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Hepato-bilio-pancreatic surgery (HBP) and liver transplantation

Until 2017, this group was constituted as a consolidated group in the VHIR under the name of "Digestive Transplants" with a consolidated research trajectory. Our group has two large areas of research: liver transplantation, which is cross-sectional adult-pediatric and; on the other hand, research, specifically in the fields of liver resections, liver cancer (primary or metastatic), biliary cancer, pancreatic cancer and pancreatitis. Both areas have very innovative aspects, with translational objectives, including artificial intelligence, transcriptomics and molecular biology.

The general objective of the liver transplant research area is to improve the preservation of liver grafts, as well as increase the survival of grafts and transplant patients. The research area related to cancer or acute pancreatitis has as a general objective to improve the management and treatment of patients with pancreatitis, as well as to improve the diagnosis and survival of cancer patients.

Team

Raquel Masip Arribas

Raquel Masip Arribas

Research technician
Hepato-bilio-pancreatic surgery (HBP) and liver transplantation
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Simone Mameli

Simone Mameli

Predoctoral researcher
Hepato-bilio-pancreatic surgery (HBP) and liver transplantation
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Concepción Gomez Gavara

Concepción Gomez Gavara

Head of group
Hepato-bilio-pancreatic surgery (HBP) and liver transplantation
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Ernest Hidalgo Llompart

Ernest Hidalgo Llompart

Main researcher
Hepato-bilio-pancreatic surgery (HBP) and liver transplantation
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Jesús Quintero Bernabeu

Jesús Quintero Bernabeu

Main researcher
Hepato-bilio-pancreatic surgery (HBP) and liver transplantation
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Laura Vidal Piñeiro

Laura Vidal Piñeiro

Research technician
Hepato-bilio-pancreatic surgery (HBP) and liver transplantation
Read more
Raquel Masip Arribas

Raquel Masip Arribas

Research technician
Hepato-bilio-pancreatic surgery (HBP) and liver transplantation
Read more
Simone Mameli

Simone Mameli

Predoctoral researcher
Hepato-bilio-pancreatic surgery (HBP) and liver transplantation
Read more
Concepción Gomez Gavara

Concepción Gomez Gavara

Head of group
Hepato-bilio-pancreatic surgery (HBP) and liver transplantation
Read more
Ernest Hidalgo Llompart

Ernest Hidalgo Llompart

Main researcher
Hepato-bilio-pancreatic surgery (HBP) and liver transplantation
Read more
Jesús Quintero Bernabeu

Jesús Quintero Bernabeu

Main researcher
Hepato-bilio-pancreatic surgery (HBP) and liver transplantation
Read more
Laura Vidal Piñeiro

Laura Vidal Piñeiro

Research technician
Hepato-bilio-pancreatic surgery (HBP) and liver transplantation
Read more

Research lines

L'estudi de la microbiota sobre trasplantament hepàtic

L'objectiu comprendre els tipus de microbiota intestinal en pacients cirròtics des del dia en què figuren en llista d'espera per al trasplantament hepàtic fins al primer any després del trasplantament.

IP: Itxarone Izaskun Bilbao Aguirre, Cristina Dopazo Taboada

L'estudi del perfil de microRNA com a biomarcador de dany hepàtic en diferents tipus de donants de fetge

L'objectiu es si existeix un perfil d'expressió diferencial entre donants, així com un biomarcador objectiu i precís de la viabilitat de l'empelt.

IP: Ramon Charco Torra, Concepción Gomez Gavara

Medicina personalitzada i càncer de pàncreas en fase localitzada

Rol de la endoscòpia en el tumor primari per la detecció de perfil genètic tumoral. 

IP: Elizabeth Pando Rau, Joaquin Balsells Valls

Milloria en la presevacio i recuperacio d'organs

IP: Ernest Hidalgo Llompart, Mireia Caralt Barba

Projects

LIVERCOLOR: algoritmo de cuantificación de esteatosis hepática utilizando machine learning y procesamiento de imágenes.

IP: Concepción Gomez Gavara
Collaborators: Itxarone Izaskun Bilbao Aguirre
Funding agency: Instituto de Salud Carlos III
Funding: 90200
Reference: DTS22/00178
Duration: 01/01/2023 - 31/12/2025

"LIVERCOLOR": ALGORITMO DE CUANTIFICACIÓN DE ESTEATOSIS HEPÁTICA UTILIZANDO "MACHINE LEARNING" Y PROCESAMIENTO DE IMÁGENES.

