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Infection and Immunity in pediatric patients

The Infection and Immunity in pediatric patients research group is a multidisciplinary pediatric research group made up of health professionals involved in translational research in the field of pediatric infectious diseases and immunodeficiencies, two related fields in terms of pathophysiology and clinical implications. It is a consolidated research group recognized by the AGAUR and is the only one with the accreditation of the Jeffrey Modell Foundation in research in the field of primary immunodeficiencies throughout the state.

The group was officially created in 2010, belongs to the area of Infectious Diseases and participates in the transversal programs of Advanced Translational Immunology and Rare Diseases and actively participates in national and international competitive projects, carries out multiple academic and industry-linked clinical trials and has increased the number and quality in recent years. In addition, it has its own laboratory specially dedicated to advanced immune studies.

Publications

Higher COVID-19 pneumonia risk associated with anti-IFN-alpha than with anti-IFN-omega auto-Abs in children.

PMID: 38175961
Journal: JOURNAL OF EXPERIMENTAL MEDICINE
Year: 2024
Reference: J Exp Med. 2024 Feb 5;221(2):e20231353. doi: 10.1084/jem.20231353. Epub 2024 Jan 4.
Impact factor:
Publication type: Paper in international publication
Authors: Abel, Laurent; Abi Haidar, Anthony; Abolhassani, Hassan; Ahlijah, Gloria; Andreakos, Evangelos; Arseguel, Vincent; Asano, Takaki; Bastard, Paul; Belot, Alexandre; Beziat, Vivien et al.
DOI: 10.1084/jem.20231353

Correction: Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19.

PMID: 38184654
Journal: Genome Medicine
Year: 2024
Reference: Genome Med. 2024 Jan 6;16(1):6. doi: 10.1186/s13073-023-01278-0.
Impact factor:
Publication type: Other (letters to the editor, abstracts, corrigendum, etc.)
Authors: Abel, Laurent; Abolhassani, Hassan; Aiuti, Alessandro; Akcan, Ozge Metin; Al-Muhsen, Saleh Zaid; Allende, Luis M; Alonso-Arias, Rebeca; Alosaimi, Mohammed Faraj; Alsohime, Fahad M; Arias, Andres Augusto et al.
DOI: 10.1186/s13073-023-01278-0

TALAPRO-3 clinical trial protocol: phase III study of talazoparib plus enzalutamide in metastatic castration-sensitive prostate cancer.

PMID: 37882449
Journal: Future Oncology
Year: 2023
Reference: Future Oncol. 2023 Oct 26. doi: 10.2217/fon-2023-0526.
Impact factor:
Publication type: Paper in international publication
Authors: Agarwal, Neeraj; Alonso, Lucia; Azad, Arun A; Bordas, Anna; Casabona, Jordi; Chakrabarti, Jayeta; Chen, Hsiang-Chun; Colom-Cadena, Andreu; Fizazi, Karim; Ganem, Fabiana et al.
DOI: 10.2217/fon-2023-0526

Transmitted Drug Resistance and HIV Diversity Among Adolescents Newly Diagnosed With HIV in Spain.

PMID: 37922511
Journal: PEDIATRIC INFECTIOUS DISEASE JOURNAL
Year: 2023
Reference: Pediatr Infect Dis J. 2023 Nov 3. doi: 10.1097/INF.0000000000004138.
Impact factor:
Publication type: Paper in international publication
Authors: Beltran-Pavez, Carolina; Epalza, Cristina; Fortuny, Claudia; Frick, Marie Antoinette; Gonzalez-Alba, Jose Maria; Gutierrez-Lopez, Miguel; Holguin, Africa; Moreno, Santiago; Munoz Medina, Leopoldo; Navarro, Maria Luisa et al.
DOI: 10.1097/INF.0000000000004138

Response to the letter entitled 'On finding acceptance'.

PMID: 37925847
Journal: ESMO Open
Year: 2023
Reference: ESMO Open. 2023 Nov 3;8(6):102059. doi: 10.1016/j.esmoop.2023.102059.
Impact factor:
Publication type: Other (letters to the editor, abstracts, corrigendum, etc.)
Authors: Amaral, T; Beltran-Pavez, Carolina; Epalza, Cristina; Fortuny, Claudia; Frick, Marie Antoinette; Gonzalez-Alba, Jose Maria; Gutierrez-Lopez, Miguel; Holguin, Africa; Lambertini, M; Lim, K H J et al.
DOI: 10.1016/j.esmoop.2023.102059

Prevalence and morbidity of urogenital schistosomiasis among pre-school age children in Cubal, Angola.

