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Infection and Immunity in pediatric patients

The Infection and Immunity in pediatric patients research group is a multidisciplinary pediatric research group made up of health professionals involved in translational research in the field of pediatric infectious diseases and immunodeficiencies, two related fields in terms of pathophysiology and clinical implications. It is a consolidated research group recognized by the AGAUR and is the only one with the accreditation of the Jeffrey Modell Foundation in research in the field of primary immunodeficiencies throughout the state.

The group was officially created in 2010, belongs to the area of Infectious Diseases and participates in the transversal programs of Advanced Translational Immunology and Rare Diseases and actively participates in national and international competitive projects, carries out multiple academic and industry-linked clinical trials and has increased the number and quality in recent years. In addition, it has its own laboratory specially dedicated to advanced immune studies.

Publications

Immunomolecular and reactivity landscapes of gut IgA subclasses in homeostasis and inflammatory bowel disease.

PMID: 39560666
Journal: JOURNAL OF EXPERIMENTAL MEDICINE
Year: 2024
Reference: J Exp Med. 2024 Dec 2;221(12):e20230079. doi: 10.1084/jem.20230079. Epub 2024 Nov 19.
Impact factor:
Publication type: Paper in international publication
Authors: Berenguer-Molins, Pau; Cerutti, Andrea; Comerma, Laura; Corral-Vazquez, Celia; Garrido-Pontnou, Marta; Gonzalez Farre, Monica; Grasset, Emilie K; Grassi, Fabio; Guarner, Francisco; Guerra, Joana et al.
DOI: 10.1084/jem.20230079

Heterozygous Predicted Loss-of-function Variants of TRAF3 in Patients with Common Variable Immunodeficiency.

PMID: 39579173
Journal: JOURNAL OF CLINICAL IMMUNOLOGY
Year: 2024
Reference: J Clin Immunol. 2024 Nov 23;45(1):47. doi: 10.1007/s10875-024-01833-3.
Impact factor:
Publication type: Paper in international publication
Authors: Aguilo-Cucurull, Aina; Antolin, Maria; Batlle-Maso, Laura; Colobran, Roger; Dieli-Crimi, Romina; Franco-Jarava, Clara; Garcia-Prat, Marina; Martinez-Gallo, Monica; Moushib, Laith; Parra-Martinez, Alba et al.
DOI: 10.1007/s10875-024-01833-3

PEDIATRIC DENGUE IN NONENDEMIC AREAS: THE IMPORTANCE OF THE AWARENESS TO DETECT NEW CASES AND WARNING SIGNS: A CASE REPORT.

PMID: 39637298
Journal: PEDIATRIC INFECTIOUS DISEASE JOURNAL
Year: 2024
Reference: Pediatr Infect Dis J. 2024 Dec 4. doi: 10.1097/INF.0000000000004653.
Impact factor:
Publication type: Paper in international publication
Authors: de Haan-Bosch, Marian; Espiau, Maria; Esquirol-Herrero, Cristina; Melendo-Perez, Susana; Mendoza-Palomar, Natalia; Soler-Palacin, Pere; Soriano-Arandes, Antoni; Sulleiro, Elena et al.
DOI: 10.1097/INF.0000000000004653

Recommendations for Transitioning Young People with Primary Immunodeficiency Disorders and Autoinflammatory Diseases to Adult Care.

PMID: 39690292
Journal: JOURNAL OF CLINICAL IMMUNOLOGY
Year: 2024
Reference: J Clin Immunol. 2024 Dec 17;45(1):57. doi: 10.1007/s10875-024-01838-y.
Impact factor:
Publication type: Paper in international publication
Authors: Alderson, Eliska; Anton, Jordi; Avramovic, Mojca Zajc; Berg, Stefan; Burns, Siobhan O; Campbell, Mari; Cattalini, Marco; Dalm, Virgil; Gennery, Andrew R; Guffroy, Aurelien et al.
DOI: 10.1007/s10875-024-01838-y

Age, Successive Waves, Immunization, and Mortality in Elderly COVID-19 Haematological Patients: EPICOVIDEHA Findings.

