About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The Biomedical Research in Urology group is interested in the study of hormone-dependent cancers, in particular prostate cancer (but not limited to it).
Our efforts are focused on finding, on the one hand, tools that help us in the early diagnosis of the disease, in the best differentiation of tumors according to their aggressiveness and their response to therapy, and finally in finding effective therapies against it.
From a molecular point of view, we focus our studies mainly on cell signaling processes related to the cell cycle and mitosis (with kinesins, kinases and ubiquitin ligases as main targets).
Our multidisciplinary group is made up of molecular biologists and urologists, and we collaborate with oncologists, pathologists and specialists in other diseases when required.
We work with in silico data obtained with different "omics" techniques, samples and clinical data from patients, in vitro and in vivo models, to answer the questions raised.
All the above strategies leading to the discovery of new biomarkers, are validated in specifically designed tissue microarrays using immuno-histochemistry in FFPE samples from radical prostatectomies.
IP: Inés de Torres Ramirez
PMID: 37444439 Journal: Cancers Year: 2023 Reference: Cancers (Basel). 2023 Jun 24;15(13):3329. doi: 10.3390/cancers15133329. Impact factor: Publication type: Review in international publication Authors: Catala, Violeta; Morote, Juan; Paesano, Nahuel; Tcholakian, Larisa; Trilla, Enric et al. DOI: 10.3390/cancers15133329
PMID: 37468678 Journal: ONCOGENE Year: 2023 Reference: Oncogene. 2023 Jul 19. doi: 10.1038/s41388-023-02778-4. Impact factor: Publication type: Paper in international publication Authors: Abad, Maria; Alemany-Chavarria, Merce; Bellio, Chiara; Canals, Francesc; Fasani, Roberta; Greco, Emanuela; Greco, Emanuela; Mayans, Carla; Mendez, Olga; Mitjans, Francesc et al. DOI: 10.1038/s41388-023-02778-4
PMID: 37509344 Journal: Cancers Year: 2023 Reference: Cancers (Basel). 2023 Jul 19;15(14):3683. doi: 10.3390/cancers15143683. Impact factor: Publication type: Paper in international publication Authors: Carrion, Albert; Dinares, Carme; Hernandez, Javier; Hernandez, Javier; Lozano, Fernando; Morote, Juan; Raventos, Carles X; Trilla, Enrique et al. DOI: 10.3390/cancers15143683
PMID: 37661460 Journal: European Urology Oncology Year: 2023 Reference: Eur Urol Oncol. 2023 Sep 1:S2588-9311(23)00169-4. doi: 10.1016/j.euo.2023.08.008. Impact factor: Publication type: Letter or abstract Authors: Aguilar, Adriana; Aguilar, Adriana; Morote, Juan; Morote, Juan; Trilla, Enrique; Trilla, Enrique et al. DOI: 10.1016/j.euo.2023.08.008
PMID: 35625978 Journal: Cancers Year: 2022 Reference: Cancers (Basel). 2022 May 11;14(10). pii: cancers14102374. doi: 10.3390/cancers14102374. Impact factor: Publication type: Paper in international publication Authors: Abascal, Jose M; Borque-Fernando, Angel; Celma, Anna; de Torres, Ines M; Esteban, Luis M; Mast, Richard; Morote, Juan; Planas, Jacques; Regis, Lucas; Santamaria, Anna et al. DOI: 10.3390/cancers14102374
