About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The research group is focused on finding new molecular therapeutic targets and biomarkers based on knowledge of the biology of paediatric tumours, leukemias and hematologic diseases. The experience of the group in recent years has permitted the identification of new molecular targets that are very close to the clinical phase. In this stage, we have consolidated collaborations with the biotechnological industry in order to develop small molecules able to inhibit pro-oncogenic processes such as invasion or proliferation, with the aim of providing patients with innovative and more specific biological evidence-based therapies.
Another line of research is based on the study of liquid biopsy to develop a system based on NGS to monitor the probability of relapses.
Furthermore, we have implemented a personalized medicine program to guide the management of patients based on the molecular alterations of their tumours
IP: Miguel Segura Ginard Collaborators: Marta Miera Maluenda, Judit Álvarez González Funding agency: Fundació Institut de Recerca HUVH Funding: 102820.06 Reference: VHIR-PHD-2023-003 Duration: 01/12/2023 - 30/11/2027
IP: Miguel Segura Ginard Collaborators: María Rosario Pérez- Torres Lobato, Maria Jose Pérez García, Lorena Valero Arrese, Development of prognostic and therapeutic tools targeting epigenetic regulators in metastatic neuroblastoma, Adria Molero Valenzuela, Khloud Abdo Soliman Elsharawy Funding agency: Instituto de Salud Carlos III Funding: 315000 Reference: PI23/01144 Duration: 01/01/2024 - 31/12/2026
IP: Miguel Segura Ginard Collaborators: Khloud Abdo Soliman Elsharawy, Judit Álvarez González Funding agency: Instituto de Salud Carlos III Funding: 95000 Reference: CD23/00035 Duration: 01/01/2024 - 31/12/2026
IP: Ramon Martí Seves Collaborators: Alfons Macaya Ruíz, Lucas Moreno Martín-Retortillo Funding agency: Agència Gestió Ajuts Universitaris i de Recerca Funding: 0.01 Reference: 2022 XARDI 00006 Duration: 01/01/2023 - 31/12/2025
PMID: 37533171 Journal: VOX SANGUINIS Year: 2023 Reference: Vox Sang. 2023 Aug 2. doi: 10.1111/vox.13499. Impact factor: Publication type: Paper in international publication Authors: Azqueta, Carmen; Badell, Isabel; Carreras, Enric; Diaz-de-Heredia, Cristina; Esquirol, Albert; Fernandez-Sojo, Jesus; Ferra, Christelle; Garcia-Buendia, Ana; Gomez, David; Lozano, Miquel et al. DOI: 10.1111/vox.13499
PMID: 37595686 Journal: Transplantation and cellular therapy Year: 2023 Reference: Transplant Cell Ther. 2023 Aug 16:S2666-6367(23)01473-2. doi: 10.1016/j.jtct.2023.08.016. Impact factor: Publication type: Paper in international publication Authors: Belendez, Cristina; Benitez, Isabel; Bueno, David; de Heredia, Cristina Diaz; Echecopar, Carlos; Estival, Pablo; Fuentes, Carolina; Fuster, Jose Luis; Galan, Victor; Margarit, Adriana et al. DOI: 10.1016/j.jtct.2023.08.016
