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Biomedical Research in Urology

The Biomedical Research in Urology group is interested in the study of hormone-dependent cancers, in particular prostate cancer (but not limited to it).

Our efforts are focused on finding, on the one hand, tools that help us in the early diagnosis of the disease, in the best differentiation of tumors according to their aggressiveness and their response to therapy, and finally in finding effective therapies against it.

From a molecular point of view, we focus our studies mainly on cell signaling processes related to the cell cycle and mitosis (with kinesins, kinases and ubiquitin ligases as main targets).

Our multidisciplinary group is made up of molecular biologists and urologists, and we collaborate with oncologists, pathologists and specialists in other diseases when required.

We work with in silico data obtained with different "omics" techniques, samples and clinical data from patients, in vitro and in vivo models, to answer the questions raised.

Team

Ana Sarrias Gimenez

Ana Sarrias Gimenez

Postdoctoral researcher
Biomedical Research in Urology
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Lucas Regis Plácido

Lucas Regis Plácido

Postdoctoral researcher
Biomedical Research in Urology
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Ramirez Morales, Lidia del Carmen

Ramirez Morales, Lidia del Carmen

Research technician
Biomedical Research in Urology
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Yáiza Nuñez Amela

Yáiza Nuñez Amela

Postdoctoral researcher
Biomedical Research in Urology
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Carlos Serrano Burgos

Carlos Serrano Burgos

Research assistant
Biomedical Research in Urology
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David Ruiz Casajuana

David Ruiz Casajuana

Research technician
Biomedical Research in Urology
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Ana Sarrias Gimenez

Ana Sarrias Gimenez

Postdoctoral researcher
Biomedical Research in Urology
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Lucas Regis Plácido

Lucas Regis Plácido

Postdoctoral researcher
Biomedical Research in Urology
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Ramirez Morales, Lidia del Carmen

Ramirez Morales, Lidia del Carmen

Research technician
Biomedical Research in Urology
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Yáiza Nuñez Amela

Yáiza Nuñez Amela

Postdoctoral researcher
Biomedical Research in Urology
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Carlos Serrano Burgos

Carlos Serrano Burgos

Research assistant
Biomedical Research in Urology
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David Ruiz Casajuana

David Ruiz Casajuana

Research technician
Biomedical Research in Urology
Read more

Research lines

Early diagnosis and staging of prostate cancer (Clinical research)

This research line evaluates better strategies able to improve the process of Early Diagnosis of Prostate Cancer, detecting significant tumors and avoiding unnecessary biopsies. In addition, this line also studies the outcomes of the Active Surveillance Program and the Robotic Program.

IP: Joan Morote Robles, Ana Celma Domènech

Exosomes as a new source of biomarkers (Translational research in prostate cancer)

Since the prostate is in direct contact with the urethra, desquamated cells and secreted products, including exosomes, are abundant in human urine and serve as potential source for PC biomarkers. We aim to identify protein biomarkers in urinary exosomes for early detection of PC in a non-invasive manner.

IP: -

Experimental laparoscopy (Clinical research)

This is a research and teaching line in porcine model of laparoscopy. The influence of pneumo-peritoneum and ischemia in kidney function has been main objectives in the past. Now, the use of bioengineering materials in bladder substitution is the main objective of this line.  

IP: Carles Xavier Raventós Busquets

Hormone therapy and castrate resistant prostate cancer (Clinical research)

One main objective is the optimization of androgen suppression and to know its safety profile, specifically in the areas of bone mass loss, the metabolic disturbances and cognitive performance. How to perform early diagnosis of CRPC, and how to follow up the new treatments are also objectives of this line.

IP: Jacques Planas Morin

Projects

KidneyColor: machine learning sobre fotografía digital macroscópica para la predicción de la funcionalidad del trasplante renal de cadáver

IP: Enric Trilla Herrera
Collaborators: -
Funding agency: Asociación Española de Urología
Funding: 25000
Reference: FIU2022/TRILLA
Duration: 29/07/2023 - 28/07/2025

THE APPLICATION OF ARTIFICIAL INTELLIGENCE METHODS FOR ORGANS ASSESSMENT

IP: Concepción Gomez Gavara
Collaborators: Ramon Charco Torra, Ernest Hidalgo Llompart, Enric Miret Alomar, Elizabeth Pando Rau
Funding agency: Agència Gestió Ajuts Universitaris i de Recerca
Funding: 0.01
Reference: 2021 SGR 01236
Duration: 01/01/2022 - 30/06/2025

Rercerca biomèdica en urologia

IP: Joan Morote Robles
Collaborators: Fernando Lozano Palacio, Inés de Torres Ramirez, Enric Trilla Herrera, Olga Méndez Fernández, Ana Celma Domènech, Mercè Cuadras Solé, Carlos Serrano Burgos, Albert Carrión Puig , Enric Miret Alomar, Maria Eugenia Semidey Raven, Carles Xavier Raventós Busquets, David Ruiz Casajuana, Jacques Planas Morin, Richard Mast, Anna Santamaria Margalef
Funding agency: Agència Gestió Ajuts Universitaris i de Recerca
Funding: 0.01
Reference: 2021 SGR 00858
Duration: 01/01/2022 - 30/06/2025

Radiogenomics for the prediction of prostate cancer aggressiveness through artificial intelligence.

IP: Joan Morote Robles
Collaborators: Inés de Torres Ramirez, Ana Celma Domènech, Jacques Planas Morin, Richard Mast, Lucas Regis Plácido
Funding agency: Instituto de Salud Carlos III
Funding: 159720
Reference: PI20/01666
Duration: 01/01/2021 - 30/06/2025

Publications

Accurate diagnosis of prostate cancer by combining Proclarix with magnetic resonance imaging.

