About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
Our group aims to unravel the molecular mechanisms of cancer progression and metastasis to identify new diagnostic, prognostic and therapeutic targets in cancer. By combining the knowledge and availability of human tumors in the Pathology department with the expertise of the basic molecular cell biology research group, we focus on:
To study the degree and types of skeletal muscle involvement in CF patients who present exercise intolerance and its relationship with the genotype.
To determine the relationship between the type and/or degree of skeletal muscle involvement by histologic and mitochondrial respiratory chain function study, and the CF genotype.
Correlation study between exercise capacity, pulmonary function and genotype.
IP: -
Connexins and pannexins are structural units of gap junctions permitting direct intercellular communication. Deregulation of gap junctions is a frequent feature of carcinogenesis. We are characterizing the expression level of a variety of connexins and pannexins in primary and metastatic human tumours. In vitro we are studying how these proteins affect features related to the degree of malignancy such as migration, invasion and resistance to hypoxia. In connexin-deficient cell lines we are over-expressing specific wild-type or truncated forms of connexins and pannexins using retroviral constructs recently generated. In cell lines expressing high levels of specific connexins, we knockdown the expression levels using established lentiviral shRNA strategies. We aim to correlate connexin expression and cell communication with malignancy using a variety of well characterized assays with particular focus on colony formation, migration, invasion, epithelial-to-mesenchymal transition, changes in tumour stem cell populations, and hypoxia and drug resistance. The aim of the study is to: 1) Identify any significant correlation between the expression of various gap junction proteins and the malignancy, prognosis, chemo-resistance and overall survival in a variety of cancers 2) Gain mechanistic insight and identify direct functional roles of connexins and pannexins during tumour progression.
IP: Trond Aasen
To analyse transcriptional profiles of normal, PIA (proliferative inflammatory atrophy), PIN (prostatic intraepithelial neoplasia) and tumoral prostate using microarrays of selected tumoral tissue of prostatectomy specimens, in order to characterize gene expression modifications in prostate cancer versus PIN and PIA.
To analyse the biological response on tumoral / non-tumoral and co-culture them with monocytes in order to study transcriptional profile changes.
From all the data obtained, overexpressed / underexpressed genes are being identified and validated. Stromal and inflammatory genes also will be explored for their potential use as early markers for prostatic cancer and their ability to identify PIA as a precursor lesion.
(Prostate Research Traslational Unit.)
IP: Inés de Torres Ramirez
Studying in colorectal cancer mechanisms of action of the central signal transduction pathways, identify potential molecular alterations that can be used as therapeutic targets and characterize the degree of genetic inestability.
IP: Santiago Ramon y Cajal Agüeras
IP: Carles Zafon Llopis Collaborators: Jordi Temprana Salvador, Carmela Iglesias i Felip Funding agency: Fundación Sdad Española Endocrinologia y Nutrición Funding: 10000 Reference: SEEN/PROJECTE/ZAFON/2024 Duration: 01/01/2025 - 01/01/2026
IP: Santiago Ramon y Cajal Agüeras Collaborators: - Funding agency: EUROPEAN COMMISSION Funding: 609600 Reference: EC/PATHFINDER_OPEN/2024/RAMON_Y_CAJAL Duration: 01/08/2025 - 31/07/2028
