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Infectious Diseases

The VHIR Infectious Diseases research group is made up of medical professionals, with healthcare and clinical or basic translational research activities; of Biomedicine dedicated to basic research; and Nursing, with activities to support clinical research.

The group's lines of research are mainly focused on four areas:

Infections related to immunosuppression. Includes infectious diseases related to immunocompromised patients, solid organ or hematopoietic stem cell transplant recipients and recipients of biological therapies.

Sexually transmitted diseases, including HIV infection and other highly prevalent infections in our country (syphilis, gonorrhea, lymphogranuloma venere or infections caused by the human papillomavirus).

Infections related to health care, with special emphasis on those difficult to treat (cardiovascular infections or infections related to prosthetic materials) or caused by multi-resistant pathogens (MDRO) or affecting vulnerable populations.

Global Health and Tropical Diseases with special emphasis on prevalent diseases in our environment that affect the immigrant or displaced population.

Publications

Empirical use of beta-lactam/beta-lactamase inhibitor combinations does not increase mortality compared with cloxacillin and cefazolin in methicillin-susceptible Staphylococcus aureus bacteraemia: a propensity-weighted cohort study.

PMID: 35552420
Journal: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Year: 2022
Reference: J Antimicrob Chemother. 2022 May 12. pii: 6584695. doi: 10.1093/jac/dkac152.
Impact factor: 5.79
Publication type: Paper in international publication
Authors: Pigrau, Carles, Almirante, Benito, Rodriguez-Pardo, Dolors, Gonzalez-Lopez, Juan J, Larrosa, Maria N, Fernandez-Hidalgo, Nuria, Willekens, Rein, Puig-Asensio, Mireia, Suanzes, Paula et al.
DOI: 10.1093/jac/dkac152

Real-Life Use of Ceftolozane/Tazobactam for the Treatment of Bloodstream Infection Due to Pseudomonas aeruginosa in Neutropenic Hematologic Patients: a Matched Control Study (ZENITH Study).

PMID: 35475683
Journal: Microbiology Spectrum
Year: 2022
Reference: Microbiol Spectr. 2022 Jun 29;10(3):e0229221. doi: 10.1128/spectrum.02292-21. Epub 2022 Apr 27.
Impact factor: 7.171
Publication type: Paper in international publication
Authors: Ruiz-Camps, Isabel, Bergas, Alba, Albasanz-Puig, Adaia, Fernandez-Cruz, Ana, Machado, Marina, Novo, Andres, van Duin, David, Garcia-Vidal, Carolina, Hakki, Morgan, Gudiol, Carlota et al.
DOI: 10.1128/spectrum.02292-21

Early predictors of corticosteroid response in acute severe autoimmune hepatitis: A nationwide multicenter study.

PMID: 35470447
Journal: ALIMENTARY PHARMACOLOGY & THERAPEUTICS
Year: 2022
Reference: Aliment Pharmacol Ther. 2022 Jul;56(1):131-143. doi: 10.1111/apt.16926. Epub 2022 Apr 25.
Impact factor: 8.171
Publication type: Paper in international publication
Authors: Berenguer, Marina, Riveiro-Braciela, Mar, Salcedo, Magdalena, Rodriguez, Manuel, Londono, Maria Carlota, Albillos, Agustin, Hernandez-Guerra, Manuel, Romero, Manuel, Crespo, Javier, Calleja, Jose Luis et al.
DOI: 10.1111/apt.16926

Health promotion strategies toward improved healthcare access for migrants and refugees in Europe: MyHealth recommendations.

PMID: 35462396
Journal: HEALTH PROMOTION INTERNATIONAL
Year: 2022
Reference: Health Promot Int. 2022 Apr 23. pii: 6573374. doi: 10.1093/heapro/daac047.
Impact factor: 2.483
Publication type: Paper in international publication
Authors: Serre-Delcor, Nuria, Denial, Abdallah, Kirkgoeze, Nur, Ntetsika, Maria, Evangelidou, Stella, Schouler-Ocak, Meryam, Movsisyan, Narine, Gionakis, Nikos et al.
DOI: 10.1093/heapro/daac047

Isolation strategy for controlling the spread of multidrug-resistant organisms: Is this still an essential option in hospitals?

PMID: 34736746
Journal: ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
Year: 2021
Reference: Enferm Infecc Microbiol Clin (Engl Ed). 2021 Nov;39(9):425-428. doi: 10.1016/j.eimce.2021.04.007.
Impact factor: 1.731
Publication type: Editorail in international publication
Authors: Larrosa, Maria Nieves, Almirante, Benito et al.
DOI: 10.1016/j.eimce.2021.04.007

Trypanocidal treatment of Chagas disease.

