y Cajal, Santiago, Fuentes, Pedro, Sese, Marta et al.
DOI: 10.18632/oncotarget.23145

Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer.

PMID: 29170280
Journal: SCIENCE
Year: 2017
Reference: Science. 2017 Dec 15;358(6369):1443-1448. doi: 10.1126/science.aal5240. Epub 2017 Nov 23.
Impact factor: 37.205
Publication type: Paper in international publication
Authors: Hahn, William C, Cai, Diana, Neuberg, Donna, Huang, Katherine, Guevara, Fatima, Nelson, Timothy, Chipashvili, Otari, Hagan, Timothy, Walker, Mark, Ramachandran, Aruna et al.
DOI: 10.1126/science.aal5240

miR-99a reveals two novel oncogenic proteins E2F2 and EMR2 and represses stemness in lung cancer.

PMID: 29072692
Journal: Cell Death & Disease
Year: 2017
Reference: Cell Death Dis. 2017 Oct 26;8(10):e3141. doi: 10.1038/cddis.2017.544.
Impact factor: 5.965
Publication type: Paper in international publication
Authors: Mir, Cristina, Feliciano, Andrea, Garcia-Mayea, Yoelsis, Jubierre, Luz, Hernandez-Losa, Javier, Paciucci, Rosanna, Sansano, Irene, Sun, Yilin, Cajal, Santiago Ramon Y, Kondon, Hiroshi et al.
DOI: 10.1038/cddis.2017.544

Cancer as an ecomolecular disease and a neoplastic consortium.

PMID: 28947238
Journal: BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
Year: 2017
Reference: Biochim Biophys Acta. 2017 Dec;1868(2):484-499. doi: 10.1016/j.bbcan.2017.09.004. Epub 2017 Sep 23.
Impact factor: 9.452
Publication type: Review in international publication
Authors: Ramon Y Cajal, Santiago, Capdevila, Claudia, Hernandez-Losa, Javier, de Mattos, Leticia, Ghosh, Abhishek, Lorent, Julie, Larsson, Ola, Aasen, Trond, Postovit, Lynne-Marie, Topisirovic, Ivan et al.
DOI: 10.1016/j.bbcan.2017.09.004

High HER2 protein levels correlate with increased survival in breast cancer patients treated with anti-HER2 therapy.

PMID: 26422389
Journal: Molecular Oncology
Year: 2016
Reference: Mol Oncol. 2016 Jan;10(1):138-147. doi: 10.1016/j.molonc.2015.09.002. Epub 2015 Sep 15.
Impact factor: 5.331
Publication type: Paper in international publication
Authors: Burrows, Jon, Nuciforo, Paolo, Thyparambil, Sheeno, Aura, Claudia, Garrido-Castro, Ana, Vilaro, Marta, Peg, Vicente, Jimenez, Jose, Vicario, Rocio, Cecchi, Fabiola et al.
DOI: 10.1016/j.molonc.2015.09.002

RAS/MAPK pathway hyperactivation determines poor prognosis in undifferentiated pleomorphic sarcomas.

PMID: 26479291
Journal: CANCER
Year: 2016
Reference: Cancer. 2016 Jan 1;122(1):99-107. doi: 10.1002/cncr.29733. Epub 2015 Oct 19.
Impact factor: 5.649
Publication type: Paper in international publication
Authors: Simonetti, Sara, Serrano, Cesar, Romagosa, Cleofe, Hernandez-Losa, Javier, Somoza, Rosa, Perez, Manuel, Velez, Roberto, Verges, Ramona, Dominguez, Rosa, Carles, Joan et al.
DOI: 10.1002/cncr.29733

Prediction of Response to Neoadjuvant Chemotherapy Using Core Needle Biopsy Samples with the Prosigna Assay.