PMID: 36855895
Journal: BJU INTERNATIONAL
Year: 2023
Reference: BJU Int. 2023 Aug;132(2):188-195. doi: 10.1111/bju.15998. Epub 2023 Mar 21.
Impact factor:
Publication type: Paper in international publication
Authors: Ahmed, Hashim U; Athanasiou, Alcibiade; Campistol, Miriam; Celma, Anna; de Torres, Ines; Emberton, Mark; Freeman, Alex; Haider, Aiman; Heavey, Susan; Mast, Richard et al.
DOI: 10.1111/bju.15998

Re: Jonas Hugosson, Marianne Mansson, Jona Wallstrom, et al. Prostate Cancer Screening with PSA and MRI Followed by Targeted Biopsy Only. N Engl J Med 2022;387:2126-37.

PMID: 36894492
Journal: European Urology Oncology
Year: 2023
Reference: Eur Urol Oncol. 2023 Apr;6(2):234. doi: 10.1016/j.euo.2023.02.002. Epub 2023 Mar 7.
Impact factor:
Publication type: Letter or abstract
Authors: Morote, Juan et al.
DOI: 10.1016/j.euo.2023.02.002

Stratifying the initial prostate cancer suspicion to avoid magnetic resonance exams by sequencing men according to serum prostate-specific antigen, digital rectal examination and the prostate-specific antigen density based on digital rectal prostate volume category.

PMID: 37025471
Journal: BJUI compass
Year: 2023
Reference: BJUI Compass. 2022 Dec 28;4(3):266-268. doi: 10.1002/bco2.211. eCollection 2023 May.
Impact factor:
Publication type: Paper in international publication
Authors: Abascal, Jose M; Campistol, Miriam; Morote, Juan; Servian, Pol; Trilla, Enrique; Triquell, Marina et al.
DOI: 10.1002/bco2.211

Are magnetic resonance imaging and targeted biopsies needed in men with serum prostate-specific antigen over 10 ng/ml and an abnormal digital rectal examination?

PMID: 37244767
Journal: UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
Year: 2023
Reference: Urol Oncol. 2023 May 25:S1078-1439(23)00161-8. doi: 10.1016/j.urolonc.2023.05.003.
Impact factor:
Publication type: Paper in international publication
Authors: Abascal, Jose M; Asiain, Ignacio; Celma, Anna; de Manuel, Gemma Garcia; Morote, Juan; Munoz-Rivero, Marta V; Munoz-Rodriguez, Jesus; Paesano, Nahuel; Picola, Natalia; Ruiz-Plazas, Xavier et al.
DOI: 10.1016/j.urolonc.2023.05.003

Surgeon preimplantation macroscopic graft appraisal improves risk stratification of deceased kidney donors: a prospective study.

PMID: 33887895
Journal: Minerva Urology and Nephrology
Year: 2022
Reference: Minerva Urol Nephrol. 2022 Oct;74(5):615-624. doi: 10.23736/S2724-6051.21.04345-7. Epub 2021 Apr 22.
Impact factor:
Publication type: Paper in international publication
Authors: Lorente, David; Miret, Enric; Moreso, Francesc; Morote, Juan; Perez-Hoyos, Santiago; Pont, Teresa; Seron, Daniel; Toapanta, Nestor; Trilla, Enrique; Triquell, Marina et al.
DOI: 10.23736/S2724-6051.21.04345-7

Effect of LHRH analogs on lower urinary tract symptoms associated with advanced prostate cancer in real clinical practice: ANALUTS study.

PMID: 36069170
Journal: NEUROUROLOGY AND URODYNAMICS
Year: 2022
Reference: Neurourol Urodyn. 2022 Nov;41(8):1824-1833. doi: 10.1002/nau.25031. Epub 2022 Sep 7.
Impact factor:
Publication type: Paper in international publication
Authors: Angulo, Javier C; Calleja, Jesus; Ciria, Juan P; de Celis, Raul Poza; Extramiana, Javier; Gomez-Caamano, Antonio; Gomez-Veiga, Francisco; Morote, Juan; Perez-Sampietro, Maria; Perrot, Valerie et al.
DOI: 10.1002/nau.25031

Development of castration resistance in prostate cancer patients treated with luteinizing hormone-releasing hormone analogues (LHRHa): results of the ANARESISTANCE study.

PMID: 36057895
Journal: WORLD JOURNAL OF UROLOGY
Year: 2022
Reference: World J Urol. 2022 Oct;40(10):2459-2466. doi: 10.1007/s00345-022-04108-x. Epub 2022 Sep 4.
Impact factor:
Publication type: Paper in international publication
Authors: Abascal, Jose Manuel; Angulo, J C; Barrond, Victor; Benedicto, Antonio; Carballo, Ana; Ciria Santos, J P; Cortinas, Jose Ramon; Fernandez, Manuel; Ferrer, Eduardo; Galan-Llopis, J A et al.
DOI: 10.1007/s00345-022-04108-x

Multiparametric MRI for Staging of Prostate Cancer: A Multicentric Analysis of Predictive Factors to Improve Identification of Extracapsular Extension before Radical Prostatectomy.

PMID: 36010963
Journal: Cancers
Year: 2022
Reference: Cancers (Basel). 2022 Aug 17;14(16). pii: cancers14163966. doi: 10.3390/cancers14163966.
Impact factor:
Publication type: Paper in international publication
Authors: Celma, Ana; Cuadras, Merce; Morote, Juan; Planas, Jacques; Regis, Lucas; Trilla, Enrique; Triquell, Marina; Valdes, Nicolas; Winkler, Mathias et al.
DOI: 10.3390/cancers14163966

The current value of histological findings in negative prostate biopsies to predict the future risk of clinically significant prostate cancer.

