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Biomedical Research in Urology

The Biomedical Research in Urology group is interested in the study of hormone-dependent cancers, in particular prostate cancer (but not limited to it).

Our efforts are focused on finding, on the one hand, tools that help us in the early diagnosis of the disease, in the best differentiation of tumors according to their aggressiveness and their response to therapy, and finally in finding effective therapies against it.

From a molecular point of view, we focus our studies mainly on cell signaling processes related to the cell cycle and mitosis (with kinesins, kinases and ubiquitin ligases as main targets).

Our multidisciplinary group is made up of molecular biologists and urologists, and we collaborate with oncologists, pathologists and specialists in other diseases when required.

We work with in silico data obtained with different "omics" techniques, samples and clinical data from patients, in vitro and in vivo models, to answer the questions raised.

Team

Jacques Planas Morin

Jacques Planas Morin

Biomedical Research in Urology
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Maria Carme Altadill Sanchez

Maria Carme Altadill Sanchez

Biomedical Research in Urology
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Olga Mendez Fernández

Olga Mendez Fernández

Main researcher
Biomedical Research in Urology
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Richard Mast

Richard Mast

Research assistant
Biomedical Research in Urology
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Jacques Planas Morin

Jacques Planas Morin

Biomedical Research in Urology
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Maria Carme Altadill Sanchez

Maria Carme Altadill Sanchez

Biomedical Research in Urology
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Olga Mendez Fernández

Olga Mendez Fernández

Main researcher
Biomedical Research in Urology
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Richard Mast

Richard Mast

Research assistant
Biomedical Research in Urology
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Research lines

Lasers in benign prostatic hyperplasia (Clinical research)

The development of the HOLEP (Holmium Laser Enucleation of the Prostate) technique and its outcome is the main objective of this line. We are presently testing different lasers in order to increase the efficacy of the technique.

IP: José Placer Santos

Markers, prognosis and outcomes of kidney cancer (Clinical research)

One main objective is the discovery of useful markers for detection and prognosis of tumors of the kidney. In addition, we are analysing the outcomes of minimal invasive radio-frequence ablation technique. 

IP: Enric Trilla Herrera

miRNAs and metastasic prostate cancer (Translational research in prostate cancer)

It is still difficult by current risk stratification strategies, to distinguish patients with rapidly progressing PC, requiring aggressive treatment, from those with an indolent tumour that will not progress. One aim of our group is to identify miRNA signatures that closely correlate with clinical outcome of PC and characterize the role in cancer progression of the most relevant miRNAs associated to the metastatic profile in order to identify new potential therapeutic targets for aggressive PC.


Sequeiros T*, Garcia M*, et al. BioMed Research Int?2013; doi:10.1155/2013/283635

IP: Joan Morote Robles

PIA and HGPIN as premalignant lesions of prostate cancer (Clinical research)

The main objective of this line is to understand the clinical significance of PIA and/or HGPIN lesions present in prostate biopsy. Once these are diagnosed, the search of markers specific for each lesion is also an objective of this line.   

IP: Inés de Torres Ramirez

Projects

Nuevas estrategias para la mejora del diagnóstico y el manejo terapéutico de los portadores de mutaciones en BRCA2

IP: Anna Santamaria Margalef
Collaborators: Mercè Cuadras Solé, Jacques Planas Morin
Funding agency: Instituto de Salud Carlos III
Funding: 159720
Reference: PI21/00977
Duration: 01/01/2022 - 30/06/2026

Publications

Metastatic solid tumors to the testis: a clinicopathologic evaluation of 157 cases from an international collaboration.

PMID: 37331529
Journal: HUMAN PATHOLOGY
Year: 2023
Reference: Hum Pathol. 2023 Jun 16:S0046-8177(23)00135-1. doi: 10.1016/j.humpath.2023.06.002.
Impact factor:
Publication type: Paper in international publication
Authors: Acosta, Andres M; Akgul, Mahmut; Alvarado-Cabrero, Isabel; Aron, Manju; Celada, Manuel Manrique; Cheng, Liang; Chou, Angela; Collins, Katrina; Contreras, Felix; de Torres, Ines et al.
DOI: 10.1016/j.humpath.2023.06.002

A risk-organised model for clinically significant prostate cancer early detection.

PMID: 37334020
Journal: BJUI compass
Year: 2023
Reference: BJUI Compass. 2023 Mar 7;4(4):420-422. doi: 10.1002/bco2.230. eCollection 2023 Jul.
Impact factor:
Publication type: Paper in international publication
Authors: Abascal, Jose M; Borque-Fernando, Angel; Esteban, Luis M; Mendez, Olga; Morote, Juan; Planas, Jacques; Servian, Pol; Tilla, Enrique; Triquell, Marina et al.
DOI: 10.1002/bco2.230

Comparison of Rotterdam and Barcelona Magnetic Resonance Imaging Risk Calculators for Predicting Clinically Significant Prostate Cancer.

