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Biomedical Research in Melanoma

The Biomedical Research in Melanoma group is interested in skin cancer. We investigate the molecular causes for these diseases to design effective therapies against them. Our research is done in close proximity to patients, where our goal is to translate our discoveries as fast as possible to the clinic. To that end, we have a multidisciplinary group that associate dermatologists, oncologists, pathologists and basic-scientists that ask relevant clinical questions that need biological answers.

Our workflow contemplates information obtained from patients (genetic information, clinical history, functional data…) that is translated into animal models (genetic modified mouse models, PDX…) and in vitro experiments to answer the formulated questions. These results are used to design novel therapeutic approaches, including drug development and preclinical studies that ultimately will be translated to patients. 

The main lines of investigation are: 
•    Molecular mechanisms involved in melanoma development and progression, 
•    Targeting metabolism for melanoma treatment,
•    The mechanisms of resistance to immunotherapy.
 

Publications

[Not Available].

PMID: 39566728
Journal: Actas Dermo-Sifiliograficas
Year: 2024
Reference: Actas Dermosifiliogr. 2024 Nov 18:S0001-7310(24)00896-2. doi: 10.1016/j.ad.2024.11.006.
Impact factor:
Publication type: Paper in international publication
Authors: Afonso-Martin, J L; Alonso-Alonso, R; Borregon, J; Cereceda, L; Cerroni, L; Chamizo, C; de la Fuente, L; de la Pinta, F J Diaz; Estrach, T; Fernandez, E Garcia et al.
DOI: 10.1016/j.ad.2024.11.006

p53 Immunohistochemistry Defines a Subset of Human Papillomavirus-independent Penile Squamous Cell Carcinomas With Adverse Prognosis.

PMID: 39654380
Journal: AMERICAN JOURNAL OF SURGICAL PATHOLOGY
Year: 2024
Reference: Am J Surg Pathol. 2024 Dec 10. doi: 10.1097/PAS.0000000000002341.
Impact factor:
Publication type: Paper in international publication
Authors: Ajami, Tarek; Algaba, Ferran; Corral, Juan Manuel; Darecka, Katarzyna; de Torres, Ines; Del Pino, Marta; Diez-Ahijado, Laia; Ferrandiz-Pulido, Carla; Garcia-Herrera, Adriana; Gaya, Josep Maria et al.
DOI: 10.1097/PAS.0000000000002341

Mucosal Melanoma Clinical Management and Prognostic Implications: A Retrospective Cohort Study.

PMID: 38201654
Journal: Cancers
Year: 2024
Reference: Cancers (Basel). 2024 Jan 3;16(1):227. doi: 10.3390/cancers16010227.
Impact factor:
Publication type: Paper in international publication
Authors: Bassas-Freixas, Patricia; Bodet, Domingo; Clavero-Rovira, Laia; Ferrandiz-Pulido, Carla; Ferrer, Berta; Garcia-Patos, Vicente; Gomez-Tomas, Alvaro; Hernandez-Losa, Javier; Munoz-Couselo, Eva; Perez-Benavente, Assumpcio et al.
DOI: 10.3390/cancers16010227

Oral linezolid compared with benzathine penicillin G for treatment of early syphilis in adults (Trep-AB Study) in Spain: a prospective, open-label, non-inferiority, randomised controlled trial.

PMID: 38211601
Journal: LANCET INFECTIOUS DISEASES
Year: 2024
Reference: Lancet Infect Dis. 2024 Jan 8:S1473-3099(23)00683-7. doi: 10.1016/S1473-3099(23)00683-7.
Impact factor:
Publication type: Paper in international publication
Authors: Alemany, Andrea; Alvarez, Marlene; Arando, Maider; Canut, Andres; Descalzo Jorro, Vicent; Farre, Magi; G-Beiras, Camila; Galvan-Casas, Cristina; Garcia-Patos, Vicente; Giacani, Lorenzo et al.
DOI: 10.1016/S1473-3099(23)00683-7

Can the microcystic, elongated and fragmented pattern of invasion influence the evaluation of the depth of myometrial invasion in low-grade endometrioid endometrial cancer using imaging techniques?

PMID: 37929250
Journal:
Year: 2023
Reference: Ultrasound. 2023 Nov;31(4):292-299. doi: 10.1177/1742271X231157618. Epub 2023 Mar 17.
Impact factor:
Publication type: Paper in international publication
Authors: Albert, Eliseo; Amat, Paula; Balaguer, Aitana; Barba, Pere; Beas, Francisco; Benzaquen, Ana; Bradbury, Melissa; Campos, Diana; Capell-Morell, Montserrat; Carpio, Cecilia et al.
DOI: 10.1177/1742271X231157618

Impact of a successful percutaneous mitral paravalvular leak closure on long-term major clinical outcomes.