PMID: 34140257
Journal: Actas Urologicas Espanolas
Year: 2021
Reference: Actas Urol Esp (Engl Ed). 2021 Jul-Aug;45(6):447-454. doi: 10.1016/j.acuroe.2020.09.008. Epub 2021 Jun 16.
Impact factor:
Publication type: Paper in national publication
Authors: Celma, A; de Torres, I M; Morote, J; Planas, J; Regis, L; Roche, S; Schwartzmann, I; Semidey, M E et al.
DOI: 10.1016/j.acuroe.2020.09.008

Is Sarcopenic Obesity an Indicator of Poor Prognosis in Gastric Cancer Surgery? A Cohort Study in a Western Population.

PMID: 32661833
Journal: JOURNAL OF GASTROINTESTINAL SURGERY
Year: 2021
Reference: J Gastrointest Surg. 2021 Jun;25(6):1388-1403. doi: 10.1007/s11605-020-04716-1. Epub 2020 Jul 13.
Impact factor:
Publication type: Paper in international publication
Authors: Armengol, M; Castro, S; Gantxegi, A; Landi, F; Lopez-Cano, M; Mast, R; Pradell, J; Rodrigues, V; Rodriguez, N et al.
DOI: 10.1007/s11605-020-04716-1

The Novel KIF1A Missense Variant (R169T) Strongly Reduces Microtubule Stimulated ATPase Activity and Is Associated With NESCAV Syndrome.

PMID: 34121983
Journal: Frontiers in Neuroscience
Year: 2021
Reference: Front Neurosci. 2021 May 26;15:618098. doi: 10.3389/fnins.2021.618098. eCollection 2021.
Impact factor:
Publication type: Paper in international publication
Authors: Aguilera, Cinthia; Gabau, Elisabeth; Guitart, Miriam; Hummer, Stefan; Jeyaprakash, A Arockia; Masanas, Marc; Ruiz, Anna; Santamaria, Anna; Segura, Miguel F et al.
DOI: 10.3389/fnins.2021.618098

The role of liver steatosis as measured with transient elastography and transaminases on hard clinical outcomes in patients with COVID-19.

PMID: 34104210
Journal: Therapeutic Advances in Gastroenterology
Year: 2021
Reference: Therap Adv Gastroenterol. 2021 May 30;14:17562848211016567. doi: 10.1177/17562848211016567. eCollection 2021.
Impact factor:
Publication type: Paper in international publication
Authors: Aguilera-Castro, Lara; Alvarez-Lopez, Patricia; Anton, Adrian; Augustin, Salvador; Banares, Juan; Barber, Claudia; Barreira-Diaz, Ana; Biagetti, Betina; Campos-Varela, Isabel; Camps-Relats, Laura et al.
DOI: 10.1177/17562848211016567

Kidney cancer PDOXs reveal patient-specific pro-malignant effects of antiangiogenics and its molecular traits.

PMID: 33151035
Journal: EMBO Molecular Medicine
Year: 2020
Reference: EMBO Mol Med. 2020 Dec 7;12(12):e11889. doi: 10.15252/emmm.201911889. Epub 2020 Nov 5.
Impact factor:
Publication type: Paper in international publication
Authors: Aguilar, Susana; Amadori, Alberto; Carles, Joan; Casanovas, Oriol; de Torres, Ines; Jimenez, Jose; Jimenez-Valerio, Gabriela A; Martinez-Lozano, Mar; Moserle, Lidia; Palomero, Luis et al.
DOI: 10.15252/emmm.201911889

Genomic predictors of good outcome, recurrence or progression in High grade T1 non-muscle invasive bladder cancer.

PMID: 32868381
Journal: CANCER RESEARCH
Year: 2020
Reference: Cancer Res. 2020 Oct 15;80(20):4476-4486. doi: 10.1158/0008-5472.CAN-20-0977. Epub 2020 Aug 31.
Impact factor:
Publication type: Paper in international publication
Authors: Barletta, Justine A; Bellmunt, Joaquim; Bowden, Michaela; Cejas, Paloma; de Torres, Ines; Getz, Gad; Juanpere, Nuria; Kim, Jaegil; Kwiatkowski, David J; Lloreta-Trull, Josep et al.
DOI: 10.1158/0008-5472.CAN-20-0977

Androgen deprivation therapy in patients with localized disease: Comparison with curative intent treatments and time to castration resistance. Results of the Spanish Prostate Cancer Registry.

PMID: 32113829
Journal: Actas Urologicas Espanolas
Year: 2020
Reference: Actas Urol Esp. 2020 Apr;44(3):156-163. doi: 10.1016/j.acuro.2019.06.006. Epub 2020 Feb 26.
Impact factor:
Publication type: Paper in national publication
Authors: Alonso, J; Alvarez, L; Alvarez, S; Amon, J; Areche, J; Asuar Aydillo, S; Baena, V; Blaha, I; Blanco, E; Buendia, E et al.
DOI: 10.1016/j.acuro.2019.06.006

STAT3 inhibition with galiellalactone effectively targets the prostate cancer stem-like cell population.

PMID: 32811873
Journal: Scientific Reports
Year: 2020
Reference: Sci Rep. 2020 Aug 18;10(1):13958. doi: 10.1038/s41598-020-70948-5.
Impact factor:
Publication type: Paper in international publication
Authors: Bjartell, Anders; Canesin, Giacomo; Castellon, Enrique A; Contreras, Hector R; Hellsten, Rebecka; Maggio, Valentina; Maitland, Norman J; Morote, Juan; Paciucci, Rosanna; Palominos, Macarena et al.
DOI: 10.1038/s41598-020-70948-5

Are targeted prostate biopsies ready to replace systematic prostate biopsies?