PMID: 37863310
Journal: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
Year: 2023
Reference: Int J Infect Dis. 2023 Oct 18:S1201-9712(23)00749-X. doi: 10.1016/j.ijid.2023.10.013.
Impact factor:
Publication type: Paper in international publication
Authors: Abu-Zeinah, Ghaith; Adzic-Vukicevic, Tatjana; Aiello, Tommaso Francesco; Ammatuna, Emanuele; Arellano, Elena; Barac, Aleksandra; Bavastro, Martina; Bergantim, Rui; Besson, Caroline; Biernat, Monika M et al.
DOI: 10.1016/j.ijid.2023.10.013

Determinants of school absences due to respiratory tract infections among children during COVID-19 pandemic: A cross-sectional study of the Sentinel Schools Network.

PMID: 37877732
Journal: Pediatric pulmonology
Year: 2023
Reference: Pediatr Pulmonol. 2023 Oct 25. doi: 10.1002/ppul.26736.
Impact factor:
Publication type: Other (letters to the editor, abstracts, corrigendum, etc.)
Authors: Alonso, Lucia; Bordas, Anna; Casabona, Jordi; Castells-Sanchez, Alba; Colom-Cadena, Andreu; Dacosta-Aguayo, Rosalia; Dimitriadis, Stavros I; Ganem, Fabiana; Garcia-Molina, Alberto; Gascon, Mireia et al.
DOI: 10.1002/ppul.26736

Novel frameshift variants expand the map of the genetic defects in IRF2BP2.

PMID: 37876937
Journal: Frontiers in Immunology
Year: 2023
Reference: Front Immunol. 2023 Oct 9;14:1279171. doi: 10.3389/fimmu.2023.1279171. eCollection 2023.
Impact factor:
Publication type: Paper in international publication
Authors: Acuna Perez, Maria Jose; Bai, Yuxian; Bhagia, Pooja; Bilici, Mehmet; Calavia, Olga; Chung, Hyun Cheol; Colobran, Roger; Garcia Ramos, Maite; Garcia-Aznar, Jose Maria; Janjigian, Yelena Y et al.
DOI: 10.3389/fimmu.2023.1279171

[TOGETHER, WE FORM A GREAT TEAM, THE SEAP!].

PMID: 37879817
Journal: Revista espanola de patologia
Year: 2023
Reference: Rev Esp Patol. 2023 Oct-Dec;56(4):217-218. doi: 10.1016/j.patol.2023.09.001.
Impact factor:
Publication type: Editorial in national publication
Authors: Acuna Perez, Maria Jose; Agueras, Cajal; Calavia, Olga; Colobran, Roger; Garcia Ramos, Maite; Garcia-Aznar, Jose Maria; Maneiro Pampin, Emilia; Minguell Domingo, Laura; Novoa Bolivar, Erika M; Ocejo Vinyals, Javier Gonzalo et al.
DOI: 10.1016/j.patol.2023.09.001

Respiratory syncytial virus infections requiring hospitalization in patients with primary immunodeficiency.

PMID: 35637145
Journal: ANALES DE PEDIATRIA
Year: 2022
Reference: An Pediatr (Engl Ed). 2022 Jun;96(6):492-500. doi: 10.1016/j.anpede.2022.03.002. Epub 2022 May 28.
Impact factor:
Publication type: Paper in international publication
Authors: Alsina, Laia; Gonzalez-Granado, Luis Ignacio; Martin-Nalda, Andrea; Neth, Olaf; Santamaria, Manuel; Soler-Palacin, Pere et al.
DOI: 10.1016/j.anpede.2022.03.002

SARS-CoV-2 vaccination in children with a history of MIS-C: an international survey.

