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Hepato-bilio-pancreatic surgery (HBP) and liver transplantation

Until 2017, this group was constituted as a consolidated group in the VHIR under the name of "Digestive Transplants" with a consolidated research trajectory. Our group has two large areas of research: liver transplantation, which is cross-sectional adult-pediatric and; on the other hand, research, specifically in the fields of liver resections, liver cancer (primary or metastatic), biliary cancer, pancreatic cancer and pancreatitis. Both areas have very innovative aspects, with translational objectives, including artificial intelligence, transcriptomics and molecular biology.

The general objective of the liver transplant research area is to improve the preservation of liver grafts, as well as increase the survival of grafts and transplant patients. The research area related to cancer or acute pancreatitis has as a general objective to improve the management and treatment of patients with pancreatitis, as well as to improve the diagnosis and survival of cancer patients.

Research lines

Transcriptómica molecular en model clínic de càncer de pàncreas i lesions premalignas

Estudi INVISIBLE (Detecció de DNA tumoral per biòpsia líquida en cirurgia del càncer de pàncreas), Estudio: Biòpsia líquida en lesions pre-malignas IPMN i  N. quística Mucinosa.

IP: Elizabeth Pando Rau, Joaquin Balsells Valls

Ús del Verd de Indiocianina en la detecció de tumors hepàtics durant la cirurgia guiada per la imatge

Avaluar l´ús de l´ICG per la identificació de noves lesions i comportament tumoral de manera intraoperatòria.

IP: Ernest Hidalgo Llompart, Concepción Gomez Gavara

Publications

Impact of the COVID-19 pandemic in the early-onset colorectal cancer.

PMID: 37031602
Journal: Translational Oncology
Year: 2023
Reference: Transl Oncol. 2023 Jun;32:101668. doi: 10.1016/j.tranon.2023.101668. Epub 2023 Apr 5.
Impact factor:
Publication type: Paper in international publication
Authors: Baraibar, Iosune; Capdevila, Jaume; Castells, Marta R; Castillo, Gloria; Comas, Raquel; Comas, Raquel; Dopazo, Cristina; Elez, Elena; Espin, Eloy; Garcia, Ariadna et al.
DOI: 10.1016/j.tranon.2023.101668

Assessment of the level III of Inoue by preoperative endoscopic ultrasound and elastography: a novel approach to predict a periarterial divestment technique in borderline resectable (BR) or locally advanced (LA) pancreatic adenocarcinoma-How I do it.

PMID: 37731066
Journal: LANGENBECKS ARCHIVES OF SURGERY
Year: 2023
Reference: Langenbecks Arch Surg. 2023 Sep 21;408(1):367. doi: 10.1007/s00423-023-03105-x.
Impact factor:
Publication type: Paper in international publication
Authors: Abu-Suboh, Monder; Abu-Suboh, Monder; Alberti, Piero; Balsells, Joaquin; Balsells, Joaquin; Charco, Ramon; Charco, Ramon; Macarulla, Teresa; Macarulla, Teresa; Masachs, Miquel et al.
DOI: 10.1007/s00423-023-03105-x

International Liver Transplantation Society Global Census: First Look at Pediatric Liver Transplantation Activity Around the World.

PMID: 37750781
Journal: TRANSPLANTATION
Year: 2023
Reference: Transplantation. 2023 Oct 1;107(10):2087-2097. doi: 10.1097/TP.0000000000004644. Epub 2023 Sep 25.
Impact factor:
Publication type: Paper in international publication
Authors: Anand; Antonini, Teresa M; Apinyachon, Worapot; Arnon, Ronen; Bakar Hafeez Bhatti, Abu; Balci, Deniz; Bedregal-Mendoza, Tayana; Bellemare, Sarah; Bhalerao, Suryabhan; Boillot, Olivier et al.
DOI: 10.1097/TP.0000000000004644

Intestinal perforation after pediatric liver transplantation: risk factors and management.

PMID: 37093116
Journal: Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica
Year: 2023
Reference: Cir Pediatr. 2023 Apr 1;36(2):73-77. doi: 10.54847/cp.2023.02.14.
Impact factor:
Publication type: Paper in national publication
Authors: Barila, P; Bilbao, I; Charco, R; Hidalgo, E; Juamperez, J; Mercadal-Hally, M; Molino, J A; Ortega, J; Quintero, J et al.
DOI: 10.54847/cp.2023.02.14

Beneficial effect of ursodeoxycholic acid in patients with acyl-CoA oxidase 2 (ACOX2) deficiency-associated hypertransaminasemia.

PMID: 35395098
Journal: HEPATOLOGY
Year: 2022
Reference: Hepatology. 2022 Nov;76(5):1259-1274. doi: 10.1002/hep.32517. Epub 2022 Jul 1.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso-Pena, Marta; Andrade, Raul J; Briz, Oscar; Bujanda, Luis; Cagigal, Maria Luisa; Calvo Sanchez, Marta; Crespo, Javier; D Avola, Delia; Diago, Moises; Diaz-Gonzalez, Alvaro et al.
DOI: 10.1002/hep.32517

The role of procalcitonin as a prognostic factor for acute cholangitis and infections in acute pancreatitis: a prospective cohort study from a European single center.

