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Clinical Biochemistry, Drug Delivery & Therapy

The Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT) group arises from the merger of two VHIR groups, the Clinical Biochemistry group and the Drug Delivery and Targeting group, which they develop preclinical and clinical research in the diagnosis and therapy of different diseases.

With a direct link to the Clinical Biochemistry service of the Vall d'Hebron Hospital, our scope of action ranges from the analysis of massive data coming from the service, the development of diagnostic and prognostic biomarkers, evaluation of existing therapies and the development of new therapeutic strategies based on nanotechnology.

In terms of specific pathologies or indications, the group has an extensive track record in basic and applied research in cancer (new biomarkers, therapeutic targets and new treatments), metabolopathies (biomarkers and improvements in enzyme replacement therapy), kidney disease and liver disease.

Publications

The CYP24A1 gene variant rs2762943 is associated with low serum 1,25-dihydroxyvitamin D levels in multiple sclerosis patients.

PMID: 37183562
Journal: EUROPEAN JOURNAL OF NEUROLOGY
Year: 2023
Reference: Eur J Neurol. 2023 May 14. doi: 10.1111/ene.15866.
Impact factor:
Publication type: Paper in international publication
Authors: Chuquisana, Omar; Comabella, Manuel; Ferrer, Roser; Fissolo, Nicolas; Gil-Varea, Elia; Giralt, Marina; Lunemann, Jan D; Malhotra, Sunny; Midaglia, Luciana; Montalban, Xavier et al.
DOI: 10.1111/ene.15866

Aluminum blood concentration in adult patients: effect of multichamber-bag versus hospital-compounded parenteral nutrition.

PMID: 37073757
Journal: Nutricion Hospitalaria
Year: 2023
Reference: Nutr Hosp. 2023 Apr 11. doi: 10.20960/nh.04436.
Impact factor:
Publication type: Paper in international publication
Authors: Albertos, Raquel; Albertos, Raquel; Barquin, Raquel; Berlana, David; Cea, Cristina; Lopez-Hellin, Juan; Montoro-Ronsano, J Bruno; Pau-Parra, Alba; Zabalegui, Alba et al.
DOI: 10.20960/nh.04436

Anaphylaxis.

PMID: 37833106
Journal: MEDICINA CLINICA
Year: 2023
Reference: Med Clin (Barc). 2023 Oct 11:S0025-7753(23)00552-3. doi: 10.1016/j.medcli.2023.08.010.
Impact factor:
Publication type: Other (letters to the editor, abstracts, corrigendum, etc.)
Authors: Andrade, Fernanda; Cardona, Victoria; Duran-Lara, Esteban F; Galvan-Blasco, Paula; Gil-Serrano, Johana; Lobos G, Olga; Rafael, Diana; Vijayakumar, Sekar et al.
DOI: 10.1016/j.medcli.2023.08.010

Accuracy of a sequential algorithm based on FIB-4 and ELF to identify high-risk advanced liver fibrosis at the primary care level.

PMID: 37952070
Journal: Internal and Emergency Medicine
Year: 2023
Reference: Intern Emerg Med. 2023 Nov 11. doi: 10.1007/s11739-023-03441-2.
Impact factor:
Publication type: Paper in international publication
Authors: Abrisqueta, Pau; Augustin, Salvador; Campo, Elias; Casanueva-Eliceiry, Sebastian; Ciudin, Andreea; Correa, Juan Gonzalo; Delgado, Julio; Ferrer-Costa, Roser; Gabriel-Medina, Pablo; Gine, Eva et al.
DOI: 10.1007/s11739-023-03441-2

The COVID-19 pandemic: progress in nephrology.

PMID: 34873314
Journal: Nature Reviews Nephrology
Year: 2022
Reference: Nat Rev Nephrol. 2022 Feb;18(2):80-81. doi: 10.1038/s41581-021-00521-4.
Impact factor:
Publication type: Review in international publication
Authors: Jacobs-Cacha, Conxita; Soler, Maria Jose et al.
DOI: 10.1038/s41581-021-00521-4

Letter to the Editor: standardization of HBV RNA assay for the different phases of chronic hepatitis B is essential.

PMID: 34758113
Journal: HEPATOLOGY
Year: 2022
Reference: Hepatology. 2022 Feb;75(2):501-502. doi: 10.1002/hep.32227. Epub 2021 Dec 18.
Impact factor:
Publication type: Letter or abstract
Authors: Buti, Maria; Cortese, Maria Francesca; Rando-Segura, Ariadna; Rodriguez-Frias, Francisco; Tabernero, David et al.
DOI: 10.1002/hep.32227

Colorectal cancer inhibition by BET inhibitor JQ1 is MYC-independent and not improved by nanoencapsulation.