PMID: 37646983 Journal: Clinical & Translational Oncology Year: 2023 Reference: Clin Transl Oncol. 2023 Aug 30. doi: 10.1007/s12094-023-03301-7. Impact factor: Publication type: Paper in international publication Authors: Cruz Martinez, Ofelia; de Noriega, Inigo; Garcia Abos, Miriam; Garrido Colino, Carmen; Gros Subias, Luis; Huidobro Labarga, Beatriz; Lassaletta, Alvaro; Llort Sales, Anna; Lopez Ibor, Blanca; Marquez Vega, Catalina et al. DOI: 10.1007/s12094-023-03301-7
PMID: 37682330 Journal: PEDIATRIC RADIOLOGY Year: 2023 Reference: Pediatr Radiol. 2023 Sep 8. doi: 10.1007/s00247-023-05745-z. Impact factor: Publication type: Paper in international publication Authors: Adams, Madeleine; Bertolini, Patrizia; Bisogno, Gianni; Bouhamama, Amine; Caro-Dominguez, Pablo; Charon, Valerie; Chatziantoniou, Cyrano; Coma, Ana; Coma, Ana; Dandis, Rana et al. DOI: 10.1007/s00247-023-05745-z
PMID: 35767111 Journal: JOURNAL OF CLINICAL IMMUNOLOGY Year: 2022 Reference: J Clin Immunol. 2022 Jun 29. pii: 10.1007/s10875-022-01305-6. doi: 10.1007/s10875-022-01305-6. Impact factor: 8.317 Publication type: Paper in international publication Authors: Schneiderman, Jennifer; Caorsi, Roberta; Lucioni, Federica; Volpi, Stefano; Giardino, Stefano; Lang, Abigail; Khojah, Amer; Papadatou, Ionanna; Faraci, Maura; Gattorno, Marco et al. DOI: 10.1007/s10875-022-01305-6
PMID: 35804055 Journal: BONE MARROW TRANSPLANTATION Year: 2022 Reference: Bone Marrow Transplant. 2022 Jul 8. pii: 10.1038/s41409-022-01750-2. doi: 10.1038/s41409-022-01750-2. Impact factor: 5.483 Publication type: Paper in international publication Authors: Martino, Rodrigo, Fernandez-Sojo, Jesus, Horton, Roger, Cid, Joan, Azqueta, Carmen, Garcia-Buendia, Ana, Valdivia, Elena, Martorell, Lluis, Rubio-Lopez, Nuria, Codinach, Margarita et al. DOI: 10.1038/s41409-022-01750-2
PMID: 35715627 Journal: Targeted Oncology Year: 2022 Reference: Target Oncol. 2022 Jun 17. pii: 10.1007/s11523-022-00888-9. doi: 10.1007/s11523-022-00888-9. Impact factor: 4.493 Publication type: Paper in international publication Authors: Trippett, Tanya, Toledano, Helen, Campbell Hewson, Quentin, Verschuur, Arnauld, Langevin, Anne-Marie, Aerts, Isabelle, Howell, Lisa, Gallego, Soledad, Rossig, Claudia, Smith, Amy et al. DOI: 10.1007/s11523-022-00888-9
PMID: 35709412 Journal: JOURNAL OF CLINICAL ONCOLOGY Year: 2022 Reference: J Clin Oncol. 2022 Jun 16:JCO2102981. doi: 10.1200/JCO.21.02981. Impact factor: 44.544 Publication type: Paper in international publication Authors: Merks, Johannes H M, Schoot, Reineke A, Chisholm, Julia C, Casanova, Michela, Minard-Colin, Veronique, Geoerger, Birgit, Cameron, Alison L, Coppadoro, Beatrice, Zanetti, Ilaria, Orbach, Daniel et al. DOI: 10.1200/JCO.21.02981
PMID: 34451907 Journal: Pharmaceuticals Year: 2021 Reference: Pharmaceuticals (Basel). 2021 Aug 18;14(8). pii: ph14080810. doi: 10.3390/ph14080810. Impact factor: 5.863 Publication type: Review in international publication Authors: Giralt, Irina, Zarzosa, Patricia, Pons, Guillem, Magdaleno, Ainara, Segura, Miguel F, Sanchez de Toledo, Jose, Moreno, Lucas, Gallego, Soledad, Roma, Josep, Navarro, Natalia et al. DOI: 10.3390/ph14080810