IP: Concepción Gomez Gavara
Collaborators: -
Funding agency: Instituto de Salud Carlos III
Funding: 32670
Reference: PI20/00552
Duration: 01/01/2021 - 30/06/2025

Aislamiento y caracterización molecular de Células Tumorales Circulantes (CTCs): potenciales biomarcadores en Carcinoma Hepatocelular

IP: Beatriz Minguez Rosique
Collaborators: Itxarone Izaskun Bilbao Aguirre, Elena Vargas Accarino, Maria Teresa Salcedo Allende, Monica Higuera Urbano
Funding agency: Instituto de Salud Carlos III
Funding: 183920
Reference: PI21/00714
Duration: 01/01/2022 - 31/12/2025

Publications

Routine Imaging or Symptomatic Follow-Up After Resection of Pancreatic Adenocarcinoma.

PMID: 39504033
Journal: JAMA Surgery
Year: 2024
Reference: JAMA Surg. 2024 Nov 6. doi: 10.1001/jamasurg.2024.5024.
Impact factor:
Publication type: Paper in international publication
Authors: Andel, Paul C M; Augustinus, Simone; Berrevoet, Frederik; Besselink, Marc G; Bhojwani, Rajesh; Boggi, Ugo; Bouwense, Stefan A W; Cirkel, Geert A; Daamen, Lois A; de Meijer, Vincent E et al.
DOI: 10.1001/jamasurg.2024.5024

Prediction of Severe Acute Pancreatitis at a Very Early Stage of the Disease Using Artificial Intelligence Techniques, Without Laboratory Data or Imaging Tests: The PANCREATIA Study.

PMID: 39498559
Journal: ANNALS OF SURGERY
Year: 2024
Reference: Ann Surg. 2024 Nov 5. doi: 10.1097/SLA.0000000000006579.
Impact factor:
Publication type: Paper in international publication
Authors: Alberti, Piero; Blanco, Laia; Charco, Ramon; Cordobes, Miguel Angel; Fernandes, Nair; Gomez-Gavara, Concepcion; Martinez, Maria; Pando, Elizabeth; Perez, Marc; Piella, Gemma et al.
DOI: 10.1097/SLA.0000000000006579

Successful Ex Situ Reduction During Hypothermic Oxygenated Machine Perfusion in a Severely Steatotic Graft From a Donor After Brain Death: An Anecdote?

PMID: 39810582
Journal: Experimental and Clinical Transplantation
Year: 2024
Reference: Exp Clin Transplant. 2024 Dec;22(12):957-960. doi: 10.6002/ect.2024.0224.
Impact factor:
Publication type: Paper in international publication
Authors: Caralt Barba, Mireia; Dopazo Toboada, Cristina; Fernandes Montes, Nair S; Hidalgo Llompart, Ernest; Pichardo Merejildo, Karem O; Salcedo Allende, Maria T; Vidal Pineiro, Laura et al.
DOI: 10.6002/ect.2024.0224

Robot-Assisted Versus Laparoscopic Distal Pancreatectomy in Patients with Resectable Pancreatic Cancer: An International, Retrospective, Cohort Study.

PMID: 36800127
Journal: ANNALS OF SURGICAL ONCOLOGY
Year: 2023
Reference: Ann Surg Oncol. 2023 May;30(5):3023-3032. doi: 10.1245/s10434-022-13054-2. Epub 2023 Feb 17.
Impact factor:
Publication type: Paper in international publication
Authors: Abu Hilal, Mohammad; Al-Sarireh, Bilal; Aussilhou, Beatrice; Besselink, Marc G; Bjornsson, Bergthor; Boggi, Ugo; Burdio, Fernando; Butturini, Giovanni; Casadei, Riccardo; Chen, Jeffrey W et al.
DOI: 10.1245/s10434-022-13054-2

ASO Visual Abstract: Robot-Assisted Versus Laparoscopic Distal Pancreatectomy in Patients with Resectable Pancreatic Cancer-An International Retrospective Cohort Study.

PMID: 36809605
Journal: ANNALS OF SURGICAL ONCOLOGY
Year: 2023
Reference: Ann Surg Oncol. 2023 May;30(5):3035-3037. doi: 10.1245/s10434-023-13161-8.
Impact factor:
Publication type: Paper in international publication
Authors: Al-Sarireh, Bilal; Aussilhou, Beatrice; Besselink, Marc G; Bjornsson, Bergthor; Boggi, Ugo; Burdio, Fernando; Butturini, Giovanni; Casadei, Riccardo; Chen, Jeffrey W; Coratti, Andrea et al.
DOI: 10.1245/s10434-023-13161-8

The role of high serum triglyceride levels on pancreatic necrosis development and related complications.