PMID: 34736749
Journal: ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
Year: 2021
Reference: Enferm Infecc Microbiol Clin (Engl Ed). 2021 Nov;39(9):458-470. doi: 10.1016/j.eimce.2020.04.012.
Impact factor: 1.731
Publication type: Review in international publication
Authors: Perez-Molina, Jose A, Crespillo-Andujar, Clara, Bosch-Nicolau, Pau, Molina, Israel et al.
DOI: 10.1016/j.eimce.2020.04.012

Analytical Evaluation of Dried Blood Spot and Rapid Diagnostic Test as a New Strategy for Serological Community Screening for Chronic Chagas Disease.

PMID: 34604116
Journal: Frontiers in Cellular and Infection Microbiology
Year: 2021
Reference: Front Cell Infect Microbiol. 2021 Sep 15;11:736630. doi: 10.3389/fcimb.2021.736630. eCollection 2021.
Impact factor: 5.293
Publication type: Paper in international publication
Authors: Silgado, Aroa, Gual-Gonzalez, Lidia, Oliveira-Souto, Ines, Goterris, Lidia, Serre-Delcor, Nuria, Esperalba, Juliana, Gomez-I-Prat, Jordi, Fernandez-Naval, Candela, Molina, Israel, Pumarola, Tomas et al.
DOI: 10.3389/fcimb.2021.736630

Clinical profile and mortality in patients with T. cruzi/HIV co-infection from the multicenter data base of the "Network for healthcare and study of Trypanosoma cruzi/HIV co-infection and other immunosuppression conditions".

PMID: 34591866
Journal: PLoS Neglected Tropical Diseases
Year: 2021
Reference: PLoS Negl Trop Dis. 2021 Sep 30;15(9):e0009809. doi: 10.1371/journal.pntd.0009809. eCollection 2021 Sep.
Impact factor: 4.411
Publication type: Paper in international publication
Authors: Shikanai-Yasuda, Maria Aparecida, Mediano, Mauro Felippe Felix, Novaes, Christina Terra Gallafrio, Sousa, Andrea Silvestre de, Sartori, Ana Marli Christovam, Santana, Rodrigo Carvalho, Correia, Dalmo, Castro, Cleudson Nery de, Severo, Marilia Maria Dos Santos, Hasslocher-Moreno, Alejandro Marcel et al.
DOI: 10.1371/journal.pntd.0009809

Clinical portrait of the SARS-CoV-2 epidemic in European cancer patients.

PMID: 32737082
Journal: Cancer Discovery
Year: 2020
Reference: Cancer Discov. 2020 Jul 31. pii: 2159-8290.CD-20-0773. doi: 10.1158/2159-8290.CD-20-0773.
Impact factor: 29.497
Publication type: Paper in international publication
Authors: Chopra, Neha, Salazar, Ramon, Bertuzzi, Alexia, Brunet, Joan, Mesia, Ricard, Segui, Elia, Biello, Federica, Generali, Daniele, Grisanti, Salvatore, Rizzo, Gianpiero et al.
DOI: 10.1158/2159-8290.CD-20-0773

Comparative evaluation of community interventions for the immigrant population of Latin American origin at risk for Chagas disease in the city of Barcelona.

PMID: 32663211
Journal: PLoS One
Year: 2020
Reference: PLoS One. 2020 Jul 14;15(7):e0235466. doi: 10.1371/journal.pone.0235466. eCollection 2020.
Impact factor: 2.74
Publication type: Paper in international publication
Authors: de Los Santos, Juan Jose, Gomez I Prat, Jordi, Peremiquel-Trillas, Paula, Claveria Guiu, Isabel, Caro Mendivelso, Johanna, Choque, Estefa, Albajar Vinas, Pedro, Ascaso Terren, Carlos, Ouaarab Essadek, Hakima, Sulleiro, Elena et al.
DOI: 10.1371/journal.pone.0235466

Presenting Features and Early Mortality from SARS-CoV-2 Infection in Cancer Patients during the Initial Stage of the COVID-19 Pandemic in Europe.

PMID: 32650523
Journal: Cancers
Year: 2020
Reference: Cancers (Basel). 2020 Jul 8;12(7). pii: cancers12071841. doi: 10.3390/cancers12071841.
Impact factor: 6.126
Publication type: Paper in international publication
Authors: Sng, Christopher C T, Biello, Federica, Segui, Elia, Aguilar-Company, Juan, Carbo, Anna, Bruna, Riccardo, Bower, Mark, Rizzo, Gianpiero, Benafif, Sarah, Carmona, Carme et al.
DOI: 10.3390/cancers12071841

["Heparjoc-Actua": educational tool created through a process of participatory action research with vulnerable immigrant groups to improve accessibility to diagnosis of hepatitis B.]