PMID: 34413474 Journal: BONE MARROW TRANSPLANTATION Year: 2021 Reference: Bone Marrow Transplant. 2021 Oct;56(10):2615. doi: 10.1038/s41409-021-01424-5. Impact factor: 5.483 Publication type: Letter or abstract Authors: Sedlacek, Petr, Willasch, Andre Manfred, Peters, Christina, Klingebiel, Thomas Erich, Styczynski, Jan, Bierings, Marc, Nagy, Kalman, Abecasis, Manuel, Afanasyev, Boris, Ansari, Marc et al. DOI: 10.1038/s41409-021-01424-5
PMID: 34416158 Journal: LANCET ONCOLOGY Year: 2021 Reference: Lancet Oncol. 2021 Sep;22(9):1312-1321. doi: 10.1016/S1470-2045(21)00387-9. Epub 2021 Aug 17. Impact factor: 41.316 Publication type: Paper in international publication Authors: Casanova, Michela, Gaspar, Nathalie, Venkatramani, Rajkumar, Hecker-Nolting, Stefanie, Melcon, Soledad Gallego, Locatelli, Franco, Bautista, Francisco, Longhi, Alessandra, Lervat, Cyril, Entz-Werle, Natacha et al. DOI: 10.1016/S1470-2045(21)00387-9
PMID: 34406671 Journal: AMERICAN JOURNAL OF HEMATOLOGY Year: 2021 Reference: Am J Hematol. 2021 Nov 1;96(11):E416-E420. doi: 10.1002/ajh.26323. Epub 2021 Aug 30. Impact factor: 10.047 Publication type: Letter or abstract Authors: Papasavva, Panayiota, Zulkipli, Ihsan Nazurah, Yusof, Hajah Noorainun Haji Mohd, Ghani, Muhammad Hazim Haji Abdul, Wong, Seow Chin, Lim, Mei Ann, Lettre, Guillaume, Kuo, Kevin, Justiniano, Anneliesse, Chin-Yee, Benjamin et al. DOI: 10.1002/ajh.26323
PMID: 32869534 Journal: Cancer Medicine Year: 2020 Reference: Cancer Med. 2020 Oct;9(20):7580-7589. doi: 10.1002/cam4.3365. Epub 2020 Sep 1. Impact factor: 3.491 Publication type: Paper in international publication Authors: Terwisscha van Scheltinga, Sheila E J, Wijnen, Marc H W A, Martelli, Helene, Rogers, Timothy, Mandeville, Henry, Gaze, Mark N, McHugh, Keiran, Corradini, Nadege, Orbach, Daniel, Jenney, Meriel et al. DOI: 10.1002/cam4.3365
PMID: 32801295 Journal: Cell Death & Disease Year: 2020 Reference: Cell Death Dis. 2020 Aug 15;11(8):634. doi: 10.1038/s41419-020-02887-y. Impact factor: 6.304 Publication type: Paper in international publication Authors: Alcon, Clara, Manzano-Munoz, Albert, Prada, Estela, Mora, Jaume, Soriano, Aroa, Guillen, Gabriela, Gallego, Soledad, Roma, Josep, Samitier, Josep, Villanueva, Alberto et al. DOI: 10.1038/s41419-020-02887-y
PMID: 32708733 Journal: Cancers Year: 2020 Reference: Cancers (Basel). 2020 Jul 16;12(7). pii: cancers12071922. doi: 10.3390/cancers12071922. Impact factor: 6.126 Publication type: Paper in international publication Authors: Martini, Maurizio, Ruggiero, Antonio, Moreno, Lucas, Sanchez de Toledo, Josep, Gallego, Soledad, Bove, Jordi, Hooker, Jacob M, Segura, Miguel F, Martinez-Saez, Elena, Roma, Josep et al. DOI: 10.3390/cancers12071922
