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Antonio Gil Moreno

Head of the Department of Obstetrics and Gynecology at the Vall d'Hebron University Hospital since 2013. Professor of the Chair of Gynecology and Obstetrics at the Autonomous University of Barcelona since 2010 and Principal Investigator of the Biomedical Research Group in Gynecology. My involvement in clinical and translational research in endometrial cancer began in 1997. Currently, research is also carried out in ovarian cancer, endometriosis and cervical pathology. From here, and with the aim of improving the healthcare system, I have participated in 45 research projects, 20 of them as principal researcher. These projects have resulted in a total of 285 articles with an Impact Factor, 38 articles in national magazines, 37 book chapters, and 5 patents. Between directed and in progress, I accumulate a total of 35 doctoral theses.

Institutions of which they are part

Head of group
Biomedical Research in Gynaecology
Vall Hebron Institut de Recerca
Head of Department
Gynaecology
Children's Hospital and Woman's Hospital

Antonio Gil Moreno

Institutions of which they are part

Head of group
Biomedical Research in Gynaecology
Vall Hebron Institut de Recerca
Head of Department
Gynaecology
Children's Hospital and Woman's Hospital

Head of the Department of Obstetrics and Gynecology at the Vall d'Hebron University Hospital since 2013. Professor of the Chair of Gynecology and Obstetrics at the Autonomous University of Barcelona since 2010 and Principal Investigator of the Biomedical Research Group in Gynecology. My involvement in clinical and translational research in endometrial cancer began in 1997. Currently, research is also carried out in ovarian cancer, endometriosis and cervical pathology. From here, and with the aim of improving the healthcare system, I have participated in 45 research projects, 20 of them as principal researcher. These projects have resulted in a total of 285 articles with an Impact Factor, 38 articles in national magazines, 37 book chapters, and 5 patents. Between directed and in progress, I accumulate a total of 35 doctoral theses.

Graduate in Medicine and Surgery in the Teaching Unit of the Vall d'Hebron Hospital. Medical specialist in Obstetrics and Gynecology (MIR), Hospital Residency between 1991 and 1994 at the Vall d'Hebron Maternity-Children's Hospital. Doctoral thesis presented in 2004 with an Excellent Cum Laude rating, and Extraordinary Doctorate Award from the Department of Paediatrics, Obstetrics and Gynecology and Preventive Medicine, of the UAB. Specialist in Obstetrics and Gynecology at the Vall d'Hebron Maternal-Child Hospital, in the Oncological Gynecology Unit, from 1995 to 2010. Head of the Oncological Gynecology and Early Cancer Diagnosis Section at the Maternal-Child Hospital of the Vall Hebron Hospital from 2010 to 2013. Head of the HUVH Gynecology and Obstetrics Service since 2013. Associate Professor of Gynecology and Obstetrics at the UAB from 2000 to 2010. Associate Professor at Universitat Autònoma de Barcelona since 2010 to June 2023 and I have held the position of professor since then. Member of the Central Commission for Teaching at Vall d'Hebron (2005-2008). Director of the Master's Degree in Gynecological Endoscopy at Universitat Autònoma de Barcelona (2005-present). ASSOCIATE FELLOW of the European Society of Gynecological Oncology. Principal Investigator of the Biomedical Research Group in Gynecology. My involvement in clinical and translational research in endometrial cancer began in 1997. I have participated in 45 research projects, 20 of them as principal investigator, which have resulted in a total of 285 articles, 38 journal articles and 37 chapters of books, with an H index of 35. I have also participated as inventor of 5 patents. I have directed a total of 35 doctoral theses, of which 25 have already been defended, the remaining 10 are still in progress. Numerous oral presentations and oral communications, in the form of posters and in video format, international and national since 1992. Received 25 prizes awarded to communications presented at congresses and the Victor Conill and Montobbio Award from the Academy of Medical Sciences 2005 for the best work published in a scientific journal (Cancer Research). Reviewer of articles in the Gynecologic Oncology; European Journal of Cancer; Journal of Gynecologic Oncology; International Journal Gynecological Cancer; European Journal of Obstetrics & Gynecology and Reproductive Biology; Journal of Medical Robotics and Computer Assisted Surgery; Journal of Minimally Invasive Gynecology, among others.

Among his tasks we find Director of the Department of Pediatrics, Obstetrics and Gynecology, Preventive Medicine and Public Health, since 2021, Director and coordinator of the Research Network of the Section of Oncology Gynecology and Breast Pathology of the Spanish Society of Oncology Gynecology (SEGO), since 2017, vicepresident Member of the Sección de Ginecología Oncológica y Patología Mamaria de la Sociedad Española de Ginecología Oncológica (SEGO), since 2017 and Member of the Internal Scientific Committee (CCI) of the VHIR since 2018.

In addition, I am accredited by ANECA and AQU as a university professor.

