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Infection and Immunity in pediatric patients

The Infection and Immunity in pediatric patients research group is a multidisciplinary pediatric research group made up of health professionals involved in translational research in the field of pediatric infectious diseases and immunodeficiencies, two related fields in terms of pathophysiology and clinical implications. It is a consolidated research group recognized by the AGAUR and is the only one with the accreditation of the Jeffrey Modell Foundation in research in the field of primary immunodeficiencies throughout the state.

The group was officially created in 2010, belongs to the area of Infectious Diseases and participates in the transversal programs of Advanced Translational Immunology and Rare Diseases and actively participates in national and international competitive projects, carries out multiple academic and industry-linked clinical trials and has increased the number and quality in recent years. In addition, it has its own laboratory specially dedicated to advanced immune studies.

Publications

Expanding the landscape of systemic sclerosis-related autoantibodies through RNA immunoprecipitation coupled with massive parallel sequencing.

PMID: 39500147
Journal: JOURNAL OF AUTOIMMUNITY
Year: 2024
Reference: J Autoimmun. 2024 Nov 4;149:103328. doi: 10.1016/j.jaut.2024.103328.
Impact factor:
Publication type: Paper in international publication
Authors: Andres-Leon, Eduardo; Batlle-Maso, Laura; Codina-Clavaguera, Claudia; Colobran, Roger; Gordillo-Gonzalez, Fernando; Guillen-Del-Castillo, Alfredo; Martin, Javier; McHugh, Neil J; Perurena-Prieto, Janire; Pujol, Ricardo et al.
DOI: 10.1016/j.jaut.2024.103328

Newborn screening for SCID and severe T lymphocytopenia in Europe.

PMID: 39510364
Journal: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Year: 2024
Reference: J Allergy Clin Immunol. 2024 Nov 5:S0091-6749(24)01162-X. doi: 10.1016/j.jaci.2024.10.018.
Impact factor:
Publication type: Paper in international publication
Authors: Blom, Maartje; Gennery, Andrew R; Sediva, Anna; Soler-Palacin, Pere; Soomann, Maarja; Speckmann, Carsten; Stray-Pedersen, Asbjorg; van der Burg, Mirjam; Zetterstrom, Rolf et al.
DOI: 10.1016/j.jaci.2024.10.018

Transition to Enteral Triazole Antifungal Therapy for Pediatric Invasive Candidiasis: Secondary Analysis of a Multicenter Cohort Study Conducted by the Pediatric Fungal Network.

PMID: 39513400
Journal: Journal of the Pediatric Infectious Diseases Society
Year: 2024
Reference: J Pediatric Infect Dis Soc. 2024 Nov 8:piae116. doi: 10.1093/jpids/piae116.
Impact factor:
Publication type: Paper in international publication
Authors: Abzug, Mark J; Aftandilian, Catherine; Ardura, Monica I; Arrieta, Antonio C; Aviles-Robles, Martha; Belani, Kiran; Berman, David M; Boge, Craig L K; Bucayu, Robert F T; Carlesse, Fabianne et al.
DOI: 10.1093/jpids/piae116

[Translated article] National registry and analysis of pharmaceutical interventions in critical care units: PHARMACRITIC study.

PMID: 39550252
Journal: FARMACIA HOSPITALARIA
Year: 2024
Reference: Farm Hosp. 2024 Nov 15:S1130-6343(24)00163-6. doi: 10.1016/j.farma.2024.10.003.
Impact factor:
Publication type: Paper in international publication
Authors: Cerezuela, Maria Martin; Chiva, Esther Domingo; Fernandez, Carla Bastida; Fernandez, Marta Albanell; Garcia, Miguel Angel Amor; Garcia, Tatiana Betancor; Gonzalez, Irene Aquerreta; Lugea, Amaia Egues; Moral, Laura Domenech; Moreno, Fernando Becerril et al.
DOI: 10.1016/j.farma.2024.10.003

Characterization and real-live results of nebulized voriconazole: A single-center observational study.

PMID: 37612182
Journal: Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia H
Year: 2023
Reference: Farm Hosp. 2023 Aug 21:S1130-6343(23)00102-2. doi: 10.1016/j.farma.2023.07.010.
Impact factor:
Publication type: Paper in national publication
Authors: Campanario, Sonia Terradas; Herrero, David Campany; Larrosa-Garcia, Maria; Parra, Alba Pau; Polo, Aurora Fernandez; Ramirez, Carme Canete et al.
DOI: 10.1016/j.farma.2023.07.010

A biobank of pediatric patient-derived-xenograft models in cancer precision medicine trial MAPPYACTS for relapsed and refractory tumors.