PMID: 37939154
Journal: PLoS Neglected Tropical Diseases
Year: 2023
Reference: PLoS Negl Trop Dis. 2023 Nov 8;17(11):e0011751. doi: 10.1371/journal.pntd.0011751.
Impact factor:
Publication type: Paper in international publication
Authors: Aixut, Sandra; Bargues, Ma Dolores; Bocanegra, Cristina; Espiau, Maria; Fernandez-Polo, Aurora; Martinez-Camprecios, Joan; Mas-Coma, Santiago; Molina, Israel; Mossalilo, Patricia; Nindia, Arlette et al.
DOI: 10.1371/journal.pntd.0011751

Case Report: X-Linked SASH3 Deficiency Presenting as a Common Variable Immunodeficiency.

PMID: 35464398
Journal: Frontiers in Immunology
Year: 2022
Reference: Front Immunol. 2022 Apr 8;13:881206. doi: 10.3389/fimmu.2022.881206. eCollection 2022.
Impact factor:
Publication type: Paper in international publication
Authors: Aguilo-Cucurull, Aina; Antolin, Maria; Colobran, Roger; Franco-Jarava, Clara; Garcia-Prat, Marina; Labrador-Horrillo, Moises; Martinez-Gallo, Monica; Parra-Martinez, Alba; Salgado-Perandres, Sandra et al.
DOI: 10.3389/fimmu.2022.881206

Epstein-Barr virus-associated risk factors for post-transplant lymphoproliferative disease in pediatric liver transplant recipients.

PMID: 35466492
Journal: PEDIATRIC TRANSPLANTATION
Year: 2022
Reference: Pediatr Transplant. 2022 Sep;26(6):e14292. doi: 10.1111/petr.14292. Epub 2022 Apr 24.
Impact factor:
Publication type: Paper in international publication
Authors: Bilbao Aguirre, Itxarone; Camacho Soriano, Jessica; Charco Torra, Itzarone; Esperalba, Juliana; Gallego Melcon, Soledad; Garrido Pontnou, Marta; Gros Subias, Luis; Hidalgo Llompart, Ernest; Juamperez, Javier; Larrarte King, Mauricio et al.
DOI: 10.1111/petr.14292

Tobacco Smoking and Second-Hand Smoke Exposure Impact on Tuberculosis in Children.

PMID: 35407608
Journal: Journal of Clinical Medicine
Year: 2022
Reference: J Clin Med. 2022 Apr 2;11(7). pii: jcm11072000. doi: 10.3390/jcm11072000.
Impact factor:
Publication type: Paper in international publication
Authors: Altet, Neus; Comella-Del-Barrio, Patricia; de Souza-Galvao, Maria Luiza; Dominguez, Jose; Godoy, Pere; Jimenez-Fuentes, Maria Angeles; Jimenez-Ruiz, Carlos A; Latorre, Irene; Mila, Celia; Millet, Joan-Pau et al.
DOI: 10.3390/jcm11072000

Studying severe long COVID to understand post-infectious disorders beyond COVID-19.

PMID: 35383311
Journal: NATURE MEDICINE
Year: 2022
Reference: Nat Med. 2022 Apr 5. pii: 10.1038/s41591-022-01766-7. doi: 10.1038/s41591-022-01766-7.
Impact factor:
Publication type: Letter or abstract
Authors: Abel, Laurent; Aiuti, Alessandro; Al-Muhsen, Saleh; Al-Mulla, Fahd; Anderson, Mark S; Andreakos, Evangelos; Arias, Andres A; Baghdadi, Jamila El; Belot, Alexandre; Biggs, Catherine M et al.
DOI: 10.1038/s41591-022-01766-7

Activation-induced deaminase is critical for the establishment of DNA methylation patterns prior to the germinal center reaction.

