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Childhood Cancer and Blood Disorders

The research group is focused on finding new molecular therapeutic targets and biomarkers based on knowledge of the biology of paediatric tumours, leukemias and hematologic diseases. The experience of the group in recent years has permitted the identification of new molecular targets that are very close to the clinical phase. In this stage, we have consolidated collaborations with the biotechnological industry in order to develop small molecules able to inhibit pro-oncogenic processes such as invasion or proliferation, with the aim of providing patients with innovative and more specific biological evidence-based therapies.

Another line of research is based on the study of liquid biopsy to develop a system based on NGS to monitor the probability of relapses.

Furthermore, we have implemented a personalized medicine program to guide the management of patients based on the molecular alterations of their tumours

Team

Pablo Velasco Puyó

Pablo Velasco Puyó

Predoctoral researcher
Childhood Cancer and Blood Disorders
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Carlota Aguilera Ordoñez

Carlota Aguilera Ordoñez

Research technician
Childhood Cancer and Blood Disorders
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Gabriela Guillén Burrieza

Gabriela Guillén Burrieza

Predoctoral researcher
Childhood Cancer and Blood Disorders
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Juan Manuel López Oliva

Juan Manuel López Oliva

Research technician
Childhood Cancer and Blood Disorders
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Marina Bonfill Ralló

Marina Bonfill Ralló

Research technician
Childhood Cancer and Blood Disorders
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Aina Llenas Bladé

Aina Llenas Bladé

Research technician
Childhood Cancer and Blood Disorders
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Pablo Velasco Puyó

Pablo Velasco Puyó

Predoctoral researcher
Childhood Cancer and Blood Disorders
Read more
Carlota Aguilera Ordoñez

Carlota Aguilera Ordoñez

Research technician
Childhood Cancer and Blood Disorders
Read more
Gabriela Guillén Burrieza

Gabriela Guillén Burrieza

Predoctoral researcher
Childhood Cancer and Blood Disorders
Read more
Juan Manuel López Oliva

Juan Manuel López Oliva

Research technician
Childhood Cancer and Blood Disorders
Read more
Marina Bonfill Ralló

Marina Bonfill Ralló

Research technician
Childhood Cancer and Blood Disorders
Read more
Aina Llenas Bladé

Aina Llenas Bladé

Research technician
Childhood Cancer and Blood Disorders
Read more

Projects

HELIOS: Haemoglobinopathies in European Liaison of Medicine and Science

IP: M Mar Mañu Pereira
Collaborators: -
Funding agency: EUROPEAN COMMISSION
Funding:
Reference: EC / COST-ACTION / 2022 / MAÑU
Duration: 20/09/2023 - 19/09/2027

MONALISA: A SIOPEN pragmatic clinical trial to MOnitor NeuroblastomA relapse with LIquid biopsy Sensitive Analysis

IP: Lucas Moreno Martín-Retortillo
Collaborators: Maria Jose Pérez García, Miguel Segura Ginard
Funding agency: EUROPEAN COMMISSION
Funding: 8000
Reference: MONALISA_HE-MISS2023
Duration: 01/01/2024 - 31/12/2028

TACTIC: Explorando soluciones a los retos de salud mediante ciencia disruptiva, terapias avanzadas y medicina de sistemas

IP: Begoña Benito Villabriga
Collaborators: Carmen Escudero Iriarte, Laia Ventura i Expósito, Susana Otero Romero, Ibane Abasolo Olaortua, Ignacio Ferreira González, José Antonio Barrabés Riu, Carlos Nos Llopis, Pablo Velasco Puyó, Jose Fernando Rodríguez Palomares, María Rosario Pérez- Torres Lobato, Sunny Malhotra Sareen, Belen Perez Dueñas, Jaume Sastre Garriga, Joan López Hellin, Antonia Sambola Ayala, Jordi Rio Izquierdo, Nuria Rivas Gandara, Jordi Perez Rodon, Aroa Soriano Fernández, Manuel Comabella Lopez, Antonio Rodríguez Sinovas, Gisela Teixido Tura, Antonia Pijuan Domenech, Roser Ferrer Costa, Joaquin Seras Franzoso, Carmen Tur Gomez, Maria Cristina Díaz de Heredia Rubio, Laia Yañez Bisbe, Julia German Cortes, Maria Jose Pérez García, Miguel Segura Ginard, Diego Baranda Martínez-Abasca, Cristina Auger Acosta, Neus Bellera Gotarda, Herena Eixarch Ahufinger, M Mar Mañu Pereira, Deborah Pareto Onghena, Lorena Valero Arrese, Aitor Uribarri Gonzalez, Jordi Bañeras Rius, Alex Rovira Cañellas, Mar Tintore Subirana, Bruno García del Blanco, Maria Teresa Salcedo Allende, Marisol Ruiz Meana, Ana Belén Méndez Fernández, Xavier Montalban Gairín, Simon Schwartz Navarro, Anna Llort Sales, Carmen Espejo Ruiz, Raquel Hladun Alvaro, Angels Alcina Mila, Sandra Mancilla Zamora, Zamira Vanessa Diaz Riascos, Ana Zabalza de Torres, Marc Miquel Moltó Abad, Javier Inserte Igual, Luciana Midaglia Fernandez, Elizabeth Pando Rau, Gabriela Guillén Burrieza, Ana Laura Cazurro Gutierrez, David Gómez Andrés, Alvaro Cobo Calvo, Alvaro Calabuig Goena, Joaquin Castillo Justribo, Lydia Dux-Santoy Hurtado, Lucas Moreno Martín-Retortillo, Andres Miguez Gonzalez, Josep Roma Castanyer, Laura Dos Subirá, Nicolás Miguel Fissolo, Maria Nazarena Pizzi, Tian Tian, Fernanda Raquel Da Silva Andrade, Diana Fernandes de Rafael, Andrea Guala
Funding agency: Instituto de Salud Carlos III
Funding: 2494527.53
Reference: FORT23/00034
Duration: 01/01/2024 - 31/12/2027

Development of epigenetic therapies for the treatment of pediatric tumors of the nervous system

IP: Miguel Segura Ginard
Collaborators: Marta Miera Maluenda, Judit Álvarez González
Funding agency: Fundació Institut de Recerca HUVH
Funding: 102820.06
Reference: VHIR-PHD-2023-003
Duration: 01/12/2023 - 30/11/2027

Publications

Cancer is not a risk factor for severe COVID-19 in children, except in patients with recent allogeneic hematopoietic stem cell transplantation or comorbidities.