PMID: 36829113
Journal: BMC GASTROENTEROLOGY
Year: 2023
Reference: BMC Gastroenterol. 2023 Feb 24;23(1):51. doi: 10.1186/s12876-023-02684-9.
Impact factor:
Publication type: Paper in international publication
Authors: Adell, Montse; Alberti, Piero; Balsells, Joaquim; Blanco, Laia; Charco, Ramon; Fernandes, Nair; Hidalgo, Nils Jimmy; Mata, Rodrigo; Pando, Elizabeth; Villasante, Sara et al.
DOI: 10.1186/s12876-023-02684-9

Liver transplantation in metastatic colorectal cancer: are we ready for it?

PMID: 36879000
Journal: BRITISH JOURNAL OF CANCER
Year: 2023
Reference: Br J Cancer. 2023 May;128(10):1797-1806. doi: 10.1038/s41416-023-02213-1. Epub 2023 Mar 6.
Impact factor:
Publication type: Review in international publication
Authors: Baraibar, Iosune; Charco, Ramon; Dopazo, Cristina; Elez, Elena; Lopez, Daniel; Ros, Javier; Salva, Francesc; Saoudi, Nadia; Tabernero, Josep et al.
DOI: 10.1038/s41416-023-02213-1

Myosin Vb as a tumor suppressor gene in intestinal cancer.

PMID: 36316444
Journal: ONCOGENE
Year: 2022
Reference: Oncogene. 2022 Dec;41(49):5279-5288. doi: 10.1038/s41388-022-02508-2. Epub 2022 Nov 1.
Impact factor:
Publication type: Paper in international publication
Authors: Anguita, Estefania; Arango, Diego; Brotons, Bruno; Carton-Garcia, Fernando; Dalmau, Mariona; Dopeso, Higinio; Garcia-Vidal, Elia; Hernandez-Losa, Javier; Landolfi, Stefania; Macaya, Irati et al.
DOI: 10.1038/s41388-022-02508-2

A case of pylephlebitis complicating an acute appendicitis: Uncommon cholangitis-like situation.

PMID: 36162358
Journal: International journal of surgery case reports
Year: 2022
Reference: Int J Surg Case Rep. 2022 Oct;99:107657. doi: 10.1016/j.ijscr.2022.107657. Epub 2022 Sep 15.
Impact factor:
Publication type: Letter or abstract
Authors: Armengol, Manel; Dalmau, Mar; Garcia Ruiz de Gordejuela, Amador; Lopez, Pablo; Petrola, Carlos; Vilallonga, Ramon et al.
DOI: 10.1016/j.ijscr.2022.107657

Use of failure-to-rescue after emergency surgery as a dynamic indicator of hospital resilience during the COVID-19 pandemic. A multicenter retrospective propensity score-matched cohort study.

PMID: 36089261
Journal: International Journal of Surgery
Year: 2022
Reference: Int J Surg. 2022 Oct;106:106890. doi: 10.1016/j.ijsu.2022.106890. Epub 2022 Sep 9.
Impact factor:
Publication type: Paper in international publication
Authors: Aldeano, Aurora; Artigau, Eva; Biondo, Sebastiano; Calle, Miguel; Campillo, Beatriz; Campos, Andrea; Clavell, Arantxa; Echenagusia, Victor; Garcia-Ruiz-de-Gordejuela, Amador; Gil-Barrionuevo, Marta et al.
DOI: 10.1016/j.ijsu.2022.106890

Impact of Preoperative Chemotherapy Features on Patient Outcomes after Hepatectomy for Initially Unresectable Colorectal Cancer Liver Metastases: A LiverMetSurvey Analysis.

PMID: 36077874
Journal: Cancers
Year: 2022
Reference: Cancers (Basel). 2022 Sep 5;14(17). pii: cancers14174340. doi: 10.3390/cancers14174340.
Impact factor:
Publication type: Paper in international publication
Authors: Adam, Rene; Allard, Marc-Antoine; Cailliez, Valerie; Chen, Jinn-Shiun; Chibaudel, Benoist; Costa-Maia, Jose; Cugat, Esteban; de Gramont, Aimery; Dopazo, Cristina; Ferrero, Alessandro et al.
DOI: 10.3390/cancers14174340

Low seroprevalence of SARS-CoV-2 antibodies in a liver transplant cohort.

