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Hepato-bilio-pancreatic surgery (HBP) and liver transplantation

Until 2017, this group was constituted as a consolidated group in the VHIR under the name of "Digestive Transplants" with a consolidated research trajectory. Our group has two large areas of research: liver transplantation, which is cross-sectional adult-pediatric and; on the other hand, research, specifically in the fields of liver resections, liver cancer (primary or metastatic), biliary cancer, pancreatic cancer and pancreatitis. Both areas have very innovative aspects, with translational objectives, including artificial intelligence, transcriptomics and molecular biology.

The general objective of the liver transplant research area is to improve the preservation of liver grafts, as well as increase the survival of grafts and transplant patients. The research area related to cancer or acute pancreatitis has as a general objective to improve the management and treatment of patients with pancreatitis, as well as to improve the diagnosis and survival of cancer patients.

Team

Martín Huerta García

Martín Huerta García

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Paula Fernandez Perez

Paula Fernandez Perez

Research technician
Hepato-bilio-pancreatic surgery (HBP) and liver transplantation
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Piero Arturo Alberti Delgado

Piero Arturo Alberti Delgado

Predoctoral researcher
Hepato-bilio-pancreatic surgery (HBP) and liver transplantation
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Raquel Masip Arribas

Raquel Masip Arribas

Research technician
Hepato-bilio-pancreatic surgery (HBP) and liver transplantation
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Simone Mameli

Simone Mameli

Predoctoral researcher
Hepato-bilio-pancreatic surgery (HBP) and liver transplantation
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Concepción Gomez Gavara

Concepción Gomez Gavara

Main researcher
Hepato-bilio-pancreatic surgery (HBP) and liver transplantation
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Martín Huerta García

Martín Huerta García

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Paula Fernandez Perez

Paula Fernandez Perez

Research technician
Hepato-bilio-pancreatic surgery (HBP) and liver transplantation
Read more
Piero Arturo Alberti Delgado

Piero Arturo Alberti Delgado

Predoctoral researcher
Hepato-bilio-pancreatic surgery (HBP) and liver transplantation
Read more
Raquel Masip Arribas

Raquel Masip Arribas

Research technician
Hepato-bilio-pancreatic surgery (HBP) and liver transplantation
Read more
Simone Mameli

Simone Mameli

Predoctoral researcher
Hepato-bilio-pancreatic surgery (HBP) and liver transplantation
Read more
Concepción Gomez Gavara

Concepción Gomez Gavara

Main researcher
Hepato-bilio-pancreatic surgery (HBP) and liver transplantation
Read more

Research lines

Infusió intraportal de cèl·lules mare hepàtiques

Podria restaurar la ureagènesi en pacients pediàtrics amb trastorns del cicle de la urea.

IP: Jesús Quintero Bernabeu, Javier Juamperez Goñi, Maria Margaret Mercadal Hally

Intel·ligència Artificial i malalties pancreàtiques

- PancreatIA-EmergencyCare: Algoritme de predicció de la gravetat de la pancreatitis aguda utilitzant "machine learning" i processament de imatges.

- PancreatIA-Cancer: Algoritme de predicció de recurrència del càncer de pàncreas post- cirurgia utilitzant "machine learning" i processament de imatges així como las mutacions genètiques del tumor.

IP: Elizabeth Pando Rau, Joaquin Balsells Valls

L'aplicació de la intel.ligencia artificial en la cuantificació de la esteatosi hepática en el donants de fetge.

El desenvolupament de algoritmes de “machine learning” de forma objectiva, ràpida i reproduïble, per detectar i quantificar el grau d´esteatosi. També plataforma d´entrenament d´algoritmes amb dades i imatges médiques.

IP: Concepción Gomez Gavara, Itxarone Izaskun Bilbao Aguirre, Elizabeth Pando Rau

L'estudi de l'evolució a nivell histològic dels empelts hepàtics

La seva correlació  amb dades clíniques, analítiques, d'imatge i amb un panell de miRNA (miR-155-5p, miR-122-5p, miR-181a -5p, miR-148-3p ) podria permetre la individualització del tractament immunosupressor.