PMID: 38825724
Journal: PEDIATRIC BLOOD & CANCER
Year: 2024
Reference: Pediatr Blood Cancer. 2024 Jun 2:e31120. doi: 10.1002/pbc.31120.
Impact factor:
Publication type: Paper in international publication
Authors: Astigarraga, Itziar; Bardon Cancho, Eduardo J; Canete, Adela; Castrillo Bustamante, Sara; Dominguez-Pinilla, Nerea; Escobar Fernandez, Laura; Faura Morros, Anna; Galan-Gomez, Victor; Gallego Mingo, Nerea; Garcia de Andoin Barandiaran, Nagore et al.
DOI: 10.1002/pbc.31120

Incorporation of patient-reported outcomes in early-phase clinical trials for childhood and adolescent cancer.

PMID: 38961582
Journal: PEDIATRIC BLOOD & CANCER
Year: 2024
Reference: Pediatr Blood Cancer. 2024 Jul 3:e31165. doi: 10.1002/pbc.31165.
Impact factor:
Publication type: Paper in international publication
Authors: Carceller, Fernando; Crowe, Tracey; de Rojas, Teresa; Marshall, Lynley V; Morell, Mariona; Moreno, Lucas; Romero, Laura; Salo, Anna; Valero-Arrese, Lorena; Vilaplana, Andrea et al.
DOI: 10.1002/pbc.31165

Determinants of Metastatic Colorectal Cancer With Permanent Liver- Limited Disease.

PMID: 38981843
Journal: Clinical Colorectal Cancer
Year: 2024
Reference: Clin Colorectal Cancer. 2024 Jun 1:S1533-0028(24)00055-0. doi: 10.1016/j.clcc.2024.05.010.
Impact factor:
Publication type: Paper in international publication
Authors: Baraibar, Iosune; Elez, Elena; Garcia, Ariadna; Rodriguez, Marta; Ros, Javier; Salva, Francesc; Saoudi, Nadia; Tabernero, Josep et al.
DOI: 10.1016/j.clcc.2024.05.010

Current and Emerging Treatment Paradigms in Colorectal Cancer: Integrating Hallmarks of Cancer.

PMID: 39000083
Journal:
Year: 2024
Reference: Int J Mol Sci. 2024 Jun 26;25(13):6967. doi: 10.3390/ijms25136967.
Impact factor:
Publication type: Paper in international publication
Authors: Alcaraz, Adriana; Baraibar, Iosune; Elez, Elena; Garcia, Ariadna; Rodriguez-Castells, Marta; Ros, Javier; Salva de Torres, Clara; Salva, Francesc; Saoudi Gonzalez, Nadia; Tabernero, Josep et al.
DOI: 10.3390/ijms25136967

Single-cell profiling of alveolar rhabdomyosarcoma reveals RAS pathway inhibitors as cell-fate hijackers with therapeutic relevance.

PMID: 36753540
Journal: Science Advances
Year: 2023
Reference: Sci Adv. 2023 Feb 10;9(6):eade9238. doi: 10.1126/sciadv.ade9238. Epub 2023 Feb 8.
Impact factor:
Publication type: Paper in international publication
Authors: Bechtold, Ingrid; Blau, Helen M; Bode, Peter K; Buhlmann, Peter; Danielli, Sara G; De Micheli, Andrea J; Delattre, Olivier; Gurgen, Dennis; Henssen, Anton G; Kasper, Stephanie et al.
DOI: 10.1126/sciadv.ade9238

Targeting the Hedgehog Pathway in Rhabdomyosarcoma.

PMID: 36765685
Journal: Cancers
Year: 2023
Reference: Cancers (Basel). 2023 Jan 24;15(3):727. doi: 10.3390/cancers15030727.
Impact factor:
Publication type: Review in international publication
Authors: Gallego, Soledad; Gallo-Oller, Gabriel; Garcia-Gilabert, Lia; Garcia-Gilabert, Lia; Guillen, Gabriela; Hladun, Raquel; Moreno, Lucas; Pons, Guillem; Roma, Josep; Sanchez de Toledo, Josep et al.
DOI: 10.3390/cancers15030727

Outcome of haematopoietic cell transplantation in children with lysosomal acid lipase deficiency: a study on behalf of the EBMT Inborn Errors Working Party.

PMID: 36788366
Journal: BONE MARROW TRANSPLANTATION
Year: 2023
Reference: Bone Marrow Transplant. 2023 May;58(5):594-596. doi: 10.1038/s41409-023-01918-4. Epub 2023 Feb 14.
Impact factor:
Publication type: Letter whit IF
Authors: Albert, Michael H; Diaz de Heredia, Cristina; Diaz, Miguel Angel; Garban, Frederic; Gruhn, Bernd; Hazelaar, Sheree; Jones, Simon A; Kaya, Zuhre; Lankester, Arjan C; Lindemans, Caroline et al.
DOI: 10.1038/s41409-023-01918-4

Epigenome profiling reveals aberrant DNA methylation signature in GATA2 deficiency.

PMID: 36815365
Journal: HAEMATOLOGICA
Year: 2023
Reference: Haematologica. 2023 Sep 1;108(9):2551-2557. doi: 10.3324/haematol.2022.282305.
Impact factor:
Publication type: Paper in international publication
Authors: Aretini, Paolo; Ballestar, Esteban; Bigas, Anna; Bodor, Csaba; Bueno, Clara; Castano, Julio; Catala, Albert; Cervera, Jose; De Heredia, Cristina Diaz; Distefano, Maximiliano et al.
DOI: 10.3324/haematol.2022.282305

Diverse mutations and structural variations contribute to Notch signaling deregulation in paediatric T-cell lymphoblastic lymphoma.

PMID: 36000950
Journal: PEDIATRIC BLOOD & CANCER
Year: 2022
Reference: Pediatr Blood Cancer. 2022 Nov;69(11):e29926. doi: 10.1002/pbc.29926. Epub 2022 Aug 24.
Impact factor:
Publication type: Paper in international publication
Authors: Andres, Mara; Astigarraga, Itziar; Balague, Olga; Campo, Elias; Carron, Maxime; Celis, Veronica; Colomer, Dolors; Galera, Ana; Garcia, Noelia; Garrido, Marta et al.
DOI: 10.1002/pbc.29926

Langerhans cell histiocytosis. Advances in pathogenesis and clinical practice.

