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Translational Molecular Pathology

Our group aims to unravel the molecular mechanisms of cancer progression and metastasis to identify new diagnostic, prognostic and therapeutic targets in cancer. By combining the knowledge and availability of human tumors in the Pathology department with the expertise of the basic molecular cell biology research group, we focus on:

  • Understanding: the molecular mechanisms underlying clonal cooperation and intercellular communication in heterogeneous tumors.
  • The role of MNK kinases in cellular stress resistance.
  • The role of ITGB3 in intercellular communication via extracellular vesicles in cancer metastasis (Santiago Ramon y Cajal).
  • The role of direct cell-cell communication via gap junctions and intercellular protrusions in cancer (Trond Aasen)
  • The malignant transition of Plexiform Neurofibromas (Cleofe Romagosa).

Team

Elena Muro Blanc

Elena Muro Blanc

Predoctoral researcher
Translational Molecular Pathology
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Marès Pagès, Roso

Marès Pagès, Roso

Research technician
Translational Molecular Pathology
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Sara Garcia Ortega

Sara Garcia Ortega

Predoctoral researcher
Translational Molecular Pathology
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Sonia Borao Arriazu

Sonia Borao Arriazu

Research technician
Translational Molecular Pathology
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Aldo Di  Vito

Aldo Di Vito

Predoctoral researcher
Translational Molecular Pathology
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Cleofé Romagosa Pérez-Portabell

Cleofé Romagosa Pérez-Portabell

Main researcher
Translational Molecular Pathology
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Elena Muro Blanc

Elena Muro Blanc

Predoctoral researcher
Translational Molecular Pathology
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Marès Pagès, Roso

Marès Pagès, Roso

Research technician
Translational Molecular Pathology
Read more
Sara Garcia Ortega

Sara Garcia Ortega

Predoctoral researcher
Translational Molecular Pathology
Read more
Sonia Borao Arriazu

Sonia Borao Arriazu

Research technician
Translational Molecular Pathology
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Aldo Di  Vito

Aldo Di Vito

Predoctoral researcher
Translational Molecular Pathology
Read more
Cleofé Romagosa Pérez-Portabell

Cleofé Romagosa Pérez-Portabell

Main researcher
Translational Molecular Pathology
Read more

Research lines

Study of CAP-dependent and CAP-independent signalling pathways in breast carcinomas.

In previous works we studied several factors involved in cell signalling pathways that control cell growth. The found that the phosphorylated form of 4E-BP1 was the only factor that correlated with prognosis, and histologic aggressive features in several types of cancers. 4E-BP1 is a key regulator of CAP-dependent traslation and its main function is the inactivation of eIF4E. However, not all the aggressive tumors show activation of this factor. On the other hand, it has been shown that under hypoxia conditions cells the translation of some key factors can be regulated by CAP-independent pathways, mediated by factors known as ITAFs. The aim of our study is to find the CAP-depdendent/CAP-independent balance in tumors in relation to hypoxia, and evaluate its impact on prognosis.

IP: Josep Castellví Vives

Study of Cell Signalling pathway in human tumors. Identification of funnel factors.

We have characterized the levels of activation in Cell Signalling in a spectrum of solid tumors and correlated the levels of various factors, including mTOR and downstream proteins (p70S6K, S6, 4EBP1, eIF4E) with prognosis and grade of malignancy. Also, are being characterized, at the molecular level, the factors involved in controlling the translation cap dependent and independent in malignant tumors.


IP: Santiago Ramon y Cajal Agüeras

Study of gene expression of senescence in human tumors

The expression of mARN genes identified by Dr.R. Bernards has been studied in normal and tumor tissue of cancer patients. This study identifies for the first time, RSK4 and KIAA0828 genes as genes whose role may be relevant in cancer. The expression of these genes is being studied in protein by Western blot and immunohistochemistry. Also are characterizing the biochemical pathways where these genes may be involved.

IP: Santiago Ramon y Cajal Agüeras

Study of new genes involved in proliferation

Searching for new proliferative genes/tumor suppressor genes is being performed at our laboratory by carring out genetic screens. By the use of retroviral vectors as carriers of a cDNA libraries (formed by mRNA from murine embryonic stem cells), primary cells are infected and screening for those clones able to bypass senescence are selected for further characterization. The marked morphological heterogeneity observed in several tumorigenic process, support the hypothesis that several cancers have their origin in a stem cell. It is believed that genes expressed by embryonic stem cells, may play an important role in the tumorigenic mechanism.This project unravels the effect of immortal genes existing in embryonic stem cells, when are forced to be expressed in primary and thereby mortal cells. These immortal genes are future candidate markers in tumors with potential prognosis value. The novel genes discovered, are being analyzed in the biopsies from patients with different kinds of tumors collected at the Pathology Department of the Vall d´Hebrón Hospital.

IP: Matilde Lleonart Pajarin

Projects

ESTUDIO DEL PAPEL DE LA CENTRALIZACIÓN DEL DIAGNÓSTICO ANATOMOPATOLÓGICO Y LA APLICACIÓN DE ESTRATÉGIAS DE MEDICINA DE PRECISIÓN EN SARCOMAS

IP: Cleofé Romagosa Pérez-Portabell
Collaborators: Xavier Martínez Gómez, Ximena Garcia Torres
Funding agency: Asociación Española Contra el Cáncer
Funding: 270130
Reference: ECAEC222952DEAL
Duration: 01/12/2022 - 30/11/2027

Targeting the polyglutamylation enzyme TTLL11 - a novel strategy for cancer therapy (MITOCANCER)

IP: Stefan Hummer
Collaborators: -
Funding agency: Fundació Institut Bioenginyeria de Catalunya
Funding: 0.01
Reference: IBEC/2022/ HUMMER
Duration: 02/01/2023 - 31/12/2024