PMID: 26152740
Journal: CLINICAL CANCER RESEARCH
Year: 2016
Reference: Clin Cancer Res. 2016 Feb 1;22(3):560-6. doi: 10.1158/1078-0432.CCR-15-0630. Epub 2015 Jul 7.
Impact factor: 8.738
Publication type: Paper in international publication
Authors: Schaper, Carl, Vidal, Maria, Alvarez, Martina, Diaz, Sherley, Ellis, Catherine, Nuciforo, Paolo, Ferree, Sean, Ribelles, Nuria, Adamo, Barbara, Ramon Y Cajal, Santiago et al.
DOI: 10.1158/1078-0432.CCR-15-0630

Immunohistochemical Expression of Estrogen Receptor-alpha and Progesterone Receptor in Patients with Papillary Thyroid Cancer.

PMID: 28101486
Journal: European thyroid journal
Year: 2016
Reference: Eur Thyroid J. 2016 Dec;5(4):224-230. doi: 10.1159/000452488. Epub 2016 Nov 24.
Impact factor: 0
Publication type: Paper in international publication
Authors: Sturniolo, Giacomo, Zafon, Carles, Moleti, Mariacarla, Castellvi, Josep, Vermiglio, Francesco, Mesa, Jordi et al.
DOI: 10.1159/000452488

Long-term follow-up of dose-adjusted EPOCH plus rituximab (DA-EPOCH-R) in untreated patients with poor prognosis large B-cell lymphoma. A phase II study conducted by the Spanish PETHEMA Group.

PMID: 25521006
Journal: BRITISH JOURNAL OF HAEMATOLOGY
Year: 2015
Reference: Br J Haematol. 2015 Apr;169(2):188-98. doi: 10.1111/bjh.13273. Epub 2014 Dec 18.
Impact factor: 4.959
Publication type: Paper in international publication
Authors: Purroy, Noelia, Bergua, Juan, Gallur, Laura, Prieto, Julio, Lopez, Luis A, Sancho, Juan M, Garcia-Marco, Jose A, Castellvi, Josep, Montes-Moreno, Santiago, Batlle, Ana et al.
DOI: 10.1111/bjh.13273

Pleuroparenchymal Fibroelastosis: A New Entity within the Spectrum of Rare Idiopathic Interstitial Pneumonias.

PMID: 26380141
Journal: Case reports in pulmonology
Year: 2015
Reference: Case Rep Pulmonol. 2015;2015:810515. doi: 10.1155/2015/810515. Epub 2015 Aug 26.
Impact factor: 0
Publication type: Paper in international publication
Authors: Portillo, Karina, Guasch, Ignasi, Becker, Caroline, Andreo, Felipe, Fernandez-Figueras, Maria Teresa, Ramirez Ruz, Jose, Martinez-Barenys, Carlos, Garcia-Reina, Samuel, Lopez de Castro, Pedro, Sansano, Irene et al.
DOI: 10.1155/2015/810515

[Numb chin syndrome. A case report].

PMID: 26350780
Journal: REVISTA DE NEUROLOGIA
Year: 2015
Reference: Rev Neurol. 2015 Sep 16;61(6):286-7.
Impact factor: 0.83
Publication type: Paper in national publication
Authors: Aller-Alvarez, J S, Palasi, A, Olivera, P, Salamero, O, Barios, M, Siurana, S, Rovira, A, Alvarez-Sabin, J, Castellvi, J et al.
DOI:

Cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma.

PMID: 26554728
Journal: Nature Communications
Year: 2015
Reference: Nat Commun. 2015 Nov 10;6:8839. doi: 10.1038/ncomms9839.
Impact factor: 11.47
Publication type: Paper in international publication
Authors: De Mattos-Arruda, Leticia, Mayor, Regina, Ng, Charlotte K Y, Weigelt, Britta, Martinez-Ricarte, Francisco, Torrejon, Davis, Oliveira, Mafalda, Arias, Alexandra, Raventos, Carolina, Tang, Jiabin et al.
DOI: 10.1038/ncomms9839

Effect of p95HER2/611CTF on the response to trastuzumab and chemotherapy.