PMID: 38013065
Journal: CANADIAN JOURNAL OF CARDIOLOGY
Year: 2023
Reference: Can J Cardiol. 2023 Nov 25:S0828-282X(23)01952-9. doi: 10.1016/j.cjca.2023.11.025.
Impact factor:
Publication type: Paper in international publication
Authors: Abadias-Granado, Isabel; Aguasca, Gerard Marti; Almagro, Manuel; Almenara-Blasco, Manuel; Alujas, Teresa Gonzalez; Arias-Santiago, Salvador; Banuls, Jose; Barcelo, Maria Calvo; Barrabes, Jose A; Belahnech, Yassin et al.
DOI: 10.1016/j.cjca.2023.11.025

Mediastinal FDG-positive lymph nodes simulating melanoma progression: drug-induced sarcoidosis like/lymphadenopathy related to ipilimumab.

PMID: 33509865
Journal: BMJ case reports
Year: 2021
Reference: BMJ Case Rep. 2021 Jan 28;14(1). pii: 14/1/e237310. doi: 10.1136/bcr-2020-237310.
Impact factor:
Publication type: Letter or abstract
Authors: Bodet, Domingo; Garcia-Patos, Vicente; Gonzalez-Cruz, Carlos; Munoz-Couselo, Eva et al.
DOI: 10.1136/bcr-2020-237310

Effects of COVID-19 Lockdown on Tumour Burden of Melanoma and Cutaneous Squamous Cell Carcinoma.

PMID: 34396424
Journal: ACTA DERMATO-VENEREOLOGICA
Year: 2021
Reference: Acta Derm Venereol. 2021 Aug 25;101(8):adv00525. doi: 10.2340/00015555-3890.
Impact factor: 4.437
Publication type: Paper in international publication
Authors: Tejera-Vaquerizo, Antonio, Paradela, Sabela, Toll, Agusti, Santos-Juanes, Jorge, Jaka, Ane, Taberner, Rosa, Rodenas-Herranz, Teresa, Garcia-Donoso, Carmen, Puig, Susana, Nagore, Eduardo et al.
DOI: 10.2340/00015555-3890

Posttransplant Kaposi sarcoma: Analysis of a series of 13 patients.

PMID: 34246484
Journal: MEDICINA CLINICA
Year: 2021
Reference: Med Clin (Barc). 2021 Oct 8;157(7):339-343. doi: 10.1016/j.medcli.2021.04.030. Epub 2021 Jul 7.
Impact factor: 1.725
Publication type: Letter or abstract
Authors: Ferrer Fabregas, Berta, Gonzalez-Cruz, Carlos, Ferrandiz-Pulido, Carla, Garcia-Patos Briones, Vicente et al.
DOI: 10.1016/j.medcli.2021.04.030

Melanoma in Solid Organ Transplant Recipients.

PMID: 33197437
Journal: Actas dermo-sifiliograficas
Year: 2021
Reference: Actas Dermosifiliogr. 2021 Mar;112(3):216-224. doi: 10.1016/j.ad.2020.11.005. Epub 2020 Nov 13.
Impact factor: 0
Publication type: Review in national publication
Authors: Gonzalez-Cruz, C, Ferrandiz-Pulido, C, Garcia-Patos Briones, V et al.
DOI: 10.1016/j.ad.2020.11.005

A review of the clinically distinguishing features of nodular or keloidal scleroderma in systemic sclerosis.

PMID: 31984476
Journal: AUSTRALASIAN JOURNAL OF DERMATOLOGY
Year: 2020
Reference: Australas J Dermatol. 2020 May;61(2):e269-e273. doi: 10.1111/ajd.13239. Epub 2020 Jan 27.
Impact factor:
Publication type: Letter whit IF
Authors: Bielsa, Isabel; Fernandez Figueras, Maria Teresa; Garcia-Patos, Vicente; Olive, Alejandro; Quirant, Bibiana; Richarz, Nina A et al.
DOI: 10.1111/ajd.13239

Leucocytoclastic vasculitis in a patient with COVID-19 with positive SARS-CoV-2 PCR in skin biopsy.

PMID: 33122236
Journal: BMJ case reports
Year: 2020
Reference: BMJ Case Rep. 2020 Oct 29;13(10). pii: 13/10/e238039. doi: 10.1136/bcr-2020-238039.
Impact factor: 0
Publication type: Paper in international publication
Authors: Camprodon Gomez, Maria, Gonzalez-Cruz, Carlos, Ferrer, Berta, Barbera, Maria Jesus et al.
DOI: 10.1136/bcr-2020-238039

Maculopapular eruptions associated to COVID-19: a subanalysis of the COVID-Piel study.

