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Antonio Gil Moreno

I have a strong commitment towards the improvement and the innovation of the health system. I am the Head of the Gynaecology Service of the Vall Hebron Hospital since 2013 and chief and Principal Investigator of the Biomedical Research Group in Gynecology at Vall d'Hebron Research Institute from 2014. My involvement in clinical and translational research began in 1997 as a gynecologist at Vall d'Hebron Hospital and collaborator in Dr. Jaume Reventós group: the Biomedical Research Unit at VHIR. 

Institutions of which they are part

Head of group
Biomedical Research in Gynaecology
Vall Hebron Institut de Recerca
Head of Department
Gynaecology
Children's Hospital and Woman's Hospital
In the year 2004 I obtained my PhD in Medicine and Surgery at the University Autonomous of Barcelona (UAB) with the Cum Laude qualification. I also received the extraordinary award from the Department of Pediatric, Obstetrics and Gynecology, Preventive Medicine and Public Health. Since then I have been participating in more than 38 research projects, 9 of them as Principal Investigator in the last 5 years. As a result of this research, I have published more than 163 peer-reviewed articles in international journals (H index 28), as well as many articles in national journals, 23 book chapters, and 4 patents, one is licensed and ended up in a the first commercialized IVD in endometrial cancer.
I have broad experience in clinical oncology as well as great deal of experience as coordinator of translational oncology projects. Currently, all the ongoing projects carry out by my research group are based on unmet clinical issues on gynecologic cancers of the endometrium, ovary, cervix and vulva; and on gynecologic benign pathologies, such as endometriosis; combining both basic and translational research. In addition, I am a member of the SEGO SPAIN-GOG network.
 On the other hand, in relation to my academic profile, I have supervised or co-supervised 28 doctoral theses (14 completed and 14 in progress) and many other undergraduate and master's degree students who have obtained their degree after practicing in our group (GRB-G). I have also served on several thesis committees and I’m a reviewer for prestigious research journals. Regarding my teaching activity, I’m associate professor of Gynecology and Obstetrics at the Autonomous University of Barcelona (UAB) since 2010 (with AQU and ANECA professor accreditation) and director of the Master's degree in Gynecology Endoscopy at the Vall d'Hebron / UAB Hospital since 2005.
 Thanks to the commitment to carry out translational research, our results can be transferred from the laboratory to the patient, as is the case with GynEC-DX®, marketed by Reig Jofre since 2014 and CEMARK in development (PCT / EP2017 / 057635, EP17382483.0).
 

Research lines

Ovarian Cancer Research

Research team: Dr. Melissa Bardbury (Principal researcher) Dr. Antonio Gil-Moreno (Principal researcher) Dra. Anna Santamaría (Stable collaborator) Dr. Eva Coll (PhD student) Dr. Carlos López (PhD student) Dr. Melek Denizli (Technician) Dr. José Luís Sánchez Iglesias (Clinical associated investigator) Dr. Armando Reques (Clinical associated investigator) Dr. Assumpció Pérez-Benavente (Clinical associated investigator) Dr. Vicente Bebia Conesa (Clinical associated investigator) Dr. Natalia Rodríguez Gómez-Hidalgo (Clinical associated investigator) Dr. Javier de la Torre Fernández de Vega (Clinical associated investigator) Research focus PERIOPERATIVE IMMUNOMODULATION IN OVARIAN CANCER Surgery for advanced ovarian cancer is a stressful stimulus that results in a pro-catabolic hormonal and cytokine environment, which significantly impacts metabolism. This metabolic response is accompanied by immune system impairment, increasing the risk of post-operative complications. In this research line the group is working in a multidisplinary project within the ERAS® program at the Vall d’Hebron Hospital for the: Identification of inflammatory markers predicting improved recovery after surgery within an ERAS® protocol. MOLECULAR DIAGNOSTICS AND PREDICTION OF TREATMENT RESPONSE IN OVARIAN CANCER Ovarian cancer remains the leading cause of death from gynecological malignancies due to its late diagnosis and high recurrence rates following treatment. There is a need to improve the early detection of the disease and identify predictive markers of treatment response. These diagnostic and predictive markers are being identified in proximal body fluids and patient-tissue samples. In this research line, the group has 3 ongoing projects: Proteomic biomarkers for an improved diagnosis in uterine aspirates and pap-smears. Proteomic biomarkers for the prediction of treatment response. SalivOmiX: A salivary miRNA-based test for ovarian cancer early diagnosis.