Proyecto colaborativo europeo-latinoamericano y caribeño sobre medicina personalizada para el estudio de trastornos neurológicos

IP: Maria Mar Hernandez Guillamon
Collaborators: Anna Penalba Morenilla, Jessica Camacho Soriano, Anas Chaachou Charradi, Elena Antima Martinez Saez
Funding agency: Instituto de Salud Carlos III
Funding: 174845
Reference: AC22/00051
Duration: 01/01/2023 - 31/12/2025

MnkImmunOnco) - Overcoming therapy resistance and immune evasion with a novel MNK inhibibtor

IP: Santiago Ramon y Cajal Agüeras
Collaborators: Inés de Torres Ramirez, Jordi Temprana Salvador, Vicente Peg Camara, Stefan Hummer
Funding agency: Fundació Institut Bioenginyeria de Catalunya
Funding: 0.01
Reference: M6871
Duration: 02/01/2023 - 31/12/2024

Publications

Evaluation of triple negative breast cancer with heterogeneous immune infiltration.

PMID: 37215143
Journal: Frontiers in Immunology
Year: 2023
Reference: Front Immunol. 2023 May 4;14:1149747. doi: 10.3389/fimmu.2023.1149747. eCollection 2023.
Impact factor:
Publication type: Paper in international publication
Authors: Arenas, Enrique Javier; Arribas, Joaquin; Bernado, Cristina; Cortes, Javier; Curigliano, Giuseppe; Esteve-Codina, Anna; Gonzalez, Jonatan; Marti, Merce; Moline, Teresa; Navarro, Jose Fernandez et al.
DOI: 10.3389/fimmu.2023.1149747

Peripheral T-cell lymphoma with a T follicular-helper phenotype: A different entity? Results of the Spanish Real-T study.

PMID: 37386897
Journal: BRITISH JOURNAL OF HAEMATOLOGY
Year: 2023
Reference: Br J Haematol. 2023 Jun 30. doi: 10.1111/bjh.18941.
Impact factor:
Publication type: Paper in international publication
Authors: Baeza, Lourdes; Borrero, Juan Jose; Castellvi, Josep; Climent, Fina; Cordoba, Raul; Domingo-Domenech, Eva; Fraga, Maximo; Garcia-Cosio Piqueras, Monica; Gomez Codina, Jose; Gonzalez de Villambrosia, Sonia et al.
DOI: 10.1111/bjh.18941

Endoglin, a novel biomarker and therapeutical target to prevent malignant peripheral nerve sheath tumor growth and metastasis.

PMID: 37432984
Journal: CLINICAL CANCER RESEARCH
Year: 2023
Reference: Clin Cancer Res. 2023 Jul 11:CCR-22-2462. doi: 10.1158/1078-0432.CCR-22-2462.
Impact factor:
Publication type: Paper in international publication
Authors: Alaggio, Rita; Benassi, Maria Serena; Blanco-Aparicio, Carmen; Creus-Bachiller, Edgar; De Wever, Olivier; Di Giannatale, Angela; Fernandez-Rodriguez, Juana; Fischer, Suzanne; Garcia-Silva, Susana; Gonzalez-Munoz, Teresa et al.
DOI: 10.1158/1078-0432.CCR-22-2462

A PET-CT score for discriminating malignant from benign pleural effusions.

PMID: 37487808
Journal: MEDICINA CLINICA
Year: 2023
Reference: Med Clin (Barc). 2023 Jul 22:S0025-7753(23)00368-8. doi: 10.1016/j.medcli.2023.06.011.
Impact factor:
Publication type: Paper in national publication
Authors: Aleman, Carmen; Montoro, Bruno; Persiva, Oscar; Sanchez, Leire; Sansano, Irene; Simo, Marc; Vazquez, Ana et al.
DOI: 10.1016/j.medcli.2023.06.011

Exploratory study of an oral screening dysplasia program for HIV-infected men who have sex with men.

PMID: 35730367
Journal: AIDS
Year: 2022
Reference: AIDS. 2022 Jun 23. pii: 00002030-990000000-00044. doi: 10.1097/QAD.0000000000003287.
Impact factor: 4.177
Publication type: Paper in international publication
Authors: Planas, Bibiana; Garcia, Jorge; Hernandez-Losa, Javier; Molina, Maria Del Mar; Dinares, Maria Carme; Callejo, Angela; Curran, Adria; Navarro, Jordi; Suanzes, Paula; Falco, Vicenc et al.
DOI: 10.1097/QAD.0000000000003287

Recommendations for the use of biomarkers for head and neck cancer, including salivary gland tumours: a consensus of the Spanish Society of Medical Oncology and the Spanish Society of Pathology.

PMID: 35739348
Journal: Clinical & Translational Oncology
Year: 2022
Reference: Clin Transl Oncol. 2022 Jun 23. pii: 10.1007/s12094-022-02856-1. doi: 10.1007/s12094-022-02856-1.
Impact factor: 3.405
Publication type: Paper in international publication
Authors: Garcia-Castano, Almudena; Goma, Montserrat; Mesia-Nin, Ricard; Ruiz-Bravo, Elena; Soria-Rivas, Ainara; Castillo, Paola; Brana-Garcia, Irene; Alberola-Ferranti, Margarita; Garcia-Cosio, Monica; Trigo, Jose et al.
DOI: 10.1007/s12094-022-02856-1

Transforming growth factor-beta 1: A new factor reducing hepatic SHBG production in liver fibrosis.

PMID: 35762039
Journal: JOURNAL OF CELLULAR PHYSIOLOGY
Year: 2022
Reference: J Cell Physiol. 2022 Jun 27. doi: 10.1002/jcp.30818.
Impact factor: 6.384
Publication type: Paper in international publication
Authors: Selva, David M; Simo, Rafael; Hernandez, Cristina; Salcedo-Allende, Maria Teresa; Ramos-Perez, Lorena; Fuertes-Rioja, Lidia; Brianso-Llort, Laura et al.
DOI: 10.1002/jcp.30818

Secondary organising pneumonia to persistent SARS-CoV-2 infection in immunocompromised patient.