PMID: 33950194
Journal: NUCLEIC ACIDS RESEARCH
Year: 2021
Reference: Nucleic Acids Res. 2021 May 21;49(9):5057-5073. doi: 10.1093/nar/gkab322.
Impact factor:
Publication type: Paper in international publication
Authors: Abolhassani, Hassan; Alvarez-Prado, Angel F; Ballestar, Esteban; Catala-Moll, Francesc; Ciudad, Laura; Colobran, Roger; Dieli-Crimi, Romina; Dieli-Crimi, Romina; Durandy, Anne; Ferrete-Bonastre, Anna G et al.
DOI: 10.1093/nar/gkab322

Multi-Inflammatory Syndrome in Children related to SARS-CoV-2 in Spain.

PMID: 32710613
Journal: CLINICAL INFECTIOUS DISEASES
Year: 2021
Reference: Clin Infect Dis. 2021 May 4;72(9):e397-e401. doi: 10.1093/cid/ciaa1042.
Impact factor:
Publication type: Paper in international publication
Authors: Belda, Sylvia; Castillo-Serrano, Ana; Epalza, Cristina; Fumado, Victoria; Gallego, Nerea; Gil-Villanueva, Nuria; Grasa, Carlos; Jordan, Iolanda; Lanaspa, Miguel; Mendez-Echevarria, Ana et al.
DOI: 10.1093/cid/ciaa1042

Prevalence of thrombotic complications in children with SARS-CoV-2.

PMID: 33931403
Journal: ARCHIVES OF DISEASE IN CHILDHOOD
Year: 2021
Reference: Arch Dis Child. 2021 Nov;106(11):1129-1132. doi: 10.1136/archdischild-2020-321351. Epub 2021 Apr 30.
Impact factor:
Publication type: Paper in international publication
Authors: Aguilera-Alonso, David; Alcala, Pedro; Alfayate, Santiago; Alonso, Maruchi; Alvaredo, Teresa; Amich, Ines; Antonio, Jose; Ara, Fatima; Astigarraga, Itziar; Bermejo, Amanda et al.
DOI: 10.1136/archdischild-2020-321351

SARS-CoV-2-related MIS-C: A key to the viral and genetic causes of Kawasaki disease?

PMID: 33904890
Journal: JOURNAL OF EXPERIMENTAL MEDICINE
Year: 2021
Reference: J Exp Med. 2021 Jun 7;218(6). pii: 212029. doi: 10.1084/jem.20210446.
Impact factor:
Publication type: Paper in international publication
Authors: Abel, Laurent; Abolhassani, Hassan; Abou Tayoun, Ahmad; Aguilera-Albesa, Sergio; Aiuti, Alessandro; Akcan, Ozge Metin; Al-Mulla, Fahd; Alkan, Gulsum; Almuhsen, Saleh Zaid; Alsina, Laia et al.
DOI: 10.1084/jem.20210446

Baseline Chest Computed Tomography as Standard of Care in High-Risk Hematology Patients.

PMID: 32183235
Journal: Journal of Fungi
Year: 2020
Reference: J Fungi (Basel). 2020 Mar 13;6(1). pii: jof6010036. doi: 10.3390/jof6010036.
Impact factor:
Publication type: Paper in international publication
Authors: Akan, Hamdi; Alakel, Nael; Ananda-Rajah, Michelle; Auberger, Jutta; Bojko, Peter; Bruns, Caroline; Chandrasekar, Pranatharthi H; Chayakulkeeree, Methee; Cornely, Oliver A; Cozzi, Jose A et al.
DOI: 10.3390/jof6010036

Schistosomiasis in children: review of 51 imported cases in Spain.

PMID: 31821494
Journal: JOURNAL OF TRAVEL MEDICINE
Year: 2020
Reference: J Travel Med. 2020 Feb 3;27(1). pii: 5671715. doi: 10.1093/jtm/taz099.
Impact factor:
Publication type: Paper in international publication
Authors: Espasa, Mateu; Espiau, Maria; Martin-Nalda, Andrea; Mendoza-Palomar, Natalia; Perez-Garcia, Irene; Soler-Palacin, Pere; Soriano-Arandes, Antoni; Sulleiro, Elena; Zarzuela, Francesc et al.
DOI: 10.1093/jtm/taz099

IMPACT OF BASELINE TUBERCULIN SKIN TEST AND ISONIAZID CHEMOPROPHYLAXIS ON SUBSEQUENT QUANTIFERON-TB GOLD IN-TUBE PERFORMANCE IN YOUNG CHILDREN ASSESSED AFTER TUBERCULOSIS CONTACT IN CATALONIA.