IP: Melissa Bradbury Lobato, Antonio Gil Moreno

Clinical Research in Ginecology

Research team: Dr. Antonio Gil-Moreno (Principal researcher) Dr. Assumpció Pérez-Benavente (Clinical associated investigator) Dr. José Lúís Sánchez Iglesias (Clinical associated investigator) Dra. Silvia Cabrera (Clinical associated investigator) Dr. Vicente Bebia Conesa (Clinical associated investigator) Dr. Natalia Rodríguez Gómez-Hidalgo (Clinical associated investigator) Dr. Javier de la Torre Fernández de Vega (Clinical associated investigator) Dr. José Luís Poza Barrasús (Clinical associated investigator) Dr. Sabina Salicrú Riera (Clinical associated investigator) Dr. Laura Mañalich Barrachina (Clinical associated investigator) Dr. Montse Cubo Albert (Clinical associated investigator) Dr. Cristina Centeno Mediavilla (Clinical associated investigator) Dr. Melissa Bradbury (Clinical associated investigator) Dr. Sonia Monreal (Clinical associated investigator) Dr. Angel García (Clinical associated investigator) Dr. Armando Reques (Clinical associated investigator) Dr. Elena Suárez (Clinical associated investigator) Dr. Mireia Armengol (Clinical associated investigator/resident) Dra. Eva Colás (Translational associated researcher) Dr. Melek Denizli (Technician) Research focus. Clinical Research Lines CLINICAL ENDOMETRIAL CANCER RESEARCH - Prospective, randomized study: STELLA1-2 Trial: Transperitoneal vs. Extraperitoneal Approach for Laparoscopic Staging of Endometrial/Ovarian Cancer. ClinicalTrials.gov Identifier: NCT01810874. - Implementation of radioguided surgery for clinically occult lesions (ROLL) in abdominal recurrences of gynecological tumors. - MULTISENT study: Ambiespective multicenter study of sentinel node biopsy in initial endometrial cancer. - Concordance study between morphological techniques and OSNA (one-step nucleic cid amplification) for the detection of lymph node metastases in endometrial carcinoma. - Preoperative staging of endometrial carcinoma by ultrasound 2D and 3D. CLINICAL OVARIAN CANCER RESEARCH - Prospective study: Postoperatory Recovery in Advanced Ovarian Cancer, Fast-Track Protocol vs. Classical Management (PROFAST). ClinicalTrials.gov Identifier: NCT02172638. - EDMOCS study in ovarian cancer. - SIMACEO study: Current Situation of the Management of Epithelial Cancer of the Ovary in initial stages in Spain. CLINICAL CERVICAL CANCER RESEARCH - Prospective study of validation of sentinel lymph node detection technique in early cervical cancer (FIGO 2018 stages IA2-IB1-IB2-IIA1). - Collaborating center in the RACC Trial study (PI: Karolynska Hospital, Sweden): International, Prospective, Randomized comparative study of robotic versus laparotomic radical hysterectomy approach in early cervical cancer. - Validation of robotic assisted and laparoscopic aortic extraperitoneal lymphadenectomy in recurrences of gynaecologic malignancies. - Preoperative staging of carcinoma of the uterine cervix by ultrasound 2D and 3D. CLINICAL RESEARCH IN BENIGN GYNECOLOGY - Prospective study: Multicentric Comparative Randomized Study of the Single-incision Sling Ajust® Versus Suburethral Transobturator Slings. ClinicalTrials.gov Identifier: NCT01699425 - “A 3 Years Naturalistic Cohort Survey Of Altis® Single Incision Sling System For Female Stress Urinary Incontinence. A post-marketing and multicenter prospective observational cohort study in subjects with female stress urinary incontinence”. - "Non-interventional study to evaluate quality of life, satisfaction with treatment, use of resources and persistence in treatment in patients with overactive bladder (OAB) who were prescribed Betmiga". - “Comparative study of polyvinylidene fluoride and polypropylene suburethral-slings in the treatment of female stress urinary incontinence.” - “Microarray analysis of differentially expressed genes in samples from patients with pelvic organ prolapse.” Estudio EME: “Estudio epidemiológico sobre la miomatosis uterina en España”. CLINICAL RESEARCH: MISCELLANEOUS Prospective study of validation of sentinel lymph node detection technique in early vulvar cancer (early stages FIGO 2009) - Prospective study of quality of life in patients with BRCA1-2 after risk-reducing adnexectomy. - Prospective study of quality of life in patients with BRCA1-2 after risk-reducing mastectomy. - Early detection of preneoplastic tubal lesions to delay ovarian cancer risk-reducing surgery in patients with BRCA1/2 mutations. - Prospective, multicenter study for the evaluation of the intraoperative HPV test. - INCIP Study: Cancer in pregnancy - Randomized, open, multicentric, parallel group and control group clinical trial to evaluate the effect of PAPILOCARE® in the normalization of cytological alterations of the cervix caused by HPV (PALOMA II Clinical Trial). - Cervical epithelium methylation as a risk marker of progression to HSIL in women with normal cytology and positive HPV. - Conservative management of high-risk cervical intraepithelial lesions. - Utility of DySIS® in the diagnosis and management of intraepithelial lesions of the lower genital tract. - Breast Cancer During Pregnancy (BRCAPRE). ClinicalTrials.gov Identifier: NCT02102282.