PMID: 37441350
Journal: European urology open science
Year: 2023
Reference: Eur Urol Open Sci. 2023 May 22;53:46-54. doi: 10.1016/j.euros.2023.03.013. eCollection 2023 Jul.
Impact factor:
Publication type: Paper in international publication
Authors: Abascal, Jose M; Borque-Fernando, Angel; Campistol, Miriam; Esteban, Luis M; Mendez, Olga; Morote, Juan; Planas, Jacques; Servian, Pol; Trilla, Enrique; Triquell, Marina et al.
DOI: 10.1016/j.euros.2023.03.013

Methods for Evaluating the Efficacy of Medical Castration: A Systematic Review.

PMID: 37444589
Journal: Cancers
Year: 2023
Reference: Cancers (Basel). 2023 Jul 3;15(13):3479. doi: 10.3390/cancers15133479.
Impact factor:
Publication type: Review in international publication
Authors: Aguilar, Adriana; Morote, Juan; Planas, Jacques; Trilla, Enrique et al.
DOI: 10.3390/cancers15133479

Reply to Nikolaos Kalampokis, Nikolaos Grivas, Markos Karavitakis, and Henk van der Poel's Letter to the Editor re: Aina Salazar, Lucas Regis, Jacques Planas, et al. A Randomised Controlled Trial to Assess the Benefit of Posterior Rhabdosphincter Reconstruction in Early Urinary Continence Recovery after Robot-assisted Radical Prostatectomy. Eur Urol Oncol. In press. https://doi.org/10.1016/j.euo.2021.02.005.

PMID: 34593354
Journal: European Urology Oncology
Year: 2022
Reference: Eur Urol Oncol. 2022 Aug;5(4):474. doi: 10.1016/j.euo.2021.09.004. Epub 2021 Sep 28.
Impact factor:
Publication type: Letter or abstract
Authors: Morote, Juan; Regis, Lucas; Salazar, Aina et al.
DOI: 10.1016/j.euo.2021.09.004

A Randomised Controlled Trial to Assess the Benefit of Posterior Rhabdosphincter Reconstruction in Early Urinary Continence Recovery after Robot-assisted Radical Prostatectomy.

PMID: 33653674
Journal: European Urology Oncology
Year: 2022
Reference: Eur Urol Oncol. 2022 Aug;5(4):460-463. doi: 10.1016/j.euo.2021.02.005. Epub 2021 Feb 27.
Impact factor:
Publication type: Paper in international publication
Authors: Celma, Anna; Morote, Juan; Planas, Jacques; Regis, Lucas; Salazar, Aina; Santamaria, Anna; Trilla, Enrique et al.
DOI: 10.1016/j.euo.2021.02.005

The True Utility of Predictive Models Based on Magnetic Resonance Imaging in Selecting Candidates for Prostate Biopsy.

PMID: 35795075
Journal: European Urology Open Science
Year: 2022
Reference: Eur Urol Open Sci. 2022 Jul 1;42:40-41. doi: 10.1016/j.euros.2022.06.002. eCollection 2022 Aug.
Impact factor:
Publication type: Letter whit IF
Authors: Borque-Fernando, Angel; Esteban, Luis M; Morote, Juan; Trilla, Enrique; Triquell, Marina et al.
DOI: 10.1016/j.euros.2022.06.002

Comparison of Proclarix, PSA Density and MRI-ERSPC Risk Calculator to Select Patients for Prostate Biopsy after mpMRI.

PMID: 35681685
Journal: Cancers
Year: 2022
Reference: Cancers (Basel). 2022 May 30;14(11). pii: cancers14112702. doi: 10.3390/cancers14112702.
Impact factor:
Publication type: Paper in international publication
Authors: Campistol, Miriam; Celma, Ana; de Torres, Ines; Mast, Richard; Morote, Juan; Planas, Jacques; Regis, Lucas; Santamaria, Anna; Semidey, Maria E; Trilla, Enrique et al.
DOI: 10.3390/cancers14112702

Is there the same requirement to obtain the PhD degree in all the departments of surgery of the Spanish universities?

PMID: 33965193
Journal: CIRUGIA ESPANOLA
Year: 2021
Reference: Cir Esp (Engl Ed). 2021 May 5:S0009-739X(21)00137-8. doi: 10.1016/j.ciresp.2021.04.006.
Impact factor:
Publication type: Paper in national publication
Authors: Amat-Lefort, Natalia; Armengol Carrasco, Manel; Espin Basany, Eloy; Morote Robles, Joan; Navarro-Soto, Salvador; Serra-Aracil, Xavier; Serra-Gomez, Alvaro et al.
DOI: 10.1016/j.ciresp.2021.04.006

Proteomic Studies on the Management of High-Grade Serous Ovarian Cancer Patients: A Mini-Review.