PMID: 35869015
Journal: ANALES DE PEDIATRIA
Year: 2022
Reference: An Pediatr (Engl Ed). 2022 Aug;97(2):130.e1-130.e7. doi: 10.1016/j.anpede.2022.05.005. Epub 2022 Jul 20.
Impact factor:
Publication type: Paper in international publication
Authors: Astigarraga, Itziar; Carrillo, Thais Murciano; Garcia-Obregon, Susana; Gutierrez-Carrasco, Ignacio; Iturrate, Carmen Rodriguez-Vigil; Perez-Martinez, Antonio; Reggiori, Mikael Lorite; Santa-Maria, Vicente; Torrent, Montse et al.
DOI: 10.1016/j.anpede.2022.05.005

Leukocytapheresis variables and transit time for allogeneic cryopreserved hpc: better safe than sorry.

PMID: 35804055
Journal: BONE MARROW TRANSPLANTATION
Year: 2022
Reference: Bone Marrow Transplant. 2022 Oct;57(10):1531-1538. doi: 10.1038/s41409-022-01750-2. Epub 2022 Jul 8.
Impact factor:
Publication type: Paper in international publication
Authors: Ancochea, Agueda; Aran, Gemma; Azqueta, Carmen; Carreras, Enric; Cid, Joan; Codinach, Margarita; Diaz-de-Heredia, Cristina; Fernandez-Sojo, Jesus; Ferra, Christelle; Garcia-Buendia, Ana et al.
DOI: 10.1038/s41409-022-01750-2

Hematopoietic Stem Cell Transplantation in ARPC1B Deficiency.

PMID: 35767111
Journal: JOURNAL OF CLINICAL IMMUNOLOGY
Year: 2022
Reference: J Clin Immunol. 2022 Oct;42(7):1535-1544. doi: 10.1007/s10875-022-01305-6. Epub 2022 Jun 29.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, Laura; Caorsi, Roberta; Faraci, Maura; Gattorno, Marco; Giardino, Stefano; Khojah, Amer; Kuijpers, Taco; Lang, Abigail; Lucioni, Federica; Marcus, Nufar et al.
DOI: 10.1007/s10875-022-01305-6

Ceritinib in paediatric patients with anaplastic lymphoma kinase-positive malignancies: an open-label, multicentre, phase 1, dose-escalation and dose-expansion study.

PMID: 34780709
Journal: LANCET ONCOLOGY
Year: 2021
Reference: Lancet Oncol. 2021 Dec;22(12):1764-1776. doi: 10.1016/S1470-2045(21)00536-2. Epub 2021 Nov 12.
Impact factor:
Publication type: Paper in international publication
Authors: Branle, Fabrice; Casanova, Michela; Fischer, Matthias; Geoerger, Birgit; Hurtado, Felipe K; Irwin, Meredith S; Marshall, Lynley V; Moreno, Lucas; Sabado, Constantino; Schulte, Johannes H et al.
DOI: 10.1016/S1470-2045(21)00536-2

The oral KIF11 inhibitor 4SC-205 exhibits antitumor activity and potentiates standard and targeted therapies in primary and metastatic neuroblastoma models.

PMID: 34709738
Journal: Clinical and Translational Medicine
Year: 2021
Reference: Clin Transl Med. 2021 Oct;11(10):e533. doi: 10.1002/ctm2.533.
Impact factor:
Publication type: Letter whit IF
Authors: Boloix, Ariadna; Burgos-Panadero, Rebeca; Devis-Jauregui, Laura; Gallego, Soledad; Guillen, Gabriela; Jimenez, Carlos; Krauss, Rolf; Llobet-Navas, David; Majem, Blanca; Masanas, Marc et al.
DOI: 10.1002/ctm2.533

Early Diagnosis and Treatment of Purine Nucleoside Phosphorylase (PNP) Deficiency through TREC-Based Newborn Screening.

PMID: 34698070
Journal: International journal of neonatal screening
Year: 2021
Reference: Int J Neonatal Screen. 2021 Sep 29;7(4). pii: ijns7040062. doi: 10.3390/ijns7040062.
Impact factor:
Publication type: Letter or abstract
Authors: Alonso, Laura; Argudo-Ramirez, Ana; Arranz-Amo, Jose Antonio; Catala-Besa, Mireia; Colobran, Roger; Garcia-Prat, Marina; Garcia-Villoria, Judit; la Marca, Giancarlo; Marin-Soria, Jose Luis; Martin-Nalda, Andrea et al.
DOI: 10.3390/ijns7040062

Neuronal Differentiation-Related Epigenetic Regulator ZRF1 Has Independent Prognostic Value in Neuroblastoma but Is Functionally Dispensable In Vitro.

PMID: 34638328
Journal: Cancers
Year: 2021
Reference: Cancers (Basel). 2021 Sep 28;13(19). pii: cancers13194845. doi: 10.3390/cancers13194845.
Impact factor:
Publication type: Paper in international publication
Authors: Antonelli, Roberta; Camacho, Jessica; Devis-Jauregui, Laura; Gallego, Soledad; Guillen, Gabriela; Hladun, Raquel; Jimenez, Carlos; Jubierre, Luz; Llobet-Navas, David; Magdaleno, Ainara et al.
DOI: 10.3390/cancers13194845

Impact of COVID-19 in paediatric early-phase cancer clinical trials in Europe: A report from the Innovative Therapies for Children with Cancer (ITCC) consortium.

PMID: 33129040
Journal: EUROPEAN JOURNAL OF CANCER
Year: 2020
Reference: Eur J Cancer. 2020 Dec;141:82-91. doi: 10.1016/j.ejca.2020.09.024. Epub 2020 Oct 9.
Impact factor:
Publication type: Paper in international publication
Authors: Aerts, Isabelle; Andre, Nicolas; Bautista, Francisco; Benezech, Sarah; Bergamaschi, Luca; Carpenter, Ben; Castaneda, Alicia; Cefalo, Maria Giuseppina; de Rojas, Teresa; De Wilde, Bram et al.
DOI: 10.1016/j.ejca.2020.09.024

Circulating tumour DNA from the cerebrospinal fluid allows the characterisation and monitoring of medulloblastoma.