PMID: 31679807
Journal: Actas Urologicas Espanolas
Year: 2019
Reference: Actas Urol Esp. 2019 Dec;43(10):573-578. doi: 10.1016/j.acuro.2018.06.011. Epub 2019 Oct 31.
Impact factor:
Publication type: Paper in national publication
Authors: Borque, A; Celma, A; de Torres, I; Esteban, L M; Lopez, R; Morote, J; Placer, J; Planas, J; Regis, L; Roche, S et al.
DOI: 10.1016/j.acuro.2018.06.011

Early continence after radical prostatectomy: A systematic review.

PMID: 31606163
Journal: Actas Urologicas Espanolas
Year: 2019
Reference: Actas Urol Esp. 2019 Dec;43(10):526-535. doi: 10.1016/j.acuro.2019.06.003. Epub 2019 Oct 10.
Impact factor:
Publication type: Review in national publication
Authors: Celma, A; Diaz, F; Gallardo, I; Morote, J; Planas, J; Regis, L; Salazar, A; Trilla, E et al.
DOI: 10.1016/j.acuro.2019.06.003

A comparative study of different surgical techniques for the management of distal ureter during laparoscopic radical nephroureterectomy.

PMID: 31447089
Journal: Actas Urologicas Espanolas
Year: 2019
Reference: Actas Urol Esp. 2019 Dec;43(10):543-550. doi: 10.1016/j.acuro.2019.07.001. Epub 2019 Aug 23.
Impact factor:
Publication type: Paper in national publication
Authors: Alcaraz, A; Carrion, A; Costa-Grau, M; Huguet, J; Lozano, F; Morote, J; Raventos, C; Ribal, M J et al.
DOI: 10.1016/j.acuro.2019.07.001

MicroRNA-654-5p suppresses ovarian cancer development impacting on MYC, WNT and AKT pathways.

PMID: 31278368
Journal: ONCOGENE
Year: 2019
Reference: Oncogene. 2019 Aug;38(32):6035-6050. doi: 10.1038/s41388-019-0860-0. Epub 2019 Jul 5.
Impact factor:
Publication type: Paper in international publication
Authors: Alameda, Francesc; Barber, Marta; Castellvi, Josep; Esteller, Manel; Gil-Moreno, Antonio; Jimenez, Carlos; Majem, Blanca; Marin, Andrea; Matias-Guiu, Xavier; Moran, Sebastian et al.
DOI: 10.1038/s41388-019-0860-0

[Embolizing cardiac hibernoma and acute respiratory failure].

PMID: 30269781
Journal: Revista espanola de patologia : publicacion oficia
Year: 2018
Reference: Rev Esp Patol. 2018 Oct - Dec;51(4):267-270. doi: 10.1016/j.patol.2018.02.003. Epub 2018 Apr 5.
Impact factor:
Publication type: Paper in national publication
Authors: de Torres Ramirez, Ines; Garcia Jimenez, Angel; Montecino Romanini, Carolina; Ramon Y Cajal, Santiago; Reques Llanos, Armando; Rodriguez Morera, Jaime; Temprana Salvador, Jordi et al.
DOI: 10.1016/j.patol.2018.02.003

Extracellular HMGA1 promotes tumor Invasion and Metastasis in Triple-Negative Breast Cancer.

PMID: 30135148
Journal: CLINICAL CANCER RESEARCH
Year: 2018
Reference: Clin Cancer Res. 2018 Dec 15;24(24):6367-6382. doi: 10.1158/1078-0432.CCR-18-0517. Epub 2018 Aug 22.
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, Ibane; Arribas, Joaquin; Cortes, Javier; Fernandez, Yolanda; Gregori, Josep; Matres, Ana; Mendez, Olga; Peg, Vicente; Perez, Jose; Pujals, Mireia et al.
DOI: 10.1158/1078-0432.CCR-18-0517

Cytogenetic and immunohistochemical study of 42 pigmented microcystic chromophobe renal cell carcinoma (PMChRCC).

PMID: 29931469
Journal: VIRCHOWS ARCHIV
Year: 2018
Reference: Virchows Arch. 2018 Aug;473(2):209-217. doi: 10.1007/s00428-018-2389-y. Epub 2018 Jun 21.
Impact factor:
Publication type: Paper in international publication
Authors: de Torres, Ines; Gutierrez, Francisco Javier Queipo; Panizo, Angel; Pardo-Mindan, Javier; Rodriguez, Irene; Sola, Jesus Javier; Temprana-Salvador, Jordi; Tienza, Antonio et al.
DOI: 10.1007/s00428-018-2389-y

Serum Testosterone Levels in Prostate Cancer Patients Undergoing Luteinizing Hormone-Releasing Hormone Agonist Therapy.

PMID: 29198640
Journal: Clinical Genitourinary Cancer
Year: 2018
Reference: Clin Genitourin Cancer. 2018 Apr;16(2):e491-e496. doi: 10.1016/j.clgc.2017.10.025. Epub 2017 Dec 2.
Impact factor:
Publication type: Paper in international publication
Authors: Carles, Joan; Celma, Ana; Comas, Inma; Ferrer, Roser; Maldonado, Xavier; Morote, Juan; Placer, Jose; Planas, Jacques; Regis, Lucas et al.
DOI: 10.1016/j.clgc.2017.10.025

Systematic review of renal carcinoma prognostic factors.