PMID: 33922979
Journal: Cancers
Year: 2021
Reference: Cancers (Basel). 2021 Apr 25;13(9). pii: cancers13092067. doi: 10.3390/cancers13092067.
Impact factor:
Publication type: Review in international publication
Authors: Borras, Eva; Bradbury, Melissa; Gil-Moreno, Antonio; Perez-Benavente, Assumpcio; Sabido, Eduard; Santamaria, Anna et al.
DOI: 10.3390/cancers13092067

Nuclear and cytosolic pS727-STAT3 levels correlate with overall survival of patients affected by clear cell renal cell carcinoma (ccRCC).

PMID: 33772065
Journal: Scientific Reports
Year: 2021
Reference: Sci Rep. 2021 Mar 26;11(1):6957. doi: 10.1038/s41598-021-86218-x.
Impact factor:
Publication type: Paper in international publication
Authors: Arevalo, Jazmine; Lorente, David; Meseguer, Anna; Morote, Juan; Salcedo, Maria Teresa; Trilla, Enrique et al.
DOI: 10.1038/s41598-021-86218-x

Are Multiparametric Magnetic Resonance Imaging and Guided Biopsies Needed in Men with Normal Digital Rectal Examination and Prostatic-specific Antigen >20 ng/ml?

PMID: 33663960
Journal: European Urology Oncology
Year: 2021
Reference: Eur Urol Oncol. 2021 Apr;4(2):334-335. doi: 10.1016/j.euo.2021.02.004. Epub 2021 Mar 2.
Impact factor:
Publication type: Letter or abstract
Authors: Celma, Anna; Morote, Juan; Planas, Jacques et al.
DOI: 10.1016/j.euo.2021.02.004

Peripheral Corticotropin-Releasing Factor Triggers Jejunal Mast Cell Activation and Abdominal Pain in Patients With Diarrhea-Predominant Irritable Bowel Syndrome.

PMID: 32740086
Journal: AMERICAN JOURNAL OF GASTROENTEROLOGY
Year: 2020
Reference: Am J Gastroenterol. 2020 Dec;115(12):2047-2059. doi: 10.14309/ajg.0000000000000789.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso-Cotoner, Carmen; Antolin, Maria; Azpiroz, Fernando; de Torres, Ines; Fortea, Marina; Gonzalez-Castro, Ana; Guilarte, Mar; Lobo, Beatriz; Martinez, Cristina; Pardo-Camacho, Cristina et al.
DOI: 10.14309/ajg.0000000000000789

Current status of genetic urinary biomarkers for surveillance of non-muscle invasive bladder cancer: a systematic review.

PMID: 32664878
Journal: BMC Urology
Year: 2020
Reference: BMC Urol. 2020 Jul 14;20(1):99. doi: 10.1186/s12894-020-00670-x.
Impact factor:
Publication type: Review in international publication
Authors: Carrion, A; Lozano, F; Morote, J; Raventos, C X; Trilla, E et al.
DOI: 10.1186/s12894-020-00670-x

STK11 (LKB1) missense somatic mutant isoforms promote tumor growth, motility and inflammation.

PMID: 32647375
Journal: Communications Biology
Year: 2020
Reference: Commun Biol. 2020 Jul 9;3(1):366. doi: 10.1038/s42003-020-1092-0.
Impact factor:
Publication type: Paper in international publication
Authors: Canals, Francesc; Espinosa-Gil, Sergio; Ferrer, Berta; Garcia-Ortega, Sara; Garcia-Patos, Vicenc; Gil, Rosa; Gonzalez-Sanchez, Elena; Granado-Martinez, Paula; Grueso, Judit; Hernandez-Losa, Javier et al.
DOI: 10.1038/s42003-020-1092-0

[Robotic and laparosocpic urological surgery during COVID-19 pandemia.]

PMID: 32538818
Journal: ARCHIVOS ESPANOLES DE UROLOGIA
Year: 2020
Reference: Arch Esp Urol. 2020 Jun;73(5):463-470.
Impact factor:
Publication type: Review in national publication
Authors: Alcaraz, Antonio; Allona, Antonio; Carracedo, David; Gutierrez, Jose Luis; Lopez-Fando, Luis; Medina, Rafael Antonio; Moncada, Ignacio; Moreno, Jesus; Palou, Joan; Pereira, Jose Gregorio et al.
DOI:

Replay by authors: Serum testosterone level is a useful biomarker for determining the optimal treatment for castration-resistant prostate cancer.

PMID: 31239185
Journal: UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
Year: 2019
Reference: Urol Oncol. 2019 Sep;37(9):571. doi: 10.1016/j.urolonc.2019.05.016. Epub 2019 Jun 22.
Impact factor:
Publication type: Letter or abstract
Authors: Comas, Imma; Morote, Juan et al.
DOI: 10.1016/j.urolonc.2019.05.016

[Prostate pathology recommendations from the Uropathology working group of the Spanish Society of Pathology].