PMID: 35786522
Journal: MEDICINA CLINICA
Year: 2022
Reference: Med Clin (Barc). 2022 Jun 10. pii: S0025-7753(22)00254-8. doi: 10.1016/j.medcli.2022.04.008.
Impact factor: 1.725
Publication type: Paper in national publication
Authors: Sansano, Irene; Villar, Ana; Granados, Galo David et al.
DOI: 10.1016/j.medcli.2022.04.008

Monocyte-to-Lymphocyte Ratio in Clot Analysis as a Marker of Cardioembolic Stroke Etiology.

PMID: 34586594
Journal: Translational Stroke Research
Year: 2021
Reference: Transl Stroke Res. 2021 Sep 29. pii: 10.1007/s12975-021-00946-w. doi: 10.1007/s12975-021-00946-w.
Impact factor: 6.829
Publication type: Paper in international publication
Authors: Ribo, Marc, Juega, Jesus, Palacio-Garcia, Carlos, Rodriguez, Maite, Deck, Matias, Rodriguez-Luna, David, Requena, Manuel, Garcia-Tornel, Alvaro, Rodriguez-Villatoro, Noelia, Rubiera, Marta et al.
DOI: 10.1007/s12975-021-00946-w

Gene expression signatures for tailoring adjuvant chemotherapy of luminal breast cancer: the pathologists' perspective.

PMID: 34461263
Journal: ANNALS OF ONCOLOGY
Year: 2021
Reference: Ann Oncol. 2021 Nov;32(11):1316-1321. doi: 10.1016/j.annonc.2021.08.1993. Epub 2021 Aug 28.
Impact factor: 32.976
Publication type: Editorail in international publication
Authors: Salgado, R, Peg, V, Ruschoff, J, Vincent-Salomon, A, Castellano, I, Perner, S, Van de Vijver, K, Quinn, C M, Varga, Z et al.
DOI: 10.1016/j.annonc.2021.08.1993

Host-dependent editing of SARS-CoV-2 in COVID-19 patients.

PMID: 34402744
Journal: Emerging Microbes & Infections
Year: 2021
Reference: Emerg Microbes Infect. 2021 Dec;10(1):1777-1789. doi: 10.1080/22221751.2021.1969868.
Impact factor: 7.163
Publication type: Paper in international publication
Authors: Quer, Josep, Anton, Andres, Rodriguez-Frias, Francisco, Esteban, Juan Ignacio, Gregori, Josep, Cortese, Maria Francesca, Pinana, Maria, Campos, Carolina, Garcia-Cehic, Damir, Andres, Cristina et al.
DOI: 10.1080/22221751.2021.1969868

Overview of Oral Potentially Malignant Disorders: From Risk Factors to Specific Therapies.

PMID: 34359597
Journal: Cancers
Year: 2021
Reference: Cancers (Basel). 2021 Jul 23;13(15). pii: cancers13153696. doi: 10.3390/cancers13153696.
Impact factor: 6.639
Publication type: Review in international publication
Authors: Thavaraj, Selvam, Muller-Richter, Urs, Alberola Ferranti, Margarita, Pamias Romero, Jorge, Saez Barba, Manel, de Pablo Garcia-Cuenca, Alba, Brana Garcia, Irene, Bossi, Paolo, Nuciforo, Paolo, Simonetti, Sara et al.
DOI: 10.3390/cancers13153696

Axillary staging based on molecular analysis: Results of the B-CLOSER-II study.

PMID: 32919301
Journal: PATHOLOGY RESEARCH AND PRACTICE
Year: 2020
Reference: Pathol Res Pract. 2020 Nov;216(11):153197. doi: 10.1016/j.prp.2020.153197. Epub 2020 Sep 3.
Impact factor: 2.05
Publication type: Paper in international publication
Authors: Sansano, Irene, Vieites, Begona, Sancho de Salas, Magdalena, Garcia, Carmen, Amendoeira, Isabel, Bernet, Laia, Perez-Garcia, Jose Manuel, Espinosa-Bravo, Martin, Rubio, Isabel T, Ramon Y Cajal, Santiago et al.
DOI: 10.1016/j.prp.2020.153197

New opacities in lung allograft after transbronchial cryobiopsy.

PMID: 32843174
Journal: RESPIRATORY MEDICINE
Year: 2020
Reference: Respir Med. 2020 Aug - Sep;170:106043. doi: 10.1016/j.rmed.2020.106043. Epub 2020 May 25.
Impact factor: 3.095
Publication type: Paper in international publication
Authors: Loor, Karina, Pallisa, Esther, Culebras, Mario, Deu, Maria, Alvarez, Antonio, Sansano, Irene, Berastegui, Cristina, Clofent, David, Polverino, Eva, de Gracia, Javier et al.
DOI: 10.1016/j.rmed.2020.106043

Five simple reasons to discard DIP, or why we should stop calling dolphins big fish.

PMID: 32843423
Journal: JOURNAL OF CLINICAL PATHOLOGY
Year: 2020
Reference: J Clin Pathol. 2020 Nov;73(11):762-768. doi: 10.1136/jclinpath-2020-206669. Epub 2020 Aug 25.
Impact factor: 2.46
Publication type: Review in international publication
Authors: Mukhopadhyay, Sanjay, Aesif, Scott W, Sansano, Irene et al.
DOI: 10.1136/jclinpath-2020-206669

ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells.