PMID: 25253614
Journal: JNCI-J NATL CANCER I
Year: 2014
Reference: J Natl Cancer Inst. 2014 Sep 24;106(11). pii: dju291. doi: 10.1093/jnci/dju291. Print 2014 Nov.
Impact factor: 15.161
Publication type: Paper in international publication
Authors: Parra-Palau, Josep Lluis, Morancho, Beatriz, Peg, Vicente, Escorihuela, Marta, Scaltriti, Maurizio, Vicario, Rocio, Pedersen, Kim, Pandiella, Atanasio, Nuciforo, Paolo, Serra, Violeta et al.
DOI: 10.1093/jnci/dju291

Nomogram including the total tumoral load in the sentinel nodes assessed by one-step nucleic acid amplification as a new factor for predicting nonsentinel lymph node metastasis in breast cancer patients.

PMID: 25164972
Journal: BREAST CANCER RES TR
Year: 2014
Reference: Breast Cancer Res Treat. 2014 Sep;147(2):371-80. doi: 10.1007/s10549-014-3108-2. Epub 2014 Aug 28.
Impact factor: 4.198
Publication type: Paper in international publication
Authors: Rubio, Isabel T, Espinosa-Bravo, Martin, Rodrigo, Maxi, Amparo Viguri Diaz, Maria, Hardisson, David, Sagasta, Amaia, Duenas, Basilio, Peg, Vicente et al.
DOI: 10.1007/s10549-014-3108-2

Document of standardization of enteral nutrition access in adults.

PMID: 25137256
Journal: NUTR HOSP
Year: 2014
Reference: Nutr Hosp. 2014 Jul 1;30(1):1-14. doi: 10.3305/nh.2014.30.1.7446.
Impact factor: 1.25
Publication type: Paper in national publication
Authors: Arribas, Lorena, Frias, Laura, Creus, Gloria, Parejo, Juana, Urzola, Carmen, Ashbaugh, Rosana, Perez-Portabella, Cleofe, Cuerda, Cristina et al.
DOI: 10.3305/nh.2014.30.1.7446

Expression of Wilms' tumor gene (WT1) is associated with survival in malignant pleural mesothelioma.

PMID: 24323466
Journal: CLIN TRANSL ONCOL
Year: 2014
Reference: Clin Transl Oncol. 2014 Sep;16(9):776-82. doi: 10.1007/s12094-013-1146-6. Epub 2013 Dec 10.
Impact factor: 1.276
Publication type: Paper in international publication
Authors: Cedres, S, Montero, M A, Zamora, E, Martinez, A, Martinez, P, Farinas, L, Navarro, A, Torrejon, D, Gabaldon, A, Ramon Y Cajal, S et al.
DOI: 10.1007/s12094-013-1146-6

Intraoperative molecular analysis of total tumor load in sentinel lymph node: a new predictor of axillary status in early breast cancer patients.

PMID: 23576079
Journal: BREAST CANCER RESEARCH AND TREATMENT
Year: 2013
Reference: Breast Cancer Res Treat. 2013 May;139(1):87-93. doi: 10.1007/s10549-013-2524-z. Epub 2013 Apr 11.
Impact factor: 4.469
Publication type: Paper in international publication
Authors: Espinosa-Bravo, Martin, Peg, Vicente, Vieites, Begona, Vilardell, Felip, Antunez, Jose R, de Salas, Magdalena Sancho, Delgado-Sanchez, Julio J, Pinto, Willy, Gozalbo, Francisco, Petit, Anna et al.
DOI: 10.1007/s10549-013-2524-z

Genomic Analyses across Six Cancer Types Identify Basal-like Breast Cancer as a Unique Molecular Entity.