PMID: 32632084
Journal: Revista Espanola de Salud Publica
Year: 2020
Reference: Rev Esp Salud Publica. 2020 Jul 7;94.
Impact factor: 0.746
Publication type: Paper in national publication
Authors: Ouaarab Essadek, Hakima, Borras Bermejo, Blanca, Caro Mendivelso, Johanna, Rodriguez Arjona, L Laia, Bisobe, Apolonia, Claveria Guiu, Isabel, Gomez I Prat, Jordi et al.
DOI:

Rapid subacute myelopathy following kidney transplantation from HTLV-1 donors: role of immunosuppresors and failure of antiretrovirals.

PMID: 31467675
Journal: Therapeutic advances in infectious disease
Year: 2019
Reference: Ther Adv Infect Dis. 2019 Aug 21;6:2049936119868028. doi: 10.1177/2049936119868028. eCollection 2019 Jan-Dec.
Impact factor: 0
Publication type: Paper in international publication
Authors: Rojo, S, Roc, Lourdes, de Mendoza, Carmen, Fernandez-Alonso, Miriam, Reina, Gabriel, Soriano, Vicente, Rodriguez, C, Vera, M, Del Romero, J, Marcaida, G et al.
DOI: 10.1177/2049936119868028

Leishmaniasis and tumor necrosis factor alpha antagonists in the Mediterranean basin. A switch in clinical expression.

PMID: 31469834
Journal: PLoS Neglected Tropical Diseases
Year: 2019
Reference: PLoS Negl Trop Dis. 2019 Aug 30;13(8):e0007708. doi: 10.1371/journal.pntd.0007708. eCollection 2019 Aug.
Impact factor: 4.487
Publication type: Paper in international publication
Authors: Bosch-Nicolau, Pau, Ubals, Maria, Salvador, Fernando, Sanchez-Montalva, Adrian, Aparicio, Gloria, Erra, Alba, Martinez de Salazar, Pablo, Sulleiro, Elena, Molina, Israel et al.
DOI: 10.1371/journal.pntd.0007708

Usefulness of FDG PET/CT in the management of tuberculosis.

PMID: 31454368
Journal: PLoS One
Year: 2019
Reference: PLoS One. 2019 Aug 27;14(8):e0221516. doi: 10.1371/journal.pone.0221516. eCollection 2019.
Impact factor: 2.776
Publication type: Paper in international publication
Authors: Sanchez-Montalva, Adrian, Barios, Marta, Salvador, Fernando, Villar, Ana, Tortola, Teresa, Molina-Morant, Daniel, Lorenzo-Bosquet, Carles, Espinosa-Pereiro, Juan, Molina, Israel et al.
DOI: 10.1371/journal.pone.0221516

HTLV-1 infection in solid organ transplant donors and recipients in Spain.

PMID: 31399112
Journal: BMC INFECTIOUS DISEASES
Year: 2019
Reference: BMC Infect Dis. 2019 Aug 9;19(1):706. doi: 10.1186/s12879-019-4346-z.
Impact factor: 2.565
Publication type: Paper in international publication
Authors: Niubo, J, de Mendoza, Carmen, Roc, Lourdes, Benito, Rafael, Reina, Gabriel, Ramos, Jose Manuel, Gomez, Cesar, Garcia, J, Paz, I, Poveda, E et al.
DOI: 10.1186/s12879-019-4346-z

Tuberculosis Recommendations for Solid Organ Transplant Recipients and Donors.

PMID: 29381579
Journal: TRANSPLANTATION
Year: 2018
Reference: Transplantation. 2018 Feb;102(2S Suppl 2):S60-S65. doi: 10.1097/TP.0000000000002014.
Impact factor: 3.96
Publication type: Paper in international publication
Authors: Santoro-Lopes, Guilherme, Subramanian, Aruna K, Molina, Israel, Aguado, Jose Maria, Rabagliatti, Ricardo, Len, Oscar et al.
DOI: 10.1097/TP.0000000000002014

Prevalence and molecular characterization of Strongyloides stercoralis, Giardia duodenalis, Cryptosporidium spp., and Blastocystis spp. isolates in school children in Cubal, Western Angola.

PMID: 29378626
Journal: Parasites & Vectors
Year: 2018
Reference: Parasit Vectors. 2018 Jan 29;11(1):67. doi: 10.1186/s13071-018-2640-z.
Impact factor: 3.163
Publication type: Paper in international publication
Authors: Aznar-Ruiz-de-Alegria, Maria L, Espasa, Mateu, Ninda, Arlette, Gandasegui, Javier, Sulleiro, Elena, Moreno, Milagros, Salvador, Fernando, Molina, Israel, Rodriguez, Esperanza, Carmena, David et al.
DOI: 10.1186/s13071-018-2640-z

Recommendations for Management of Endemic Diseases and Travel Medicine in Solid-Organ Transplant Recipients and Donors: Latin America.