PMID: 31213258
Journal: Revista espanola de patologia : publicacion oficia
Year: 2019
Reference: Rev Esp Patol. 2019 Jul - Sep;52(3):167-177. doi: 10.1016/j.patol.2019.02.001. Epub 2019 May 15.
Impact factor:
Publication type: Review in national publication
Authors: de Torres, Ines; Gallel, Pilar; Hierro Martin, M Isabel; Sanz Ortega, Julian et al.
DOI: 10.1016/j.patol.2019.02.001

In Search for risk predictors at the microscopic scenario of a negative biopsy. A systematic review.

PMID: 31109736
Journal: Actas Urologicas Espanolas
Year: 2019
Reference: Actas Urol Esp. 2019 Sep;43(7):337-347. doi: 10.1016/j.acuro.2019.01.010. Epub 2019 May 17.
Impact factor:
Publication type: Review in national publication
Authors: Celma, A; Gallardo, I; Moreno, O; Morote Robles, J; Placer, J; Planas, J; Regis, L; Schwartzmann, I; Trilla Herrero, E et al.
DOI: 10.1016/j.acuro.2019.01.010

Sclerosing Cholangitis Related to IgG4: Not Always a Curable Entity.

PMID: 31113593
Journal: Annals of Hepatology
Year: 2019
Reference: Ann Hepatol. 2019 Jan - Feb;18(1):215-219. doi: 10.5604/01.3001.0012.7916.
Impact factor:
Publication type: Paper in international publication
Authors: Buti, Maria; Esteban, Rafael; Fernandez-Codina, Andreu; Martinez-Valle, Fernando; Merino-Casabiel, Xavier; Riveiro-Barciela, Mar; Salcedo, Maria-Teresa; Torres, Ines de et al.
DOI: 10.5604/01.3001.0012.7916

Human salivary microRNAs in Cancer.

PMID: 29556321
Journal: Journal of Cancer
Year: 2018
Reference: J Cancer. 2018 Jan 6;9(4):638-649. doi: 10.7150/jca.21180. eCollection 2018.
Impact factor:
Publication type: Review in international publication
Authors: Alvarez-Castro, Ana; Gil-Moreno, Antonio; Lopez-Lopez, Rafael; Majem, Blanca; Muinelo-Romay, Laura; Rapado-Gonzalez, Oscar; Santamaria, Anna; Suarez-Cunqueiro, Maria Mercedes et al.
DOI: 10.7150/jca.21180

A systematic review of methods for quantifying serum testosterone in patients with prostate cancer who underwent castration.

PMID: 28259362
Journal: Actas Urologicas Espanolas
Year: 2018
Reference: Actas Urol Esp. 2018 Mar;42(2):86-93. doi: 10.1016/j.acuro.2017.01.007. Epub 2017 Mar 2.
Impact factor:
Publication type: Review in national publication
Authors: Celma, A; Comas, I; Ferrer, R; Morote, J; Planas, J; Regis, L et al.
DOI: 10.1016/j.acuro.2017.01.007

Cognitive function in patients on androgen suppression: A prospective, multicentric study.

PMID: 29102054
Journal: Actas Urologicas Espanolas
Year: 2018
Reference: Actas Urol Esp. 2018 Mar;42(2):114-120. doi: 10.1016/j.acuro.2017.04.007. Epub 2017 Nov 6.
Impact factor:
Publication type: Paper in national publication
Authors: Alvarez-Ossorio, J L; Angulo, J; Ciria, J P; de La Iglesia, R; Dominguez-Escrig, J L; Lopez, F J; Morote, J; Romero, J; Tabernero, A J; Vazquez, F et al.
DOI: 10.1016/j.acuro.2017.04.007

Under-expression of CK2beta subunit in ccRCC represents a complementary biomarker of p-STAT3 Ser727 that correlates with patient survival.

PMID: 29464030
Journal: Oncotarget
Year: 2018
Reference: Oncotarget. 2017 Dec 19;9(5):5736-5751. doi: 10.18632/oncotarget.23422. eCollection 2018 Jan 19.
Impact factor:
Publication type: Paper in international publication
Authors: Alcaraz, Estefania; Cuadros, Thais; de Torres, Ines; Itarte, Emilio; Meseguer, Anna; Morote, Juan; Pinna, Lorenzo A; Plana, Maria; Ramon Y Cajal, Santiago; Ruzzene, Maria et al.
DOI: 10.18632/oncotarget.23422

Accuracy of serum luteinizing hormone and serum testosterone measurements to assess the efficacy of medical castration in prostate cancer patients.