PMID: 35597418 Journal: CIRUGIA ESPANOLA Year: 2022 Reference: Cir Esp (Engl Ed). 2022 Aug;100(8):496-503. doi: 10.1016/j.cireng.2022.05.018. Epub 2022 May 18. Impact factor: Publication type: Paper in international publication Authors: Amat-Lefort, Natalia; Armengol Carrasco, Manel; Espin Basany, Eloy; Morote Robles, Joan; Navarro-Soto, Salvador; Serra-Aracil, Xavier; Serra-Gomez, Alvaro et al. DOI: 10.1016/j.cireng.2022.05.018
PMID: 34375498 Journal: BJU INTERNATIONAL Year: 2022 Reference: BJU Int. 2022 May;129(5):627-633. doi: 10.1111/bju.15568. Epub 2021 Aug 25. Impact factor: Publication type: Paper in international publication Authors: Celma, Anna; de Torres, Ines M; Mast, Richard; Morote, Juan; Planas, Jacques; Regis, Lucas; Roche, Sarai; Santamaria, Anna; Schwartzmann, Ivan; Semidey, Maria E et al. DOI: 10.1111/bju.15568
PMID: 35484379 Journal: Scientific Reports Year: 2022 Reference: Sci Rep. 2022 Apr 28;12(1):6926. doi: 10.1038/s41598-022-10352-3. Impact factor: Publication type: Paper in international publication Authors: Aranda, Miguel; Cantero-Recasens, Gerard; Castro, Luis; Ferrer, Marina; Meseguer, Anna; Morote, Joan; Nemours, Stephane; Ribatallada-Soriano, Didac; Sanchez, Alex; Semidey, Maria E et al. DOI: 10.1038/s41598-022-10352-3
PMID: 33607371 Journal: EUROPEAN JOURNAL OF RADIOLOGY Year: 2021 Reference: Eur J Radiol. 2021 Apr;137:109589. doi: 10.1016/j.ejrad.2021.109589. Epub 2021 Feb 12. Impact factor: Publication type: Paper in international publication Authors: Celma, Ana; Cuadras, Merce; Mast, Richard; Morote, Juan; Planas, Jacques; Regis, Lucas; Roche, Sarai; Salazar, Aina; Trilla, Enrique et al. DOI: 10.1016/j.ejrad.2021.109589
PMID: 33026925 Journal: JOURNAL OF UROLOGY Year: 2021 Reference: J Urol. 2021 Feb;205(2):343-345. doi: 10.1097/JU.0000000000001402. Epub 2020 Oct 7. Impact factor: Publication type: Letter or abstract Authors: Comas, Imma; Morote, Juan et al. DOI: 10.1097/JU.0000000000001402
PMID: 33408046 Journal: Actas Urologicas Espanolas Year: 2021 Reference: Actas Urol Esp. 2021 Jan-Feb;45(1):21-29. doi: 10.1016/j.acuro.2020.09.005. Epub 2020 Oct 24. Impact factor: Publication type: Paper in national publication Authors: Alvarez-Cubero, M J; Cózar, J M; Hernández, C; Miñana, B; Morote, J et al. DOI: 10.1016/j.acuro.2020.09.005
PMID: 33184988 Journal: Journal of Digestive Diseases Year: 2021 Reference: J Dig Dis. 2021 Jan;22(1):41-48. doi: 10.1111/1751-2980.12961. Epub 2020 Dec 22. Impact factor: Publication type: Paper in international publication Authors: Alberti, Piero; Armario, David; Balsells, Joaquim; Blanco, Laia; Caralt, Mireia; Charco, Ramon; Dopazo, Cristina; Gomez, Concepcion; Mast, Richard; Mata, Rodrigo et al. DOI: 10.1111/1751-2980.12961
PMID: 31911121 Journal: Clinical Genitourinary Cancer Year: 2020 Reference: Clin Genitourin Cancer. 2020 Jun;18(3):230-235. doi: 10.1016/j.clgc.2019.11.001. Epub 2019 Dec 4. Impact factor: Publication type: Paper in international publication Authors: Agreda Castaneda, Fernando; Morote Robles, Juan; Raventos Busquets, Carles Xavier et al. DOI: 10.1016/j.clgc.2019.11.001
PMID: 31628008 Journal: European Urology Oncology Year: 2020 Reference: Eur Urol Oncol. 2020 Jun;3(3):392-393. doi: 10.1016/j.euo.2019.08.009. Epub 2019 Oct 16. Impact factor: Publication type: Letter or abstract Authors: Celma, Anna; Morote, Juan; Planas, Jacques et al. DOI: 10.1016/j.euo.2019.08.009