PMID: 27659130
Journal: Actas Urologicas Espanolas
Year: 2017
Reference: Actas Urol Esp. 2017 May;41(4):215-225. doi: 10.1016/j.acuro.2016.08.003. Epub 2016 Sep 20.
Impact factor:
Publication type: Review in national publication
Authors: Celma, A; Lorente, D; Meseguer, A; Morote, J; Placer, J; Planas, J; Regis, L; Salvador, C; Trilla, E et al.
DOI: 10.1016/j.acuro.2016.08.003

Free Testosterone During Androgen Deprivation Therapy Predicts Castration-Resistant Progression Better Than Total Testosterone.

PMID: 27800640
Journal: PROSTATE
Year: 2017
Reference: Prostate. 2017 Jan;77(1):114-120. doi: 10.1002/pros.23256. Epub 2016 Nov 1.
Impact factor:
Publication type: Paper in international publication
Authors: Carles, Joan; Comas, Inma; Ferrer, Roser; Maldonado, Xavier; Morote, Juan; Planas, Jacques; Regis, Lucas et al.
DOI: 10.1002/pros.23256

The role of prostate tumor overexpressed 1 in cancer progression.

PMID: 28029646
Journal: Oncotarget
Year: 2017
Reference: Oncotarget. 2017 Feb 14;8(7):12451-12471. doi: 10.18632/oncotarget.14104.
Impact factor:
Publication type: Review in international publication
Authors: Canovas, Veronica; Lleonart, Matilde; Morote, Juan; Paciucci, Rosanna et al.
DOI: 10.18632/oncotarget.14104

[Consensus on castration-resistant prostate cancer management in Spain.]

PMID: 29099380
Journal: ARCHIVOS ESPANOLES DE UROLOGIA
Year: 2017
Reference: Arch Esp Urol. 2017 Nov;70(9):777-791.
Impact factor:
Publication type: Review in national publication
Authors: Alcaraz, Antonio; Borque, Angel; Burgos, Javier; Carballido, Joaquin; Cozar, Jose Manuel; Crespo, Itziar; Esquena, Salvador; Gomez-Veiga, Francisco; Lopez, Dionisio; Martinez-Pineiro, Luis et al.
DOI:

Utility of the RENAL index -Radius; Exophytic/endophytic; Nearness to sinus; Anterior/posterior; Location relative to polar lines- in the management of renal masses.

PMID: 27209331
Journal: Actas Urologicas Espanolas
Year: 2016
Reference: Actas Urol Esp. 2016 Dec;40(10):601-607. doi: 10.1016/j.acuro.2016.04.007. Epub 2016 May 18.
Impact factor:
Publication type: Paper in national publication
Authors: Konstantinidis, C; Lorente, D; Morote, J; Trilla, E et al.
DOI: 10.1016/j.acuro.2016.04.007

Clinical Significance of Proliferative Inflammatory Atrophy in Negative Prostatic Biopsies.

PMID: 27404228
Journal: PROSTATE
Year: 2016
Reference: Prostate. 2016 Dec;76(16):1501-1506. doi: 10.1002/pros.23234. Epub 2016 Jul 12.
Impact factor:
Publication type: Paper in international publication
Authors: Celma, Ana; de Torres, Ines M; Morote, Juan; Placer, Jose; Planas, Jacques; Servian, Pol et al.
DOI: 10.1002/pros.23234

Measurement of serum testosterone during androgenic suppression in patients with prostate cancer: A systematic review.

PMID: 26899928
Journal: Actas Urologicas Espanolas
Year: 2016
Reference: Actas Urol Esp. 2016 Oct;40(8):477-84. doi: 10.1016/j.acuro.2016.01.006. Epub 2016 Feb 18.
Impact factor:
Publication type: Paper in national publication
Authors: Celma, A; Morote, J; Planas, J; Regis, L et al.
DOI: 10.1016/j.acuro.2016.01.006

Expert opinion on first-line therapy in the treatment of castration-resistant prostate cancer.

PMID: 26363809
Journal: CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
Year: 2016
Reference: Crit Rev Oncol Hematol. 2016 Apr;100:127-36. doi: 10.1016/j.critrevonc.2015.07.011. Epub 2015 Aug 1.
Impact factor:
Publication type: Review in national publication
Authors: Alcaraz, Antonio; Arranz, Jose Angel; Climent, Miguel Angel; Gallardo, Enrique; Gomez-Veiga, Francisco; Maroto, Pablo; Mellado, Begona; Morote, Juan; Solsona, Eduardo; Unda, Miguel et al.
DOI: 10.1016/j.critrevonc.2015.07.011

Identification of somatic gene mutations in penile squamous cell carcinoma.

PMID: 26216163
Journal: GENE CHROMOSOME CANC
Year: 2015
Reference: Genes Chromosomes Cancer. 2015 Oct;54(10):629-37. doi: 10.1002/gcc.22274. Epub 2015 Jul 27.
Impact factor:
Publication type: Paper in international publication
Authors: Cajal, Y; de Torres, Ines; Ferrandiz-Pulido, Carla; Garcia-Patos, Vicente; Hernandez-Losa, Javier; Mares, Roso; Masferrer, Emili; Morote, Juan; Placer, Jose; Pujol, Ramon M et al.
DOI: 10.1002/gcc.22274

The metabolic syndrome and its components in patients with prostate cancer on androgen deprivation therapy.