PMID: 35598642
Journal: JOURNAL OF PEDIATRICS
Year: 2022
Reference: J Pediatr. 2022 Sep;248:114-118. doi: 10.1016/j.jpeds.2022.05.028. Epub 2022 May 19.
Impact factor:
Publication type: Paper in international publication
Authors: Belot, Alexandre; Buddingh, Emilie Pauline; Haerynck, Filomeen; Hoste, Levi; Olbrich, Peter; Soriano-Arandes, Antoni; Ulloa-Gutierrez, Rolando; Whittaker, Elizabeth et al.
DOI: 10.1016/j.jpeds.2022.05.028

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies.

PMID: 35576468
Journal: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Year: 2022
Reference: Proc Natl Acad Sci U S A. 2022 May 24;119(21):e2200413119. doi: 10.1073/pnas.2200413119. Epub 2022 May 16.
Impact factor:
Publication type: Paper in international publication
Authors: Abel, Laurent; Aiuti, Alessandro; AlKhater, Suzan; Amador-Borrero, Blanca; Anaya, Juan-Manuel; Anderson, Mark S; Andreakos, Evangelos; Anglicheau, Dany; Arias, Andres Augusto; Arrestier, Romain et al.
DOI: 10.1073/pnas.2200413119

Impact of JAK Inhibitors in Pediatric Patients with STAT1 Gain of Function (GOF) Mutations-10 Children and Review of the Literature.

PMID: 35486339
Journal: JOURNAL OF CLINICAL IMMUNOLOGY
Year: 2022
Reference: J Clin Immunol. 2022 Jul;42(5):1071-1082. doi: 10.1007/s10875-022-01257-x. Epub 2022 Apr 29.
Impact factor:
Publication type: Paper in international publication
Authors: Abu Jamra, Soraya Regina; Alsina, Laia; Blanco Lobo, Pilar; Bloomfield, Marketa; Deya-Martinez, Angela; Esteve-Sole, Ana; Garcia-Garcia, Ana; Guisado Hernandez, Paloma; Kanderova, Veronika; Lopez-Corbeto, Mireia et al.
DOI: 10.1007/s10875-022-01257-x

Enterovirus-A71 Rhombencephalitis Outbreak in Catalonia: Characteristics, Management and Outcome.

PMID: 34097655
Journal: PEDIATRIC INFECTIOUS DISEASE JOURNAL
Year: 2021
Reference: Pediatr Infect Dis J. 2021 Jul 1;40(7):628-633. doi: 10.1097/INF.0000000000003114.
Impact factor:
Publication type: Paper in international publication
Authors: Andres, Cristina; Anton, Andres; Campins, Magda; Casquero, Alejandro; Castellarnau, Ester; Delgado, Ignacio; Gonzalez, Sebastia; Lera, Esther; Mayol, Lluis; Mendez, Maria et al.
DOI: 10.1097/INF.0000000000003114

Atypical Inflammatory Syndrome Triggered by SARS-CoV-2 in Infants with Down Syndrome.

PMID: 34089457
Journal: JOURNAL OF CLINICAL IMMUNOLOGY
Year: 2021
Reference: J Clin Immunol. 2021 Oct;41(7):1457-1462. doi: 10.1007/s10875-021-01078-4. Epub 2021 Jun 5.
Impact factor:
Publication type: Paper in international publication
Authors: Bastard, Paul; Bogunovic, Dusan; Bush, Douglas; Carpenter, Taya; Casanova, Jean-Laurent; Colobran, Roger; Gans, Melissa; Malle, Louise; Martin-Nalda, Andrea; Patel, Roosheel et al.
DOI: 10.1007/s10875-021-01078-4

Impact of vaccinating pregnant women against pertussis on hospitalizations of children under one year of age in a tertiary hospital in Catalonia.

