About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The Liver Diseases group is a referent at the local, national and international level in research, and is one of the most active groups in clinical research at VHIR. The group's prominent involvement in clinical trials is a clear indication of our professionals' commitment to ensuring that patients have access to state-of-the-art therapies. Our participation and collaboration in international projects and consortiums are also a fundamental characteristic of the group. The main objective of the group is to become one of the best translational research groups in liver diseases. It is essential to be able to apply all the findings of basic research to clinical research to improve the health of patients with liver disease.
IP: Maria Buti Ferret Collaborators: Tamara Del Rio Higueras, Mª Eulàlia Molinas Guilera, Amaia Latasa Arrazubi, Judit Vico Romero, Alejandro López Targa, Maria del Mar Riveiro Barciela Funding agency: EUROPEAN COMMISSION Funding: 211443.8 Reference: IP-CURE-B_H2020SC1BHC2019 Duration: 01/01/2020 - 31/12/2024
IP: Juan Ignacio Esteban Mur Collaborators: Lluís Viladomiu Catà, Silvia Sauleda Oliveras, Jordi Llaneras Artigues, Marta Bes Maijo, Cristina Dopazo Taboada, Angie Rico Blazquez Funding agency: Instituto de Salud Carlos III Funding: 159720 Reference: PI19/00533 Duration: 01/01/2020 - 30/06/2024
IP: Isabel Campos Varela Collaborators: Lluis Castells Fusté, Nuria Roson Gradaille, Ernest Hidalgo Llompart Funding agency: Instituto de Salud Carlos III Funding: 84095 Reference: PI19/00330 Duration: 01/01/2020 - 30/06/2024
IP: Maria Buti Ferret Collaborators: Maria Jose Herrero Mata, Ana Barreira Diaz, Maria del Mar Riveiro Barciela, Jordi Llaneras Artigues, Adriana Palom Agusti, Maria luisa Roade Tato Funding agency: Instituto de Salud Carlos III Funding: 117370 Reference: PI20/01692 Duration: 01/01/2021 - 30/06/2025
PMID: 37801035 Journal: FASEB JOURNAL Year: 2023 Reference: FASEB J. 2023 Nov;37(11):e23220. doi: 10.1096/fj.202300077R. Impact factor: Publication type: Paper in international publication Authors: Albillos, Agustin; Alter, David N; Asselta, Rosanna; Banales, Jesus M; Brewer, Jo; Bujanda, Luis; Buti, Maria; Buti, Maria; Conway, Joseph; de Cid, Rafael et al. DOI: 10.1096/fj.202300077R
PMID: 37802221 Journal: Contemporary Clinical Trials Year: 2023 Reference: Contemp Clin Trials. 2023 Oct 4:107352. doi: 10.1016/j.cct.2023.107352. Impact factor: Publication type: Paper in international publication Authors: Agustin, Salvador; Agustin, Salvador; Aithal, Guruprasad P; Akhtar, Salma; Aller, Rocio; Allison, Michael; Anstee, Quentin M; Antonucci, Michela; Aube, Christophe; Banerjee, Rajarshi et al. DOI: 10.1016/j.cct.2023.107352
PMID: 37808908 Journal: Frontiers in Cellular and Infection Microbiology Year: 2023 Reference: Front Cell Infect Microbiol. 2023 Sep 21;13:1175996. doi: 10.3389/fcimb.2023.1175996. eCollection 2023. Impact factor: Publication type: Review in international publication Authors: Quer, Josep; Rando-Segura, Ariadna; Rodriguez-Frias, Francisco et al. DOI: 10.3389/fcimb.2023.1175996