PMID: 29058606
Journal: JOURNAL OF BIOMEDICAL SCIENCE
Year: 2017
Reference: J Biomed Sci. 2017 Oct 22;24(1):81. doi: 10.1186/s12929-017-0386-0.
Impact factor:
Publication type: Paper in international publication
Authors: Celma, Anna; Comas, Imma; Ferrer, Roser; Morote, Juan; Planas, Jacques; Regis, Lucas et al.
DOI: 10.1186/s12929-017-0386-0

Prostate Tumor Overexpressed-1 (PTOV1) promotes docetaxel-resistance and survival of castration resistant prostate cancer cells.

PMID: 28938627
Journal: Oncotarget
Year: 2017
Reference: Oncotarget. 2017 Jul 22;8(35):59165-59180. doi: 10.18632/oncotarget.19467. eCollection 2017 Aug 29.
Impact factor:
Publication type: Paper in international publication
Authors: Canovas, Veronica; Lleonart, Matilde; Maggio, Valentina; Marin, Mercedes; Mellado, Begona; Morote, Juan; Olivan, Mireia; Paciucci, Rosanna; Planas, Jacques; Punal, Yolanda et al.
DOI: 10.18632/oncotarget.19467

E-cadherin: A determinant molecule associated with ovarian cancer progression, dissemination and aggressiveness.

PMID: 28934230
Journal: PLoS One
Year: 2017
Reference: PLoS One. 2017 Sep 21;12(9):e0184439. doi: 10.1371/journal.pone.0184439. eCollection 2017.
Impact factor:
Publication type: Paper in international publication
Authors: Abascal, Maria Florencia; Besso, Maria Jose; Castellvi, Josep; Devis, Laura; Gil-Moreno, Antonio; Lanau, Lucia; Lapyckyj, Lara; Llaurado, Marta; Majem, Blanca; Matos, Maria Laura et al.
DOI: 10.1371/journal.pone.0184439

Ligand-dependent Hedgehog pathway activation in Rhabdomyosarcoma: the oncogenic role of the ligands.

PMID: 28881358
Journal: BRITISH JOURNAL OF CANCER
Year: 2017
Reference: Br J Cancer. 2017 Oct 24;117(9):1314-1325. doi: 10.1038/bjc.2017.305. Epub 2017 Sep 7.
Impact factor:
Publication type: Paper in international publication
Authors: Almazan-Moga, A; Ferreres, J C; Gallego, S; Giralt, I; Hahn, H; Molist, C; Navarro, N; Navarro, S; Pyczek, J; Roma, J et al.
DOI: 10.1038/bjc.2017.305

[Prostate cancer].

PMID: 25727526
Journal: MEDICINA CLINICA
Year: 2016
Reference: Med Clin (Barc). 2016 Feb 5;146(3):121-7. doi: 10.1016/j.medcli.2014.12.021. Epub 2015 Feb 26.
Impact factor:
Publication type: Review in national publication
Authors: Maldonado, Xavier; Morales-Barrera, Rafael; Morote, Joan et al.
DOI: 10.1016/j.medcli.2014.12.021

Diagnostic accuracy of prostate health index to identify aggressive prostate cancer. An Institutional validation study.

PMID: 26923032
Journal: Actas Urologicas Espanolas
Year: 2016
Reference: Actas Urol Esp. 2016 Jul-Aug;40(6):378-85. doi: 10.1016/j.acuro.2016.01.004. Epub 2016 Feb 26.
Impact factor:
Publication type: Paper in national publication
Authors: Celma, A; de Torres, I; Ferrer, R; Morote, J; Olivan, M; Pacciuci, R; Placer, J; Planas, J et al.
DOI: 10.1016/j.acuro.2016.01.004

Cdk1 Phosphorylates SPAT-1/Bora to Promote Plk1 Activation in C. elegans and Human Cells.

PMID: 27068477
Journal: Cell Reports
Year: 2016
Reference: Cell Rep. 2016 Apr 19;15(3):510-8. doi: 10.1016/j.celrep.2016.03.049. Epub 2016 Apr 7.
Impact factor:
Publication type: Paper in international publication
Authors: Cirillo, Luca; Gotta, Monica; Joly, Nicolas; Martino, Lisa; Panbianco, Costanza; Pintard, Lionel; Santamaria, Anna; Schwager, Francoise; Tavernier, Nicolas; Thomas, Yann et al.
DOI: 10.1016/j.celrep.2016.03.049

Mitotic entry: The interplay between Cdk1, Plk1 and Bora.

PMID: 27831827
Journal: CELL CYCLE
Year: 2016
Reference: Cell Cycle. 2016 Dec;15(23):3177-3182. doi: 10.1080/15384101.2016.1249544. Epub 2016 Nov 10.
Impact factor:
Publication type: Paper in international publication
Authors: Cirillo, Luca; Gotta, Monica; Parrilla, Alfonso; Pintard, Lionel; Santamaria, Anna; Thomas, Yann et al.
DOI: 10.1080/15384101.2016.1249544

Reexamining treatment of high-grade T1 bladder cancer according to depth of lamina propria invasion: a prospective trial of 200 patients.

