Cancer cells will be injected subcutaneously since early tumor formation

Model generated by myocardial infarction induction

Tumor cells or tumor fragments implanted subcutaneously

In this model, mice are subjected to a 40% caloric restriction compared to their ad libitum fed littermates. 60% of the food eaten by ad libitum fed littermates is provided to individually-caged calorie restricted mice.

The defects will be located in the medial and lateral distal metaphysis of the femur and in the medial and lateral proximal metaphysis of the tibia at the level of the physis mark.

This model characterizes Alzheimer's disease (AD) in which parenchymal Aβ deposits are observed and Cerebral Amyloid Angiopathy (CAA) characterized by the presence of beta-amyloid deposits in cerebral vessels and found in 80% of patients. Alzheimer's patients. Characterized by the overexpression of the Amyloid Precursor Protein (APP) gene containing the APP K670N/M671L double mutation (hAPP751 – Sweedish double-mutation) under the control of the Thy1 neuronal promoter (Sturchler-Pierrat, C. et al., 1997).

Endovascular treatment of carotid aneurysms

Model generated by the administration of a mox of different air pollutants (diesel exhaust particules)

Model generated by laparoscopic nephrectomy

In this model, mice are first aclimmated to thermoneutrality for 10-15 days and then acutely exposed to 4ºC for 5 h. Body core temperature is determined with a temperature rectal probe. Also, brown adipose tissue temperature is determined with by thermography using an infrared camera.