PMID: 32848136
Journal: Nature Communications
Year: 2020
Reference: Nat Commun. 2020 Aug 26;11(1):4261. doi: 10.1038/s41467-020-18081-9.
Impact factor: 12.121
Publication type: Paper in international publication
Authors: Fuentes, Pedro, Sese, Marta, Guijarro, Pedro J, Emperador, Marta, Sanchez-Redondo, Sara, Peinado, Hector, Hummer, Stefan, Ramon Y Cajal, Santiago et al.
DOI: 10.1038/s41467-020-18081-9

Assessment of a New ROS1 Immunohistochemistry Clone (SP384) for the Identification of ROS1 Rearrangements in Non-Small Cell Lung Carcinoma Patients: the ROSING Study.

PMID: 31349061
Journal: Journal of Thoracic Oncology
Year: 2019
Reference: J Thorac Oncol. 2019 Dec;14(12):2120-2132. doi: 10.1016/j.jtho.2019.07.005. Epub 2019 Jul 23.
Impact factor: 12.46
Publication type: Paper in international publication
Authors: Gurpide, Alfonso, Massuti, Bartomeu, Rojo, Federico, Domine, Manuel, Sansano, Irene, Garcia, Felip, Felip, Enriqueta, Mancheno, Nuria, Juan, Oscar, Sanz, Julian et al.
DOI: 10.1016/j.jtho.2019.07.005

Analysis of different levels of positive end-expiratory pressure during lung retrieval for transplantation: an experimental study.

PMID: 31314854
Journal: BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
Year: 2019
Reference: Braz J Med Biol Res. 2019;52(7):e8585. doi: 10.1590/1414-431X20198585. Epub 2019 Jul 15.
Impact factor: 1.85
Publication type: Paper in international publication
Authors: Goncalves-Ferri, W A, Martins-Celini, F P, Sansano, I, Fabro, A T, Sacramento, E M F, Aragon, D C, Ochoa, J M, Jauregui, A et al.
DOI: 10.1590/1414-431X20198585

MicroRNA-654-5p suppresses ovarian cancer development impacting on MYC, WNT and AKT pathways.

PMID: 31278368
Journal: ONCOGENE
Year: 2019
Reference: Oncogene. 2019 Aug;38(32):6035-6050. doi: 10.1038/s41388-019-0860-0. Epub 2019 Jul 5.
Impact factor: 6.634
Publication type: Paper in international publication
Authors: Majem, Blanca, Parrilla, Alfonso, Jimenez, Carlos, Suarez-Cabrera, Leticia, Barber, Marta, Marin, Andrea, Castellvi, Josep, Tamayo, Gabriel, Moreno-Bueno, Gema, Ponce, Jordi et al.
DOI: 10.1038/s41388-019-0860-0

The role of clonal communication and heterogeneity in breast cancer.

PMID: 31277602
Journal: BMC CANCER
Year: 2019
Reference: BMC Cancer. 2019 Jul 5;19(1):666. doi: 10.1186/s12885-019-5883-y.
Impact factor: 2.933
Publication type: Paper in international publication
Authors: Rodriguez-Casanova, Aitor, Diaz-Lagares, Angel, Castellvi, Josep, Miravet-Verde, Samuel, Serrano, Luis, Lluch-Senar, Maria, Sebastian, Victor, Bribian, Ana, Lopez-Mascaraque, Laura, Lopez-Lopez, Rafael et al.
DOI: 10.1186/s12885-019-5883-y

Thrombotic thrombocytopenic purpura relapse induced by acute hepatitis E transmitted by cryosupernatant plasma and successfully controlled with ribavirin.

PMID: 30284732
Journal: TRANSFUSION
Year: 2018
Reference: Transfusion. 2018 Nov;58(11):2501-2505. doi: 10.1111/trf.14831. Epub 2018 Oct 4.
Impact factor: 3.423
Publication type: Letter or abstract
Authors: Riveiro-Barciela, Mar, Bes, Marta, Quer, Josep, Valcarcel, David, Piriz, Sofia, Gregori, Josep, Llorens, Meritxell, Salcedo, Maria-Teresa, Piron, Maria, Esteban, Rafael et al.
DOI: 10.1111/trf.14831

p95HER2-T cell bispecific antibody for breast cancer treatment.

PMID: 30282693
Journal: Science Translational Medicine
Year: 2018
Reference: Sci Transl Med. 2018 Oct 3;10(461). pii: 10/461/eaat1445. doi: 10.1126/scitranslmed.aat1445.
Impact factor: 16.71
Publication type: Paper in international publication
Authors: Freimoser-Grundschober, Anne, Rius Ruiz, Irene, Vicario, Rocio, Morancho, Beatriz, Morales, Cristina Bernado, Arenas, Enrique J, Herter, Sylvia, Klein, Christian, Arribas, Joaquin, Saura, Cristina et al.
DOI: 10.1126/scitranslmed.aat1445

[Embolizing cardiac hibernoma and acute respiratory failure].

PMID: 30269781
Journal: Revista espanola de patologia : publicacion oficia
Year: 2018
Reference: Rev Esp Patol. 2018 Oct - Dec;51(4):267-270. doi: 10.1016/j.patol.2018.02.003. Epub 2018 Apr 5.
Impact factor: 0
Publication type: Paper in national publication
Authors: Montecino Romanini, Carolina, Reques Llanos, Armando, de Torres Ramirez, Ines, Rodriguez Morera, Jaime, Temprana Salvador, Jordi, Ramon Y Cajal, Santiago, Garcia Jimenez, Angel et al.
DOI: 10.1016/j.patol.2018.02.003

Expression patterns and bioinformatic analysis of miR-1260a and miR-1274a in Prostate Cancer Tunisian patients.

PMID: 30250996
Journal: MOLECULAR BIOLOGY REPORTS
Year: 2018
Reference: Mol Biol Rep. 2018 Dec;45(6):2345-2358. doi: 10.1007/s11033-018-4399-x. Epub 2018 Sep 24.
Impact factor: 1.889
Publication type: Paper in international publication
Authors: Said, Rahma, Garcia-Mayea, Yoelsis, Trabelsi, Nesrine, Setti Boubaker, Nouha, Mir, Cristina, Blel, Ahlem, Ati, Nidhal, Paciucci, Rosanna, Hernandez-Losa, Javier, Rammeh, Soumaya et al.
DOI: 10.1007/s11033-018-4399-x

E-cadherin: A determinant molecule associated with ovarian cancer progression, dissemination and aggressiveness.