PMID: 25535728
Journal: BRIT J CANCER
Year: 2015
Reference: Br J Cancer. 2015 Feb 3;112(3):468-74. doi: 10.1038/bjc.2014.633. Epub 2014 Dec 23.
Impact factor:
Publication type: Paper in international publication
Authors: Barletta, J A; Bellmunt, J; de Torres, I; Leow, J J; Lozano, F; Martin-Doyle, W; Morote, J; Mullane, S A; Orsola, A; Raventos, C X et al.
DOI: 10.1038/bjc.2014.633

Effects of Holmium Laser Enucleation of the Prostate on Sexual Function.

PMID: 25133981
Journal: J ENDOUROL
Year: 2015
Reference: J Endourol. 2015 Mar;29(3):332-9. doi: 10.1089/end.2014.0502. Epub 2014 Oct 21.
Impact factor:
Publication type: Paper in international publication
Authors: Celma, Ana; Lopez, Miguel Angel; Lorente, David; Morote, Juan; Placer, Jose; Planas, Jacques; Salvador, Carlos; Trilla, Enrique et al.
DOI: 10.1089/end.2014.0502

Implementing newer agents for the management of castrate-resistant prostate cancer: what is known and what is needed?

PMID: 24628790
Journal: BJU INT
Year: 2015
Reference: BJU Int. 2015 Mar;115(3):364-72. doi: 10.1111/bju.12736. Epub 2014 Jul 15.
Impact factor:
Publication type: Paper in international publication
Authors: Clarke, Noel; De Santis, Maria; Joniau, Steven; Morote, Juan; Mottet, Nicolas; Zattoni, Filiberto et al.
DOI: 10.1111/bju.12736

Challenges and opportunities for cell line secretomes in cancer proteomics.

PMID: 25418557
Journal: Proteomics Clinical Applications
Year: 2015
Reference: Proteomics Clin Appl. 2015 Apr;9(3-4):348-57. doi: 10.1002/prca.201400131. Epub 2015 Feb 10.
Impact factor:
Publication type: Paper in international publication
Authors: Mendez, Olga; Villanueva, Josep et al.
DOI: 10.1002/prca.201400131

SPARC mediates metastatic cooperation between CSC and non-CSC prostate cancer cell subpopulations.

PMID: 25331979
Journal: Molecular Cancer
Year: 2014
Reference: Mol Cancer. 2014 Oct 21;13:237. doi: 10.1186/1476-4598-13-237.
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, Ibane; Aguilera, Kristina Y; Alcaraz, Antonio; Bermudo, Raquel; Brekken, Rolf; Canovas, Veronica; Celia-Terrassa, Toni; Fernandez, Pedro L; Fernandez, Yolanda; Marin-Aguilera, Mercedes et al.
DOI: 10.1186/1476-4598-13-237

Comparison of the initial robot-assisted radical prostatectomy results with laparoscopic radical prostatectomy.

PMID: 24691041
Journal: Archivos españoles de urología
Year: 2014
Reference: Arch Esp Urol. 2014 Mar;67(2):185-90.
Impact factor:
Publication type: Letter or abstract
Authors: Agreda, Fernando; Morote, Juan; Planas, Jacques; Raventos, Carles; Trilla, Enrique et al.
DOI:

Prostate tumor OVerexpressed-1 (PTOV1) down-regulates HES1 and HEY1 notch targets genes and promotes prostate cancer progression.

PMID: 24684754
Journal: Molecular Cancer
Year: 2014
Reference: Mol Cancer. 2014 Mar 31;13:74. doi: 10.1186/1476-4598-13-74.
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, Ibane; Alana, Lide; Bigas, Anna; Canovas, Veronica; Corominas, Montserrat; de Torres, Ines; Espinosa, Lluis; Fernandez, Pedro L; Fernandez, Yolanda; Paciucci, Rosanna et al.
DOI: 10.1186/1476-4598-13-74

Metabolic syndrome in patients with prostate cancer undergoing androgen suppression.

PMID: 24360772
Journal: Actas Urologicas Espanolas
Year: 2014
Reference: Actas Urol Esp. 2014 Jun;38(5):285-289. doi: 10.1016/j.acuro.2013.09.008. Epub 2013 Dec 20.
Impact factor:
Publication type: Paper in national publication
Authors: Celma, A; de Torres, I; Ferrer, R; Morote, J; Placer, J; Planas, J; Ropero, J et al.
DOI: 10.1016/j.acuro.2013.09.008

Usefulness of bone turnover markers as predictors of mortality risk, disease progression and skeletal-related events appearance in patients with prostate cancer with bone metastases following treatment with zoledronic acid: TUGAMO study.