PMID: 24384914
Journal: Scientific Reports
Year: 2013
Reference: Sci Rep. 2013 Dec 18;3:3544. doi: 10.1038/srep03544.
Impact factor: 2.927
Publication type: Paper in international publication
Authors: Cortes, Javier, Tabernero, Josep, Felip, Enriqueta, Cajal, Santiago Ramony, Prat, Aleix, Adamo, Barbara, Fan, Cheng, Peg, Vicente, Vidal, Maria, Galvan, Patricia et al.
DOI: 10.1038/srep03544

The voltage-dependent K channels Kv1.3 and Kv1.5 in human cancer.

PMID: 24133455
Journal: Frontiers in physiology
Year: 2013
Reference: Front Physiol. 2013 Oct 10;4:283. eCollection 2013.
Impact factor: 2.8
Publication type: Review in international publication
Authors: Comes, Nuria, Bielanska, Joanna, Vallejo-Gracia, Albert, Serrano-Albarras, Antonio, Marruecos, Laura, Gomez, Diana, Soler, Concepcio, Condom, Enric, Ramon Y Cajal, Santiago, Hernandez-Losa, Javier et al.
DOI: 10.3389/fphys.2013.00283

ZAP-70 Promotes the Infiltration of Malignant B-Lymphocytes into the Bone Marrow by Enhancing Signaling and Migration after CXCR4 Stimulation.

PMID: 24312539
Journal: PLoS One
Year: 2013
Reference: PLoS One. 2013 Dec 3;8(12):e81221. doi: 10.1371/journal.pone.0081221.
Impact factor: 3.73
Publication type: Paper in international publication
Authors: Calpe, Eva, Purroy, Noelia, Carpio, Cecilia, Abrisqueta, Pau, Carabia, Julia, Palacio, Carles, Castellvi, Josep, Crespo, Marta, Bosch, Francesc et al.
DOI: 10.1371/journal.pone.0081221

The EMT signaling pathways in endometrial carcinoma.

PMID: 22911547
Journal: Clinical & Translational Oncology
Year: 2012
Reference: Clin Transl Oncol. 2012 Oct;14(10):715-20. doi: 10.1007/s12094-012-0866-3. Epub 2012 Aug 22.
Impact factor: 1.327
Publication type: Review in international publication
Authors: Garcia, Angel, Ramon Y Cajal, Santiago, Moreno-Bueno, Gema, Dolcet, Xavier, Alameda, Francesc, Palacios, Jose, Prat, Jaime, Doll, Andreas, Matias-Guiu, Xavier, Abal, Miguel et al.
DOI: 10.1007/s12094-012-0866-3

Guidelines for biomarker testing in colorectal carcinoma (CRC): a national consensus of the Spanish Society of Pathology (SEAP) and the Spanish Society of Medical Oncology (SEOM).

PMID: 22855150
Journal: Clinical & Translational Oncology
Year: 2012
Reference: Clin Transl Oncol. 2012 Oct;14(10):726-39. doi: 10.1007/s12094-012-0856-5. Epub 2012 Jul 27.
Impact factor: 1.327
Publication type: Paper in international publication
Authors: Garcia-Alfonso, Pilar, Salazar, Ramon, Garcia-Foncillas, Jesus, Musulen, Eva, Garcia-Carbonero, Rocio, Perez-Segura, Pedro, Ramon Y Cajal, Santiago, Navarro, Samuel, Paya, Artemio et al.
DOI: 10.1007/s12094-012-0856-5

Increased voltage-dependent K(+) channel Kv1.3 and Kv1.5 expression correlates with leiomyosarcoma aggressiveness.

PMID: 22844358
Journal: Oncology Letters
Year: 2012
Reference: Oncol Lett. 2012 Aug;4(2):227-230. Epub 2012 May 16.
Impact factor: 0.108
Publication type: Paper in international publication
Authors: Cajal, Santiago Ramon Y, Bielanska, Joanna, Hernandez-Losa, Javier, Moline, Teresa, Somoza, Rosa, Felipe, Antonio, Ferreres, Joan Carles, Condom, Enric et al.
DOI: 10.3892/ol.2012.718

Targeting the voltage-dependent K(+) channels Kv1.3 and Kv1.5 as tumor biomarkers for cancer detection and prevention.