PMID: 31506748 Journal: WORLD JOURNAL OF UROLOGY Year: 2020 Reference: World J Urol. 2020 Jun;38(6):1481-1491. doi: 10.1007/s00345-019-02946-w. Epub 2019 Sep 10. Impact factor: Publication type: Paper in international publication Authors: Borque-Fernando, Angel; Celma, Ana; de Torres, Ines; Esteban, Luis Mariano; Morote, Juan; Planas, Jacques; Regis, Lucas; Roche, Sarai; Semidey, Maria Eugenia; Trilla, Enrique et al. DOI: 10.1007/s00345-019-02946-w
PMID: 32268485 Journal: Cancers Year: 2020 Reference: Cancers (Basel). 2020 Apr 6;12(4). pii: cancers12040886. doi: 10.3390/cancers12040886. Impact factor: Publication type: Paper in international publication Authors: Barber, Marta; Castellvi, Josep; Gil-Moreno, Antonio; Majem, Blanca; Morote, Juan; Parrilla, Alfonso; Perez-Benavente, Asuncion; Sanchez, Jose Luis; Santamaria, Anna; Segura, Miguel F et al. DOI: 10.3390/cancers12040886
PMID: 31097210 Journal: Actas Urologicas Espanolas Year: 2019 Reference: Actas Urol Esp. 2019 Oct;43(8):404-413. doi: 10.1016/j.acuro.2019.03.001. Epub 2019 May 13. Impact factor: Publication type: Review in national publication Authors: Agreda Castaneda, F; Morote Robles, J; Raventos Busquets, C X et al. DOI: 10.1016/j.acuro.2019.03.001
PMID: 31036392 Journal: Actas Urologicas Espanolas Year: 2019 Reference: Actas Urol Esp. 2019 Jul - Aug;43(6):277-283. doi: 10.1016/j.acuro.2019.01.006. Epub 2019 Apr 26. Impact factor: Publication type: Paper in national publication Authors: Carrion, A; Diaz, F; Lozano, F; Morote, J; Pinero, A; Raventos, C et al. DOI: 10.1016/j.acuro.2019.01.006
PMID: 30978213 Journal: PLoS One Year: 2019 Reference: PLoS One. 2019 Apr 12;14(4):e0215232. doi: 10.1371/journal.pone.0215232. eCollection 2019. Impact factor: Publication type: Paper in international publication Authors: Cruzado, Josep M; Grinyo, Josep M; Guiteras, Roser; Manonelles, Anna; Morote, Juan; Narvaez, Alonso; Sola, Anna; Torras, Juan et al. DOI: 10.1371/journal.pone.0215232
PMID: 30466966 Journal: Actas Urologicas Espanolas Year: 2019 Reference: Actas Urol Esp. 2019 Apr;43(3):118-123. doi: 10.1016/j.acuro.2018.08.003. Epub 2018 Nov 19. Impact factor: Publication type: Review in national publication Authors: Arevalo, J; Celma, A; Lorente, D; Meseguer, A; Morote, J; Nemours, S; Placer, J; Planas, J; Regis, L; Salvador, C et al. DOI: 10.1016/j.acuro.2018.08.003
PMID: 29452710 Journal: EUROPEAN UROLOGY Year: 2018 Reference: Eur Urol. 2018 May;73(5):e134-e135. doi: 10.1016/j.eururo.2018.01.039. Epub 2018 Feb 13. Impact factor: Publication type: Letter or abstract Authors: Comas, Imma; Morote, Juan; Planas, Jacques et al. DOI: 10.1016/j.eururo.2018.01.039
PMID: 29416709 Journal: Oncotarget Year: 2018 Reference: Oncotarget. 2017 Oct 31;9(2):1494-1504. doi: 10.18632/oncotarget.22217. eCollection 2018 Jan 5. Impact factor: Publication type: Paper in international publication Authors: Aransay, Ana M; Arreal, Leire; Arruabarrena-Aristorena, Amaia; Cabrera, Diana; Camacho, Laura; Caro-Maldonado, Alfredo; Carracedo, Arkaitz; Cortazar, Ana R; Falcon-Perez, Juan M; Fernandez-Ruiz, Sonia et al. DOI: 10.18632/oncotarget.22217
PMID: 29336836 Journal: Actas Urologicas Espanolas Year: 2018 Reference: Actas Urol Esp. 2018 Sep;42(7):435-441. doi: 10.1016/j.acuro.2017.11.005. Epub 2018 Jan 11. Impact factor: Publication type: Review in national publication Authors: Gasanz, C; Morote, J; Raventos, C et al. DOI: 10.1016/j.acuro.2017.11.005
