Skip to main content

Clinical Biochemistry, Drug Delivery & Therapy

The Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT) group arises from the merger of two VHIR groups, the Clinical Biochemistry group and the Drug Delivery and Targeting group, which they develop preclinical and clinical research in the diagnosis and therapy of different diseases.

With a direct link to the Clinical Biochemistry service of the Vall d'Hebron Hospital, our scope of action ranges from the analysis of massive data coming from the service, the development of diagnostic and prognostic biomarkers, evaluation of existing therapies and the development of new therapeutic strategies based on nanotechnology.

In terms of specific pathologies or indications, the group has an extensive track record in basic and applied research in cancer (new biomarkers, therapeutic targets and new treatments), metabolopathies (biomarkers and improvements in enzyme replacement therapy), kidney disease and liver disease.

Publications

Highlights from the 24th European Congress on Gynaecological Oncology in Istanbul: an ENYGO-IJGC Fellows compilation.

PMID: 38114163
Journal: INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
Year: 2023
Reference: Int J Gynecol Cancer. 2023 Dec 18:ijgc-2023-005109. doi: 10.1136/ijgc-2023-005109.
Impact factor:
Publication type: Paper in international publication
Authors: Agusti, Nuria; Angeles, Martina Aida; Barreira-Diaz, Ana; Bilir, Esra; Bizzarri, Nicolo; Bonaldo, Giulio; Buti, Maria; Cucinella, Giuseppe; De Vitis, Luigi Antonio; du Bois, Andreas et al.
DOI: 10.1136/ijgc-2023-005109

In-Host HEV Quasispecies Evolution Shows the Limits of Mutagenic Antiviral Treatments.

PMID: 38139013
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2023
Reference: Int J Mol Sci. 2023 Dec 6;24(24):17185. doi: 10.3390/ijms242417185.
Impact factor:
Publication type: Paper in international publication
Authors: Adombi, Caroline Melanie; Buti, Maria; Campos, Carolina; Colomer-Castell, Sergi; Cortese, Maria Francesca; Esteban, Juan Ignacio; Garcia-Cehic, Damir; Gregori, Josep; Ibanez-Lligona, Marta; Quer, Josep et al.
DOI: 10.3390/ijms242417185

Isatuximab Monotherapy for Desensitization in Highly Sensitized Patients Awaiting Kidney Transplant.

PMID: 38147137
Journal: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
Year: 2023
Reference: J Am Soc Nephrol. 2023 Dec 26. doi: 10.1681/ASN.0000000000000287.
Impact factor:
Publication type: Paper in international publication
Authors: Abbadessa, Giovanni; Adombi, Caroline Melanie; Ali, Nicole; Bestard, Oriol; Brar, Amarpali; Buti, Maria; Campos, Carolina; Colomer-Castell, Sergi; Cortese, Maria Francesca; Cruzado, Josep M et al.
DOI: 10.1681/ASN.0000000000000287

Vitamin C deficiency in critically ill COVID-19 patients admitted to intensive care unit.

PMID: 38188336
Journal: Frontiers in Medicine
Year: 2023
Reference: Front Med (Lausanne). 2023 Dec 20;10:1301001. doi: 10.3389/fmed.2023.1301001. eCollection 2023.
Impact factor:
Publication type: Paper in international publication
Authors: Bajana, Ivan; Camos, Silvia; Castellanos, Sara; Chiscano-Camon, Luis; Corona, Pablo; Ferrer, Ricard; Ferrer-Costa, Roser; Joshi-Jubert, Nayana; Martin, Laura; Martin-Rodriguez, Cristina et al.
DOI: 10.3389/fmed.2023.1301001

Cut-off values for Gaussian first-trimester screening for early-onset preeclampsia with maternal history, biochemical markers and uterine artery Doppler.

PMID: 32512213
Journal: Journal of Gynecology Obstetrics and Human Reproduction
Year: 2021
Reference: J Gynecol Obstet Hum Reprod. 2021 Jan;50(1):101827. doi: 10.1016/j.jogoh.2020.101827. Epub 2020 Jun 5.
Impact factor:
Publication type: Paper in international publication
Authors: Bonacina, Erika; Carreras, Elena; Castellote, Laura; Garcia-Manau, Pablo; Hurtado, Ivan; Lopez-Martinez, Rosa Maria; Martinez, Luisa; Mendoza, Manel; Serrano, Berta; Tur, Helena et al.
DOI: 10.1016/j.jogoh.2020.101827

Leigh syndrome associated with TRMU gene mutations.

PMID: 33365252
Journal: Molecular Genetics and Metabolism Reports
Year: 2021
Reference: Mol Genet Metab Rep. 2020 Dec 15;26:100690. doi: 10.1016/j.ymgmr.2020.100690. eCollection 2021 Mar.
Impact factor:
Publication type: Paper in international publication
Authors: Arranz, Jose Antonio; Carnicer, Clara; Carreno, Lidia; de Las Heras, Javier; Del Toro, Mireia; Garcia-Arumi, Elena; Gort, Laura; Lasa-Aranzasti, Amaia; Miguel, Lucia Dougherty-de; Sala-Coromina, Julia et al.
DOI: 10.1016/j.ymgmr.2020.100690

Blog

News

Based on the study led by VHIR, a clinical trial has been approved for patients with locally advanced pancreatic cancer.

Vall d'Hebron participates in a project to develop innovative microsampling technology, making blood collection more accessible and patient-centered.

Researchers from all over Europe gathered to kick off the SPM4.0 project, an innovative Marie Curie Skłodowska (MSCA-DN) doctoral network that promotes the development of autonomous Scanning Probe Microscopy with AI.