PMID: 22204339
Journal: CURRENT MEDICINAL CHEMISTRY
Year: 2012
Reference: Curr Med Chem. 2012;19(5):661-74.
Impact factor: 4.859
Publication type: Review in international publication
Authors: Felipe, A, Bielanska, J, Comes, N, Vallejo, A, Roig, S, Ramon Y Cajal, S, Condom, E, Hernandez-Losa, J, Ferreres, J C et al.
DOI:

Consensus of the Spanish Society of Medical Oncology (SEOM) and Spanish Society of Pathology (SEAP) for HER2 testing in gastric carcinoma.

PMID: 21865135
Journal: Clinical & Translational Oncology
Year: 2011
Reference: Clin Transl Oncol. 2011 Sep;13(9):636-51.
Impact factor: 1.254
Publication type: Paper in national publication
Authors: Garcia-Caballero, T, Garcia-Garcia, E, Iglesias, M, Lopez, J A, Ramon Y Cajal, S, Rojo, F, Palacios, J, Vera-Sempere, F, Aranda, E, Colomer, R et al.
DOI:

Spinophilin acts as a tumor suppressor by regulating Rb phosphorylation.

PMID: 21772120
Journal: CELL CYCLE
Year: 2011
Reference: Cell Cycle. 2011 Aug 15;10(16):2751-62. Epub 2011 Aug 15.
Impact factor: 4.999
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI:

The effect of p-4E-BP1 and p-eIF4E on cell proliferation in a breast cancer model.

PMID: 21750861
Journal: INTERNATIONAL JOURNAL OF ONCOLOGY
Year: 2011
Reference: Int J Oncol. 2011 Nov;39(5):1337-45. doi: 10.3892/ijo.2011.1118. Epub 2011 Jul 8.
Impact factor: 2.571
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.3892/ijo.2011.1118

Apoptosis-like cell death induction and aberrant fibroblast properties in human incisional hernia fascia.

PMID: 21641387
Journal: AMERICAN JOURNAL OF PATHOLOGY
Year: 2011
Reference: Am J Pathol. 2011 Jun;178(6):2641-53.
Impact factor: 5.224
Publication type: Paper in international publication
Authors: Guillem-Marti, Jordi, Lopez-Cano, Manuel, Huguet, Pere, Ramon-Y-Cajal, Santiago, Reventos, Jaume, Armengol, Manel, Arbos, Maria A, Quiles, Maria T, Diaz, Ramon et al.
DOI: 10.1016/j.ajpath.2011.02.044

A Major Role of p95/611-CTF, a Carboxy-Terminal Fragment of HER2, in the Down-modulation of the Estrogen Receptor in HER2-Positive Breast Cancers.

PMID: 20978202
Journal: CANCER RESEARCH
Year: 2010
Reference: Cancer Res. 2010 Nov 1;70(21):8537-46. Epub 2010 Oct 26.
Impact factor: 7.543
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1158/0008-5472.CAN-10-1701

Voltage-dependent potassium channels Kv1.3 and Kv1.5 in human fetus.

PMID: 20798505
Journal: CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
Year: 2010
Reference: Cell Physiol Biochem. 2010;26(2):219-26. Epub 2010 Aug 24.
Impact factor: 3.563
Publication type: Paper in international publication
Authors: Bielanska, Joanna, Hernandez-Losa, Javier, Moline, Teresa, Somoza, Rosa, Ramon Y Cajal, Santiago, Condom, Enric, Ferreres, Joan Carles, Felipe, Antonio et al.
DOI: 10.1159/000320528

Aprataxin tumor levels predict response of colorectal cancer patients to irinotecan-based treatment.