PMID: 32672895 Journal: PEDIATRIC BLOOD & CANCER Year: 2020 Reference: Pediatr Blood Cancer. 2020 Sep;67(9):e28557. doi: 10.1002/pbc.28557. Epub 2020 Jul 16. Impact factor: 2.355 Publication type: Letter whit IF Authors: Fernandez Sanmartin, Manuel, Baragano, Marta, Gorostegui, Maite, Perez-Jaume, Sara, Fernandez-Teijeiro, Ana, Morales La Madrid, Andres, Dapena, Jose Luis, Perez-Alonso, Vanesa, Juan Ribelles, Antonio, Fuster, Jose Luis et al. DOI: 10.1002/pbc.28557
PMID: 31556188 Journal: PEDIATRIC TRANSPLANTATION Year: 2019 Reference: Pediatr Transplant. 2019 Dec;23(8):e13584. doi: 10.1111/petr.13584. Epub 2019 Sep 26. Impact factor: 1.326 Publication type: Paper in international publication Authors: Querol, Sergio, Alonso, Laura, Rudilla, Francesc, Gimeno, Ramon, Codinach, Margarita, Blanco, Margarita, Diaz de Heredia, Cristina et al. DOI: 10.1111/petr.13584
PMID: 31543384 Journal: EUROPEAN JOURNAL OF CANCER Year: 2019 Reference: Eur J Cancer. 2019 Nov;121:224-235. doi: 10.1016/j.ejca.2019.07.027. Epub 2019 Sep 19. Impact factor: 6.68 Publication type: Paper in international publication Authors: George, Sally L, Izquierdo, Elisa, Campbell, James, Moreno, Lucas, Pearson, Andrew, Shipley, Janet, Jones, Chris, Hargrave, Darren, Jacques, Thomas S, Hubank, Michael et al. DOI: 10.1016/j.ejca.2019.07.027
PMID: 31501599 Journal: NATURE MEDICINE Year: 2019 Reference: Nat Med. 2019 Sep;25(9):1396-1401. doi: 10.1038/s41591-019-0550-z. Epub 2019 Sep 9. Impact factor: 30.641 Publication type: Paper in international publication Authors: Rio, Paula, Navarro, Susana, Wang, Wei, Sanchez-Dominguez, Rebeca, Pujol, Roser M, Segovia, Jose C, Bogliolo, Massimo, Merino, Eva, Wu, Ning, Salgado, Rocio et al. DOI: 10.1038/s41591-019-0550-z
PMID: 31493701 Journal: LEUKEMIA RESEARCH Year: 2019 Reference: Leuk Res. 2019 Oct;85:106217. doi: 10.1016/j.leukres.2019.106217. Epub 2019 Aug 13. Impact factor: 2.066 Publication type: Paper in international publication Authors: Carceller, Fernando, Hirsch, Steffen G, Khabra, Komel, Petterson, Toni, Malik, Rubina, Guerra-Garcia, Pilar, Moreno, Lucas, Marshall, Lynley V, Taj, Mary, Atra, Ayad et al. DOI: 10.1016/j.leukres.2019.106217
PMID: 29936064 Journal: EUROPEAN JOURNAL OF CANCER Year: 2018 Reference: Eur J Cancer. 2018 Sep;100:27-34. doi: 10.1016/j.ejca.2018.05.002. Epub 2018 Jun 21. Impact factor: 7.191 Publication type: Clinical Trials Authors: Moreno, Lucas, Casanova, Michela, Chisholm, Julia C, Berlanga, Pablo, Chastagner, Pascal B, Baruchel, Sylvain, Amoroso, Loredana, Melcon, Soledad Gallego, Gerber, Nicolas U, Bisogno, Gianni et al. DOI: 10.1016/j.ejca.2018.05.002
PMID: 29797665 Journal: CANCER Year: 2018 Reference: Cancer. 2018 Aug 1;124(15):3201-3209. doi: 10.1002/cncr.31553. Epub 2018 May 24. Impact factor: 6.537 Publication type: Paper in international publication Authors: Ferman, Sima, Gallego, Soledad, Zanetti, Ilaria, Orbach, Daniel, Ranchere, Dominique, Shipley, Janet, Zin, Angelica, Bergeron, Christophe, de Salvo, Gian Luca, Chisholm, Julia et al. DOI: 10.1002/cncr.31553