IP: Lucas Moreno Martín-Retortillo Collaborators: Andrea Vilaplana Blanes, Aroa Soriano Fernández, Jessica Camacho Soriano, Lorena Valero Arrese, Raquel Hladun Alvaro, Gabriela Guillén Burrieza Funding agency: Instituto de Salud Carlos III Funding: 240000 Reference: PI24/01576 Duration: 01/01/2025 - 31/12/2027
IP: Eva Colas Ortega Collaborators: Elena Suarez Salvador, Francesc Xavier Serra Marin, Carina Masferrer Ferragutcasas, Anna Ruano Lopez, Josep Castellví Vives, Sonia Monreal Clua, Diana Alejandra Guerrero Lojano, Raquel Delgado Gil Funding agency: Fundació La Marató de TV3 Funding: 200000 Reference: 202407-10 Duration: 20/02/2025 - 19/02/2028
PhD student: Nikaoly Ciriaco Cortés Director/s: Vicente Peg Camara, Santiago Ramon y Cajal Agüeras University: Year: 2024
PhD student: Irene Sansano Valero Director/s: Vicente Peg Camara University: Universidad Autònoma de Barcelona Year: 2021
PhD student: Jessica Camacho Soriano Director/s: Maria Mar Hernandez Guillamon, Elena Antima Martinez Saez, Santiago Ramon y Cajal Agüeras University: Universidad Autònoma de Barcelona Year: 2021
PhD student: Carmela Iglesias i Felip Director/s: Santiago Ramon y Cajal Agüeras University: Universidad Autònoma de Barcelona Year: 2020
PhD student: Pedro Fuentes Varela Director/s: Santiago Ramon y Cajal Agüeras University: Universidad Autònoma de Barcelona Year: 2020
PhD student: Maria José Muñoz Guijarro Director/s: Trond Aasen University: Universidad Autònoma de Barcelona Year: 2019
PhD student: Alejandra Fernández Martín Director/s: Mario Marotta Baleriola, José Luis Peiró Ibáñez University: Universidad Autònoma de Barcelona Year: 2017
PhD student: Maria Carme Dinarès Fernández Director/s: Javier Hernandez Losa, Santiago Ramon y Cajal Agüeras University: Universidad Autònoma de Barcelona Year: 2017
PhD student: Paul Augusto Espinoza Madrid Director/s: Miriam Cuatrecasas Freixas, Santiago Ramon y Cajal Agüeras University: Universidad Autònoma de Barcelona Year: 2016
PhD student: Josep Castellví Vives, Josep Castellví Vives Director/s: Angel García Jiménez, Santiago Ramon y Cajal Agüeras, Angel García Jiménez University: Universidad Autònoma de Barcelona Year: 2016
PhD student: Elena Antima Martinez Saez Director/s: Amparo Santamaría Ortiz, Amparo Santamaría Ortiz, Amparo Santamaría Ortiz University: Universidad Autònoma de Barcelona Year: 2016
PhD student: Elena Antima Martinez Saez Director/s: Santiago Ramon y Cajal Agüeras University: Universidad Autònoma de Barcelona Year: 2015
PhD student: Maria Teresa Salcedo Allende, Maria Teresa Salcedo Allende Director/s: Javier Hernandez Losa, Santiago Ramon y Cajal Agüeras University: Universidad Autònoma de Barcelona Year: 2015
PhD student: Vicente Peg Camara, Vicente Peg Camara, Vicente Peg Camara Director/s: Josep Lluis Parra Palau, Santiago Ramon y Cajal Agüeras, Isabel Teresa Rubio Rodríguez University: Universidad Autònoma de Barcelona Year: 2015
PhD student: Alba Martinez Diaz Director/s: Trond Aasen , Santiago Ramon y Cajal Agüeras University: Universidad Autònoma de Barcelona Year: 2014
PhD student: César Serrano Garcia Director/s: Joan Carles Galceran, Santiago Ramon y Cajal Agüeras, Cleofé Romagosa Pérez-Portabell University: Universidad Autònoma de Barcelona Year: 2014
The grants promote new therapeutic strategies and diagnostic tools in highly complex tumors such as glioblastoma, triple-negative breast cancer, and endometrial cancer.
The Department of Health of the Generalitat de Catalunya grants subsidies for carrying out validation tests on innovative projects in the field of health that are in the early stages of development.
The meeting was an opportunity to get to know projects from both institutions and to promote interaction between professionals.
Check the current rates for the services offered by the Translational Molecular Pathology research group.
Current Rates
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Rates Anatomia Patologica VHIR 2021
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