PMID: 37723198
Journal: Communications Biology
Year: 2023
Reference: Commun Biol. 2023 Sep 18;6(1):949. doi: 10.1038/s42003-023-05320-0.
Impact factor:
Publication type: Paper in international publication
Authors: Berlanga, Pablo; Cairo, Stefano; Calvo, Julien; Casanova, Michela; Chastagner, Pascal; Cherkaoui, Sarah; Daudigeos-Dubus, Estelle; Delattre, Olivier; Dessen, Philippe; Droit, Robin et al.
DOI: 10.1038/s42003-023-05320-0

The emergence, impact, and evolution of human metapneumovirus variants from 2014 to 2021 in Spain.

PMID: 37178807
Journal: JOURNAL OF INFECTION
Year: 2023
Reference: J Infect. 2023 May 11:S0163-4453(23)00262-1. doi: 10.1016/j.jinf.2023.05.004.
Impact factor:
Publication type: Paper in international publication
Authors: Abanto, Michel; Andres, Cristina; Anton, Andres; Codina, Maria Gema; Creus, Anna; Espartosa, Elena; Esperalba, Juliana; Folgueira, Dolores; Gonzalez-Sanchez, Alejandra; Martinez-Urtaza, Jaime et al.
DOI: 10.1016/j.jinf.2023.05.004

Bartonella henselae neuroretinitis: a case report.

PMID: 37164827
Journal: Anales de pediatria
Year: 2023
Reference: An Pediatr (Engl Ed). 2023 May 8:S2341-2879(23)00097-2. doi: 10.1016/j.anpede.2023.04.006.
Impact factor:
Publication type: Paper in international publication
Authors: Martin Begue, Nieves; Melendo Perez, Susana; Mirabet Mas, Julia; Morell Daniel, Mariona; Morell Daniel, Mariona et al.
DOI: 10.1016/j.anpede.2023.04.006

Impact of vaccinating pregnant women against pertussis on hospitalizations of children under one year of age in a tertiary hospital in Catalonia.

PMID: 35752569
Journal: ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
Year: 2022
Reference: Enferm Infecc Microbiol Clin. 2022 Nov;40(9):473-478. doi: 10.1016/j.eimce.2022.06.002. Epub 2022 Jun 22.
Impact factor:
Publication type: Paper in international publication
Authors: Armadans-Gil, Lluis; Balcells-Ramirez, Joan; Melendo, Susana; Moraga-Llop, Fernando; Otero-Romero, Susana; Riera-Bosch, M Teresa; Rodriguez-Losada, Olalla; Ruiz-Botia, Irene; Soler-Palacin, Pere et al.
DOI: 10.1016/j.eimce.2022.06.002

Whole-genome sequencing reveals host factors underlying critical COVID-19.

PMID: 35255492
Journal: NATURE
Year: 2022
Reference: Nature. 2022 Jul;607(7917):97-103. doi: 10.1038/s41586-022-04576-6. Epub 2022 Mar 7.
Impact factor:
Publication type: Paper in international publication
Authors: Abd Elghafar, Mohamed S; Abdel-Aziz, Mahmoud; Abdelrazik, Marwa; Abdollahi, Hamed; Abdullah, Tala; Abecasis, Goncalo R; Abecasis, Goncalo R; Abedalthagafi, Malak; Abel, Lynn; Abernathy, Caroline et al.
DOI: 10.1038/s41586-022-04576-6

Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia.

PMID: 35708626
Journal: JOURNAL OF EXPERIMENTAL MEDICINE
Year: 2022
Reference: J Exp Med. 2022 Aug 1;219(8). pii: 213287. doi: 10.1084/jem.20220131. Epub 2022 Jun 16.
Impact factor:
Publication type: Paper in international publication
Authors: Abel, Laurent; Abel, Laurent; Abolhassani, Hassan; Abolhassani, Hassan; Abou Tayoun, Ahmad; Aiuti, Alessandro; Akcan, Ozge Metin; Al-Muhsen, Saleh; Al-Mulla, Fahd; Alkan, Gulsum et al.
DOI: 10.1084/jem.20220131

Respiratory viral infections in otherwise healthy humans with inherited IRF7 deficiency.

PMID: 35670811
Journal: JOURNAL OF EXPERIMENTAL MEDICINE
Year: 2022
Reference: J Exp Med. 2022 Jul 4;219(7). pii: 213267. doi: 10.1084/jem.20220202. Epub 2022 Jun 7.
Impact factor:
Publication type: Paper in international publication
Authors: Abel, Laurent; Abel, Laurent; Aiuti, Alessandro; Al-Muhsen, Saleh; Al-Mulla, Fahd; Alavi Darazam, Ilad; Anderson, Mark S; Andreakos, Evangelos; Arias, Andres A; Arias, Andres Augusto et al.
DOI: 10.1084/jem.20220202

Prevalence of M184V and K65R in proviral DNA from PBMCs in HIV-infected youths with lamivudine/emtricitabine exposure.