PMID: 29781567 Journal: PEDIATRIC BLOOD & CANCER Year: 2018 Reference: Pediatr Blood Cancer. 2018 Sep;65(9):e27096. doi: 10.1002/pbc.27096. Epub 2018 May 21. Impact factor: 2.646 Publication type: Paper in international publication Authors: Minard-Colin, Veronique, Walterhouse, David, Bisogno, Gianni, Martelli, Helene, Anderson, James, Rodeberg, David A, Ferrari, Andrea, Jenney, Meriel, Wolden, Suzanne, Arndt, Carola et al. DOI: 10.1002/pbc.27096
PMID: 29776868 Journal: Journal of Pediatric Urology Year: 2018 Reference: J Pediatr Urol. 2018 Oct;14(5):366-373. doi: 10.1016/j.jpurol.2018.03.018. Epub 2018 Apr 20. Impact factor: 1.935 Publication type: Review in national publication Authors: Gander, Romy, Asensio, Marino, Guillen, Gabriela, Royo, Gloria Fatou, Bolanos, Andrea, Perez, Mercedes, Diaz-De-Heredia, Cristina, Benitez, Maribel, Lopez, Manuel et al. DOI: 10.1016/j.jpurol.2018.03.018
PMID: 29296947 Journal: Blood advances Year: 2017 Reference: Blood Adv. 2017 Jan 23;1(5):319-329. doi: 10.1182/bloodadvances.2016000943. eCollection 2017 Jan 24. Impact factor: 0 Publication type: Paper in international publication Authors: Reina-Castillon, Judith, Pujol, Roser, Lopez-Sanchez, Marcos, Rodriguez-Santiago, Benjamin, Aza-Carmona, Miriam, Gonzalez, Juan Ramon, Casado, Jose Antonio, Bueren, Juan Antonio, Sevilla, Julian, Badel, Isabel et al. DOI: 10.1182/bloodadvances.2016000943
PMID: 28881358 Journal: BRITISH JOURNAL OF CANCER Year: 2017 Reference: Br J Cancer. 2017 Oct 24;117(9):1314-1325. doi: 10.1038/bjc.2017.305. Epub 2017 Sep 7. Impact factor: 6.176 Publication type: Paper in international publication Authors: Velasco, P, Pyczek, J, Simon-Keller, K, Giralt, I, Vidal, I, Navarro, N, Segura, M F, Soriano, A, Navarro, S, Tirado, O M et al. DOI: 10.1038/bjc.2017.305
PMID: 28801449 Journal: BLOOD Year: 2017 Reference: Blood. 2017 Sep 28;130(13):1535-1542. doi: 10.1182/blood-2017-03-774174. Epub 2017 Aug 11. Impact factor: 13.164 Publication type: Paper in international publication Authors: Segovia, Jose C, Diaz de Heredia, Cristina, Sevilla, Julian, Bueren, Juan, Galy, Anne, Charrier, Sabine, Pujol, Maria Roser, Rio, Paula, Navarro, Susana, Guenechea, Guillermo et al. DOI: 10.1182/blood-2017-03-774174
PMID: 28797779 Journal: BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION Year: 2017 Reference: Biol Blood Marrow Transplant. 2017 Nov;23(11):1939-1948. doi: 10.1016/j.bbmt.2017.08.004. Epub 2017 Aug 7. Impact factor: 4.704 Publication type: Paper in international publication Authors: Comoli, Patrizia, Vettenranta, Kim, Diaz, Miguel Angel, Reuven, Or, Bertrand, Yves, de Heredia, Cristina Diaz, Nagler, Arnon, Ghavamzadeh, Ardeshir, Sufliarska, Sabina, Lawson, Sarah et al. DOI: 10.1016/j.bbmt.2017.08.004
PMID: 26824183 Journal: Oncotarget Year: 2016 Reference: Oncotarget. 2016 Feb 23;7(8):9271-87. doi: 10.18632/oncotarget.7005. Impact factor: 5.008 Publication type: Paper in international publication Authors: Segura, Miguel F, Gallego, Soledad, Sanchez de Toledo, Jose, Stallings, Raymond L, Casanovas, Oriol, Soriano, Aroa, Jubierre, Luz, Martinez, Alba, Zhou, Xiangyu, Piskareva, Olga et al. DOI: 10.18632/oncotarget.7005