PMID: 29342137 Journal: NATURE Year: 2018 Reference: Nature. 2018 Feb 22;554(7693):554. doi: 10.1038/nature25470. Epub 2018 Jan 17. Impact factor: Publication type: Letter or abstract Authors: Alimonti, Andrea; Anguita, Juan; Aransay, Ana M; Arreal, Leire; Arruabarrena-Aristorena, Amaia; Astobiza, Ianire; Azkargorta, Mikel; Bago, Ruzica; Barnett, Amelia; Barrio, Rosa et al. DOI: 10.1038/nature25470
PMID: 28658205 Journal: NATURE Year: 2017 Reference: Nature. 2017 Jul 6;547(7661):109-113. doi: 10.1038/nature22964. Epub 2017 Jun 28. Impact factor: Publication type: Paper in international publication Authors: Alimonti, Andrea; Anguita, Juan; Aransay, Ana M; Arreal, Leire; Arruabarrena-Aristorena, Amaia; Astobiza, Ianire; Azkargorta, Mikel; Bago, Ruzica; Barnett, Amelia; Barrio, Rosa et al. DOI: 10.1038/nature22964
PMID: 28581399 Journal: INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS Year: 2017 Reference: Int J Radiat Oncol Biol Phys. 2017 Jul 1;98(3):590-594. doi: 10.1016/j.ijrobp.2017.02.219. Epub 2017 Mar 6. Impact factor: Publication type: Paper in international publication Authors: Alvarez Ossorio, Jose Luis; Angulo, Javier; Benedicto, Antonio; Campa, Josep; Ciria, Juan Pablo; de La Iglesia, Ramon; Dominguez-Escrig, Jose Luis; Fernandez, Manuel; Gutierrez, Carlos; Gutierrez, Jose Luis et al. DOI: 10.1016/j.ijrobp.2017.02.219
PMID: 28487100 Journal: JOURNAL OF UROLOGY Year: 2017 Reference: J Urol. 2017 Oct;198(4):817-823. doi: 10.1016/j.juro.2017.04.102. Epub 2017 May 6. Impact factor: Publication type: Paper in international publication Authors: Bellmunt, Joaquim; Bowden, Michaela; Choueiri, Toni K; de Torres, Ines; Freeman, Gordon J; Morote, Juan; Novak, Jesse; Orsola, Anna; Signoretti, Sabina; Wankowicz, Stephanie A M et al. DOI: 10.1016/j.juro.2017.04.102
PMID: 28457496 Journal: Actas Urologicas Espanolas Year: 2017 Reference: Actas Urol Esp. 2017 Oct;41(8):497-503. doi: 10.1016/j.acuro.2017.03.001. Epub 2017 Apr 28. Impact factor: Publication type: Paper in national publication Authors: Celma, A; Kosntantinidis, C; Lorente, D; Montealegre, C; Morote, J; Placer, J; Planas, J; Salvador, C; Serres, X; Trilla, E et al. DOI: 10.1016/j.acuro.2017.03.001
PMID: 27743530 Journal: CANCER TREATMENT REVIEWS Year: 2016 Reference: Cancer Treat Rev. 2016 Nov;50:208-216. doi: 10.1016/j.ctrv.2016.09.018. Epub 2016 Oct 1. Impact factor: Publication type: Paper in international publication Authors: Bastaros, Juan Maria; Carles, Joan; de Castro, Ana Martinez; Maldonado, Xavier; Morales-Barrera, Rafael; Morote, Juan; Racca, Fabricio; Suarez, Cristina; Valverde, Claudia et al. DOI: 10.1016/j.ctrv.2016.09.018
PMID: 27697923 Journal: JOURNAL OF CELL BIOLOGY Year: 2016 Reference: J Cell Biol. 2016 Oct 10;215(1):77-93. doi: 10.1083/jcb.201603019. Epub 2016 Oct 3. Impact factor: Publication type: Paper in international publication Authors: Gasic, Ivana; Meraldi, Patrick; Nigg, Erich A; Redli, Patrick M; Santamaria, Anna et al. DOI: 10.1083/jcb.201603019