PMID: 33110059
Journal: Nature Communications
Year: 2020
Reference: Nat Commun. 2020 Oct 27;11(1):5376. doi: 10.1038/s41467-020-19175-0.
Impact factor:
Publication type: Paper in international publication
Authors: Arias, Alexandra; Caratu, Ginevra; Diaz-Navarro, Ander; Escudero, Laura; Gallego, Soledad; Gros, Luis; Hladun, Raquel; Lesende-Rodriguez, Ivan; Llort, Anna; Martinez-Ricarte, Francisco et al.
DOI: 10.1038/s41467-020-19175-0

The variable manifestations of disease in pyruvate kinase deficiency and their management.

PMID: 33054048
Journal: HAEMATOLOGICA
Year: 2020
Reference: Haematologica. 2020 Jun 5;105(9):2229-2239. doi: 10.3324/haematol.2019.240846.
Impact factor:
Publication type: Paper in international publication
Authors: Al-Samkari, Hanny; Barcellini, Wilma; Bianchi, Paola; Del Mar Manu Pereira, Maria; Glader, Bertil; Glenthoj, Andreas; Grace, Rachael F; Kuo, Kevin H M; Van Beers, Eduard J; Van Wijk, Richard et al.
DOI: 10.3324/haematol.2019.240846

The antitumour drug ABTL0812 impairs neuroblastoma growth through endoplasmic reticulum stress-mediated autophagy and apoptosis.

PMID: 32943619
Journal: Cell Death & Disease
Year: 2020
Reference: Cell Death Dis. 2020 Sep 17;11(9):773. doi: 10.1038/s41419-020-02986-w.
Impact factor:
Publication type: Paper in international publication
Authors: Alfon, Jose; Antonelli, Roberta; Boloix, Ariadna; Domenech, Carles; Erazo, Tatiana; Gallego, Soledad; Jimenez, Carlos; Lizcano, Jose M; Masanas, Marc; Moreno, Lucas et al.
DOI: 10.1038/s41419-020-02986-w

ECLIM-SEHOP, a new platform to set up and develop international academic clinical trials for childhood cancer and blood disorders in Spain.

PMID: 31598904
Journal: Clinical & Translational Oncology
Year: 2019
Reference: Clin Transl Oncol. 2019 Dec;21(12):1763-1770. doi: 10.1007/s12094-019-02221-9. Epub 2019 Oct 9.
Impact factor:
Publication type: Paper in international publication
Authors: Acha, T; Andres, M Del M; Astigarraga, I; Bautista, F; Bermudez, M Del M; Canete, A; Carbone, A; Catala, A; Cruz, O; Dapena, J L et al.
DOI: 10.1007/s12094-019-02221-9

Vinorelbine and continuous low-dose cyclophosphamide as maintenance chemotherapy in patients with high-risk rhabdomyosarcoma (RMS 2005): a multicentre, open-label, randomised, phase 3 trial.

PMID: 31562043
Journal: LANCET ONCOLOGY
Year: 2019
Reference: Lancet Oncol. 2019 Nov;20(11):1566-1575. doi: 10.1016/S1470-2045(19)30617-5. Epub 2019 Sep 24.
Impact factor:
Publication type: Paper in international publication
Authors: Ben-Arush, Myriam; Bergeron, Christophe; Bisogno, Gianni; Casanova, Michela; Chisholm, Julia; De Salvo, Gian Luca; Devalck, Christine; Ferman, Sima; Ferrari, Andrea; Gallego Melcon, Soledad et al.
DOI: 10.1016/S1470-2045(19)30617-5

Successful treatment of post-transplant CMV meningoencephalitis with third-party CMV virus-specific T cells: Lessons learned.

PMID: 31556188
Journal: PEDIATRIC TRANSPLANTATION
Year: 2019
Reference: Pediatr Transplant. 2019 Dec;23(8):e13584. doi: 10.1111/petr.13584. Epub 2019 Sep 26.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, Laura; Blanco, Margarita; Codinach, Margarita; Diaz de Heredia, Cristina; Gimeno, Ramon; Querol, Sergio; Rudilla, Francesc et al.
DOI: 10.1111/petr.13584

A tailored molecular profiling programme for children with cancer to identify clinically actionable genetic alterations.

PMID: 31543384
Journal: EUROPEAN JOURNAL OF CANCER
Year: 2019
Reference: Eur J Cancer. 2019 Nov;121:224-235. doi: 10.1016/j.ejca.2019.07.027. Epub 2019 Sep 19.
Impact factor:
Publication type: Paper in international publication
Authors: Ahmed, Saira W; Al-Lazikani, Bissan; Anderson, John; Angelini, Paola; Barone, Giuseppe; Barton, Jack; Bexelius, Tomas; Campbell, James; Carceller, Fernando; Chesler, Louis et al.
DOI: 10.1016/j.ejca.2019.07.027

Unexpected High Incidence of Human Herpesvirus-6 Encephalitis After Naive T Cell-Depleted Graft of Haploidentical Stem Cell Transplantation in Pediatric Patients.

PMID: 30031939
Journal: BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
Year: 2018
Reference: Biol Blood Marrow Transplant. 2018 Nov;24(11):2316-2323. doi: 10.1016/j.bbmt.2018.07.016. Epub 2018 Jul 19.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, L; Badell, I; Bueno, D; de Paz, R; Diaz de Heredia, C; Escudero, A; Fernandez, L; Gasior, M; Gimeno, R; L, Sisinni et al.
DOI: 10.1016/j.bbmt.2018.07.016

Outcome of haematopoietic stem cell transplantation in dyskeratosis congenita.

PMID: 29984823
Journal: BRITISH JOURNAL OF HAEMATOLOGY
Year: 2018
Reference: Br J Haematol. 2018 Oct;183(1):110-118. doi: 10.1111/bjh.15495. Epub 2018 Jul 9.
Impact factor:
Publication type: Paper in international publication
Authors: Aljurf, Mahmoud; Arcuri, Luca; Bresters, Dorine; Dalle, Jean-Hugues; de la Fuente, Josue; Diaz de Heredia, Cristina; Diaz, Miguel A; Dufour, Carlo; Fagioli, Franca; Faraci, Maura et al.
DOI: 10.1111/bjh.15495

Addition of dose-intensified doxorubicin to standard chemotherapy for rhabdomyosarcoma (EpSSG RMS 2005): a multicentre, open-label, randomised controlled, phase 3 trial.

