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Clinical Biochemistry, Drug Delivery & Therapy

The Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT) group arises from the merger of two VHIR groups, the Clinical Biochemistry group and the Drug Delivery and Targeting group, which they develop preclinical and clinical research in the diagnosis and therapy of different diseases.

With a direct link to the Clinical Biochemistry service of the Vall d'Hebron Hospital, our scope of action ranges from the analysis of massive data coming from the service, the development of diagnostic and prognostic biomarkers, evaluation of existing therapies and the development of new therapeutic strategies based on nanotechnology.

In terms of specific pathologies or indications, the group has an extensive track record in basic and applied research in cancer (new biomarkers, therapeutic targets and new treatments), metabolopathies (biomarkers and improvements in enzyme replacement therapy), kidney disease and liver disease.

Publications

[Not Available].

PMID: 38075162
Journal: Advances in Laboratory Medicine
Year: 2023
Reference: Adv Lab Med. 2023 Sep 8;4(3):205-206. doi: 10.1515/almed-2023-0113. eCollection 2023 Sep.
Impact factor:
Publication type: Editorial in national publication
Authors: Arribas, Ignacio; Augustin, Salvador; Fernandez-Calle, Pilar; Ferrer-Costa, Roser; Ferrer-Costa, Roser; Gabriel-Medina, Pablo; Gonzalez, Alvaro; Guerrero, Rafael A; Jimenez, Wladimiro; Jimenez-Masip, Alba et al.
DOI: 10.1515/almed-2023-0113

Community-based screening enhances hepatitis B virus linkage to care among West African migrants in Spain.

PMID: 38097770
Journal: Communications medicine
Year: 2023
Reference: Commun Med (Lond). 2023 Dec 14;3(1):182. doi: 10.1038/s43856-023-00420-8.
Impact factor:
Publication type: Paper in international publication
Authors: Araujo, Silvia G; Buti, Maria; Cardona, V; de la Hoz, B; Dieguez, M C; Fernandez, Emma; Forns, Xavier; Gonzalez-de-Olano, D; Habernau, A; Lazarus, Jeffrey V et al.
DOI: 10.1038/s43856-023-00420-8

Phase II trial of afatinib in patients with advanced urothelial carcinoma with genetic alterations in ERBB1-3 (LUX-Bladder 1).

PMID: 38102226
Journal: BRITISH JOURNAL OF CANCER
Year: 2023
Reference: Br J Cancer. 2023 Dec 15. doi: 10.1038/s41416-023-02513-6.
Impact factor:
Publication type: Paper in international publication
Authors: Aldecoa, Iban; Araujo, Silvia G; Buti, Maria; Castellano, Daniel; Climent, Miguel A; Fernandez, Emma; Fernandez, Pedro L; Font, Albert; Forns, Xavier; Gibson, Neil et al.
DOI: 10.1038/s41416-023-02513-6

Assessing the rate of non-linkage to care and identifying barriers in individuals living with hepatitis B. Results of the LINK-B study.

PMID: 38111084
Journal: LIVER INTERNATIONAL
Year: 2023
Reference: Liver Int. 2023 Dec 18. doi: 10.1111/liv.15814.
Impact factor:
Publication type: Paper in international publication
Authors: Barreira-Diaz, Ana; Buti, Maria; Esteban, Rafael; Feliu-Prius, Anna; Palom, Adriana; Rando, Ariadna; Riveiro-Barciela, Mar; Rodriguez-Frias, Francisco; Ruiz-Cobo, Juan C; Vargas-Accarino, Elena et al.
DOI: 10.1111/liv.15814

[The renin-angiotensin system and the brain].

PMID: 33526381
Journal: Hipertension y riesgo vascular
Year: 2021
Reference: Hipertens Riesgo Vasc. 2021 Jul-Sep;38(3):125-132. doi: 10.1016/j.hipert.2020.12.001. Epub 2021 Jan 30.
Impact factor:
Publication type: Review in national publication
Authors: Jacobs-Cacha, C; Molina-Van den Bosch, M; Seron, D; Soler, M J; Vergara, A et al.
DOI: 10.1016/j.hipert.2020.12.001

Reflex viral load testing in dried blood spots generated by plasma separation card allows the screening and diagnosis of chronic viral hepatitis.

PMID: 33338545
Journal: JOURNAL OF VIROLOGICAL METHODS
Year: 2021
Reference: J Virol Methods. 2021 Mar;289:114039. doi: 10.1016/j.jviromet.2020.114039. Epub 2020 Dec 15.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez-Lopez, Patricia; Barbosa, Gisela; Barreira-Diaz, Ana; Buti, Maria; Esteban, Rafael; Ferreira, Vicelma; Ferrer-Costa, Roser; Kuchta, Alison; Lopez, Eva; Martinez-Camprecios, Joan et al.
DOI: 10.1016/j.jviromet.2020.114039

Plasma intact fibroblast growth factor 23 level is a useful tool for diagnostic approach of renal hypophosphatemia.

PMID: 33492457
Journal: PEDIATRIC NEPHROLOGY
Year: 2021
Reference: Pediatr Nephrol. 2021 Apr;36(4):1025-1028. doi: 10.1007/s00467-020-04906-8. Epub 2021 Jan 25.
Impact factor:
Publication type: Paper in international publication
Authors: Ariceta, Gema; Chocron, Sara; Ferrer, Roser; Giralt, Marina et al.
DOI: 10.1007/s00467-020-04906-8

Polymeric micelles targeted against CD44v6 receptor increase niclosamide efficacy against colorectal cancer stem cells and reduce circulating tumor cells in vivo.

PMID: 33482272
Journal: JOURNAL OF CONTROLLED RELEASE
Year: 2021
Reference: J Control Release. 2021 Mar 10;331:198-212. doi: 10.1016/j.jconrel.2021.01.022. Epub 2021 Jan 20.
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, Ibane; Andrade, Fernanda; Arango, Diego; Boullosa, Ana; Camara-Sanchez, Patricia; Diaz-Riascos, Zamira V; Garcia-Aranda, Natalia; Martinez-Trucharte, Francesc; Montero, Sara; Nestor, Marika et al.
DOI: 10.1016/j.jconrel.2021.01.022

Blog

News

Based on the study led by VHIR, a clinical trial has been approved for patients with locally advanced pancreatic cancer.

Vall d'Hebron participates in a project to develop innovative microsampling technology, making blood collection more accessible and patient-centered.

Researchers from all over Europe gathered to kick off the SPM4.0 project, an innovative Marie Curie Skłodowska (MSCA-DN) doctoral network that promotes the development of autonomous Scanning Probe Microscopy with AI.