PMID: 37183551 Journal: LIVER INTERNATIONAL Year: 2023 Reference: Liver Int. 2023 May 15. doi: 10.1111/liv.15606. Impact factor: Publication type: Paper in international publication Authors: Abraldes, Juan G; Albillos, Agustin; Alvarado, Edilmar; Amitrano, Lucio; Banares, Rafael; Bataller, Ramon; Bosch, Jaime; Bureau, Christophe; Calleja, Jose L; Canete, Nuria et al. DOI: 10.1111/liv.15606
PMID: 35625929 Journal: Biomedicines Year: 2022 Reference: Biomedicines. 2022 May 21;10(5). pii: biomedicines10051194. doi: 10.3390/biomedicines10051194. Impact factor: 6.081 Publication type: Paper in international publication Authors: Rodriguez-Frias, Francisco, Garcia-Garcia, Selene, Caballero-Garralda, Andrea, Tabernero, David, Cortese, Maria Francesca, Gregori, Josep, Rodriguez-Algarra, Francisco, Quer, Josep, Riveiro-Barciela, Mar, Homs, Maria et al. DOI: 10.3390/biomedicines10051194
PMID: 35625927 Journal: Biomedicines Year: 2022 Reference: Biomedicines. 2022 May 20;10(5). pii: biomedicines10051191. doi: 10.3390/biomedicines10051191. Impact factor: 6.081 Publication type: Paper in international publication Authors: Augustin, Salvador, Martell, Maria, Salcedo, Maria Teresa, Pinheiro, Iris, Barbera, Aurora, Raurell, Imma, Estrella, Federico, de Leeuw, Marcel, Bolca, Selin, Gottardi, Davide et al. DOI: 10.3390/biomedicines10051191
PMID: 35588100 Journal: PLoS One Year: 2022 Reference: PLoS One. 2022 May 19;17(5):e0268522. doi: 10.1371/journal.pone.0268522. eCollection 2022. Impact factor: 3.24 Publication type: Paper in international publication Authors: den Elzen, Wendy P J, Rodriguez-Frias, Francisco, Casis, Ernesto, Thelen, Marc, Martinez-Sanchez, Luisa, Cobbaert, Christa M, Noordam, Raymond, Brouwer, Nannette, Blanco-Grau, Albert, Villena-Ortiz, Yolanda et al. DOI: 10.1371/journal.pone.0268522
PMID: 34256936 Journal: MEDICINA CLINICA Year: 2022 Reference: Med Clin (Barc). 2022 May 27;158(10):466-471. doi: 10.1016/j.medcli.2021.05.013. Epub 2021 Jun 16. Impact factor: 1.725 Publication type: Paper in national publication Authors: Sempere-Gonzalez, Abiu, Llaneras-Artigues, Jordi, Pinal-Fernandez, Iago, Canas-Ruano, Esperanza, Orozco-Galvez, Olimpia, Domingo-Baldrich, Eva, Michelena, Xabier, Meza, Beatriz, Garcia-Vives, Eloi, Gil-Vila, Albert et al. DOI: 10.1016/j.medcli.2021.05.013
PMID: 32663522 Journal: Clinical Gastroenterology and Hepatology Year: 2021 Reference: Clin Gastroenterol Hepatol. 2021 May;19(5):1030-1037. doi: 10.1016/j.cgh.2020.07.006. Epub 2020 Jul 11. Impact factor: 11.382 Publication type: Paper in international publication Authors: Riveiro-Barciela, M, Rando-Segura, A, Marcos-Fosch, C, Roade, L, Velazquez, F, Rodriguez-Frias, F, Esteban, R, Buti, M, Llaneras, J et al. DOI: 10.1016/j.cgh.2020.07.006
PMID: 33849720 Journal: ARCHIVOS DE BRONCONEUMOLOGIA Year: 2021 Reference: Arch Bronconeumol (Engl Ed). 2021 Mar 18. pii: S0300-2896(21)00106-X. doi: 10.1016/j.arbres.2021.03.008. Impact factor: 4.872 Publication type: Paper in national publication Authors: Boldo, Alba, Ojanguren, Amaia, Santamaria, Maite, Milla-Collado, Lucia, Fraile, Carlos, Gatius-Caldero, Sonia, Puy, Sara, Esquinas, Cristina, Saez-Gimenez, Berta, Ojanguren, Inigo et al. DOI: 10.1016/j.arbres.2021.03.008