PMID: 29941280
Journal: LANCET ONCOLOGY
Year: 2018
Reference: Lancet Oncol. 2018 Aug;19(8):1061-1071. doi: 10.1016/S1470-2045(18)30337-1. Epub 2018 Jun 22.
Impact factor:
Publication type: Paper in international publication
Authors: Alaggio, Rita; Ben-Arush, Myriam; Bergeron, Christophe; Bernier, Valerie; Bisogno, Gianni; Carli, Modesto; Cecchetto, Giovanni; Cesen, Maja; Chisholm, Julia; Dal Bianco, Paola et al.
DOI: 10.1016/S1470-2045(18)30337-1

Phase I results of a phase I/II study of weekly nab-paclitaxel in paediatric patients with recurrent/refractory solid tumours: A collaboration with innovative therapies for children with cancer.

PMID: 29936064
Journal: EUROPEAN JOURNAL OF CANCER
Year: 2018
Reference: Eur J Cancer. 2018 Sep;100:27-34. doi: 10.1016/j.ejca.2018.05.002. Epub 2018 Jun 21.
Impact factor:
Publication type: Clinical Trials
Authors: Aerts, Isabelle; Amoroso, Loredana; Baruchel, Sylvain; Bergeron, Christophe; Berlanga, Pablo; Bisogno, Gianni; Casanova, Michela; Chastagner, Pascal B; Chen, Nianhang; Chisholm, Julia C et al.
DOI: 10.1016/j.ejca.2018.05.002

MicroRNA-200, associated with metastatic breast cancer, promotes traits of mammary luminal progenitor cells.

PMID: 29137351
Journal: Oncotarget
Year: 2017
Reference: Oncotarget. 2017 Sep 7;8(48):83384-83406. doi: 10.18632/oncotarget.20698. eCollection 2017 Oct 13.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, Immaculada; Arguimbau, Judit; Bermudo, Raquel; Blanco, Jeronimo; Caparros, Xavier; Cascante, Marta; Fernandez, Pedro L; Fueyo, Raquel; Guerra-Rebollo, Marta; Kang, Yibin et al.
DOI: 10.18632/oncotarget.20698

miR-99a reveals two novel oncogenic proteins E2F2 and EMR2 and represses stemness in lung cancer.

PMID: 29072692
Journal: Cell Death & Disease
Year: 2017
Reference: Cell Death Dis. 2017 Oct 26;8(10):e3141. doi: 10.1038/cddis.2017.544.
Impact factor:
Publication type: Paper in international publication
Authors: Cajal, Santiago Ramon Y; Castellvi, Josep; Feliciano, Andrea; Garcia-Mayea, Yoelsis; Hernandez-Losa, Javier; Hummel, Manuela; Jubierre, Luz; Kondon, Hiroshi; LLeonart, Matilde E; Lyakhovich, Alex et al.
DOI: 10.1038/cddis.2017.544

Ligand-dependent Hedgehog pathway activation in Rhabdomyosarcoma: the oncogenic role of the ligands.

PMID: 28881358
Journal: BRITISH JOURNAL OF CANCER
Year: 2017
Reference: Br J Cancer. 2017 Oct 24;117(9):1314-1325. doi: 10.1038/bjc.2017.305. Epub 2017 Sep 7.
Impact factor:
Publication type: Paper in international publication
Authors: Almazan-Moga, A; Ferreres, J C; Gallego, S; Giralt, I; Hahn, H; Molist, C; Navarro, N; Navarro, S; Pyczek, J; Roma, J et al.
DOI: 10.1038/bjc.2017.305

Engraftment and in vivo proliferation advantage of gene corrected mobilized CD34+ cells from Fanconi anemia patients.

PMID: 28801449
Journal: BLOOD
Year: 2017
Reference: Blood. 2017 Sep 28;130(13):1535-1542. doi: 10.1182/blood-2017-03-774174. Epub 2017 Aug 11.
Impact factor:
Publication type: Paper in international publication
Authors: Bueren, Juan; Casado, Jose A; Charrier, Sabine; Diaz de Heredia, Cristina; Galy, Anne; Guenechea, Guillermo; Lamana, Maria Luisa; Mehta, Parinda A; Navarro, Susana; Pujol, Maria Roser et al.
DOI: 10.1182/blood-2017-03-774174

Cord Blood Units with High CD3(+) Cell Counts Predict Early Lymphocyte Recovery After In Vivo T Cell-Depleted Single Cord Blood Transplantation.

PMID: 27038860
Journal: BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
Year: 2016
Reference: Biol Blood Marrow Transplant. 2016 Jun;22(6):1073-9. doi: 10.1016/j.bbmt.2016.03.009. Epub 2016 Mar 30.
Impact factor:
Publication type: Paper in international publication
Authors: Badell, Isabel; Barba, Pere; Canals, Carme; Castillo, Nerea; Diaz-Heredia, Cristina; Elorza, Izaskun; Ferra, Christelle; Garcia-Cadenas, Irene; Martino, Rodrigo; Olive, Teresa et al.
DOI: 10.1016/j.bbmt.2016.03.009

Successful Treatment of Sinusitis by Acanthamoeba in a Pediatric Patient After Allogeneic Stem Cell Transplantation.

PMID: 27626919
Journal: PEDIATRIC INFECTIOUS DISEASE JOURNAL
Year: 2016
Reference: Pediatr Infect Dis J. 2016 Dec;35(12):1350-1351.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, Laura; Diaz de Heredia, Cristina; Juan, Antonio; Navarro, Alexandra; Olive, Teresa; Sanchez de Toledo, Jose; Sulleiro, Elena et al.
DOI: 10.1097/INF.0000000000001329

FAIMs: more than death-receptor antagonists in the nervous system.

PMID: 27385439
Journal: JOURNAL OF NEUROCHEMISTRY
Year: 2016
Reference: J Neurochem. 2016 Oct;139(1):11-21. doi: 10.1111/jnc.13729. Epub 2016 Aug 3.
Impact factor:
Publication type: Paper in international publication
Authors: Barneda-Zahonero, Bruna; Calleja-Yague, Isabel; Carriba, Paulina; Coccia, Elena; Comella, Joan X; Galenkamp, Koen M O; Lopez-Soriano, Joaquin; Planells-Ferrer, Laura; Segura, Miguel F; Urresti, Jorge et al.
DOI: 10.1111/jnc.13729

Consensus expert recommendations for identification and management of asparaginase hypersensitivity and silent inactivation.