Research lines

Ovarian Cancer Research

Research team:


Dr. Melissa Bardbury (Principal researcher)

Dr. Antonio Gil-Moreno (Principal researcher)

Dra. Anna Santamaría (Stable collaborator)

Dr. Eva Coll (PhD student)

Dr. Carlos López (PhD student)

Dr. Melek Denizli (Technician)

Dr. José Luís Sánchez Iglesias (Clinical associated investigator)

Dr. Armando Reques (Clinical associated investigator)

Dr. Assumpció Pérez-Benavente (Clinical associated investigator)

Dr. Vicente Bebia Conesa (Clinical associated investigator)

Dr. Natalia Rodríguez Gómez-Hidalgo (Clinical associated investigator)

Dr. Javier de la Torre Fernández de Vega (Clinical associated investigator)


Research focus


PERIOPERATIVE IMMUNOMODULATION IN OVARIAN CANCER

Surgery for advanced ovarian cancer is a stressful stimulus that results in a pro-catabolic hormonal and cytokine environment, which significantly impacts metabolism. This metabolic response is accompanied by immune system impairment, increasing the risk of post-operative complications. In this research line the group is working in a multidisplinary project within the ERAS® program at the Vall d’Hebron Hospital for the: 

Identification of inflammatory markers predicting improved recovery after surgery within an ERAS® protocol.


MOLECULAR DIAGNOSTICS AND PREDICTION OF TREATMENT RESPONSE IN OVARIAN CANCER

Ovarian cancer remains the leading cause of death from gynecological malignancies due to its late diagnosis and high recurrence rates following treatment. There is a need to improve the early detection of the disease and identify predictive markers of treatment response. These diagnostic and predictive markers are being identified in proximal body fluids and patient-tissue samples. In this research line, the group has 3 ongoing projects:

Proteomic biomarkers for an improved diagnosis in uterine aspirates and pap-smears.

Proteomic biomarkers for the prediction of treatment response.

SalivOmiX: A salivary miRNA-based test for ovarian cancer early diagnosis.


IP: Bradbury Lobato, Melissa, Gil Moreno, Antonio

Clinical Research in Ginecology

Research team:


Dr. Antonio Gil-Moreno (Principal researcher)

Dr. Assumpció Pérez-Benavente (Clinical associated investigator)

Dr. José Lúís Sánchez Iglesias (Clinical associated investigator)

Dra. Silvia Cabrera (Clinical associated investigator)

Dr. Vicente Bebia Conesa (Clinical associated investigator)

Dr. Natalia Rodríguez Gómez-Hidalgo (Clinical associated investigator)

Dr. Javier de la Torre Fernández de Vega (Clinical associated investigator)

Dr. José Luís Poza Barrasús (Clinical associated investigator)

Dr. Sabina Salicrú Riera (Clinical associated investigator)

Dr. Laura Mañalich Barrachina (Clinical associated investigator)

Dr. Montse Cubo Albert (Clinical associated investigator)

Dr. Cristina Centeno Mediavilla (Clinical associated investigator)

Dr. Melissa Bradbury (Clinical associated investigator)

Dr. Sonia Monreal (Clinical associated investigator)

Dr. Angel García (Clinical associated investigator)

Dr. Armando Reques (Clinical associated investigator)

Dr. Elena Suárez (Clinical associated investigator)

Dr. Mireia Armengol (Clinical associated investigator/resident)

Dra. Eva Colás (Translational associated researcher)

Dr. Melek Denizli (Technician)



Research focus. Clinical Research Lines



CLINICAL ENDOMETRIAL CANCER RESEARCH

- Prospective, randomized study: STELLA1-2 Trial: Transperitoneal vs. Extraperitoneal Approach for Laparoscopic Staging of Endometrial/Ovarian Cancer. ClinicalTrials.gov Identifier: NCT01810874.

- Implementation of radioguided surgery for clinically occult lesions (ROLL) in abdominal recurrences of gynecological tumors.

- MULTISENT study: Ambiespective multicenter study of sentinel node biopsy in initial endometrial cancer.

- Concordance study between morphological techniques and OSNA (one-step nucleic cid amplification) for the detection of lymph node metastases in endometrial carcinoma.

- Preoperative staging of endometrial carcinoma by ultrasound 2D and 3D.


CLINICAL OVARIAN CANCER RESEARCH

- Prospective study: Postoperatory Recovery in Advanced Ovarian Cancer, Fast-Track Protocol vs. Classical Management (PROFAST). ClinicalTrials.gov Identifier: NCT02172638.

- EDMOCS study in ovarian cancer.

- SIMACEO study: Current Situation of the Management of Epithelial Cancer of the Ovary in initial stages in Spain.


CLINICAL CERVICAL CANCER RESEARCH

- Prospective study of validation of sentinel lymph node detection technique in early cervical cancer (FIGO 2018 stages IA2-IB1-IB2-IIA1).

- Collaborating center in the RACC Trial study (PI: Karolynska Hospital, Sweden): International, Prospective, Randomized comparative study of robotic versus laparotomic radical hysterectomy approach in early cervical cancer.