PMID: 32779280
Journal: Dermatologic Therapy
Year: 2020
Reference: Dermatol Ther. 2020 Nov;33(6):e14170. doi: 10.1111/dth.14170. Epub 2020 Sep 9.
Impact factor: 2.327
Publication type: Paper in international publication
Authors: Llamas-Velasco, Mar, Carnero-Gonzalez, Lucia, Garcia-Gavin, Juan, Baniandres, Ofelia, Gonzalez-Cruz, Carlos, Morillas-Lahuerta, Victor, Cubiro, Xavier, Figueras, Ignasi, Selda-Enriquez, Gerald, Fusta-Novell, Xavier et al.
DOI: 10.1111/dth.14170

STK11 (LKB1) missense somatic mutant isoforms promote tumor growth, motility and inflammation.

PMID: 32647375
Journal: Communications Biology
Year: 2020
Reference: Commun Biol. 2020 Jul 9;3(1):366. doi: 10.1038/s42003-020-1092-0.
Impact factor: 4.165
Publication type: Paper in international publication
Authors: Granado-Martinez, Paula, Garcia-Ortega, Sara, Gonzalez-Sanchez, Elena, McGrail, Kimberley, Selgas, Rafael, Grueso, Judit, Gil, Rosa, Naldaiz-Gastesi, Neia, Rhodes, Ana C, Hernandez-Losa, Javier et al.
DOI: 10.1038/s42003-020-1092-0

Cutaneous infections by dematiaceous opportunistic fungi: diagnosis and management in 11 solid organ transplant recipients.

PMID: 30230044
Journal: MYCOSES
Year: 2019
Reference: Mycoses. 2019 Feb;62(2):121-127. doi: 10.1111/myc.12853. Epub 2018 Oct 17.
Impact factor: 3.065
Publication type: Paper in international publication
Authors: Ferrandiz-Pulido, C, Martin-Gomez, M T, Repiso, T, Juarez, C, Ferrer, B, Lopez-Lerma, I, Gonzalez-Cruz, C, Moreso, F, Roman, A, Garcia-Patos, V et al.
DOI: 10.1111/myc.12853

Lupus panniculitis: Clinicopathological features of a series of 12 patients.

PMID: 30154008
Journal: MEDICINA CLINICA
Year: 2018
Reference: Med Clin (Barc). 2018 Dec 14;151(11):444-449. doi: 10.1016/j.medcli.2018.06.024. Epub 2018 Aug 25.
Impact factor: 1.168
Publication type: Paper in national publication
Authors: Gonzalez-Cruz, Carlos, Aparicio Espanol, Gloria, Ferrer Fabrega, Berta, Cabezas Calderon, Victor, Giner Pichel, Mario, Garcia-Patos Briones, Vicente et al.
DOI: 10.1016/j.medcli.2018.06.024

Genetic Profiles of Squamous Cell Carcinomas Associated with Recessive Dystrophic Epidermolysis Bullosa Unveil NOTCH and TP53 Mutations and an Increased MYC Expression.

PMID: 29291383
Journal: JOURNAL OF INVESTIGATIVE DERMATOLOGY
Year: 2018
Reference: J Invest Dermatol. 2018 Jun;138(6):1423-1427. doi: 10.1016/j.jid.2017.12.026. Epub 2017 Dec 29.
Impact factor: 6.448
Publication type: Paper in international publication
Authors: Vivancos, A, Garcia-Patos, V, Recio, J A, Bodet, D, Hernandez-Losa, J, Perez-Alea, M, Sans-DeSanNicolas, L, Caratu, G, Vidal-Cortes, O, Sanchez-Redondo, S et al.
DOI: 10.1016/j.jid.2017.12.026

Use of biological treatments in patients with hidradenitis suppurativa.

PMID: 24629001
Journal: J EUR ACAD DERMATOL
Year: 2015
Reference: J Eur Acad Dermatol Venereol. 2015 Jan;29(1):56-60. doi: 10.1111/jdv.12438. Epub 2014 Mar 13.
Impact factor:
Publication type: Paper in international publication
Authors: Alsina, M; Aparicio, G; Bordas, X; Collgros, H; Ferran, M; Garcia-Patos, V; Gil, I; Izquierdo, N; Martin-Ezquerra, G; Masferrer, E et al.
DOI: 10.1111/jdv.12438

Blog

News

The meeting was an opportunity to get to know projects from both institutions and to promote interaction between professionals.

On World Cancer Research Day, we highlight research aimed at improving treatments for both pediatric and adult cancers through innovative techniques.

On World Cancer Research Day, we highlight the oncology research model of the Vall d'Hebron Campus that allows laboratory results to be transferred as quickly as possible to clinical practice.