PMID: 26928249
Journal: HAEMATOLOGICA
Year: 2016
Reference: Haematologica. 2016 Mar;101(3):279-85. doi: 10.3324/haematol.2015.137380.
Impact factor:
Publication type: Paper in international publication
Authors: Baruchel, Andre; Escherich, Gabriele; Goulden, Nicholas; Mondelaers, Veerle; Pieters, Rob; Rizzari, Carmelo; Sanchez de Toledo, Jose; Silverman, Lewis B; van der Sluis, Inge M; Vrooman, Lynda M et al.
DOI: 10.3324/haematol.2015.137380

Few and nonsevere adverse infusion events using an automated method for diluting and washing before unrelated single cord blood transplantation.

PMID: 25545727
Journal: BIOL BLOOD MARROW TR
Year: 2015
Reference: Biol Blood Marrow Transplant. 2015 Apr;21(4):682-7. doi: 10.1016/j.bbmt.2014.12.015. Epub 2014 Dec 27.
Impact factor:
Publication type: Paper in international publication
Authors: Azqueta, Carmen; Badell, Isabel; Barba, Pere; Canals, Carme; Castillo, Nerea; Diaz-Heredia, Cristina; Duarte, Rafael; Elorza, Izaskun; Ferra, Christelle; Garcia, Olga et al.
DOI: 10.1016/j.bbmt.2014.12.015

Perceived positive and negative consequences after surviving cancer and their relation to quality of life.

PMID: 25660107
Journal: SCAND J PRIM HEALTH
Year: 2015
Reference: Scand J Psychol. 2015 Jun;56(3):306-14. doi: 10.1111/sjop.12199. Epub 2015 Feb 6.
Impact factor:
Publication type: Paper in international publication
Authors: Blasco-Blasco, Tomas; Capdevila, Lluis; Castellano-Tejedor, Carmina; Eiroa-Orosa, Francisco-Jose; Perez-Campdepadros, Marta; Sanchez de Toledo, Jose et al.
DOI: 10.1111/sjop.12199

TNFalpha sensitizes neuroblastoma cells to FasL-, cisplatin- and etoposide-induced cell death by NF-kappaB-mediated expression of Fas.

PMID: 25890358
Journal: MOL CANCER
Year: 2015
Reference: Mol Cancer. 2015 Mar 19;14:62. doi: 10.1186/s12943-015-0329-x.
Impact factor:
Publication type: Paper in international publication
Authors: Barneda-Zahonero, Bruna; Carriba, Paulina; Coccia, Elena; Comella, Joan X; Galenkamp, Koen Mo; Lopez-Soriano, Joaquin; Moubarak, Rana S; Planells-Ferrer, Laura; Segura, Miguel F; Urresti, Jorge et al.
DOI: 10.1186/s12943-015-0329-x

Recommendations on hematopoietic stem cell transplantation for inherited bone marrow failure syndromes.

PMID: 26052913
Journal: BONE MARROW TRANSPLANTATION
Year: 2015
Reference: Bone Marrow Transplant. 2015 Sep;50(9):1168-72. doi: 10.1038/bmt.2015.117. Epub 2015 Jun 8.
Impact factor: 3.57
Publication type: Review in international publication
Authors: Leblanc, T, Dufour, C, Dalle, J-H, Samarasinghe, S, Bonanomi, S, Corbacioglu, S, Wlodarski, M, Peffault de Latour, R, Peters, C, Gibson, B et al.
DOI: 10.1038/bmt.2015.117

The role of leptin in diencephalic syndrome.

PMID: 24366994
Journal: PEDIATRICS
Year: 2014
Reference: Pediatrics. 2014 Jan;133(1):e263-6. doi: 10.1542/peds.2012-3196. Epub 2013 Dec 23.
Impact factor:
Publication type: Paper in international publication
Authors: Clemente, Maria; Gallego, Soledad; Gros, Luis; Lorite, Raquel; Sanchez de Toledo, Jose; Velasco, Pablo; Ventura, M Clara et al.
DOI: 10.1542/peds.2012-3196

Conservative approach in localised rhabdomyosarcoma of the bladder and prostate: Results from International Society of Paediatric Oncology (SIOP) studies: Malignant mesenchymal tumour (MMT) 84, 89 and 95.

PMID: 23997024
Journal: PEDIATRIC BLOOD & CANCER
Year: 2014
Reference: Pediatr Blood Cancer. 2014 Feb;61(2):217-22. doi: 10.1002/pbc.24727. Epub 2013 Aug 29.
Impact factor:
Publication type: Paper in international publication
Authors: Audry, Georges; Gallego, Soledad; Haie-Meder, Christine; Jenney, Meriel; Kelsey, Anna; Martelli, Helene; Merks, Johannes Hm; Oberlin, Odile; Rey, Annie; Stevens, Michael Cg et al.
DOI: 10.1002/pbc.24727

Hematopoietic stem cell transplantation in thalassemia major and sickle cell disease: indications and management recommendations from an international expert panel.

PMID: 24790059
Journal: HAEMATOLOGICA
Year: 2014
Reference: Haematologica. 2014 May;99(5):811-20. doi: 10.3324/haematol.2013.099747.
Impact factor: 5.868
Publication type: Paper in international publication
Authors: Hussein, Ayad Achmed, Kamani, Naynesh, Minkov, Milen, Locatelli, Franco, Rocha, Vanderson, Sedlacek, Petr, Smiers, Frans, Thuret, Isabelle, Yaniv, Isaac, Cavazzana, Marina et al.
DOI: 10.3324/haematol.2013.099747

Impact of HLA mismatch direction on outcomes after umbilical cord blood transplantation for hematological malignant disorders: a retrospective Eurocord-EBMT analysis.

PMID: 23955634
Journal: BONE MARROW TRANSPL
Year: 2014
Reference: Bone Marrow Transplant. 2014 Jan;49(1):24-9. doi: 10.1038/bmt.2013.120. Epub 2013 Aug 19.
Impact factor: 3.466
Publication type: Paper in international publication
Authors: O'Brien, T A, Cunha, R, Loiseau, P, Ruggeri, A, Sanz, G, Michel, G, Iori, A P, Socie, G, Arcese, W, Picardi, A et al.
DOI: 10.1038/bmt.2013.120

microRNAs as pharmacological targets in cancer.