PMID: 29381647
Journal: TRANSPLANTATION
Year: 2018
Reference: Transplantation. 2018 Feb;102(2):193-208. doi: 10.1097/TP.0000000000002027.
Impact factor: 3.96
Publication type: Paper in international publication
Authors: Vilela, Eduardo Garcia, Clemente, Wanessa Trindade, Pierrotti, Ligia Camera, Abdala, Edson, Morris, Michele I, Azevedo, Luiz S, Lopez-Velez, Rogelio, Cuenca-Estrella, Manuel, Torre-Cisneros, Julian, Petersen, Eskild et al.
DOI: 10.1097/TP.0000000000002027

High-dose daptomycin is effective as an antibiotic-lock therapy in a rabbit model of Staphylococcus epidermidis catheter-related infection.

PMID: 29158277
Journal: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Year: 2018
Reference: Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: AAC.01777-17. doi: 10.1128/AAC.01777-17. Print 2018 Feb.
Impact factor: 4.255
Publication type: Paper in international publication
Authors: Almirante, Benito, Gavalda, Joan, Torrents, Eduard, Gomis, Xavier, Martin-Gomez, Maria Teresa, Luis Del Pozo, Jose, Basas, Jana, Palau, Marta, Ratia, Carlos et al.
DOI: 10.1128/AAC.01777-17

[On site-screening for Chagas disease supported by a community intervention: can it improve accessibility for diagnosis and treatment?]

PMID: 28641864
Journal: Gaceta Sanitaria
Year: 2017
Reference: Gac Sanit. 2017 Sep - Oct;31(5):439-440. doi: 10.1016/j.gaceta.2017.04.007. Epub 2017 Jun 20.
Impact factor: 1.768
Publication type: Letter or abstract
Authors: Ouaarab Essadek, Hakima, Claveria Guiu, Isabel, Caro Mendivelso, Johanna, Sulleiro, Elena, Pastoret, Conxita, Navarro, Miriam, Barrabeig, Irene, Gomez I Prat, Jordi et al.
DOI: 10.1016/j.gaceta.2017.04.007

Epidemiology and Immediate Indirect Effects of Respiratory Viruses in Lung Transplant Recipients: A 5-Year Prospective Study.

PMID: 27615811
Journal: AMERICAN JOURNAL OF TRANSPLANTATION
Year: 2017
Reference: Am J Transplant. 2017 May;17(5):1304-1312. doi: 10.1111/ajt.14042. Epub 2016 Oct 14.
Impact factor: 6.165
Publication type: Paper in international publication
Authors: Roman, A, Peghin, M, Hirsch, H H, Len, O, Codina, G, Berastegui, C, Saez, B, Sole, J, Cabral, E, Sole, A et al.
DOI: 10.1111/ajt.14042

Efficacy of beta-lactam/beta-lactamase inhibitor combinations for the treatment of bloodstream infection due to extended-spectrum beta-lactamase-producing Enterobacteriaceae in hematological patients with neutropenia.

PMID: 28584145
Journal: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Year: 2017
Reference: Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00164-17. doi: 10.1128/AAC.00164-17. Print 2017 Aug.
Impact factor: 4.302
Publication type: Paper in international publication
Authors: Abdala, Edson, Akova, Murat, Alvarez, Rocio, Maestro-de la Calle, Guillermo, Cano, Angela, Cervera, Carlos, Clemente, Wanessa T, Martin-Davila, Pilar, Freifeld, Alison, Gomez, Lucia et al.
DOI: 10.1128/AAC.00164-17

Pathogenic Characteristics of Staphylococcus aureus Endovascular Infection Isolates from Different Clonal Complexes.

PMID: 28579985
Journal: Frontiers in Microbiology
Year: 2017
Reference: Front Microbiol. 2017 May 19;8:917. doi: 10.3389/fmicb.2017.00917. eCollection 2017.
Impact factor: 4.076
Publication type: Paper in international publication
Authors: Perez-Montarelo, Dafne, Viedma, Esther, Murcia, Mercedes, Munoz-Gallego, Irene, Larrosa, Nieves, Branas, Patricia, Fernandez-Hidalgo, Nuria, Gavalda, Joan, Almirante, Benito, Chaves, Fernando et al.
DOI: 10.3389/fmicb.2017.00917

Blog

News

The meeting was an opportunity to get to know projects from both institutions and to promote interaction between professionals.

On European Antibiotic Awareness Day, we highlight the importance of using these medications responsibly and finding innovative solutions to combat this issue.

Vall d'Hebron has coordinated this initiative that has carried out numerous training and community awareness activities aimed at empowering young people in sexual and reproductive health issues.