PMID: 34121244
Journal: TRANSPLANT INTERNATIONAL
Year: 2021
Reference: Transpl Int. 2021 Oct;34(10):1908-1913. doi: 10.1111/tri.13946. Epub 2021 Jul 27.
Impact factor:
Publication type: Paper in international publication
Authors: Anton, Andres; Campos-Varela, Isabel; Castells, Lluis; Dopazo, Cristina; Esperalba, Juliana; Len, Oscar; Los-Arcos, Ibai; Marquez-Algaba, Ester; Villagrasa, Ares et al.
DOI: 10.1111/tri.13946

The role of liver steatosis as measured with transient elastography and transaminases on hard clinical outcomes in patients with COVID-19.

PMID: 34104210
Journal: Therapeutic Advances in Gastroenterology
Year: 2021
Reference: Therap Adv Gastroenterol. 2021 May 30;14:17562848211016567. doi: 10.1177/17562848211016567. eCollection 2021.
Impact factor:
Publication type: Paper in international publication
Authors: Aguilera-Castro, Lara; Alvarez-Lopez, Patricia; Anton, Adrian; Augustin, Salvador; Banares, Juan; Barber, Claudia; Barreira-Diaz, Ana; Biagetti, Betina; Campos-Varela, Isabel; Camps-Relats, Laura et al.
DOI: 10.1177/17562848211016567

Radiofrequency ablation and chemotherapy versus chemotherapy alone for locally advanced pancreatic cancer (PELICAN): study protocol for a randomized controlled trial.

PMID: 33926539
Journal: Trials
Year: 2021
Reference: Trials. 2021 Apr 29;22(1):313. doi: 10.1186/s13063-021-05248-y.
Impact factor:
Publication type: Paper in international publication
Authors: Besselink, M G; Borel Rinkes, I H; Bosscha, K; Brada, L J H; Bruijnen, R C; Busch, O R; Creemers, G J; D'Hondt, M; Daams, F; de Groot, D J et al.
DOI: 10.1186/s13063-021-05248-y

Use of endoluminal vacuum-assisted therapy for treatment of gastric fistula after Appleby procedure.

PMID: 33234232
Journal: CIRUGIA ESPANOLA
Year: 2021
Reference: Cir Esp. 2021 Apr;99(4):316-319. doi: 10.1016/j.ciresp.2020.10.006. Epub 2020 Nov 21.
Impact factor:
Publication type: Letter whit IF
Authors: Curell Garcia, Anna; Dopazo Taboada, Cristina; Dot Bach, Joan; Pando Rau, Elizabeth; Pando Rau, Elizabeth; Tudela, Arturo Cirera de et al.
DOI: 10.1016/j.ciresp.2020.10.006

Transition to Adult Care for Pediatric Liver Transplant Recipients.

PMID: 32247593
Journal: TRANSPLANTATION PROCEEDINGS
Year: 2020
Reference: Transplant Proc. 2020 Jun;52(5):1496-1499. doi: 10.1016/j.transproceed.2020.02.056. Epub 2020 Apr 1.
Impact factor:
Publication type: Paper in international publication
Authors: Castells, Lluis; Charco, Ramon; Juamperez, Javier; Larrarte, Mauricio; Mercadal-Hally, Maria; Quintero, Jesus; Vidal, Lis et al.
DOI: 10.1016/j.transproceed.2020.02.056

Successful Treatment with Rituximab and Immunoadsorption for an Auto-Antibody Induced Bile Salt Export Pump Deficiency in a Liver Transplanted Patient.

PMID: 32206630
Journal: Pediatric gastroenterology, hepatology & nutrition
Year: 2020
Reference: Pediatr Gastroenterol Hepatol Nutr. 2020 Mar;23(2):174-179. doi: 10.5223/pghn.2020.23.2.174. Epub 2020 Mar 4.
Impact factor:
Publication type: Letter or abstract
Authors: Charco, Ramon; Collado-Hilly, Mauricette; Gonzales, Emmanuel; Juamperez, Javier; Julio, Ecaterina; Marin-Sanchez, Ana; Mercadal-Hally, Maria; Quintero, Jesus et al.
DOI: 10.5223/pghn.2020.23.2.174

Liver Transplantation with "Hors Tour" Allocated Versus Standard MELD Allocated Grafts: Single-Center Audit and Impact on the Liver Pool in France.

