Jaume Alijotas Reig Institutions of which they are part Head of group Systemic Diseases Vall Hebron Institut de Recerca Email Jaume Alijotas Reig Email Institutions of which they are part Head of group Systemic Diseases Vall Hebron Institut de Recerca
Research lines Proinflammatory cytokines TNF and IL-6 in cellular senescence. A HUVEC aging model. Cells that are chronically exposed to inflammatory signals are more prone to aging than those which are not exposed to such signals. Human vascular endothelial cell (HUVEC) primary cultures activated with TNF-alpha probably increase the expression of ICAM and VCAM, synthesize ROS, and express senescence markers. It is not known what the principal intracellular pathway is (although it is thought that STAT may play a role) and it is unknown if one or more proinflammatory cytokines are needed to activate NF-KB. We are trying to find out the role that IFN-alpha and/or IL-6 and IL-1B may have on the aging inflammatory phenomena and we aim at detecting the intracellular signal pathways (STAT). We are also working on the characterization of the genes involved in these abnormal biologic responses. IP: Jaume Alijotas Reig Immunological basis and new therapeutic options in severe preeclampsia. Three to five percent of pregnancies are complicated by preeclampsia (PE). PE is a multisystemic-related endothelial dysfunction disorder characterized by hypertension, proteinuria and renal injury. Despite considerable research, its etiology and pathophysiology still remains unclear. Different theories involving many pathways including thrombophilia, immunologic changes, circulating angiogenic /antiangiogenic factors and increased oxidative stress have been related to its pathogenesis. The role played by antiphospholipid antibodies (aPL) is a matter of discussion in PE. Biological evidence of endothelial dysfunction related to PE/FGR has been shown by modified plasma markers including fibronectin, von Willebrand factor and ICAM-1 in a similar manner to that which occurs in aPL-related obstetric complications. We are searching now the role played by different aPL and cofactor antibodies, as well as its relationship with angiogenic /antiangiogenic factors and microparticle number in severe PE. IP: Jaume Alijotas Reig, Elisa Llurba Olivé, Anna Suy Franch Immunological alterations as basis of inmunosenescencein pathological aging. This research line is centered into the study of the role of cross-reactivity among oxidized lipoproteins (oxLDL), antiB2-GP1 and membrane phospholipids, as well as between these complexes and heat shock proteins. We also focus into the role of proinflamatory (IL2 / IL6 / TNFalpha) and anti-inflamatory (IL4 / IL-10) cytokines, as well as with the different activation profiles of TCR and/or CD14 (TLR4) and the role of hormones such as melatonin and the growth hormone. IP: Jaume Alijotas Reig Endothelial senescence and their pleiotropic effects onto inflamatory processes, inmunological response and angiogenesis. Identification at the molecular level of pathways and proteins associated with the senescence of endothelial cells linked to aging and inflamatory responses. New candidate targets for therapeutic intervention at the clinical level and as new molecular moieties for nanomedicine approaches to improve aging related pathologies caused by endothelial inflamatory based senescence. IP: Jaume Alijotas Reig Pagination Current page 1 Page 2 Page 3 Next page › Last page » Projects Anticuerpos antifosfolipídicos inductores de memoria inmune innata en monocitos como causa de morbilidad obstétrica en el síndrome antifosfolipídico. IP: Francesc Miro Mur Collaborators: Jaume Alijotas Reig, José Pardos Gea, Ariadna Anunciacion Llunell, Joana Rita Marques Soares Funding agency: Instituto de Salud Carlos III Funding: 102500 Reference: PI24/01302 Duration: 01/01/2025 - 31/12/2027 Ajuts Grups de Recerca (SGR) 2022 IP: Jaume Alijotas Reig Collaborators: Moisés Labrador Horrillo, Carmen Pilar Simeón i Aznar, Anna Sala Cunill, Roser Solans Laque, Segundo Bujan Rivas, Mar Guilarte Clavero, Vicenç Fonollosa Pla, Fernando Martínez Valle, Victòria Cardona Dahl, Francesc Miro Mur, Alfredo Guillen Del Castillo, Albert Selva O'Callaghan, José Pardos Gea, Ariadna Anunciacion Llunell Funding agency: Agència Gestió Ajuts Universitaris i de Recerca Funding: 0.01 Reference: 2021 SGR 00048 Duration: 01/01/2022 - 30/06/2025 Be Sure genetic test to determine dermal filler implant adverse reactions IP: Jaume Alijotas Reig Collaborators: - Funding agency: CERCA (Centres de Recerca de Catalunya) Funding: 10000 Reference: 2020-07-010 Duration: 01/01/2019 - 31/12/2020 Factores angiogénicos durante la gestación y riesgo cardiovascular a medio-largo plazo en las pacientes con preeclampsia. Abordaje clínico y experimental. IP: Jaume Alijotas Reig Collaborators: Manel Mendoza Cobaleda, Josep Perapoch López Funding agency: Instituto de Salud Carlos III Funding: 71995 Reference: PI16/01997 Duration: 01/01/2017 - 31/12/2019 Pagination Current page 1 Page 2 Page 3 Next page › Last page »