PMID: 34020822
Journal: ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
Year: 2021
Reference: Enferm Infecc Microbiol Clin (Engl Ed). 2021 May 18. pii: S0213-005X(21)00088-4. doi: 10.1016/j.eimc.2021.04.004.
Impact factor:
Publication type: Paper in national publication
Authors: Armadans-Gil, Lluis; Balcells-Ramirez, Joan; Melendo, Susana; Moraga-Llop, Fernando; Otero-Romero, Susana; Riera-Bosch, M Teresa; Rodriguez-Losada, Olalla; Ruiz-Botia, Irene; Soler-Palacin, Pere et al.
DOI: 10.1016/j.eimc.2021.04.004

Interferon-Gamma Release Assays Differentiate Between Mycobacterium avium Complex and Tuberculous Lymphadenitis in Children.

PMID: 33984332
Journal: JOURNAL OF PEDIATRICS
Year: 2021
Reference: J Pediatr. 2021 Sep;236:211-218.e2. doi: 10.1016/j.jpeds.2021.05.008. Epub 2021 May 10.
Impact factor:
Publication type: Paper in international publication
Authors: Baquero-Artigao, Fernando; Blazquez-Gamero, Daniel; Bustillo-Alonso, Matilde; Calavia, Olga; Canet, Anna; Del Rosal, Teresa; Falcon-Neyra, Lola; Fortuny, Claudia; Gale, Ines; Guerrero, Carmelo et al.
DOI: 10.1016/j.jpeds.2021.05.008

The IL2RG R328X nonsense mutation allows partial STAT5 phosphorylation and defines a critical region involved in leaky-SCID phenotype.

PMID: 31799703
Journal: CLINICAL AND EXPERIMENTAL IMMUNOLOGY
Year: 2020
Reference: Clin Exp Immunol. 2020 Apr;200(1):61-72. doi: 10.1111/cei.13405. Epub 2020 Jan 19.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, Laura; Arcas-Garcia, Andrea; Colobran, Roger; Drechsel, Oliver; Franco-Jarava, Clara; Garcia-Prat, Marina; Magallon-Lorenz, Miriam; Martin-Nalda, Andrea; Martinez-Gallo, Monica; Ossowski, Stephan et al.
DOI: 10.1111/cei.13405

Pneumocystis jirovecii pneumonia in children. A retrospective study in a single center over three decades.

PMID: 31272810
Journal: ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
Year: 2020
Reference: Enferm Infecc Microbiol Clin. 2020 Mar;38(3):111-118. doi: 10.1016/j.eimc.2019.05.005. Epub 2019 Jul 1.
Impact factor:
Publication type: Paper in national publication
Authors: Balcells-Ramirez, Joan; Frick, Marie Antoinette; Garcia-Moreno, Jorge; Martin-Gomez, Maria Teresa; Martin-Nalda, Andrea; Melendo-Perez, Susana; Mendoza-Palomar, Natalia; Pujol-Jover, Montserrat; Soler-Palacin, Pere et al.
DOI: 10.1016/j.eimc.2019.05.005

Newborn Screening for Presymptomatic Diagnosis of Complement and Phagocyte Deficiencies.

PMID: 32256498
Journal: Frontiers in Immunology
Year: 2020
Reference: Front Immunol. 2020 Mar 17;11:455. doi: 10.3389/fimmu.2020.00455. eCollection 2020.
Impact factor:
Publication type: Paper in international publication
Authors: Abolhassani, Hassan; Aghamohammadi, Asghar; Allende-Martinez, Luis M; Bergstrom, Sofia; Dezfouli, Mahya; Fernandez Pereira, Luis M; Ferrer Balaguer, Juana M; Franco Jarava, Clara; Friman, Vanda; Gonzalez-Granado, Luis I et al.
DOI: 10.3389/fimmu.2020.00455

Tuberculosis in a Spanish cohort of children living with HIV: the CHOTIS study (Childhood HIV & TB study).