PMID: 31832704
Journal: WORLD JOURNAL OF SURGERY
Year: 2020
Reference: World J Surg. 2020 Mar;44(3):912-924. doi: 10.1007/s00268-019-05271-w.
Impact factor:
Publication type: Paper in international publication
Authors: Azoulay, Daniel; Compagnon, Philippe; Disabato, Mara; Feray, Cyrille; Gomez-Gavara, Concepcion; Hentati, Hassen; Levesque, Eric; Lim, Chetana; Ngonggang, Norbert; Salloum, Chady et al.
DOI: 10.1007/s00268-019-05271-w

Endoscopic variceal ligation as primary prophylaxis for upper GI bleeding in children.

PMID: 32119939
Journal: GASTROINTESTINAL ENDOSCOPY
Year: 2020
Reference: Gastrointest Endosc. 2020 Aug;92(2):269-275. doi: 10.1016/j.gie.2020.02.035. Epub 2020 Feb 29.
Impact factor:
Publication type: Paper in international publication
Authors: Abu-Suboh, Monder; Armengol, Josep Ramon; Bernabeu, Jesus Quintero; Charco, Ramon; Dot, Joan; Juamperez, Javier; King, Mauricio Larrarte; Mercadal-Hally, Maria; Molino, Jose A; Montferrer, Nuria et al.
DOI: 10.1016/j.gie.2020.02.035

Different approaches to liver transplantation in propionic acidemia patients.

PMID: 30472769
Journal: LIVER TRANSPLANTATION
Year: 2019
Reference: Liver Transpl. 2019 Jan;25(1):178-179. doi: 10.1002/lt.25389.
Impact factor:
Publication type: Letter or abstract
Authors: Bilbao, Itxarone; Charco, Ramon; Del Toro, Mireia; Garcia, Angels; Garcia, Camila; Juamperez, Javier; Martin de Carpi, Javier; Meavilla, Silvia; Molera, Cristina; Nunez, Raquel et al.
DOI: 10.1002/lt.25389

"The role of Molecular Adsorbent Recirculating System in Pediatric Acute Liver Failure".

PMID: 29080238
Journal: LIVER TRANSPLANTATION
Year: 2018
Reference: Liver Transpl. 2018 Feb;24(2):308-310. doi: 10.1002/lt.24966.
Impact factor:
Publication type: Paper in international publication
Authors: Bilbao Aguirre, Itxarone; Charco Torra, Ramon; Juamperez Goni, Javier; Julio Tatis, Ecaterina; Mercadal, Maria; Ortega Lopez, Juan; Quintero Bernabeu, Jesus; Rodrigo Gonzalo de Liria, Carlos et al.
DOI: 10.1002/lt.24966

Successful long-term outcome of pediatric liver-kidney transplantation: a single-center study.

PMID: 28842757
Journal: PEDIATRIC NEPHROLOGY
Year: 2018
Reference: Pediatr Nephrol. 2018 Feb;33(2):351-358. doi: 10.1007/s00467-017-3782-5. Epub 2017 Aug 25.
Impact factor:
Publication type: Paper in international publication
Authors: Ariceta, Gema; Asensio, Marino; Bilbao, Itxarone; Charco, Ramon; Juamperez, Javier; Molino, Jose A; Munoz, Marina; Quintero Bernabeu, Jesus; Rodrigo, Carlos; Rodriguez, Olalla et al.
DOI: 10.1007/s00467-017-3782-5

Conversion from twice-daily to once-daily tacrolimus formulation in pediatric liver transplant recipients.

PMID: 28833714
Journal: TRANSPLANT INTERNATIONAL
Year: 2018
Reference: Transpl Int. 2018 Jan;31(1):38-44. doi: 10.1111/tri.13037. Epub 2017 Sep 27.
Impact factor:
Publication type: Paper in international publication
Authors: Bilbao, Itxarone; Castells, Lluis; Charco, Ramon; Juamperez, Javier; Molino, Jose A; Ortega, Juan; Quintero, Jesus; Rodrigo, Carlos et al.
DOI: 10.1111/tri.13037

Outcome of patients following hepatic resection for metastatic cutaneous and ocular melanoma.

PMID: 21057964
Journal: Journal of Hepato-Biliary-Pancreatic Sciences
Year: 2011
Reference: J Hepatobiliary Pancreat Sci. 2011 Mar;18(2):268-75.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1007/s00534-010-0341-x

Blog

News

The consensus establishes recommendations that could correct the current disparities related to muscle mass, weight and height and would allow for more precise prioritization of patients who require transplants more urgently.

The meeting was an opportunity to get to know projects from both institutions and to promote interaction between professionals.

The study also linked improved microbiota diversity to better liver function.