PMID: 25541340
Journal: J UROLOGY
Year: 2015
Reference: J Urol. 2015 Jun;193(6):1963-9. doi: 10.1016/j.juro.2014.12.086. Epub 2014 Dec 23.
Impact factor:
Publication type: Paper in international publication
Authors: Abascal, Ramon; Alvarez-Ossorio, Jose L; Alvarez-Ossorio, Jose Luis; Amon, Jose; Barranco, Miguel Angel; Carballido, Joaquin; Casana, Manuel; Ciria, Juan Pablo; Comet, Jose; Freire, Camilo Garcia et al.
DOI: 10.1016/j.juro.2014.12.086

Simultaneous treatment with statins and aspirin reduces the risk of prostate cancer detection and tumorigenic properties in prostate cancer cell lines.

PMID: 25649906
Journal: BIOMED RES INT
Year: 2015
Reference: Biomed Res Int. 2015;2015:762178. doi: 10.1155/2015/762178. Epub 2015 Jan 12.
Impact factor:
Publication type: Paper in international publication
Authors: Celma, A; Colas, E; de Torres, I; Doll, A; Garcia, M; Montes, M; Morote, J; Olivan, M; Placer, J; Planas, J et al.
DOI: 10.1155/2015/762178

Urinary biomarkers for the detection of prostate cancer in patients with high-grade prostatic intraepithelial neoplasia.

PMID: 25845829
Journal: PROSTATE
Year: 2015
Reference: Prostate. 2015 Jul;75(10):1102-13. doi: 10.1002/pros.22995. Epub 2015 Apr 1.
Impact factor:
Publication type: Paper in international publication
Authors: Bastaros, Juan M; de Torres, Ines; Doll, Andreas; Montes, Melania; Morote, Juan; Olivan, Mireia; Pegtel, D Michiel; Placer, Jose; Planas, Jaques; Reventos, Jaume et al.
DOI: 10.1002/pros.22995

[Optimization of follow up in prostate cancer active surveillance].

PMID: 24914843
Journal: Archivos españoles de urología
Year: 2014
Reference: Arch Esp Urol. 2014 Jun;67(5):442-51.
Impact factor:
Publication type: Letter or abstract
Authors: Celma Domenech, Ana; Morote Robles, Juan; Planas Morin, Jacques et al.
DOI:

Bone mass behavior after 1 year of different treatment strategies in prostate cancer patients subjected to androgen deprivation therapy.

PMID: 24615021
Journal: RHEUMATOLOGY INTERNATIONAL
Year: 2014
Reference: Rheumatol Int. 2014 Oct;34(10):1419-25. doi: 10.1007/s00296-014-2977-3. Epub 2014 Mar 11.
Impact factor:
Publication type: Paper in international publication
Authors: Carles Galceran, J; Celma Domenech, A; Lorente Garcia, D; Morote Robles, J; Placer Santos, J; Planas Morin, J; Regis, L; Salvador Lacambra, C; Trilla Herrera, E et al.
DOI: 10.1007/s00296-014-2977-3

Degarelix as an intermittent androgen deprivation therapy for one or more treatment cycles in patients with prostate cancer.

PMID: 24954791
Journal: EUROPEAN UROLOGY
Year: 2014
Reference: Eur Urol. 2014 Oct;66(4):655-63. doi: 10.1016/j.eururo.2014.05.037. Epub 2014 Jun 18.
Impact factor:
Publication type: Clinical Trials
Authors: Albers, Peter; Boccon-Gibod, Laurent; de la Rosette, Jean; Malmberg, Anders; Montorsi, Francesco; Morote, Juan; Neijber, Anders; van Poppel, Hendrik; Villers, Arnauld et al.
DOI: 10.1016/j.eururo.2014.05.037

Role of serum cholesterol and statin use in the risk of prostate cancer detection and tumor aggressiveness.

PMID: 25101846
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2014
Reference: Int J Mol Sci. 2014 Aug 6;15(8):13615-23. doi: 10.3390/ijms150813615.
Impact factor:
Publication type: Paper in international publication
Authors: Carles, Juan; Celma, Anna; de Torres, Ines; Doll, Andreas; Morote, Juan; Olivan, Mireia; Placer, Jose; Planas, Jacques; Reventos, Jaume et al.
DOI: 10.3390/ijms150813615

mTOR Signaling Pathway in Penile Squamous Cell Carcinoma: pmTOR and peIF4E Over Expression Correlate with Aggressive Tumor Behavior.

PMID: 23764082
Journal: JOURNAL OF UROLOGY
Year: 2013
Reference: J Urol. 2013 Dec;190(6):2288-95. doi: 10.1016/j.juro.2013.06.015. Epub 2013 Jun 11.
Impact factor:
Publication type: Paper in international publication
Authors: de Torres, Ines; Ferrandiz-Pulido, Carla; Garcia-Patos, Vicente; Hernandez-Losa, Javier; Masferrer, Emili; Mojal, Sergio; Pujol, Ramon M; Ramon Y Cajal, Santiago; Toll, Agustin et al.
DOI: 10.1016/j.juro.2013.06.015

Diabetes Protects from Prostate Cancer by Downregulating Androgen Receptor: New Insights from LNCaP Cells and PAC120 Mouse Model.

PMID: 24058525
Journal: PLoS One
Year: 2013
Reference: PLoS One. 2013 Sep 10;8(9):e74179. doi: 10.1371/journal.pone.0074179.
Impact factor:
Publication type: Paper in international publication
Authors: Barbosa-Desongles, Anna; De Torres, Ines; Hernandez, Cristina; Munell, Francina; Poupon, Marie-France; Selva, David M; Simo, Rafael et al.
DOI: 10.1371/journal.pone.0074179

The present and future of prostate cancer urine biomarkers.