PMID: 25190197 Journal: J CLIN IMMUNOL Year: 2014 Reference: J Clin Immunol. 2014 Nov;34(8):1015-7. doi: 10.1007/s10875-014-0096-2. Epub 2014 Sep 5. Impact factor: 2.654 Publication type: Paper in international publication Authors: Figueras, Concepcio, Martinez-Cutillas, Julio, Oliveras, Maria, Soler-Palacin, Pere, Gaso-Gago, Ingrid, Fernandez-Polo, Aurora, Martin-Nalda, Andrea et al. DOI: 10.1007/s10875-014-0096-2
PMID: 24614843 Journal: BONE MARROW TRANSPL Year: 2014 Reference: Bone Marrow Transplant. 2014 Jun;49(6):767-72. doi: 10.1038/bmt.2014.30. Epub 2014 Mar 10. Impact factor: 3.466 Publication type: Paper in international publication Authors: Diaz de Heredia, C, Gonzalez, M, Verdeguer, A, Elorza, I, Rodriguez, A, Martinez, A, Perez, J M, Badell, I, Gonzalez, M E, Olive, T et al. DOI: 10.1038/bmt.2014.30
PMID: 24366994 Journal: PEDIATRICS Year: 2014 Reference: Pediatrics. 2014 Jan;133(1):e263-6. doi: 10.1542/peds.2012-3196. Epub 2013 Dec 23. Impact factor: 5.297 Publication type: Paper in international publication Authors: Velasco, Pablo, Clemente, Maria, Lorite, Raquel, Ventura, M Clara, Gros, Luis, Sanchez de Toledo, Jose, Gallego, Soledad et al. DOI: 10.1542/peds.2012-3196
PMID: 23997024 Journal: PEDIATR BLOOD CANCER Year: 2014 Reference: Pediatr Blood Cancer. 2014 Feb;61(2):217-22. doi: 10.1002/pbc.24727. Epub 2013 Aug 29. Impact factor: 2.562 Publication type: Paper in international publication Authors: Martelli, Helene, Jenney, Meriel, Oberlin, Odile, Audry, Georges, Stevens, Michael Cg, Rey, Annie, Merks, Johannes Hm, Kelsey, Anna, Gallego, Soledad, Haie-Meder, Christine et al. DOI: 10.1002/pbc.24727
PMID: 21345076 Journal: PEDIATRIC HEMATOLOGY AND ONCOLOGY Year: 2011 Reference: Pediatr Hematol Oncol. 2011 Aug;28(5):451-3. Epub 2011 Feb 23. Impact factor: 0.81 Publication type: Letter or abstract Authors: , , , , et al. DOI: 10.3109/08880018.2010.543450
PMID: 21273304 Journal: BLOOD Year: 2011 Reference: Blood. 2011 Apr 7;117(14):3759-69. Epub 2011 Jan 27. Impact factor: 10.558 Publication type: Paper in international publication Authors: , , , , , , , , , et al. DOI: 10.1182/blood-2010-08-299917
PMID: 21217111 Journal: JOURNAL OF MEDICAL GENETICS Year: 2011 Reference: J Med Genet. 2011 Apr;48(4):242-50. Epub 2011 Jan 7. Impact factor: 7.037 Publication type: Paper in international publication Authors: , , , , , , , , , et al. DOI: 10.1136/jmg.2010.084210
The meeting was an opportunity to get to know projects from both institutions and to promote interaction between professionals.
A study jointly led by the Hospital Clínic of Barcelona and the Vall d'Hebron Research Institute (VHIR) confirms the effectiveness of neonatal screening in reducing morbidity among children with sickle cell disease (SCD).
Active participation by patients and families in studies helps identify more effective therapies that improve quality of life and survival.
