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Antonio Gil Moreno

Cap de Servei d'Obstetrícia i Ginecologia de l'Hospital Universitari Vall d'Hebron des del 2013. Professor Titular de la Càtedra de Ginecologia i Obstetrícia de la Universitat Autònoma de Barcelona des de l'any 2010 i Investigador Principal del Grup de Recerca Biomèdica en Ginecologia. La meva implicació en la investigació clínica i traslacional en càncer d'endometri es va iniciar el 1997. A partir d'aquí, i amb l'objectiu de millorar el sistema sanitari, he participat en 27 projectes de recerca, 7 d'ells com a investigador principal en els darrers 5 anys. Aquests projectes han donat com a fruit un total de 81 articles amb Factor d'Impacte, 36 articles en revistes, 30 capítols de llibres, i 3 patents. He dirigit i/o estic dirigint un total de 18 tesis doctorals.

Instituciones de las que forman parte

Jefe de grupo
Investigación Biomédica en Ginecología
Vall Hebron Institut de Recerca
Jefe de Servicio
Ginecología
Hospital Infantil i Hospital de la Mujer
Llicenciat en Medicina i Cirurgia a la Unitat Docent de l'Hospital Vall d'Hebron (1983-1989). Metge especialista en Obstetrícia i Ginecologia via MIR, Residència hospitalària entre 1991 i 1994 a l'Hospital Materno-Infantil Vall d'Hebron. Tesi doctoral presentada el 2004 amb qualificació Excel·lent Cum Laude, i Premi extraordinari de Doctorat del Departament de Pediatria, Obstetrícia i Ginecologia i de Medicina Preventiva, de la UAB. Facultatiu Especialista d'Obstetrícia i Ginecologia a l'Hospital Materno-Infantil Vall d'Hebron, a la Unitat de Ginecologia Oncològica, de 1995 a 2010. Cap de Secció de Ginecologia Oncològica i Diagnòstic Precoç del Càncer a l'Hospital Materno-Infantil Vall d'Hebron de 2010 a 2013. Cap de Servei d'Obstetrícia i Ginecologia de l'HUVH des de 2013. Professor associat de Ginecologia i Obstetrícia de la UAB de 2000 a 2010. Professor Titular de la Universitat Autònoma de Barcelona des de l'any 2010. Tutor de residents de l'especialitat d'Obstetrícia i Ginecologia, acreditat per la Comissió de Docència des de juny de 2001, i per la "Xarxa de Comissions de Docència i Assessors de Catalunya, de l'IES", des de desembre de 2005. Membre de la Comissió Central de Docència de Vall d'Hebron (2005-2008). Director del Màster d'Endoscòpia Ginecològica de la Universitat Autònoma de Barcelona, Codirector de curs de doctorat organitzat pel Servei de Ginecologia (2008-2010). En formació de postgrau: Assistència a més de congressos i Cursos nacionals i més de 30 Congressos, Symposium i Cursos Internacionals. ASSOCIATE FELLOW de l'European Society of Gynaecological Oncology Investigador Principal del Grup de Recerca Biomèdica en Ginecologia. La meva implicació en la investigació clínica i traslacional en càncer d'endometri es va iniciar el 1997. He participat en 27 projectes de recerca, 7 d'ells com a investigador principal en els darrers 5 anys, que han donat com a fruit un total de 81 articles, 36 articles en revistes, 30 capítols de llibres, i 3 patents. He dirigit/estic dirigint un total de 18 tesis doctorals. Nombroses ponències orals, comunicacions orals, en forma de pòsters i en format de vídeo internacionals i nacionals des de 1992. Rebuts 13 premis concedits a comunicacions presentades a congressos i Premi Victor Conill i Montobbio de l'Acadèmia de Ciències Mèdiques 2005 al millor treball publicat en una revista científica (Cancer Research). Revisor d'articles de les revistes Gynecologic Oncology; European Journal of Obstetrics & Gynecology and Reproductive Biology, i Journal of Medical Robotics and Computer Assisted Surgery Membre del Comitè Editorial i revisor de la revista "Ginecologia Oncològica. Un enfocament multidisciplinari" des de 2007.