PMID: 23537752
Journal: PHARMACOLOGICAL RESEARCH
Year: 2013
Reference: Pharmacol Res. 2013 Sep;75:3-14. doi: 10.1016/j.phrs.2013.03.006. Epub 2013 Mar 25.
Impact factor:
Publication type: Review in international publication
Authors: Almazan-Moga, Ana; de Toledo, Jose Sanchez; Gallego, Soledad; Jubierre, Luz; Molist, Carla; Roma, Josep; Segura, Miguel F; Soriano, Aroa et al.
DOI: 10.1016/j.phrs.2013.03.006

[Results of hematopoietic stem cell transplantation in hemoglobinopathies: Thalassemia major and sickle cell disease.]

PMID: 23402775
Journal: ANALES DE PEDIATRIA
Year: 2013
Reference: An Pediatr (Barc). 2013 Aug;79(2):75-82. doi: 10.1016/j.anpedi.2012.12.002. Epub 2013 Feb 9.
Impact factor:
Publication type: Paper in national publication
Authors: Dapena, J L; Diaz de Heredia, C; Elorza, I; Hladun, R; Llort, A; Olive, T; Sanchez de Toledo, J et al.
DOI: 10.1016/j.anpedi.2012.12.002

Polymorphisms in the methotrexate transport pathway: a new tool for MTX plasma level prediction in pediatric acute lymphoblastic leukemia.

PMID: 23222202
Journal: Pharmacogenetics and Genomics
Year: 2013
Reference: Pharmacogenet Genomics. 2013 Feb;23(2):53-61. doi: 10.1097/FPC.0b013e32835c3b24.
Impact factor:
Publication type: Paper in international publication
Authors: Ballesteros, Javier; Garcia de Andoin, Nagore; Garcia-Miguel, Purificacion; Garcia-Orad, Africa; Lopez-Lopez, Elixabet; Navajas, Aurora; Pinan, Maria A; Sanchez de Toledo, Jose et al.
DOI: 10.1097/FPC.0b013e32835c3b24

Analysis of risk factors influencing outcomes after cord blood transplantation in children with juvenile myelomonocytic leukemia: a EUROCORD, EBMT, EWOG-MDS, CIBMTR study.

PMID: 23926304
Journal: BLOOD
Year: 2013
Reference: Blood. 2013 Sep 19;122(12):2135-41. doi: 10.1182/blood-2013-03-491589. Epub 2013 Aug 7.
Impact factor: 9.06
Publication type: Paper in international publication
Authors: Locatelli, Franco, Crotta, Alessandro, Ruggeri, Annalisa, Eapen, Mary, Wagner, John E, Macmillan, Margaret L, Zecca, Marco, Kurtzberg, Joanne, Bonfim, Carmem, Vora, Ajay et al.
DOI: 10.1182/blood-2013-03-491589

[Chromosomal translocations in soft tissue sarcomas: from molecular biology to clinical application.]

PMID: 22075174
Journal: ANALES DE PEDIATRIA
Year: 2012
Reference: An Pediatr (Barc). 2012 Feb;76(2):103.e1-7. Epub 2011 Nov 9.
Impact factor:
Publication type: Review in national publication
Authors: ; ; ; ; ; ; et al.
DOI: 10.1016/j.anpedi.2011.09.007

Notch, wnt, and hedgehog pathways in rhabdomyosarcoma: from single pathways to an integrated network.

PMID: 22550422
Journal: Sarcoma
Year: 2012
Reference: Sarcoma. 2012;2012:695603. doi: 10.1155/2012/695603. Epub 2012 Mar 11.
Impact factor: 2.16
Publication type: Letter or abstract
Authors: Gallego, Soledad, Sanchez de Toledo, Josep, Almazan-Moga, Anna, Roma, Josep et al.
DOI: 10.1155/2012/695603

Notch-mediated induction of N-cadherin and alpha9-integrin confers higher invasive phenotype on rhabdomyosarcoma cells.

PMID: 22976797
Journal: BRITISH JOURNAL OF CANCER
Year: 2012
Reference: Br J Cancer. 2012 Oct 9;107(8):1374-83. doi: 10.1038/bjc.2012.411. Epub 2012 Sep 13.
Impact factor: 5.042
Publication type: Paper in international publication
Authors: Sanchez de Toledo, J, Roma, J, Gallego, S, Toran, N, Reventos, J, Almazan-Moga, A, Masia, A, Velasco, P et al.
DOI: 10.1038/bjc.2012.411

Transplantation in patients with SCID: mismatched related stem cells or unrelated cord blood?

PMID: 22308292
Journal: BLOOD
Year: 2012
Reference: Blood. 2012 Mar 22;119(12):2949-55. Epub 2012 Feb 3.
Impact factor: 9.898
Publication type: Paper in international publication
Authors: Auiti, A, Diaz de Heredia, Cristina, Wall, Donna, Bertrand, Yves, Veys, Paul, Slatter, Mary, Schulz, Ansgar, Chan, Ka Wah, Grimley, Michael, Ayas, Mouhab et al.
DOI: 10.1182/blood-2011-06-363572

Perioperative use of dexmedetomidine is associated with decreased incidence of ventricular and supraventricular tachyarrhythmias after congenital cardiac operations.

PMID: 21871284
Journal: ANNALS OF THORACIC SURGERY
Year: 2011
Reference: Ann Thorac Surg. 2011 Sep;92(3):964-72.
Impact factor:
Publication type: Paper in international publication
Authors: Callahan, Patrick M; Chrysostomou, Constantinos; Haney, Jamie; Jooste, Edmund H; Lichtenstein, Steven E; Morell, Victor O; Munoz, Ricardo; O'Malley, Elizabeth; Orr, Richard; Sanchez-de-Toledo, Joan et al.
DOI: 10.1016/j.athoracsur.2011.04.099

[Severe congenital neutropenia: analysis of clinical features, diagnostic methods, treatment and long-term outcome.]