PMID: 27667719 Journal: Scientific Reports Year: 2016 Reference: Sci Rep. 2016 Sep 26;6:34042. doi: 10.1038/srep34042. Impact factor: Publication type: Paper in international publication Authors: Abad, Maria Alba; Jeyaprakash, A Arockia; Medina-Pritchard, Bethan; Nigg, Erich A; Rappsilber, Juri; Santamaria, Anna; Zou, Juan et al. DOI: 10.1038/srep34042
PMID: 24156935 Journal: Actas Urologicas Espanolas Year: 2014 Reference: Actas Urol Esp. 2014 May;38(4):232-237. doi: 10.1016/j.acuro.2013.09.001. Epub 2013 Oct 21. Impact factor: Publication type: Paper in international publication Authors: Celma, A; de Torres, I M; Doll, A; Iztueta, I; Konstantinidis, C; Morote, J; Olivan, M; Placer, J; Planas, J; Reventos, J et al. DOI: 10.1016/j.acuro.2013.09.001
PMID: 24129226 Journal: Actas Urologicas Espanolas Year: 2014 Reference: Actas Urol Esp. 2014 Mar;38(2):122-126. doi: 10.1016/j.acuro.2013.04.008. Epub 2013 Oct 13. Impact factor: Publication type: Paper in international publication Authors: Arbos, M A; Celma, A; de Torres, I; Morote, J; Placer, J; Planas, J; Quilez, M T; Servian, P et al. DOI: 10.1016/j.acuro.2013.04.008
PMID: 24127882 Journal: BJU INTERNATIONAL Year: 2014 Reference: BJU Int. 2014 May;113(5b):E164-77. doi: 10.1111/bju.12503. Epub 2014 Feb 14. Impact factor: Publication type: Paper in international publication Authors: Doll, Andreas; Garcia, Marta; Gomis, Roger R; Guiu, Marc; Majem, Blanca; Morote, Juan; Pedrola, Nuria; Reventos, Jaume; Rigau, Marina; Romagosa, Cleofe et al. DOI: 10.1111/bju.12503
PMID: 24284518 Journal: KIDNEY INTERNATIONAL Year: 2014 Reference: Kidney Int. 2014 May;85(5):1161-8. doi: 10.1038/ki.2013.461. Epub 2013 Nov 27. Impact factor: Publication type: Paper in international publication Authors: Antonieta Azancot, M; Antonieta Azancot, M; Cantarell, Carme; Montero, Angeles; Moreso, Francesc; Morote, Joan; Perello, Manel; Salcedo, Maite; Sellares, Joana; Seron, Daniel et al. DOI: 10.1038/ki.2013.461
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PMID: 22759231 Journal: BJU INTERNATIONAL Year: 2013 Reference: BJU Int. 2013 Apr;111(4):549-58. doi: 10.1111/j.1464-410X.2012.11333.x. Epub 2012 Jul 3. Impact factor: Publication type: Paper in international publication Authors: ; ; ; ; ; ; ; ; ; et al. DOI: 10.1111/j.1464-410X.2012.11333.x
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PMID: 20231125 Journal: Clinical & Translational Oncology Year: 2010 Reference: Clin Transl Oncol. 2010 Mar;12(3):211-214. Impact factor: Publication type: Paper in international publication Authors: ; ; ; ; Alfaro, J; Arnau, J M; Artigas, V; Aunon, M C; Barrios, P; Bellmunt, J et al. DOI:
PMID: 20231124 Journal: Clinical & Translational Oncology Year: 2010 Reference: Clin Transl Oncol. 2010 Mar;12(3):188-211. Impact factor: Publication type: Paper in international publication Authors: ; ; ; ; Alfaro, J; Arnau, J M; Artigas, V; Aunon, M C; Barrios, P; Bellmunt, J et al. DOI:
On World Cancer Research Day, we highlight research aimed at improving treatments for both pediatric and adult cancers through innovative techniques.
The work led by Dr. Regis demonstrates that performing robotic reconstruction after radical prostatectomy is associated with better urinary control.
A clinical trial with the prototype of the device shows that the use of this technology improves patient monitoring by nurses and reduces post-surgical complications.