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Jordi Barquinero Mañez

I am an MD, specialized in Internal Medicine, and senior researcher at the Vall d'Hebron Research Institute (VHIR). Doctor from the UAB with Extraordinary Award. I received post-doctoral training at the Fred Hutchinson Cancer Research Center (Seattle). I am currently leading the Gene and Cell Therapy group at the VHIR. My interest has focused on understanding disease mechanisms and finding effective therapies for orphan diseases. In our laboratory we have worked on gene therapy research projects for several rare diseases, mainly of genetic origin.

Institutions of which they are part

Head of group
Gene and Cell Therapy
Vall Hebron Institut de Recerca

Jordi Barquinero Mañez

Institutions of which they are part

Head of group
Gene and Cell Therapy
Vall Hebron Institut de Recerca

I am an MD, specialized in Internal Medicine, and senior researcher at the Vall d'Hebron Research Institute (VHIR). Doctor from the UAB with Extraordinary Award. I received post-doctoral training at the Fred Hutchinson Cancer Research Center (Seattle). I am currently leading the Gene and Cell Therapy group at the VHIR. My interest has focused on understanding disease mechanisms and finding effective therapies for orphan diseases. In our laboratory we have worked on gene therapy research projects for several rare diseases, mainly of genetic origin.

I am an MD specialized in Internal Medicine (Vall d'Hebron University Hospital). I worked at the Intensive Care Unit (HUVH) and the Emergency Department of the Hospital de l'Esperança. I did pre-doctoral studies on autoimmunity at the University of Louisville (Dr. N. Harris) and got my PhD at the Autonomous University of Barcelona with Extraordinary Award, with a work that contributed to the description of a new disease, the primary antiphospholipid syndrome. I was a postdoc at the Fred Hutchinson Cancer Research Center (Dr. R. Storb, Seattle), where I was trained in hematopoietic stem cell gene therapy. I am currently group leader of the gene and cell therapy group (VHIR), where we investigate new therapeutic strategies for rare genetic diseases, mostly in collaboration with other groups on campus and from other national and international institutions. We have participated in research projects using models of multiple sclerosis, hemophilia, MNGIE, in a clinical trial for Fanconi anemia type A (coordinated by Drs. J. Bueren and P. Río, at the CIEMAT (Madrid)), and more recently, in a novel gene therapy approach for muscular dystrophy due to merosin deficiency, in collaboration with the Pediatric Neurology group (Drs. F. Munell and D. Gómez). Our group is part of the national network TERAV (RICORS). I have participated in European projects (INHERINET, CONSERT), including one as coordinator (HEMO-IPS, e-Rare-2), in which we experimentally demonstrated the mutagenic mechanism of the "Royal disease", the form of hemophilia B that affected several European royal families in the 19th and 20th centuries. I participate as a teacher in different master's degrees and I am a member of the American and European Gene and Cell Therapy Societies, and was one of the founding members of the Spanish Society of Gene and Cell Therapy.

Research lines

Gene therapy of congenital muscular dystrophy due to merosin deficiency

Development of a new gene therapy strategy based on high-capacity adenoviral vectors, which we carry out in collaboration with the group of Dr. Rubén Hernández, from the University of Navarra.

IP: Jordi Barquinero Mañez

Projects

Teràpia gènica en MDC1A

IP: Jordi Barquinero Mañez
Collaborators: Laia Perez Lasarte, Maria Pallares Masmitja
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 67400
Reference: JDC2022-049508-I
Duration: 01/01/2024 - 31/12/2025

Ministerio de Ciencia

Activitat del pèptid K18-8R com a potenciador de la transducció

IP: Jordi Barquinero Mañez
Collaborators: -
Funding agency: Agència Gestió Ajuts Universitaris i de Recerca
Funding: 20000
Reference: 2021 LLAV 00032
Duration: 12/10/2022 - 11/07/2023

Distrofia muscular congénita tipo 1A: inhibición de la fibrosis y corrección mediante edición génica

IP: Jordi Barquinero Mañez
Collaborators: Laura Costa Comellas, Francina Munell Casadesus, Gómez Andrés, David, Rocío Piñera Moreno
Funding agency: Instituto de Salud Carlos III
Funding: 117370
Reference: PI22/01027
Duration: 01/01/2023 - 31/12/2025

Fisiologia i fisiopatologia digestiva

IP: Chaysavanh Manichanh
Collaborators: Itxarone Izaskun Bilbao Aguirre, Zaida Soler Luque, Jordi Barquinero Mañez, Oscar Segarra Canton, Gerard Serrano Gomez, Cristina Dopazo Taboada, Rocío Piñera Moreno
Funding agency: Agència Gestió Ajuts Universitaris i de Recerca
Funding: 40000
Reference: 2021 SGR 00459
Duration: 01/01/2022 - 30/06/2025

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