PMID: 21757412
Journal: ANALES DE PEDIATRIA
Year: 2011
Reference: An Pediatr (Barc). 2011 Dec;75(6):396-400. Epub 2011 Jul 14.
Impact factor:
Publication type: Paper in national publication
Authors: ; ; ; ; ; ; ; et al.
DOI: 10.1016/j.anpedi.2011.05.017

Malignancies After Hematopoietic Cell Transplantation for Primary Immune Deficiencies: A Report from the Center for International Blood and Marrow Transplant Research.

PMID: 21658461
Journal: BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
Year: 2011
Reference: Biol Blood Marrow Transplant. 2011 Dec;17(12):1783-9. Epub 2011 May 20.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1016/j.bbmt.2011.05.008

Observational prospective study of viral infections in children undergoing allogeneic hematopoietic cell transplantation: a 3-year GETMON experience.

PMID: 20228849
Journal: BONE MARROW TRANSPLANTATION
Year: 2011
Reference: Bone Marrow Transplant. 2011 Jan;46(1):119-24. Epub 2010 Mar 15.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1038/bmt.2010.52

Outcome after relapse of acute lymphoblastic leukemia (ALL) in adult patients included in four consecutive risk-adapted trials from the PETHEMA Study Group.

PMID: 20145276
Journal: Haematologica-The Hematology Journal
Year: 2010
Reference: Haematologica. 2010 Apr;95(4):589-96. Epub 2010 Feb 9.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.3324/haematol.2009.014274

Long-term follow-up and factors influencing outcomes after related HLA-identical cord blood transplantation for patients with malignancies: an analysis on behalf of Eurocord-EBMT.

PMID: 20538797
Journal: BLOOD
Year: 2010
Reference: Blood. 2010 Sep 16;116(11):1849-56. doi: 10.1182/blood-2010-02-271692. Epub 2010 Jun 10.
Impact factor: 10.555
Publication type: Paper in international publication
Authors: Diaz de Heredia, Cristina, Peters, Christina, Chaves, Wagnara, Nabhan, Samir K, Ionescu, Irina, Gluckman, Eliane, Rocha, Vanderson, Bertrand, Yves, Messina, Chiara, Jouet, Jean-Pierre et al.
DOI: 10.1182/blood-2010-02-271692

Relationship between minimal residual disease measured by multiparametric flow cytometry prior to allogeneic hematopoietic stem cell transplantation and outcome in children with acute lymphoblastic leukemia.

PMID: 20179088
Journal: Haematologica-The Hematology Journal
Year: 2010
Reference: Haematologica. 2010 Jun;95(6):936-41. Epub 2010 Feb 23.
Impact factor: 6.416
Publication type: Paper in international publication
Authors: , , , , , et al.
DOI: 10.3324/haematol.2009.010843

Post-transplant lymphoproliferative disorders in children: the role of chemotherapy in the era of rituximab.

PMID: 19344338
Journal: PEDIATRIC TRANSPLANTATION
Year: 2010
Reference: Pediatr Transplant. 2010 Feb;14(1):61-6. Epub 2009 Mar 31.
Impact factor: 1.573
Publication type: Paper in international publication
Authors: Gallego, S, Gros, L, Sanchez de Toledo, J Jr, Bueno, J, Moreno, A, Nieto, J, Sanchez de Toledo, J, Llort, A et al.
DOI: 10.1111/j.1399-3046.2009.01181.x

Lentiviral-mediated genetic correction of hematopoietic and mesenchymal progenitor cells from Fanconi anemia patients.

PMID: 19277017
Journal: MOLECULAR THERAPY
Year: 2009
Reference: Mol Ther. 2009 Jun;17(6):1083-92.
Impact factor:
Publication type: Paper in international publication
Authors: Badell, Isabel; Bueren, Juan A; Casado, Jose; Diaz-Heredia, Cristina; Estella, Jesus; Gonzalez-Murillo, Africa; Guenechea, Guillermo; Jacome, Ariana; Lamana, Maria Luisa; Lozano, M Luz et al.
DOI: 10.1038/mt.2009.26

Therapeutic indications of fetoscopy: a 5-year institutional experience.

PMID: 19260783
Journal: Journal of Laparoendoscopic & Advanced Surgical Techniques
Year: 2009
Reference: J Laparoendosc Adv Surg Tech A. 2009 Apr;19(2):229-36.
Impact factor:
Publication type: Paper in international publication
Authors: Arevalo, Silvia; Carreras, Elena; Castillo, Felix; Guillen, Gabriela; Higueras, Teresa; Lloret, Josep; Marhuenda, Claudia; Martinez-Ibanez, Vicenc; Peiro, Jose L; Sanchez-Duran, M Angeles et al.
DOI: 10.1089/lap.2007.0149

Allogeneic stem cell transplantation for myelodysplastic syndromes in children: a report from the Spanish Working Party for Blood and Marrow Transplantation in Children (GETMON).

PMID: 19579081
Journal: PEDIATRIC HEMATOLOGY AND ONCOLOGY
Year: 2009
Reference: Pediatr Hematol Oncol. 2009 Jul-Aug;26(5):345-55.
Impact factor:
Publication type: Paper in international publication
Authors: Badell, Isabel; Bureo, Encarna; Diaz-Heredia, Cristina; Fernandez-Delgado, Rafael; Gomez, Pedro; Gonzalez-Vicent, Marta; Maldonado, Maria Soledad; Martinez, Ana; Munoz, Arturo; Perez-Hurtado, Jose Maria et al.
DOI: 10.1080/08880010902976742

A novel G6PC3 homozygous 1-bp deletion as a cause of severe congenital neutropenia.

PMID: 19696212
Journal: BLOOD
Year: 2009
Reference: Blood. 2009 Aug 20;114(8):1718-9.
Impact factor:
Publication type: Letter or abstract
Authors: Arostegui, Juan I; de Toledo, Jose Sanchez; Diaz de Heredia, Cristina; Garcia, Carlos; Pascal, Mariona; Yague, Jordi et al.
DOI: 10.1182/blood-2009-04-219451

Blog

News

The association, once again, has shown its commitment to oncological research with a donation of €19,197 to the Cancer and Hematological Diseases Group for Children at VHIR.

The prestigious journal The Lancet has published the results of this study, which is the result of more than 20 years of pre-clinical research and 7 years of patient follow-up.

During the meeting, the role of the Vall d'Hebron Paediatric Research Hub in promoting research on children and adolescents was highlighted.