PMID: 23774836
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2013
Reference: Int J Mol Sci. 2013 Jun 17;14(6):12620-49. doi: 10.3390/ijms140612620.
Impact factor:
Publication type: Paper in international publication
Authors: Clark, Jeremy; Colas, Eva; Cooper, Colin; Doll, Andreas; Garcia, Marta; Llaurado, Marta; Montes, Melania; Morote, Juan; Olivan, Mireia; Planas, Jacques et al.
DOI: 10.3390/ijms140612620

[Molecular biology of bone metastases].

PMID: 23793764
Journal: Archivos españoles de urología
Year: 2013
Reference: Arch Esp Urol. 2013 Jun;66(5):463-74.
Impact factor:
Publication type: Letter or abstract
Authors: Colas, Eva; Doll, Andreas; Garcia, Marta; Llaurado, Marta; Montes, Melania; Morote, Juan; Olivan, Mireia; Reventos, Jaume; Rigau, Marina; Sequeiros, Tamara et al.
DOI:

The beautiful history of pertuzumab.

PMID: 22716485
Journal: Expert Review of Anticancer Therapy
Year: 2012
Reference: Expert Rev Anticancer Ther. 2012 Jun;12(6):703-5. doi: 10.1586/era.12.46.
Impact factor:
Publication type: Editorail in international publication
Authors: Cortes, Javier; Munoz-Couselo, Eva; Ortega, Vanesa; Perez-Garcia, Jose et al.
DOI: 10.1586/era.12.46

Impact of Androgen Deprivation on the Lipid Profile and Atherogenic Risk in Prostate Cancer Patients.

PMID: 22178349
Journal: Actas Urologicas Espanolas
Year: 2012
Reference: Actas Urol Esp. 2012 Apr;36(4):205-209. Epub 2011 Dec 16.
Impact factor:
Publication type: Paper in national publication
Authors: ; ; ; ; ; ; et al.
DOI: 10.1016/j.acuro.2011.09.006

Re: Bas W.G. van Rhijn, Theo H. van der Kwast, Sultan S. Alkhateeb, et al. A New and Highly Prognostic System to Discern T1 Bladder Cancer Substage. Eur Urol 2012;61:378-84.

PMID: 22445221
Journal: EUROPEAN UROLOGY
Year: 2012
Reference: Eur Urol. 2012 Jun;61(6):e53-4; author reply e55-6. doi: 10.1016/j.eururo.2012.03.016. Epub 2012 Mar 21.
Impact factor:
Publication type: Letter whit IF
Authors: ; ; et al.
DOI: 10.1016/j.eururo.2012.03.016

The Jejunum of Diarrhea-Predominant Irritable Bowel Syndrome Shows Molecular Alterations in the Tight Junction Signaling Pathway That Are Associated With Mucosal Pathobiology and Clinical Manifestations.

PMID: 22415197
Journal: AMERICAN JOURNAL OF GASTROENTEROLOGY
Year: 2012
Reference: Am J Gastroenterol. 2012 May;107(5):736-46. doi: 10.1038/ajg.2011.472. Epub 2012 Mar 13.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1038/ajg.2011.472

Loss of androgen receptor expression is not associated with pathological stage, grade, gender or outcome in bladder cancer: a large multi-institutional study.

PMID: 21070579
Journal: BJU INTERNATIONAL
Year: 2011
Reference: BJU Int. 2011 Jul;108(1):24-30. doi: 10.1111/j.1464-410X.2010.09834.x. Epub 2010 Nov 10.
Impact factor:
Publication type: Review in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1111/j.1464-410X.2010.09834.x

Altered transcription factor E3 expression in unclassified adult renal cell carcinoma indicates adverse pathological features and poor outcome.

PMID: 21070573
Journal: BJU INTERNATIONAL
Year: 2011
Reference: BJU Int. 2011 Jul;108(2 Pt 2):E71-6. doi: 10.1111/j.1464-410X.2010.09818.x. Epub 2010 Nov 10.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; et al.
DOI: 10.1111/j.1464-410X.2010.09818.x

Holmium laser enucleation of the prostatic adenoma.

PMID: 21498890
Journal: Arch Esp Urol
Year: 2011
Reference: Arch Esp Urol. 2011 Apr;64(3):246-256.
Impact factor:
Publication type: Letter or abstract
Authors: ; ; ; ; ; ; et al.
DOI:

A Three-Gene panel on urine increases PSA specificity in the detection of prostate cancer.

PMID: 21520154
Journal: PROSTATE
Year: 2011
Reference: Prostate. 2011 Dec;71(16):1736-45. doi: 10.1002/pros.21390. Epub 2011 Apr 25.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1002/pros.21390

A transcriptional signature associated with the onset of benign prostate hyperplasia in a canine model.

PMID: 20687213
Journal: PROSTATE
Year: 2010
Reference: Prostate. 2010 Sep 15;70(13):1402-12.
Impact factor:
Publication type: Paper in international publication
Authors: Abal, M; Doll, A; Gallardo-Arrieta, F; Garcia, F; Juanpere, N; Lloreta, J; Mogas, T; Morote, J; Nunez, F; Reventos, J et al.
DOI: 10.1002/pros.21175

Antiproliferative and apoptotic effects of the herbal agent Pygeum africanum on cultured prostate stromal cells from patients with benign prostatic hyperplasia (BPH).

PMID: 20503393
Journal: PROSTATE
Year: 2010
Reference: Prostate. 2010 Jul 1;70(10):1044-53.
Impact factor:
Publication type: Paper in international publication
Authors: Arbos, Maria A; de Torres, Ines M; Fraga, Antonia; Morote, Juan; Quiles, Maria T; Reventos, Jaume et al.
DOI: 10.1002/pros.21138

Evidence-based consensus recommendations to improve the quality of life in prostate cancer treatment.