PMID: 31738322
Journal: PEDIATRIC INFECTIOUS DISEASE JOURNAL
Year: 2020
Reference: Pediatr Infect Dis J. 2020 Feb;39(2):e22-e25. doi: 10.1097/INF.0000000000002517.
Impact factor:
Publication type: Paper in international publication
Authors: Altet, Neus; Espiau, Maria; Fortuny, Claudia; Monsonis, Manuel; Noguera-Julian, Antoni; Soriano-Arandes, Antoni; Tebruegge, Marc; Velasco-Arnaiz, Eneritz et al.
DOI: 10.1097/INF.0000000000002517

The parasite that came in from the cold.

PMID: 31504704
Journal: JOURNAL OF TRAVEL MEDICINE
Year: 2020
Reference: J Travel Med. 2020 Feb 3;27(1). pii: 5554872. doi: 10.1093/jtm/taz065.
Impact factor:
Publication type: Paper in international publication
Authors: Espiau, Maria; Gomez-Serrano, Maria; Soriano-Arandes, Antoni; Sulleiro, Elena; Vidal-Moreso, Anna; Zarzuela, Francesc et al.
DOI: 10.1093/jtm/taz065

First Universal Newborn Screening Program for Severe Combined Immunodeficiency in Europe. Two-Years' Experience in Catalonia (Spain).

PMID: 31695692
Journal: Frontiers in Immunology
Year: 2019
Reference: Front Immunol. 2019 Oct 22;10:2406. doi: 10.3389/fimmu.2019.02406. eCollection 2019.
Impact factor: 4.716
Publication type: Paper in international publication
Authors: Argudo-Ramirez, Ana, Martin-Nalda, Andrea, Pajares-Garcia, Sonia, Gonzalez de Aledo-Castillo, Jose M, Martinez-Gallo, Monica, Garcia-Prat, Marina, Colobran, Roger, Riviere, Jacques G, Quintero, Yania, Collado, Tatiana et al.
DOI: 10.3389/fimmu.2019.02406

Expanding the Clinical and Genetic Spectra of Primary Immunodeficiency-Related Disorders With Clinical Exome Sequencing: Expected and Unexpected Findings.

PMID: 31681265
Journal: Frontiers in Immunology
Year: 2019
Reference: Front Immunol. 2019 Oct 1;10:2325. doi: 10.3389/fimmu.2019.02325. eCollection 2019.
Impact factor: 4.716
Publication type: Paper in international publication
Authors: Rudilla, Francesc, Franco-Jarava, Clara, Martinez-Gallo, Monica, Garcia-Prat, Marina, Martin-Nalda, Andrea, Riviere, Jacques, Aguilo-Cucurull, Aina, Mongay, Laura, Vidal, Francisco, Solanich, Xavier et al.
DOI: 10.3389/fimmu.2019.02325

Identification of 22q11.2 deletion syndrome via newborn screening for severe combined immunodeficiency. Two years' experience in Catalonia (Spain).

PMID: 31663686
Journal: Molecular Genetics & Genomic Medicine
Year: 2019
Reference: Mol Genet Genomic Med. 2019 Dec;7(12):e1016. doi: 10.1002/mgg3.1016. Epub 2019 Oct 30.
Impact factor: 2.448
Publication type: Paper in international publication
Authors: Martin-Nalda, Andrea, Cueto-Gonzalez, Anna M, Argudo-Ramirez, Ana, Marin-Soria, Jose L, Martinez-Gallo, Monica, Colobran, Roger, Plaja, Albert, Castells, Neus, Riviere, Jacques, Tizzano, Eduardo F et al.
DOI: 10.1002/mgg3.1016

Blog

News

The study seeks to better understand blood disorders in children and young people, analyzing the role of immunological alterations to improve diagnosis and treatment.

Members of the RBDCOV project, which involves VHIR, gathered at the Palau Macaya to review progress and achievements made during the final phase of the project.

During the meeting, the role of the Vall d'Hebron Paediatric Research Hub in promoting research on children and adolescents was highlighted.