PMID: 28934230
Journal: PLoS One
Year: 2017
Reference: PLoS One. 2017 Sep 21;12(9):e0184439. doi: 10.1371/journal.pone.0184439. eCollection 2017.
Impact factor: 2.806
Publication type: Paper in international publication
Authors: Rosso, Marina, Majem, Blanca, Devis, Laura, Lapyckyj, Lara, Besso, Maria Jose, Llaurado, Marta, Abascal, Maria Florencia, Matos, Maria Laura, Lanau, Lucia, Castellvi, Josep et al.
DOI: 10.1371/journal.pone.0184439

Aberrant expression of epithelial leucine-rich repeat containing G protein-coupled receptor 5-positive cells in the eutopic endometrium in endometriosis and implications in deep-infiltrating endometriosis.

PMID: 28923287
Journal: FERTILITY AND STERILITY
Year: 2017
Reference: Fertil Steril. 2017 Nov;108(5):858-867.e2. doi: 10.1016/j.fertnstert.2017.08.018. Epub 2017 Sep 15.
Impact factor: 4.373
Publication type: Paper in international publication
Authors: Vallve-Juanico, Julia, Suarez-Salvador, Elena, Castellvi, Josep, Ballesteros, Agustin, Taylor, Hugh S, Gil-Moreno, Antonio, Santamaria, Xavier et al.
DOI: 10.1016/j.fertnstert.2017.08.018

Selective sentinel lymph node biopsy in papillary thyroid carcinoma in patients with no preoperative evidence of lymph node metastasis.

PMID: 28895542
Journal: Endocrinologia, diabetes y nutricion
Year: 2017
Reference: Endocrinol Diabetes Nutr. 2017 Oct;64(8):451-455. doi: 10.1016/j.endinu.2017.05.001. Epub 2017 Jun 29.
Impact factor: 0
Publication type: Paper in national publication
Authors: Gonzalez, Oscar, Zafon, Carles, Caubet, Enric, Garcia-Burillo, Amparo, Serres, Xavier, Fort, Jose Manuel, Mesa, Jordi, Castell, Joan, Roca, Isabel, Ramon Y Cajal, Santiago et al.
DOI: 10.1016/j.endinu.2017.05.001

Convergent Akt activation drives acquired EGFR inhibitor resistance in lung cancer.

PMID: 28871105
Journal: Nature Communications
Year: 2017
Reference: Nat Commun. 2017 Sep 4;8(1):410. doi: 10.1038/s41467-017-00450-6.
Impact factor: 12.124
Publication type: Paper in international publication
Authors: Jacobsen, Kirstine, Bertran-Alamillo, Jordi, Molina, Miguel Angel, Teixido, Cristina, Karachaliou, Niki, Pedersen, Martin Haar, Castellvi, Josep, Garzon, Monica, Codony-Servat, Carles, Codony-Servat, Jordi et al.
DOI: 10.1038/s41467-017-00450-6

Intraoperative Ultrasound-Guided Lumpectomy Versus Mammographic Wire Localization for Breast Cancer Patients After Neoadjuvant Treatment.

PMID: 26514120
Journal: ANNALS OF SURGICAL ONCOLOGY
Year: 2016
Reference: Ann Surg Oncol. 2016 Jan;23(1):38-43. doi: 10.1245/s10434-015-4935-z. Epub 2015 Oct 29.
Impact factor: 3.655
Publication type: Paper in international publication
Authors: Rubio, Isabel T, Esgueva-Colmenarejo, Antonio, Espinosa-Bravo, Martin, Salazar, Juan Pablo, Miranda, Ignacio, Peg, Vicente et al.
DOI: 10.1245/s10434-015-4935-z

Effect of Previous Irradiation on Vascular Thrombosis of Microsurgical Anastomosis: A Preclinical Study in Rats.

PMID: 27975009
Journal: Plastic and reconstructive surgery. Global open
Year: 2016
Reference: Plast Reconstr Surg Glob Open. 2016 Nov 23;4(11):e1073. eCollection 2016 Nov.
Impact factor: 0
Publication type: Paper in international publication
Authors: Verges, Ramona, Barrera-Ochoa, Sergi, Gallardo-Calero, Irene, Lopez-Fernandez, Alba, Romagosa, Cleofe, Velez, Roberto, Soldado, Francisco, Aguirre-Canyadell, Marius et al.
DOI: 10.1097/GOX.0000000000001073

A 40-Year-Old Woman With Back Pain.

PMID: 27938773
Journal: CHEST
Year: 2016
Reference: Chest. 2016 Dec;150(6):e159-e165. doi: 10.1016/j.chest.2016.08.1449.
Impact factor: 5.94
Publication type: Paper in international publication
Authors: Fernandez-Codina, Andreu, Aranda-Rodriguez, Santiago, Romagosa, Cleofe, Deu-Martin, Maria, Parra-Farinas, Carmen, Bujan-Rivas, Segundo et al.
DOI: 10.1016/j.chest.2016.08.1449

Gasdermin B expression predicts poor clinical outcome in HER2-positive breast cancer.

PMID: 27462779
Journal: Oncotarget
Year: 2016
Reference: Oncotarget. 2016 Aug 30;7(35):56295-56308. doi: 10.18632/oncotarget.10787.
Impact factor: 5.008
Publication type: Paper in international publication
Authors: Hergueta-Redondo, Marta, Sarrio, David, Molina-Crespo, Angela, Vicario, Rocio, Bernado-Morales, Cristina, Martinez, Lidia, Rojo-Sebastian, Alejandro, Serra-Musach, Jordi, Mota, Alba, Martinez-Ramirez, Angel et al.
DOI: 10.18632/oncotarget.10787

Interplay between YB-1 and IL-6 promotes the metastatic phenotype in breast cancer cells.