IP: Jesús Quintero Bernabeu, Javier Juamperez Goñi, Maria Margaret Mercadal Hally

Projects

THE APPLICATION OF ARTIFICIAL INTELLIGENCE METHODS FOR ORGANS ASSESSMENT

IP: Concepción Gomez Gavara
Collaborators: Ramon Charco Torra, Ernest Hidalgo Llompart, Enric Miret Alomar, Elizabeth Pando Rau
Funding agency: Agència Gestió Ajuts Universitaris i de Recerca
Funding: 0.01
Reference: 2021 SGR 01236
Duration: 01/01/2022 - 30/06/2025

Fisiologia i fisiopatologia digestiva

IP: Chaysavanh Manichanh
Collaborators: Itxarone Izaskun Bilbao Aguirre, Zaida Soler Luque, Jordi Barquinero Mañez, Oscar Segarra Canton, Gerard Serrano Gomez, Cristina Dopazo Taboada, Rocío Piñera Moreno
Funding agency: Agència Gestió Ajuts Universitaris i de Recerca
Funding: 40000
Reference: 2021 SGR 00459
Duration: 01/01/2022 - 30/06/2025

Modelos 3D innovadores derivados de tejido hepático humano para ensayos de desarrollo y toxicidad de fármacos

IP: Alberto Sandiumenge Camps
Collaborators: Ernest Hidalgo Llompart, Jesús Quintero Bernabeu
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 124939
Reference: CPP2021-008633
Duration: 01/09/2022 - 31/08/2025

Ministerio de Ciencia

TRANS-GENE - Caracterización en Sangre Periférica de una Firma Génica de Rechazo Humoral Común en Trasplantes de Órganos Sólidos.

IP: Maria Antonia Emilia Meneghini
Collaborators: Lluis Castells Fusté, Joana Sellarés Roig, Jesús Quintero Bernabeu, Eva Maria Revilla Lopez, Marina Muñoz López, Meritxell Boada Perez, Laura Donadeu Casassas
Funding agency: Instituto de Salud Carlos III
Funding: 111320
Reference: PI22/00749
Duration: 01/01/2023 - 31/12/2025

Publications

Impact of the COVID-19 pandemic in the early-onset colorectal cancer.

PMID: 37031602
Journal: Translational Oncology
Year: 2023
Reference: Transl Oncol. 2023 Jun;32:101668. doi: 10.1016/j.tranon.2023.101668. Epub 2023 Apr 5.
Impact factor:
Publication type: Paper in international publication
Authors: Baraibar, Iosune; Capdevila, Jaume; Castells, Marta R; Castillo, Gloria; Comas, Raquel; Comas, Raquel; Dopazo, Cristina; Elez, Elena; Espin, Eloy; Garcia, Ariadna et al.
DOI: 10.1016/j.tranon.2023.101668

Assessment of the level III of Inoue by preoperative endoscopic ultrasound and elastography: a novel approach to predict a periarterial divestment technique in borderline resectable (BR) or locally advanced (LA) pancreatic adenocarcinoma-How I do it.

PMID: 37731066
Journal: LANGENBECKS ARCHIVES OF SURGERY
Year: 2023
Reference: Langenbecks Arch Surg. 2023 Sep 21;408(1):367. doi: 10.1007/s00423-023-03105-x.
Impact factor:
Publication type: Paper in international publication
Authors: Abu-Suboh, Monder; Abu-Suboh, Monder; Alberti, Piero; Balsells, Joaquin; Balsells, Joaquin; Charco, Ramon; Charco, Ramon; Macarulla, Teresa; Macarulla, Teresa; Masachs, Miquel et al.
DOI: 10.1007/s00423-023-03105-x

Clinical effectiveness of routine first-trimester combined screening for pre-eclampsia in Spain with the addition of placental growth factor.

PMID: 37814344
Journal: ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
Year: 2023
Reference: Acta Obstet Gynecol Scand. 2023 Oct 9. doi: 10.1111/aogs.14687.
Impact factor:
Publication type: Paper in international publication
Authors: Armengol-Alsina, Mireia; Bonacina, Erika; Caamina, Sara; Carreras, Elena; Catalan, Sara; Dalmau, Marta; Del Barco, Ester; Garcia-Manau, Pablo; Hernandez, Alina; Lopez, Monica et al.
DOI: 10.1111/aogs.14687

Intestinal perforation after pediatric liver transplantation: risk factors and management.

PMID: 37093116
Journal: Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica
Year: 2023
Reference: Cir Pediatr. 2023 Apr 1;36(2):73-77. doi: 10.54847/cp.2023.02.14.
Impact factor:
Publication type: Paper in national publication
Authors: Barila, P; Bilbao, I; Charco, R; Hidalgo, E; Juamperez, J; Mercadal-Hally, M; Molino, J A; Ortega, J; Quintero, J et al.
DOI: 10.54847/cp.2023.02.14

Blog

News

The meeting was an opportunity to get to know projects from both institutions and to promote interaction between professionals.

The study also linked improved microbiota diversity to better liver function.

Over the course of two days, experts presented the latest advances in vectors, different gene modification techniques and their transfer to clinical practice.