PMID: 20466619
Journal: Clinical & Translational Oncology
Year: 2010
Reference: Clin Transl Oncol. 2010 May;12(5):346-55.
Impact factor:
Publication type: Paper in international publication
Authors: Borras, Josep Maria; Casas, Francesc; Ferrer, Ferran; Guanyabens, Nuria; Gutierrez del Pozo, Rafael; Leon, Concha; Lopez Torrecilla, Jose; Mellado, Begona; Morote, Joan; Puig, Manel et al.
DOI:

Bilateral testicular germ cell tumours: a single hospital experience.

PMID: 20462840
Journal: Clinical & Translational Oncology
Year: 2010
Reference: Clin Transl Oncol. 2010 Apr;12(4):299-302.
Impact factor:
Publication type: Paper in international publication
Authors: Carles, J; Maldonado, X; Morales-Barrera, R; Perez, J; Rodon, J; Suarez, C; Trilla, E; Valverde, C et al.
DOI:

Alendronate decreases the fracture risk in patients with prostate cancer on androgen-deprivation therapy and with severe osteopenia or osteoporosis.

PMID: 19549260
Journal: BJU INTERNATIONAL
Year: 2009
Reference: BJU Int. 2009 Dec;104(11):1637-40.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; et al.
DOI: 10.1111/j.1464-410X.2009.08622.x

Identification, characterization and expression of novel Sex Hormone Binding Globulin alternative first exons in the human prostate.

PMID: 19534810
Journal: BMC MOLECULAR BIOLOGY
Year: 2009
Reference: BMC Mol Biol. 2009 Jun 17;10:59.
Impact factor:
Publication type: Paper in international publication
Authors: Barbosa-Desongles, Anna; de Torres, Ines; Hurtado, Antoni; Morote, Joan; Munell, Francina; Pinos, Tomas; Reventos, Jaume; Santamaria-Martinez, Albert et al.
DOI: 10.1186/1471-2199-10-59

Individual variations of serum testosterone in patients with prostate cancer receiving androgen deprivation therapy.

PMID: 19007366
Journal: BJU INTERNATIONAL
Year: 2009
Reference: BJU Int. 2009 Feb;103(3):332-5; discussion 335.
Impact factor:
Publication type: Paper in international publication
Authors: Catalan, Roberto; Morote, Juan; Planas, Jacques; Raventos, Carles X; Reventos, Jaume; Salvador, Carlos et al.
DOI: 10.1111/j.1464-410X.2008.08062.x

Adhesion properties of Lactobacillus casei strains to resected intestinal fragments and components of the extracellular matrix.

PMID: 18974977
Journal: ARCHIVES OF MICROBIOLOGY
Year: 2009
Reference: Arch Microbiol. 2009 Feb;191(2):153-61.
Impact factor:
Publication type: Paper in international publication
Authors: Antolin, Maria; de Torres, Ines; Guarner, Francisco; Llopis, Marta; Monedero, Vicente; Munoz-Provencio, Diego; Perez-Martinez, Gaspar et al.
DOI: 10.1007/s00203-008-0436-9

[Benign retroperitoneal schwannoma, laparoscopic ressection].

PMID: 18540269
Journal: Actas Urológicas Españolas
Year: 2008
Reference: Actas Urol Esp. 2008 Apr;32(4):455-7.
Impact factor:
Publication type: Letter or abstract
Authors: Bestard Vallejo, J; Celma, A; Mir Maresma, C; Morote Robles, J; Orsola De los Santos, A; Raventos, C X et al.
DOI:

Estrogen receptor beta displays cell cycle-dependent expression and regulates the G1 phase through a non-genomic mechanism in prostate carcinoma cells.

PMID: 18607069
Journal: CELLULAR ONCOLOGY
Year: 2008
Reference: Cell Oncol. 2008;30(4):349-65.
Impact factor:
Publication type: Paper in international publication
Authors: Barbosa-Desongles, Anna; Barquinero, Jordi; Bellmunt, Joaquim; de Torres, Ines; Hurtado, Antoni; Lopez-Aviles, Sandra; Morote, Joan; Munell, Francina; Petriz, Jordi; Pinos, Tomas et al.
DOI:

[Bipolar versus monopolar transurethral resection of the prostate: peroperative analysis of the results].

PMID: 17058610
Journal: Actas Urológicas Españolas
Year: 2006
Reference: Actas Urol Esp. 2006 Jul-Aug;30(7):661-6.
Impact factor:
Publication type: Letter or abstract
Authors: Abascal Junquera, J M; Cecchini Rosell, L; Celma Domenech, A; Martos Calvo, R; Morote Robles, J; Salvador Lacambra, C et al.
DOI:

[Current status of radical laparoscopic prostatectomy].

PMID: 16884104
Journal: Actas Urológicas Españolas
Year: 2006
Reference: Actas Urol Esp. 2006 May;30(5):513-6.
Impact factor:
Publication type: Letter or abstract
Authors: Cecchini Rosell, L; Esquena Fernandez, S; Morote Robles, J; Orsola de los Santos, A; Planas Morin, J; Raventos Busquets, C X; Trilla Herrera, E et al.
DOI:

Blog

News

On World Cancer Research Day, we highlight research aimed at improving treatments for both pediatric and adult cancers through innovative techniques.

The work led by Dr. Regis demonstrates that performing robotic reconstruction after radical prostatectomy is associated with better urinary control.

A clinical trial with the prototype of the device shows that the use of this technology improves patient monitoring by nurses and reduces post-surgical complications.