Líneas de investigación

Ovarian Cancer Research

Research team:


Dr. Melissa Bardbury (Principal researcher)

Dr. Antonio Gil-Moreno (Principal researcher)

Dra. Anna Santamaría (Stable collaborator)

Dr. Eva Coll (PhD student)

Dr. Carlos López (PhD student)

Dr. Melek Denizli (Technician)

Dr. José Luís Sánchez Iglesias (Clinical associated investigator)

Dr. Armando Reques (Clinical associated investigator)

Dr. Assumpció Pérez-Benavente (Clinical associated investigator)

Dr. Vicente Bebia Conesa (Clinical associated investigator)

Dr. Natalia Rodríguez Gómez-Hidalgo (Clinical associated investigator)

Dr. Javier de la Torre Fernández de Vega (Clinical associated investigator)


Research focus


PERIOPERATIVE IMMUNOMODULATION IN OVARIAN CANCER

Surgery for advanced ovarian cancer is a stressful stimulus that results in a pro-catabolic hormonal and cytokine environment, which significantly impacts metabolism. This metabolic response is accompanied by immune system impairment, increasing the risk of post-operative complications. In this research line the group is working in a multidisplinary project within the ERAS® program at the Vall d’Hebron Hospital for the: 

Identification of inflammatory markers predicting improved recovery after surgery within an ERAS® protocol.


MOLECULAR DIAGNOSTICS AND PREDICTION OF TREATMENT RESPONSE IN OVARIAN CANCER

Ovarian cancer remains the leading cause of death from gynecological malignancies due to its late diagnosis and high recurrence rates following treatment. There is a need to improve the early detection of the disease and identify predictive markers of treatment response. These diagnostic and predictive markers are being identified in proximal body fluids and patient-tissue samples. In this research line, the group has 3 ongoing projects:

Proteomic biomarkers for an improved diagnosis in uterine aspirates and pap-smears.

Proteomic biomarkers for the prediction of treatment response.

SalivOmiX: A salivary miRNA-based test for ovarian cancer early diagnosis.


IP: Melissa Bradbury Lobato, Antonio Gil Moreno

Clinical Research in Ginecology

Research team:


Dr. Antonio Gil-Moreno (Principal researcher)

Dr. Assumpció Pérez-Benavente (Clinical associated investigator)

Dr. José Lúís Sánchez Iglesias (Clinical associated investigator)

Dra. Silvia Cabrera (Clinical associated investigator)

Dr. Vicente Bebia Conesa (Clinical associated investigator)

Dr. Natalia Rodríguez Gómez-Hidalgo (Clinical associated investigator)

Dr. Javier de la Torre Fernández de Vega (Clinical associated investigator)

Dr. José Luís Poza Barrasús (Clinical associated investigator)

Dr. Sabina Salicrú Riera (Clinical associated investigator)

Dr. Laura Mañalich Barrachina (Clinical associated investigator)

Dr. Montse Cubo Albert (Clinical associated investigator)

Dr. Cristina Centeno Mediavilla (Clinical associated investigator)

Dr. Melissa Bradbury (Clinical associated investigator)

Dr. Sonia Monreal (Clinical associated investigator)

Dr. Angel García (Clinical associated investigator)

Dr. Armando Reques (Clinical associated investigator)

Dr. Elena Suárez (Clinical associated investigator)

Dr. Mireia Armengol (Clinical associated investigator/resident)

Dra. Eva Colás (Translational associated researcher)

Dr. Melek Denizli (Technician)



Research focus. Clinical Research Lines



CLINICAL ENDOMETRIAL CANCER RESEARCH

- Prospective, randomized study: STELLA1-2 Trial: Transperitoneal vs. Extraperitoneal Approach for Laparoscopic Staging of Endometrial/Ovarian Cancer. ClinicalTrials.gov Identifier: NCT01810874.

- Implementation of radioguided surgery for clinically occult lesions (ROLL) in abdominal recurrences of gynecological tumors.

- MULTISENT study: Ambiespective multicenter study of sentinel node biopsy in initial endometrial cancer.

- Concordance study between morphological techniques and OSNA (one-step nucleic cid amplification) for the detection of lymph node metastases in endometrial carcinoma.

- Preoperative staging of endometrial carcinoma by ultrasound 2D and 3D.


CLINICAL OVARIAN CANCER RESEARCH

- Prospective study: Postoperatory Recovery in Advanced Ovarian Cancer, Fast-Track Protocol vs. Classical Management (PROFAST). ClinicalTrials.gov Identifier: NCT02172638.

- EDMOCS study in ovarian cancer.

- SIMACEO study: Current Situation of the Management of Epithelial Cancer of the Ovary in initial stages in Spain.


CLINICAL CERVICAL CANCER RESEARCH

- Prospective study of validation of sentinel lymph node detection technique in early cervical cancer (FIGO 2018 stages IA2-IB1-IB2-IIA1).

- Collaborating center in the RACC Trial study (PI: Karolynska Hospital, Sweden): International, Prospective, Randomized comparative study of robotic versus laparotomic radical hysterectomy approach in early cervical cancer.

- Validation of robotic assisted and laparoscopic aortic extraperitoneal lymphadenectomy in recurrences of gynaecologic malignancies.