PMID: 23722472
Journal: BRITISH JOURNAL OF CANCER
Year: 2013
Reference: Br J Cancer. 2013 Jun 25;108(12):2565-72. doi: 10.1038/bjc.2013.270. Epub 2013 May 30.
Impact factor:
Publication type: Paper in international publication
Authors: Alcaraz, A; Alvarez-Ossorio, J L; Anido, U; Bellmunt, J; Calderero, V; Carles, J; Comet-Batlle, J; Constela, M; Contreras, J A; de la Piedra, C et al.
DOI: 10.1038/bjc.2013.270

Diarrhoea-predominant irritable bowel syndrome: an organic disorder with structural abnormalities in the jejunal epithelial barrier.

PMID: 22637702
Journal: GUT
Year: 2013
Reference: Gut. 2013 Aug;62(8):1160-8. doi: 10.1136/gutjnl-2012-302093. Epub 2012 May 25.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1136/gutjnl-2012-302093

Biochemical markers of bone turnover and clinical outcome in patients with renal cell and bladder carcinoma with bone metastases following treatment with zoledronic acid: The TUGAMO study.

PMID: 23799855
Journal: BRITISH JOURNAL OF CANCER
Year: 2013
Reference: Br J Cancer. 2013 Jul 9;109(1):121-30. doi: 10.1038/bjc.2013.272. Epub 2013 Jun 25.
Impact factor:
Publication type: Paper in international publication
Authors: Alcaraz, A; Alvarez-Ossorio, J-L; Bellmunt, J; Calderero, V; Carles, J; Chirivella, I; Climent, M; Comet-Batlle, J; Contreras, J-A; de la Piedra, C et al.
DOI: 10.1038/bjc.2013.272

Management of the axilla in early breast cancer patients in the genomic era.

PMID: 23165977
Journal: ANNALS OF ONCOLOGY
Year: 2013
Reference: Ann Oncol. 2013 May;24(5):1163-70. doi: 10.1093/annonc/mds592. Epub 2012 Nov 19.
Impact factor:
Publication type: Review in international publication
Authors: Balmana, J; Bellet, M; Cortes, J; De Mattos-Arruda, L; Di Cosimo, S; Gomez, P; Munoz, E; Oliveira, M; Ortega, V; Perez, J et al.
DOI: 10.1093/annonc/mds592

Denosumab and bone-metastasis-free survival in men with castration-resistant prostate cancer: results of a phase 3, randomised, placebo-controlled trial.

PMID: 22093187
Journal: LANCET
Year: 2012
Reference: Lancet. 2012 Jan 7;379(9810):39-46. Epub 2011 Nov 15.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1016/S0140-6736(11)61226-9

[Biochemical recurrence criteria after radical prostatectomy. Natural history of the disease].

PMID: 22318173
Journal: Arch Esp Urol
Year: 2012
Reference: Arch Esp Urol. 2012 Jan;65(1):4-11.
Impact factor:
Publication type: Letter or abstract
Authors: Morote, Juan; Planas, Jacques et al.
DOI:

Penile Squamous Cell Carcinoma.

PMID: 22261674
Journal: Actas dermo-sifiliograficas
Year: 2012
Reference: Actas Dermosifiliogr. 2012 Jul-Aug;103(6):478-87. doi: 10.1016/j.ad.2011.08.008. Epub 2012 Jan 17.
Impact factor:
Publication type: Letter or abstract
Authors: ; ; et al.
DOI: 10.1016/j.ad.2011.08.008

PTOV1 is overexpressed in human high-grade malignant tumors.

PMID: 21181414
Journal: VIRCHOWS ARCHIV
Year: 2011
Reference: Virchows Arch. 2011 Mar;458(3):323-30. Epub 2010 Dec 23.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; et al.
DOI: 10.1007/s00428-010-1018-1

Loss of bone mass in patients with prostate cancer subjected to androgenic deprivation.

PMID: 21419516
Journal: Actas Urologicas Espanolas
Year: 2011
Reference: Actas Urol Esp. 2011 Apr;35(4):232-9. Epub 2011 Mar 17.
Impact factor:
Publication type: Review in national publication
Authors: ; et al.
DOI: 10.1016/j.acuro.2011.01.008

Variant Forms of Bladder Cancer: Basic Considerations on Treatment Approaches.

PMID: 21360040
Journal: Current Oncology Reports
Year: 2011
Reference: Curr Oncol Rep. 2011 Jun;13(3):216-21.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; et al.
DOI: 10.1007/s11912-011-0161-4

Re: Endo et al.: Anteroposterior dissection HoLEP: a modification to prevent transient stress urinary incontinence (Urology 2010;76:1451-1455).

PMID: 21195850
Journal: UROLOGY
Year: 2011
Reference: Urology. 2011 Jan;77(1):255-6; author reply 256-7.
Impact factor:
Publication type: Letter or abstract
Authors: Morote, Juan; Placer, Jose et al.
DOI: 10.1016/j.urology.2010.09.054

Testosterone Measurement in Patients with Prostate Cancer.