PMID: 26512918
Journal: Oncotarget
Year: 2015
Reference: Oncotarget. 2015 Nov 10;6(35):38239-56. doi: 10.18632/oncotarget.5664.
Impact factor: 6.359
Publication type: Paper in international publication
Authors: Aasen, Trond, Moreno-Bueno, Gema, Dunn, Sandra E, Ramon Y Cajal, Santiago, Castellana, Barbara et al.
DOI: 10.18632/oncotarget.5664

Detection of Thyroid Papillary Carcinoma Lymph Node Metastases Using One Step Nucleic Acid Amplification (OSNA): Preliminary Results.

PMID: 25536089
Journal: JOURNAL OF INVESTIGATIVE SURGERY
Year: 2015
Reference: J Invest Surg. 2015 Jun;28(3):153-9. doi: 10.3109/08941939.2014.990123. Epub 2014 Dec 23.
Impact factor: 1.191
Publication type: Paper in international publication
Authors: Gonzalez, Oscar, Iglesias, Carmela, Zafon, Carles, Castellvi, Josep, Garcia-Burillo, Amparo, Temprana, Jordi, Caubet, Enric, Vilallonga, Ramon, Mesa, Jordi, Cajal, Santiago Ramon Y et al.
DOI: 10.3109/08941939.2014.990123

Involvement of potassium channels in the progression of cancer to a more malignant phenotype.

PMID: 25517985
Journal: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
Year: 2015
Reference: Biochim Biophys Acta. 2015 Oct;1848(10 Pt B):2477-92. doi: 10.1016/j.bbamem.2014.12.008. Epub 2014 Dec 14.
Impact factor: 4.381
Publication type: Review in international publication
Authors: Felipe, Antonio, Ferreres, Joan Carles, Condom, Enric, Comes, Nuria, Serrano-Albarras, Antonio, Capera, Jesusa, Serrano-Novillo, Clara, Ramon Y Cajal, Santiago et al.
DOI: 10.1016/j.bbamem.2014.12.008

MicroRNA-21 links epithelial-to-mesenchymal transition and inflammatory signals to confer resistance to neoadjuvant trastuzumab and chemotherapy in HER2-positive breast cancer patients.

PMID: 26452030
Journal: Oncotarget
Year: 2015
Reference: Oncotarget. 2015 Nov 10;6(35):37269-80. doi: 10.18632/oncotarget.5495.
Impact factor: 6.359
Publication type: Paper in international publication
Authors: De Mattos-Arruda, Leticia, Bottai, Giulia, Nuciforo, Paolo G, Di Tommaso, Luca, Peg, Vicente, Losurdo, Agnese, Perez-Garcia, Jose, Masci, Giovanna, Corsi, Fabio, Cortes, Javier et al.
DOI:

Establishing the origin of metastatic deposits in the setting of multiple primary malignancies: the role of massively parallel sequencing.

PMID: 24220311
Journal: MOL ONCOL
Year: 2014
Reference: Mol Oncol. 2014 Feb;8(1):150-8. doi: 10.1016/j.molonc.2013.10.006. Epub 2013 Oct 31.
Impact factor: 5.935
Publication type: Paper in international publication
Authors: De Mattos-Arruda, Leticia, Bidard, Francois-Clement, Won, Helen H, Cortes, Javier, Ng, Charlotte K Y, Peg, Vicente, Nuciforo, Paolo, Jungbluth, Achim A, Weigelt, Britta, Berger, Michael F et al.
DOI: 10.1016/j.molonc.2013.10.006

Evolution of differentiated thyroid cancer: a decade of thyroidectomies in a single institution.

PMID: 25538902
Journal: European Thyroid Journal
Year: 2014
Reference: Eur Thyroid J. 2014 Sep;3(3):197-201. doi: 10.1159/000365416. Epub 2014 Aug 29.
Impact factor: 1.83
Publication type: Paper in international publication
Authors: Zafon, Carles, Baena, Juan Antonio, Castellvi, Josep, Obiols, Gabriel, Gonzalez, Oscar, Fort, Jose Manuel, Vilallonga, Ramon, Caubet, Enric, Armengol, Manuel, Mesa, Jordi et al.
DOI: 10.1159/000365416

Safety and efficacy of outpatient biopsy in renal transplantation.

PMID: 25415575
Journal: NEFROLOGIA
Year: 2014
Reference: Nefrologia. 2014 Nov 17;34(6):749-55. doi: 10.3265/Nefrologia.pre2014.Jul.12509.
Impact factor: 1.442
Publication type: Paper in national publication
Authors: Salcedo-Allende, Maite, Azancot-Rivero, Maria A, Perello-Carrascosa, Manel, Sellares-Roig, Joana, Cantarell-Aixandri, Carme, Moreso-Mateos, Francesc, Seron-Micas, Daniel, Serres-Creixans, Xavier, Castella-Fierro, Eva, Torres-Rodriguez, Irina B et al.
DOI: 10.3265/Nefrologia.pre2014.Jul.12509

Association of C4d deposition with clinical outcomes in IgA nephropathy.

PMID: 24578331
Journal: CLIN J AM SOC NEPHRO
Year: 2014
Reference: Clin J Am Soc Nephrol. 2014 May;9(5):897-904. doi: 10.2215/CJN.09710913. Epub 2014 Feb 27.
Impact factor: 5.25
Publication type: Paper in international publication
Authors: Gonzalez, Fayna, Camacho, Rafael, Valdivia, Miguel Angel, Cabrera, Rocio, Lopez, Katia, Pinedo, Fernando, Gutierrez, Eduardo, Valera, Alfonso, Leon, Miryam, Cobo, Maria Angeles et al.
DOI: 10.2215/CJN.09710913

Human Mesenchymal Stem Cells Overexpressing the IL-33 Antagonist Soluble IL-1 Receptor-Like-1 Attenuate Endotoxin-Induced Acute Lung Injury.