PMID: 33734374
Journal: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Year: 2021
Reference: J Antimicrob Chemother. 2021 Jun 18;76(7):1886-1892. doi: 10.1093/jac/dkab080.
Impact factor:
Publication type: Paper in international publication
Authors: Abadia, Jesica; Adsuar, Araceli; Aguilera, David; Aguilera-Alonso, David; Albendin, Helena; Aldamiz, Teresa; Alonso, Gabriel Gaspar; Alvarez, Cristina; Andres, Ana Gloria; Angulo, Raquel et al.
DOI: 10.1093/jac/dkab080

Hemadsorption as a Treatment Option for Multisystem Inflammatory Syndrome in Children Associated With COVID-19. A Case Report.

PMID: 34140949
Journal: Frontiers in Immunology
Year: 2021
Reference: Front Immunol. 2021 Jun 1;12:665824. doi: 10.3389/fimmu.2021.665824. eCollection 2021.
Impact factor:
Publication type: Letter or abstract
Authors: Chiscano-Camon, Luis; Ferrer, Ricard; Garcia-de-Acilu, Marina; Hernandez-Gonzalez, Manuel; Palmada, Clara; Perez-Carrasco, Marcos; Perurena-Prieto, Janire; Plata-Menchaca, Erika; Ruiz-Rodriguez, Juan Carlos; Ruiz-Sanmartin, Adolf et al.
DOI: 10.3389/fimmu.2021.665824

Congenital infection of SARS-CoV-2 in live-born neonates: a population-based descriptive study.

PMID: 34153457
Journal: CLINICAL MICROBIOLOGY AND INFECTION
Year: 2021
Reference: Clin Microbiol Infect. 2021 Oct;27(10):1521.e1-1521.e5. doi: 10.1016/j.cmi.2021.06.016. Epub 2021 Jun 19.
Impact factor:
Publication type: Paper in international publication
Authors: Anton-Pagarolas, Andres; Burgos, Jorge; Calle, Maria de la; Camba, Fatima; Carreras, Elena; Delgado, Juan Luis; Diago, Vicente; Esperalba-Esquerra, Juliana; Fernandez-Buhigas, Irene; Fernandez-Hidalgo, Nuria et al.
DOI: 10.1016/j.cmi.2021.06.016

Harnessing Type I IFN Immunity Against SARS-CoV-2 with Early Administration of IFN-beta.

PMID: 34101091
Journal: JOURNAL OF CLINICAL IMMUNOLOGY
Year: 2021
Reference: J Clin Immunol. 2021 Oct;41(7):1425-1442. doi: 10.1007/s10875-021-01068-6. Epub 2021 Jun 8.
Impact factor:
Publication type: Editorail in international publication
Authors: Abel, Laurent; Aiuti, Alessandro; Arkin, Lisa M; Bastard, Paul; Bolze, Alexandre; Casanova, Jean-Laurent; Charkravorty, Samya; Cheng, Matthew P; Christodoulou, John; Cicalese, Maria-Pia et al.
DOI: 10.1007/s10875-021-01068-6

Low-dose liposomal amphotericin B for antifungal prophylaxis in paediatric allogeneic haematopoietic stem cell transplantation.

PMID: 32335674
Journal: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Year: 2020
Reference: J Antimicrob Chemother. 2020 Aug 1;75(8):2264-2271. doi: 10.1093/jac/dkaa149.
Impact factor:
Publication type: Paper in international publication
Authors: Benitez-Carabante, Maria Isabel; Diaz-de-Heredia, Cristina; Fernandez-Polo, Aurora; Gonzalez-Amores, Miriam; Martin, Maria Teresa; Mendoza-Palomar, Natalia; Renedo, Berta; Soler-Palacin, Pere; Soques, Elena et al.
DOI: 10.1093/jac/dkaa149

Diagnostic Accuracy of QuantiFERON-TB Gold Plus Assays in Children and Adolescents with Tuberculosis Disease.

PMID: 32334890
Journal: JOURNAL OF PEDIATRICS
Year: 2020
Reference: J Pediatr. 2020 Aug;223:212-215.e1. doi: 10.1016/j.jpeds.2020.02.025. Epub 2020 Apr 22.
Impact factor:
Publication type: Letter or abstract
Authors: Alvarez, Javier; Baquero-Artigao, Fernando; Bustillo, Matilde; Calavia, Olga; Calvo, Cristina; Cobo, Elvira; Colino, Elena; Colino, Elena; Dapena, Marta; Espiau, Maria et al.
DOI: 10.1016/j.jpeds.2020.02.025

Health-Related Quality of Life and Multidimensional Fatigue Scale in Children with Primary Immunodeficiencies.