PMID: 32228760
Journal: INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
Year: 2020
Reference: Int J Tuberc Lung Dis. 2020 Mar 1;24(3):303-309. doi: 10.5588/ijtld.19.0237.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, M Bustillo; Amador, J T Ramos; Andres, A G Andres; Cucurull, T Vallmanya; de Ory, S Jimenez; Frick, M A; Gil, E Colino; Gomez, M L Navarro; Gonzalez-Tome, M I; Hernandez, M Mendez et al.
DOI: 10.5588/ijtld.19.0237

Clinicoepidemiological characteristics of viral hepatitis in migrants and travellers of the +Redivi network.

PMID: 30738196
Journal: Travel Medicine and Infectious Disease
Year: 2019
Reference: Travel Med Infect Dis. 2019 May - Jun;29:51-57. doi: 10.1016/j.tmaid.2019.02.001. Epub 2019 Feb 6.
Impact factor:
Publication type: Paper in international publication
Authors: Aguilera, Paloma; Aguirre, Josune Goikoetxea; Arribas, Maria Velasco; Bocanegra, Cristina; Boga Ribeiro, Jose Antonio; Ciruelo, Diana Pou; Cuello, Inmaculada Gonzalez; Delcor, Nuria Serre; Dominguez, Angel; Garcia, Magdalena et al.
DOI: 10.1016/j.tmaid.2019.02.001

Prognostic factors in 264 adults with invasive Scedosporium spp. and Lomentospora prolificans infection reported in the literature and FungiScope(R).

PMID: 30628529
Journal: CRITICAL REVIEWS IN MICROBIOLOGY
Year: 2019
Reference: Crit Rev Microbiol. 2019 Feb;45(1):1-21. doi: 10.1080/1040841X.2018.1514366. Epub 2019 Jan 10.
Impact factor:
Publication type: Paper in international publication
Authors: Aurbach, Ute; Bachmann, Bjorn; Borchert, Kersten; Burchardt, Alexander; Caggiano, Giuseppina; Chakrabarti, Arunaloke; Chander, Jagdish; Chedotal, Isabelle; Cheng, Matthew P; Christopeit, Maximilian et al.
DOI: 10.1080/1040841X.2018.1514366

Unexpected Relevant Role of Gene Mosaicism in Primary Immunodeficiency Diseases.

PMID: 30273710
Journal: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Year: 2019
Reference: J Allergy Clin Immunol. 2019 Jan;143(1):359-368. doi: 10.1016/j.jaci.2018.09.009. Epub 2018 Sep 29.
Impact factor:
Publication type: Paper in international publication
Authors: Allende, Luis M; Alsina, Laia; Arostegui, Juan I; Balderrama-Rodriguez, Angelica; Bejaoui, Mohamed; Bloomfield, Marketa; Bosque, Maria Teresa; Bravo Gallego, Luz Yadira; Campistol, Josep Maria; Canellas, Jeronima et al.
DOI: 10.1016/j.jaci.2018.09.009

Surveillance of enteroviruses from paediatric patients attended at a tertiary hospital in Catalonia from 2014 to 2017.

PMID: 30530096
Journal: JOURNAL OF CLINICAL VIROLOGY
Year: 2019
Reference: J Clin Virol. 2019 Jan;110:29-35. doi: 10.1016/j.jcv.2018.11.004. Epub 2018 Nov 30.
Impact factor:
Publication type: Paper in international publication
Authors: Alcubilla, Pilar; Andres, Cristina; Anton, Andres; Barnes, Meritxell; Codina, Maria Gema; Esperalba, Juliana; Fuentes, Francisco; Gimferrer, Laura; Martin, Maria Carmen; Pinana, Maria et al.
DOI: 10.1016/j.jcv.2018.11.004

Blog

News

The study seeks to better understand blood disorders in children and young people, analyzing the role of immunological alterations to improve diagnosis and treatment.

Members of the RBDCOV project, which involves VHIR, gathered at the Palau Macaya to review progress and achievements made during the final phase of the project.

During the meeting, the role of the Vall d'Hebron Paediatric Research Hub in promoting research on children and adolescents was highlighted.