PMID: 23656573
Journal: AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
Year: 2013
Reference: Am J Respir Cell Mol Biol. 2013 Oct;49(4):552-62. doi: 10.1165/rcmb.2012-0406OC.
Impact factor: 4.148
Publication type: Paper in international publication
Authors: Martinez-Gonzalez, Itziar, Roca, Oriol, Masclans, Joan R, Moreno, Rafael, Salcedo, Maria T, Baekelandt, Veerle, Cruz, Maria J, Rello, Jordi, Aran, Josep M et al.
DOI: 10.1165/rcmb.2012-0406OC

mTOR Signaling Pathway in Penile Squamous Cell Carcinoma: pmTOR and peIF4E Over Expression Correlate with Aggressive Tumor Behavior.

PMID: 23764082
Journal: JOURNAL OF UROLOGY
Year: 2013
Reference: J Urol. 2013 Dec;190(6):2288-95. doi: 10.1016/j.juro.2013.06.015. Epub 2013 Jun 11.
Impact factor: 3.696
Publication type: Paper in international publication
Authors: Ferrandiz-Pulido, Carla, Toll, Agustin, Hernandez-Losa, Javier, Mojal, Sergio, Pujol, Ramon M, Ramon Y Cajal, Santiago, de Torres, Ines, Garcia-Patos, Vicente, Masferrer, Emili et al.
DOI: 10.1016/j.juro.2013.06.015

miR-125b Acts as a Tumor Suppressor in Breast Tumorigenesis via Its Novel Direct Targets ENPEP, CK2-alpha, CCNJ, and MEGF9.

PMID: 24098452
Journal: PLoS One
Year: 2013
Reference: PLoS One. 2013 Oct 3;8(10):e76247. doi: 10.1371/journal.pone.0076247.
Impact factor: 3.73
Publication type: Paper in international publication
Authors: Feliciano, Andrea, Castellvi, Josep, Artero-Castro, Ana, Leal, Jose A, Romagosa, Cleofe, Hernandez-Losa, Javier, Peg, Vicente, Fabra, Angels, Vidal, Francisco, Kondoh, Hiroshi et al.
DOI: 10.1371/journal.pone.0076247

Lymphatic mapping could not be impaired in the presence of breast carcinoma and coexisting small lymphocytic lymphoma.

PMID: 23977406
Journal: The American journal of case reports
Year: 2013
Reference: Am J Case Rep. 2013 Aug 21;14:322-5. doi: 10.12659/AJCR.884000.
Impact factor:
Publication type: Letter or abstract
Authors: Arana, Sebastian, Vasquez-Del-Aguila, Jorge, Espinosa, Martin, Peg, Vicente, Rubio, Isabel T et al.
DOI: 10.12659/AJCR.884000

Association of ventricular noncompaction and histiocytoid cardiomyopathy: case report and review of the literature.

PMID: 22758650
Journal: PEDIATRIC AND DEVELOPMENTAL PATHOLOGY
Year: 2012
Reference: Pediatr Dev Pathol. 2012 Sep-Oct;15(5):397-402. doi: 10.2350/12-05-1193-CR.1. Epub 2012 Jul 3.
Impact factor: 0.986
Publication type: Review in international publication
Authors: , , , , , et al.
DOI: 10.2350/12-05-1193-CR.1

Molecular bases of endometrial cancer: New roles for new actors in the diagnosis and the therapy of the disease.

PMID: 22037169
Journal: MOLECULAR AND CELLULAR ENDOCRINOLOGY
Year: 2012
Reference: Mol Cell Endocrinol. 2012 Jul 25;358(2):244-55. Epub 2011 Oct 20.
Impact factor: 4.192
Publication type: Review in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1016/j.mce.2011.10.003

beta-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer.

PMID: 22610277
Journal: NATURE MEDICINE
Year: 2012
Reference: Nat Med. 2012 Jun;18(6):892-901. doi: 10.1038/nm.2772.
Impact factor: 22.462
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1038/nm.2772

Analysis of gene expression regulated by the ETV5 transcription factor in OV90 ovarian cancer cells identifies FoxM1 over-expression in ovarian cancer.

PMID: 22589409
Journal: MOLECULAR CANCER RESEARCH
Year: 2012
Reference: Mol Cancer Res. 2012 Jul;10(7):914-24. doi: 10.1158/1541-7786.MCR-11-0449. Epub 2012 May 15.
Impact factor: 4.288
Publication type: Paper in international publication
Authors: , , , , , , et al.
DOI: 10.1158/1541-7786.MCR-11-0449

Breast Metastasis from Rhabdomyosarcoma of the Nasal Septum in a Pregnant Adult Woman.

PMID: 21631632
Journal: Breast Journal
Year: 2011
Reference: Breast J. 2011 Jul-Aug;17(4):420-1. doi: 10.1111/j.1524-4741.2011.01092.x. Epub 2011 Jun 2.
Impact factor: 1.425
Publication type: Editorail in international publication
Authors: , , Julia Rodriguez, , et al.
DOI: 10.1111/j.1524-4741.2011.01092.x

PTOV1 is overexpressed in human high-grade malignant tumors.

PMID: 21181414
Journal: VIRCHOWS ARCHIV
Year: 2011
Reference: Virchows Arch. 2011 Mar;458(3):323-30. Epub 2010 Dec 23.
Impact factor: 2.336
Publication type: Paper in international publication
Authors: , , , , , , , , et al.
DOI: 10.1007/s00428-010-1018-1

Expression of the ribosomal proteins Rplp0, Rplp1, and Rplp2 in gynecologic tumors.