PMID: 32291562
Journal: JOURNAL OF CLINICAL IMMUNOLOGY
Year: 2020
Reference: J Clin Immunol. 2020 May;40(4):602-609. doi: 10.1007/s10875-020-00775-w. Epub 2020 Apr 15.
Impact factor:
Publication type: Paper in international publication
Authors: Fabregas-Bofill, Anna; Garcia-Prat, Marina; Gonzalez-Amores, Miriam; Lopez-Seguer, Laura; Martin-Nalda, Andrea; Melendo-Perez, Susana; Mendoza-Palomar, Natalia; Nunez-Rueda, Gloria; Ridao-Manonellas, Saida; Riviere, Jacques G et al.
DOI: 10.1007/s10875-020-00775-w

Invasive Scedosporium spp. and Lomentospora prolificans Infections in Pediatric Patients: Analysis of 55 Cases from FungiScope(R) and the Literature.

PMID: 31863876
Journal: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
Year: 2020
Reference: Int J Infect Dis. 2020 Mar;92:114-122. doi: 10.1016/j.ijid.2019.12.017. Epub 2019 Dec 19.
Impact factor:
Publication type: Paper in international publication
Authors: Carlesse, Fabianne; Cheng, Matthew P; Cornely, Oliver A; Falces-Romero, Iker; Hassler, Angela; Herbrecht, Raoul; Jover Saenz, Alfredo; Klimko, Nikolai; Koehler, Philipp; Lass-Floerl, Cornelia et al.
DOI: 10.1016/j.ijid.2019.12.017

Virological surveillance of human respiratory syncytial virus A and B at a tertiary hospital in Catalonia (Spain) during five consecutive seasons (2013-2018).

PMID: 30860397
Journal: Future Microbiology
Year: 2019
Reference: Future Microbiol. 2019 Mar;14:373-381. doi: 10.2217/fmb-2018-0261. Epub 2019 Mar 12.
Impact factor:
Publication type: Paper in international publication
Authors: Andres, Cristina; Anton, Andres; Campins-Marti, Magda; Carmen Martin, Maria Del; Codina, Maria G; Esperalba, Juliana; Fuentes, Francisco; Gimferrer, Laura; Peremiquel-Trillas, Paula; Pinana, Maria et al.
DOI: 10.2217/fmb-2018-0261

Birth Defects After Exposure to Efavirenz-Based Antiretroviral Therapy at Conception/First Trimester of Pregnancy: A Multicohort Analysis.

PMID: 30570524
Journal: JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
Year: 2019
Reference: J Acquir Immune Defic Syndr. 2019 Mar 1;80(3):316-324. doi: 10.1097/QAI.0000000000001922.
Impact factor:
Publication type: Paper in international publication
Authors: Martinez de Tejada, Begona; Mendoza Palomar, Natalia Ana; Soler Palacín, Pere et al.
DOI: 10.1097/QAI.0000000000001922

Increased proportions of gammadelta T lymphocytes in atypical SCID associate with disease manifestations.

PMID: 30776520
Journal: CLINICAL IMMUNOLOGY
Year: 2019
Reference: Clin Immunol. 2019 Apr;201:30-34. doi: 10.1016/j.clim.2018.11.006. Epub 2019 Feb 15.
Impact factor:
Publication type: Paper in international publication
Authors: Albert, Michael H; Allende, Luis M; Cancrini, Caterina; Di Cesare, Silvia; Ehl, Stephan; Felgentreff, Kerstin; Formankova, Renata; Garcia-Prat, Marina; Ghosh, Sujal; Gilmour, Kimberly et al.
DOI: 10.1016/j.clim.2018.11.006

Pregnancy outcomes after maternal Zika virus infection in a non-endemic region: prospective cohort study.

PMID: 30771526
Journal: CLINICAL MICROBIOLOGY AND INFECTION
Year: 2019
Reference: Clin Microbiol Infect. 2019 May;25(5):633.e5-633.e9. doi: 10.1016/j.cmi.2019.02.008. Epub 2019 Feb 14.
Impact factor:
Publication type: Paper in international publication
Authors: Anton, Andres; Arevalo, Silvia; Carreras, Elena; Frick, Antoinette; Garcia-Ruiz, Itziar; Garrido, Marta; Maiz, Nerea; Mendez, Elida Vazquez; Pumarola, Tomas; Rando, Ariadna et al.
DOI: 10.1016/j.cmi.2019.02.008

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News

The study seeks to better understand blood disorders in children and young people, analyzing the role of immunological alterations to improve diagnosis and treatment.

Members of the RBDCOV project, which involves VHIR, gathered at the Palau Macaya to review progress and achievements made during the final phase of the project.

During the meeting, the role of the Vall d'Hebron Paediatric Research Hub in promoting research on children and adolescents was highlighted.