PMID: 34998911
Journal: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
Year: 2022
Reference: Eur J Pharm Biopharm. 2022 Feb;171:39-49. doi: 10.1016/j.ejpb.2021.10.017. Epub 2022 Jan 5.
Impact factor:
Publication type: Paper in international publication
Authors: Arango, Diego; Colaco, Ariana; Fourniols, Thibaut; Garcia Vidal, Elia; Lopes, Alessandra; Maggio, Valentina; Martinez-Barriocanal, Agueda; Preat, Veronique; Rafael, Diana; Schwartz, Simo et al.
DOI: 10.1016/j.ejpb.2021.10.017

A year living with SARS-CoV-2: an epidemiological overview of viral lineage circulation by whole-genome sequencing in Barcelona city (Catalonia, Spain).

PMID: 34842496
Journal: Emerging Microbes & Infections
Year: 2022
Reference: Emerg Microbes Infect. 2022 Dec;11(1):172-181. doi: 10.1080/22221751.2021.2011617.
Impact factor:
Publication type: Paper in international publication
Authors: Andres, Cristina; Anton, Andres; Blanco-Grau, Albert; Borras-Bermejo, Blanca; Campins-Marti, Magda; Campos, Carolina; Castillo, Carla; Codina, Maria Gema; Colomer-Castell, Sergi; Esperalba, Juliana et al.
DOI: 10.1080/22221751.2021.2011617

The ovarian reserve as measured by the anti-Mullerian hormone is not diminished in patients with rheumatoid arthritis compared to the healthy population.

PMID: 32896242
Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
Year: 2021
Reference: Clin Exp Rheumatol. 2021 Mar-Apr;39(2):337-343. Epub 2020 Sep 3.
Impact factor:
Publication type: Paper in international publication
Authors: Barcelo, Mireia; De Agustin, Juan Jose; Ferrer, Roser; Julia, Antonio; Lopez-Corbeto, Mireia; Lopez-Lasanta, Maria; Marsal, Sara; Martinez-Mateu, Sergio; Pluma, Andrea et al.
DOI:

Stimuli-Responsive Hydrogels for Cancer Treatment: The Role of pH, Light, Ionic Strength and Magnetic Field.

PMID: 33803133
Journal: Cancers
Year: 2021
Reference: Cancers (Basel). 2021 Mar 9;13(5). pii: cancers13051164. doi: 10.3390/cancers13051164.
Impact factor:
Publication type: Review in international publication
Authors: Andrade, Fernanda; Duran-Lara, Esteban F; Rafael, Diana; Roca-Melendres, Maria Merce; Schwartz, Simo Jr et al.
DOI: 10.3390/cancers13051164

Utility of the Cobas((R)) Plasma Separation Card as a Sample Collection Device for Serological and Virological Diagnosis of Hepatitis C Virus Infection.

PMID: 33800211
Journal: Diagnostics
Year: 2021
Reference: Diagnostics (Basel). 2021 Mar 8;11(3). pii: diagnostics11030473. doi: 10.3390/diagnostics11030473.
Impact factor:
Publication type: Paper in international publication
Authors: Buti, Maria; Esteban, Angels; Martinez-Camprecios, Joan; Najarro-Centeno, Adrian; Pumarola-Sune, Tomas; Quer, Josep; Rando-Segura, Ariadna; Rodriguez-Frias, Francisco; Salmeron, Paula; Velasquez-Orozco, Fernando et al.
DOI: 10.3390/diagnostics11030473

EFFECT OF RAMIPRIL ON KIDNEY, LUNG AND HEART ACE2 IN A DIABETIC MICE MODEL.

PMID: 33811970
Journal: MOLECULAR AND CELLULAR ENDOCRINOLOGY
Year: 2021
Reference: Mol Cell Endocrinol. 2021 Jun 1;529:111263. doi: 10.1016/j.mce.2021.111263. Epub 2021 Mar 31.
Impact factor:
Publication type: Paper in international publication
Authors: Benito, Begona; Dominguez-Baez, Pamela; Garcia-Carro, Clara; Jacobs-Cacha, Conxita; Molina-Van den Bosch, Mireia; Seron, Daniel; Soler, Maria Jose; Vergara, Ander et al.
DOI: 10.1016/j.mce.2021.111263

Blog

News

Based on the study led by VHIR, a clinical trial has been approved for patients with locally advanced pancreatic cancer.

Vall d'Hebron participates in a project to develop innovative microsampling technology, making blood collection more accessible and patient-centered.

Researchers from all over Europe gathered to kick off the SPM4.0 project, an innovative Marie Curie Skłodowska (MSCA-DN) doctoral network that promotes the development of autonomous Scanning Probe Microscopy with AI.