PMID: 20434831
Journal: EUROPEAN UROLOGY
Year: 2010
Reference: Eur Urol. 2010 Jul;58(1):65-74.
Impact factor:
Publication type: Review in international publication
Authors: ; ; ; ; ; ; et al.
DOI: 10.1016/j.eururo.2010.04.001

Regulation of Aurora B kinase by the lipid raft protein Flotillin-1.

PMID: 20430883
Journal: JOURNAL OF BIOLOGICAL CHEMISTRY
Year: 2010
Reference: J Biol Chem. 2010 Jul 2;285(27):20683-90. Epub 2010 Apr 29.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; et al.
DOI: 10.1074/jbc.M110.130591

Re: Felix K. Chun, Alexandre de la Taille, Hendrik van Poppel, et al. Prostate cancer gene 3 (PCA3): development and internal validation of a novel biopsy nomogram. Eur Urol 2009;56:659-68.

PMID: 19853371
Journal: EUROPEAN UROLOGY
Year: 2010
Reference: Eur Urol. 2010 Jan;57(1):e1; author reply e2-3. Epub 2009 Oct 9.
Impact factor:
Publication type: Letter or abstract
Authors: Morote, Juan et al.
DOI: 10.1016/j.eururo.2009.09.041

Effect of dutasteride on the risk of prostate cancer.

PMID: 20357281
Journal: NEW ENGLAND JOURNAL OF MEDICINE
Year: 2010
Reference: N Engl J Med. 2010 Apr 1;362(13):1192-202.
Impact factor:
Publication type: Paper in international publication
Authors: Aaron, Lorne; Abara, Emmanuel; Abdo, Joao Afif; Abdulhakim, Essam; Abramovitch, Allan; Ackaert, Koenraad; Adams, George; Akaza, Hideyiki; Akdas, Arif; Akhtar, Muhammad et al.
DOI: 10.1056/NEJMoa0908127

The relationship between total and free serum testosterone and the risk of prostate cancer and tumour aggressiveness.

PMID: 19220251
Journal: BJU INTERNATIONAL
Year: 2009
Reference: BJU Int. 2009 Aug;104(4):486-9.
Impact factor:
Publication type: Paper in international publication
Authors: Catalan, Roberto; de Torres, Ines M; Gomez, Esther; Morote, Juan; Planas, Jacques; Ramirez, Cristobal; Raventos, Carles X et al.
DOI: 10.1111/j.1464-410X.2009.08378.x

Immunolocalization of androgen receptors, estrogen alpha receptors, and estrogen beta receptors in experimentally induced canine prostatic hyperplasia.

PMID: 19136389
Journal: JOURNAL OF ANDROLOGY
Year: 2009
Reference: J Androl. 2009 May-Jun;30(3):240-7.
Impact factor:
Publication type: Paper in international publication
Authors: Baro, Teresa; Gallardo, Fanny; Garcia, Felix; Gonzalez, Luciano A; Lloreta, Josep; Mogas, Teresa; Moll, Xavier; Morote, Joan; Reventos, Jaume et al.
DOI: 10.2164/jandrol.108.006775

Identification of multipotent mesenchymal stromal cells in the reactive stroma of a prostate cancer xenograft by side population analysis.

PMID: 19447103
Journal: EXPERIMENTAL CELL RESEARCH
Year: 2009
Reference: Exp Cell Res. 2009 Oct 15;315(17):3004-13.
Impact factor:
Publication type: Paper in international publication
Authors: Barbosa-Desongles, Anna; Barquinero, Jordi; Hurtado, Antoni; Morote, Joan; Munell, Francina; Pinos, Tomas; Poupon, Marie-France; Reventos, Jaume; Santamaria-Martinez, Albert; Seoane, Joan et al.
DOI: 10.1016/j.yexcr.2009.05.007

Regulation of replicative and stress-induced senescence by RSK4, which is down-regulated in human tumors.

PMID: 19584160
Journal: CLINICAL CANCER RESEARCH
Year: 2009
Reference: Clin Cancer Res. 2009 Jul 15;15(14):4546-53.
Impact factor:
Publication type: Paper in international publication
Authors: Argelaguet, Elisabet; Armengol, Gemma; Coch, Laura; de Torres, Ines; Hernandez-Losa, Javier; Lleonart, Matilde; Lopez-Vicente, Laura; Pons, Berta; Ramon y Cajal, Santiago et al.
DOI: 10.1158/1078-0432.CCR-08-3159

Blog

News

On World Cancer Research Day, we highlight research aimed at improving treatments for both pediatric and adult cancers through innovative techniques.

The work led by Dr. Regis demonstrates that performing robotic reconstruction after radical prostatectomy is associated with better urinary control.

A clinical trial with the prototype of the device shows that the use of this technology improves patient monitoring by nurses and reduces post-surgical complications.