- Validation of robotic assisted and laparoscopic aortic extraperitoneal lymphadenectomy in recurrences of gynaecologic malignancies.

- Preoperative staging of carcinoma of the uterine cervix by ultrasound 2D and 3D.


CLINICAL RESEARCH IN BENIGN GYNECOLOGY

- Prospective study: Multicentric Comparative Randomized Study of the Single-incision Sling Ajust® Versus Suburethral Transobturator Slings. ClinicalTrials.gov Identifier: NCT01699425

- “A 3 Years Naturalistic Cohort Survey Of Altis® Single Incision Sling System For Female Stress Urinary Incontinence. A post-marketing and multicenter prospective observational cohort study in subjects with female stress urinary incontinence”.

- "Non-interventional study to evaluate quality of life, satisfaction with treatment, use of resources and persistence in treatment in patients with overactive bladder (OAB) who were prescribed Betmiga".

- “Comparative study of polyvinylidene fluoride and polypropylene suburethral-slings in the treatment of female stress urinary incontinence.”

- “Microarray analysis of differentially expressed genes in samples from patients with pelvic organ prolapse.”

Estudio EME: “Estudio epidemiológico sobre la miomatosis uterina en España”.


CLINICAL RESEARCH: MISCELLANEOUS

Prospective study of validation of sentinel lymph node detection technique in early vulvar cancer (early stages FIGO 2009)

- Prospective study of quality of life in patients with BRCA1-2 after risk-reducing adnexectomy.

- Prospective study of quality of life in patients with BRCA1-2 after risk-reducing mastectomy.

- Early detection of preneoplastic tubal lesions to delay ovarian cancer risk-reducing surgery in patients with BRCA1/2 mutations.

- Prospective, multicenter study for the evaluation of the intraoperative HPV test.

- INCIP Study: Cancer in pregnancy

- Randomized, open, multicentric, parallel group and control group clinical trial to evaluate the effect of PAPILOCARE® in the normalization of cytological alterations of the cervix caused by HPV (PALOMA II Clinical Trial).

- Cervical epithelium methylation as a risk marker of progression to HSIL in women with normal cytology and positive HPV.

- Conservative management of high-risk cervical intraepithelial lesions.

- Utility of DySIS® in the diagnosis and management of intraepithelial lesions of the lower genital tract.

- Breast Cancer During Pregnancy (BRCAPRE). ClinicalTrials.gov Identifier: NCT02102282.

IP: Gil Moreno, Antonio

Projects

Development of a personalised non-invasive diagnosis of endometrial cancer using proteomic markers in cervical fluids and clinical data

IP: Gil Moreno, Antonio
Collaborators: De la Calle Fuentes, Irene, Izquierdo Sans , Miriam
Funding agency: Instituto de Salud Carlos III
Funding: 89900
Reference: IFI22/00019
Duration: 01/01/2023 - 31/12/2026

Formación en cirugía ginecológica e investigación clínica con desarrollo del proyecto de tesis doctoral sobre el papel de la linfadenectomía aórtica extraperitoneal en el cáncer de cérvix localmente avanzado.

IP: Gil Moreno, Antonio
Collaborators: Acosta Sánchez , Úrsula, Izquierdo Sans , Miriam
Funding agency: Instituto de Salud Carlos III
Funding: 65000
Reference: CM22/00150
Duration: 01/01/2023 - 31/12/2024

NUEVAS APROXIMACIONES PARA EL DIAGNÓSTICO DE CÁNCER DE ENDOMETRIO.

IP: Gil Moreno, Antonio
Collaborators: Cabrera Diaz, Silvia, Rebull Santamaria, Marta, NUEVAS APROXIMACIONES PARA EL DIAGNÓSTICO DE CÁNCER DE ENDOMETRIO., De la Calle Fuentes, Irene
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 369335
Reference: CPP2021-008440
Duration: 14/02/2022 - 13/02/2025

Ministerio de Ciencia

Recerca biomèdica en ginecologia

IP: Gil Moreno, Antonio
Collaborators: Rodriguez Gómez - Hidalgo , Natalia, Suarez Salvador, Elena, Poza Barrasus, Jose Luis, Bebia Conesa, Vicente , García Jiménez, Angel, Perez Benavente, Maria Asuncion, Masferrer Ferragutcasas, Carina, Colas Ortega, Eva, Salicrú Riera, Sabina, De la Torre Fdez de Vega, Fco Javier, Recerca biomèdica en ginecologia, Cubo Abert, Montserrat, Cabrera Diaz, Silvia, Mañalich Barrachina, Laura, Rebull Santamaria, Marta, Armengol Alsina, Mireia, Recerca biomèdica en ginecologia, De la Calle Fuentes, Irene, Sánchez Iglesias, José Luis, Bradbury Lobato, Melissa, Villafranca Magdalena, Beatriz, Denizli , Melek, Cabre Fernandez, Paula
Funding agency: AGAUR no fer servir-correcte 4301-37
Funding: 40000
Reference: 2021 SGR 01157
Duration: 01/01/2022 - 31/12/2024

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