IP: Antonio Gil Moreno

Projects

A dual liquid biopsy strategy in endometrial cancer: evaluation of risk of recurrence and personalized therapy

IP: Antonio Gil Moreno
Collaborators: Beatriz Villafranca Magdalena, Miriam Izquierdo Sans
Funding agency: Generalitat de Catalunya - Departament de Salut
Funding: 0.01
Reference: SLT017/20/000183
Duration: 05/07/2021 - 31/12/2021

Cytomark - Desarrollo de un test diagnóstico personalizado y no invasivo de cáncer de endometrio en el fluido cervical

IP: Eva Colas Ortega
Collaborators: Angel García Jiménez, Silvia Cabrera Diaz, Antonio Gil Moreno, Melek Denizli
Funding agency: Instituto de Salud Carlos III
Funding: 110715
Reference: AC21_2/00030
Duration: 01/01/2022 - 31/12/2024

A dual liquid biopsy strategy in endometrial cancer: evaluation of risk of recurrence and pesonalized therapy.

IP: Antonio Gil Moreno
Collaborators: Vicente Bebia Conesa, Angel García Jiménez, Carina Masferrer Ferragutcasas, A dual liquid biopsy strategy in endometrial cancer: evaluation of risk of recurrence and pesonalized therapy., Montserrat Cubo Abert, Mireia Armengol Alsina, Carlos Lopez Gil
Funding agency: Instituto de Salud Carlos III
Funding: 209330
Reference: PI20/01566
Duration: 01/01/2021 - 31/12/2023

"Estudio retrospectivo en la valoración del uso del Movilizador Uterino en el Cáncer de Endometrio estadio Inicial: estudio MUCEI".

IP: Antonio Gil Moreno
Collaborators: -
Funding agency:
Funding:
Reference: PR(AMI)273/2019
Duration: -

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