PMID: 34802942
Journal: HPB
Year: 2022
Reference: HPB (Oxford). 2022 Jun;24(6):875-884. doi: 10.1016/j.hpb.2021.10.016. Epub 2021 Nov 1.
Impact factor:
Publication type: Paper in international publication
Authors: Alberti, Piero; Balsells, Joaquim; Blanco, Laia; Caralt, Mireia; Charco, Ramon; Cirera, Arturo; Dopazo, Cristina; Fernandes, Nair; Gomez, Concepcion; Gomez-Jurado, Maria J et al.
DOI: 10.1016/j.hpb.2021.10.016

The impact of advanced patient age in liver transplantation: a European Liver Transplant Registry propensity-score matching study.

PMID: 34872865
Journal: HPB
Year: 2022
Reference: HPB (Oxford). 2022 Jun;24(6):974-985. doi: 10.1016/j.hpb.2021.11.007. Epub 2021 Nov 17.
Impact factor:
Publication type: Paper in international publication
Authors: Adam, Rene; Azoulay, Daniel; Boudjema, Karim; Cherqui, Daniel; Esono, Daniel; Esposito, Francesco; Feray, Cyrille; Fondevila, Constantino; Gomez-Gavara, Concepcion; Heneghan, Michael et al.
DOI: 10.1016/j.hpb.2021.11.007

EASY-APP: An artificial intelligence model and application for early and easy prediction of severity in acute pancreatitis.

PMID: 35653504
Journal: Clinical and Translational Medicine
Year: 2022
Reference: Clin Transl Med. 2022 Jun;12(6):e842. doi: 10.1002/ctm2.842.
Impact factor:
Publication type: Paper in international publication
Authors: Alberti, Piero; Bajor, Judit; Czimmer, Jozsef; de-Madaria, Enrique; Eross, Balint; Farkas, Hunor; Farkas, Nelli; Feher, Eszter; Fejes, Roland; Foldi, Ildiko et al.
DOI: 10.1002/ctm2.842

Infectious complications of non-surgical biliary tract manipulation in paediatric patients. Role of antibiotic prophylaxis.

PMID: 33715879
Journal: ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
Year: 2021
Reference: Enferm Infecc Microbiol Clin (Engl Ed). 2021 Mar 11. pii: S0213-005X(21)00045-8. doi: 10.1016/j.eimc.2021.01.019.
Impact factor:
Publication type: Paper in national publication
Authors: Juamperez-Gomi, Javier; Lung, Mayli; Melendo, Susana; Mendoza-Palomar, Natalia; Mercadal-Hally, Maria; Perez, Maria Mercedes; Quintero, Jesus; Soler-Palacin, Pere; Soria-Navarro, Beatriz et al.
DOI: 10.1016/j.eimc.2021.01.019

Prescription quality of prolonged antibiotherapy in pediatrics. Impact of ASP program interventions.

PMID: 32229130
Journal: ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
Year: 2021
Reference: Enferm Infecc Microbiol Clin. 2021 Mar;39(3):134-138. doi: 10.1016/j.eimc.2020.02.015. Epub 2020 Mar 27.
Impact factor:
Publication type: Paper in national publication
Authors: Alonso Garcia, Laura; Barnes-Mayolas, Meritxell; Castellnou Asens, Ivette; Castilla Fernandez, Yolanda; Estrella Barcelo, Maria; Fernandez Polo, Aurora; Fernandez-Polo, Aurora; Lopez Fernandez, Sergio; Melendo Perez, Susana; Melendo, Susana et al.
DOI: 10.1016/j.eimc.2020.02.015

Does Routine Abdominal Drain Tip Culture Anticipate Post-Operative Infection in Liver Transplantation?

PMID: 32429799
Journal: Surgical Infections
Year: 2021
Reference: Surg Infect (Larchmt). 2021 Mar;22(2):222-226. doi: 10.1089/sur.2020.031. Epub 2020 May 20.
Impact factor:
Publication type: Paper in international publication
Authors: Castells, Lluis; Gomez-Gavara, Concepcion; Hidalgo, Ernesto; Len, Oscar; Los-Arcos, Ibai; Lung, Mayli; Nuvials, Xavier; Perez-Cameo, Cristina; Vargas, Victor et al.
DOI: 10.1089/sur.2020.031

Expanding Indications of Liver Transplantation in Spain: Consensus Statement and Recommendations by the Spanish Society of Liver Transplantation.

PMID: 32345868
Journal: TRANSPLANTATION
Year: 2021
Reference: Transplantation. 2021 Mar 1;105(3):602-607. doi: 10.1097/TP.0000000000003281.
Impact factor:
Publication type: Paper in international publication
Authors: Bilbao, Itxarone; Colmenero, Jordi; De la Rosa, Gloria; Gomez-Bravo, Miguel Angel; Rodriguez-Peralvarez, Manuel; Sanchez-Antolin, Gloria et al.
DOI: 10.1097/TP.0000000000003281

Blog

News

The consensus establishes recommendations that could correct the current disparities related to muscle mass, weight and height and would allow for more precise prioritization of patients who require transplants more urgently.

The meeting was an opportunity to get to know projects from both institutions and to promote interaction between professionals.

The study also linked improved microbiota diversity to better liver function.