- Preoperative staging of carcinoma of the uterine cervix by ultrasound 2D and 3D.


CLINICAL RESEARCH IN BENIGN GYNECOLOGY

- Prospective study: Multicentric Comparative Randomized Study of the Single-incision Sling Ajust® Versus Suburethral Transobturator Slings. ClinicalTrials.gov Identifier: NCT01699425

- “A 3 Years Naturalistic Cohort Survey Of Altis® Single Incision Sling System For Female Stress Urinary Incontinence. A post-marketing and multicenter prospective observational cohort study in subjects with female stress urinary incontinence”.

- "Non-interventional study to evaluate quality of life, satisfaction with treatment, use of resources and persistence in treatment in patients with overactive bladder (OAB) who were prescribed Betmiga".

- “Comparative study of polyvinylidene fluoride and polypropylene suburethral-slings in the treatment of female stress urinary incontinence.”

- “Microarray analysis of differentially expressed genes in samples from patients with pelvic organ prolapse.”

Estudio EME: “Estudio epidemiológico sobre la miomatosis uterina en España”.


CLINICAL RESEARCH: MISCELLANEOUS

Prospective study of validation of sentinel lymph node detection technique in early vulvar cancer (early stages FIGO 2009)

- Prospective study of quality of life in patients with BRCA1-2 after risk-reducing adnexectomy.

- Prospective study of quality of life in patients with BRCA1-2 after risk-reducing mastectomy.

- Early detection of preneoplastic tubal lesions to delay ovarian cancer risk-reducing surgery in patients with BRCA1/2 mutations.

- Prospective, multicenter study for the evaluation of the intraoperative HPV test.

- INCIP Study: Cancer in pregnancy

- Randomized, open, multicentric, parallel group and control group clinical trial to evaluate the effect of PAPILOCARE® in the normalization of cytological alterations of the cervix caused by HPV (PALOMA II Clinical Trial).

- Cervical epithelium methylation as a risk marker of progression to HSIL in women with normal cytology and positive HPV.

- Conservative management of high-risk cervical intraepithelial lesions.

- Utility of DySIS® in the diagnosis and management of intraepithelial lesions of the lower genital tract.

- Breast Cancer During Pregnancy (BRCAPRE). ClinicalTrials.gov Identifier: NCT02102282.

IP: Antonio Gil Moreno

Proyectos

A dual liquid biopsy strategy in endometrial cancer: evaluation of risk of recurrence and personalized therapy

IP: Antonio Gil Moreno
Colaboradores: Beatriz Villafranca Magdalena, Miriam Izquierdo Sans
Entidad financiadora: Generalitat de Catalunya - Departament de Salut
Financiación: 0.01
Referencia: SLT017/20/000183
Duración: 05/07/2021 - 31/12/2021

Cytomark - Desarrollo de un test diagnóstico personalizado y no invasivo de cáncer de endometrio en el fluido cervical

IP: Eva Colas Ortega
Colaboradores: Angel García Jiménez, Silvia Cabrera Diaz, Antonio Gil Moreno, Melek Denizli
Entidad financiadora: Instituto de Salud Carlos III
Financiación: 110715
Referencia: AC21_2/00030
Duración: 01/01/2022 - 31/12/2024

A dual liquid biopsy strategy in endometrial cancer: evaluation of risk of recurrence and pesonalized therapy.

IP: Antonio Gil Moreno
Colaboradores: Vicente Bebia Conesa, Angel García Jiménez, Carina Masferrer Ferragutcasas, A dual liquid biopsy strategy in endometrial cancer: evaluation of risk of recurrence and pesonalized therapy., Montserrat Cubo Abert, Mireia Armengol Alsina, Carlos Lopez Gil
Entidad financiadora: Instituto de Salud Carlos III
Financiación: 209330
Referencia: PI20/01566
Duración: 01/01/2021 - 31/12/2023

"Estudio retrospectivo en la valoración del uso del Movilizador Uterino en el Cáncer de Endometrio estadio Inicial: estudio MUCEI".

IP: Antonio Gil Moreno
Colaboradores: -
Entidad financiadora:
Financiación:
Referencia: PR(AMI)273/2019
Duración: -

Noticias relacionadas

En el Día Mundial de la Investigación en Cáncer, destacamos el impacto de los proyectos del VHIR en el campo de la oncología.

La Recuperación Intensificada en Cirugía consigue que el proceso perioperatori de las pacientes de ginecología oncológica mejore, acortando la estancia hospitalaria, los reingresos, las complicaciones postoperatorias y el confort de las pacientes.

Las Ayudas en Investigación 2021 de la AECC impulsarán los trabajos liderados por la Dra. Fernanda da Silva y la Dra. Eva Colàs.

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