PMID: 21040949
Journal: HUMAN PATHOLOGY
Year: 2011
Reference: Hum Pathol. 2011 Feb;42(2):194-203. Epub 2010 Oct 30.
Impact factor: 2.998
Publication type: Paper in international publication
Authors: , , , , , et al.
DOI: 10.1016/j.humpath.2010.04.020

p16(Ink4a) overexpression in cancer: a tumor suppressor gene associated with senescence and high-grade tumors.

PMID: 21297668
Journal: ONCOGENE
Year: 2011
Reference: Oncogene. 2011 May 5;30(18):2087-97. Epub 2011 Feb 7.
Impact factor: 7.414
Publication type: Review in international publication
Authors: , , , , , , et al.
DOI: 10.1038/onc.2010.614

[Usefulness of the immunohistochemical analysis of several molecular markers in the characterization of papillary thyroid carcinoma with initial lymph node metastasis.]

PMID: 20403734
Journal: Endocrinol Nutr
Year: 2010
Reference: Endocrinol Nutr. 2010 Apr;57(4):165-9. Epub 2010 Apr 18.
Impact factor:
Publication type: Letter or abstract
Authors: , , et al.
DOI: 10.1016/j.endonu.2010.02.005

Between Bench and Bed Side: PI3K Inhibitors.

PMID: 20302563
Journal: CURRENT MOLECULAR MEDICINE
Year: 2010
Reference: Curr Mol Pharmacol. 2010 Jun;3(2):79-90.
Impact factor:
Publication type: Letter or abstract
Authors: , et al.
DOI:

Cyclo-oxygenase type 2 is dysregulated in breast ductal carcinoma in situ and correlates with poor outcome.

PMID: 20227160
Journal: European Journal of Obstetrics & Gynecology and Reproductive Biology
Year: 2010
Reference: Eur J Obstet Gynecol Reprod Biol. 2010 Jul;151(1):72-6. Epub 2010 Mar 12.
Impact factor: 1.582
Publication type: Paper in international publication
Authors: , , , , , , , et al.
DOI: 10.1016/j.ejogrb.2010.02.033

Intraoperative assessment of sentinel lymph nodes after neoadjuvant chemotherapy in patients with breast cancer.

PMID: 19777186
Journal: ANNALS OF SURGICAL ONCOLOGY
Year: 2010
Reference: Ann Surg Oncol. 2010 Jan;17(1):235-9. Epub 2009 Sep 24.
Impact factor: 4.13
Publication type: Paper in international publication
Authors: Rubio, Isabel T, Aznar, Fernando, Lirola, Jose, Peg, Vicente, Xercavins, Jordi et al.
DOI: 10.1245/s10434-009-0695-y

Guidelines for HER2 testing in breast cancer: a national consensus of the Spanish Society of Pathology (SEAP) and the Spanish Society of Medical Oncology (SEOM).

PMID: 19531451
Journal: Clin Transl Oncol
Year: 2009
Reference: Clin Transl Oncol. 2009 Jun;11(6):363-75.
Impact factor:
Publication type: Letter or abstract
Authors: Concha, Angel, Albanell, Joan, Andreu, Xavier, Calasanz, Maria Jose, Lopez, Jose Antonio, Lopez-Rios, Fernando, Ramon y Cajal, Santiago, Vera-Sempere, Francisco J, Colomer, Ramon, Martin, Miguel et al.
DOI:

A naturally occurring HER2 carboxy-terminal fragment promotes mammary tumor growth and metastasis.

PMID: 19364815
Journal: MOLECULAR AND CELLULAR BIOLOGY
Year: 2009
Reference: Mol Cell Biol. 2009 Jun;29(12):3319-31.
Impact factor: 5.942
Publication type: Paper in international publication
Authors: Pedersen, Kim, Angelini, Pier-Davide, Laos, Sirle, Bach-Faig, Alba, Cunningham, Matthew P, Ferrer-Ramon, Cristina, Luque-Garcia, Antonio, Garcia-Castillo, Jesus, Parra-Palau, Josep Lluis, Scaltriti, Maurizio et al.
DOI: 10.1128/MCB.01803-08

Overexpression of Phosphorylated 4E-BP1 Predicts for Tumor Recurrence and Reduced Survival in Cervical Carcinoma Treated with Postoperative Radiotherapy.

PMID: 19362787
Journal: INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
Year: 2009
Reference: Int J Radiat Oncol Biol Phys. 2009 Dec 1;75(5):1316-22.
Impact factor: 4.639
Publication type: Paper in international publication
Authors: , , , , , , , et al.
DOI: 10.1016/j.ijrobp.2009.01.004

Lapatinib, a HER2 tyrosine kinase inhibitor, induces stabilization and accumulation of HER2 and potentiates trastuzumab-dependent cell cytotoxicity.

PMID: 19060928
Journal: ONCOGENE
Year: 2009
Reference: Oncogene. 2009 Feb 12;28(6):803-14.
Impact factor: 7.216
Publication type: Paper in international publication
Authors: Baselga, J, Arribas, J, Ramon y Cajal, S, Landolfi, S, Smith, D J, Scaltriti, M, Verma, C, Guzman, M, Jimenez, J, Parra, J L et al.
DOI: 10.1038/onc.2008.432

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The meeting was an opportunity to get to know projects from both institutions and to promote interaction between professionals.

On World Cancer Research Day, we highlight research aimed at improving treatments for both pediatric and adult cancers through innovative techniques.

On World Cancer Research Day, we highlight the oncology research model of the Vall d'Hebron Campus that allows laboratory results to be transferred as quickly as possible to clinical practice.

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Check the current rates for the services offered by the Translational Molecular Pathology research group.

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Current Rates

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Rates Anatomia Patologica VHIR 2021

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