PMID: 20371676
Journal: CLINICAL CANCER RESEARCH
Year: 2010
Reference: Clin Cancer Res. 2010 Apr 15;16(8):2375-82. Epub 2010 Apr 6.
Impact factor: 6.747
Publication type: Paper in international publication
Authors: Dopeso, Higinio, Mateo-Lozano, Silvia, Elez, Elena, Landolfi, Stefania, Ramos Pascual, Francisco Javier, Hernandez-Losa, Javier, Mazzolini, Rocco, Rodrigues, Paulo, Bazzocco, Sarah, Carreras, Maria Josep et al.
DOI: 10.1158/1078-0432.CCR-09-3275

ADAMTS1 Contributes to the Acquisition of an Endothelial-like Phenotype in Plastic Tumor Cells.

PMID: 20484033
Journal: CANCER RESEARCH
Year: 2010
Reference: Cancer Res. 2010 Jun 1;70(11):4676-86. Epub 2010 May 18.
Impact factor: 7.543
Publication type: Paper in international publication
Authors: , , , , , , , et al.
DOI: 10.1158/0008-5472.CAN-09-4197

Clinico-pathological discrepancies in the diagnosis of causes of maternal death in sub-Saharan Africa: retrospective analysis.

PMID: 19243215
Journal: PLOS MEDICINE
Year: 2009
Reference: PLoS Med. 2009 Feb 24;6(2):e1000036.
Impact factor: 12.185
Publication type: Paper in international publication
Authors: Ordi, Jaume, Ismail, Mamudo R, Carrilho, Carla, Romagosa, Cleofe, Osman, Nafissa, Machungo, Fernanda, Bombi, Josep A, Balasch, Juan, Alonso, Pedro L, Menendez, Clara et al.
DOI: 10.1371/journal.pmed.1000036

MMPs/TIMPs and inflammatory signalling deregulation in human incisional hernia tissues.

PMID: 19397782
Journal: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
Year: 2009
Reference: J Cell Mol Med. 2009 Nov-Dec;13(11-12):4432-43.
Impact factor: 5.114
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1111/j.1582-4934.2008.00637.x

Ovarian Fibrosarcoma: Clinicopathologic Considerations about the Intraoperative and Post-Surgical Procedures.

PMID: 20168988
Journal: Case Report Med
Year: 2009
Reference: Case Report Med. 2009;2009:802817.
Impact factor:
Publication type: Letter or abstract
Authors: Ramon Y Cajal, Santiago, Garcia Jimenez, Angel, Castellvi, Josep, Perez Benavente, Assumpcio, Diaz de Corcuera Frutos, Isabela et al.
DOI: 10.1155/2009/802817

Voltage-dependent potassium channels Kv1.3 and Kv1.5 in human cancer.

PMID: 20025600
Journal: CURRENT CANCER DRUG TARGETS
Year: 2009
Reference: Curr Cancer Drug Targets. 2009 Dec;9(8):904-14.
Impact factor: 4.316
Publication type: Review in international publication
Authors: Bielanska, J, Hernandez-Losa, J, Perez-Verdaguer, M, Moline, T, Somoza, R, Ramon Y Cajal, S, Condom, E, Ferreres, J C, Felipe, A et al.
DOI:

Blog

News

On World Cancer Research Day, we highlight the oncology research model of the Vall d'Hebron Campus that allows laboratory results to be transferred as quickly as possible to clinical practice.

Vall d’Hebron ha celebrat avui la Jornada del Dia Mundial contra el Càncer, una malaltia cada cop més freqüent que patiran al llarg de la vida un de cada dos homes i una de cada tres dones del nostre entorn.

The multidisciplinary paper on papillary thyroid cancer has been considered the best original article of 2021 in the journal Endocrinología, Diabetes y Nutrición

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PhD Translational Molecular Pathology
Start date:
09/08/2023
End date:
23/08/2023
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Clinical Researcher - Translational Molecular Pathology Research Group
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22/06/2023
End date:
07/07/2023
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Project Manager IMPERAS Project Patologia Molecular Translacional
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14/02/2023
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28/02/2023
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