PMID: 33800211 Journal: Diagnostics Year: 2021 Reference: Diagnostics (Basel). 2021 Mar 8;11(3). pii: diagnostics11030473. doi: 10.3390/diagnostics11030473. Impact factor: 3.706 Publication type: Paper in international publication Authors: Rodriguez-Frias, Francisco, Velasquez-Orozco, Fernando, Rando-Segura, Ariadna, Martinez-Camprecios, Joan, Salmeron, Paula, Najarro-Centeno, Adrian, Esteban, Angels, Quer, Josep, Buti, Maria, Pumarola-Sune, Tomas et al. DOI: 10.3390/diagnostics11030473
PMID: 33793754 Journal: BRITISH JOURNAL OF SURGERY Year: 2021 Reference: Br J Surg. 2021 Apr 30;108(4):380-387. doi: 10.1093/bjs/znaa171. Impact factor: 6.939 Publication type: Paper in international publication Authors: Talavera, E, Fraccalvieri, D, Alberti, P, Ostiz, F, Frago, R, Blanco, A, Pellino, G, Espin-Basany, E, Jimenez, L M, Marinello, F G et al. DOI: 10.1093/bjs/znaa171
PMID: 32106351 Journal: JOURNAL OF VIRAL HEPATITIS Year: 2020 Reference: J Viral Hepat. 2020 Jul;27(7):747-753. doi: 10.1111/jvh.13285. Epub 2020 Mar 11. Impact factor: 3.561 Publication type: Paper in international publication Authors: Riveiro-Barciela, Mar, Rando-Segura, Ariadna, Barreira-Diaz, Ana, Bes, Marta, Ruzo, Sofia P, Piron, Maria, Quer, Josep, Sauleda, Silvia, Rodriguez-Frias, Francisco, Esteban, Rafael et al. DOI: 10.1111/jvh.13285
PMID: 32077604 Journal: LIVER INTERNATIONAL Year: 2020 Reference: Liver Int. 2020 Feb;40 Suppl 1:15-21. doi: 10.1111/liv.14367. Impact factor: 5.175 Publication type: Review in international publication Authors: Buti, Maria, Roade, Luisa, Riveiro-Barciela, Mar, Esteban, Rafael et al. DOI: 10.1111/liv.14367
PMID: 31805583 Journal: SEMINARS IN LIVER DISEASE Year: 2020 Reference: Semin Liver Dis. 2020 Feb;40(1):49-60. doi: 10.1055/s-0039-3401031. Epub 2019 Dec 5. Impact factor: 4.457 Publication type: Review in international publication Authors: Buti, Maria, Riveiro-Barciela, Mar, Rodriguez-Frias, Francisco, Tabernero, David, Esteban, Rafael et al. DOI: 10.1055/s-0039-3401031
PMID: 31944340 Journal: HEPATOLOGY Year: 2020 Reference: Hepatology. 2020 Mar;71(3):1106-1116. doi: 10.1002/hep.31117. Impact factor: 14.679 Publication type: Review in international publication Authors: Fabrellas, Nuria, Carol, Marta, Palacio, Ester, Aban, Marites, Lanzillotti, Tommaso, Nicolao, Gea, Gines, Pere, Chiappa, Maria Teresa, Esnault, Vanessa, Graf-Dirmeier, Sabine et al. DOI: 10.1002/hep.31117
PMID: 28392234 Journal: JOURNAL OF HEPATOLOGY Year: 2017 Reference: J Hepatol. 2017 Aug;67(2):246-254. doi: 10.1016/j.jhep.2017.03.027. Epub 2017 Apr 7. Impact factor: 12.486 Publication type: Paper in international publication Authors: Shirvani-Dastgerdi, Elham, Winer, Benjamin Y, Celia-Terrassa, Antoni, Kang, Yibin, Tabernero, David, Yagmur, Eray, Rodriguez-Frias, Francisco, Gregori, Josep, Luedde, Tom, Ploss, Alexander et al. DOI: 10.1016/j.jhep.2017.03.027
PMID: 28189751 Journal: JOURNAL OF HEPATOLOGY Year: 2017 Reference: J Hepatol. 2017 Jun;66(6):1138-1148. doi: 10.1016/j.jhep.2017.01.028. Epub 2017 Feb 9. Impact factor: 12.486 Publication type: Paper in international publication Authors: Llerena, Susana, Pascasio, Juan Manuel, Turnes, Juan, Torras, Xavier, Morillas, Rosa Maria, Llaneras, Jordi, Serra, Miguel A, Diago, Moises, Rodriguez, Conrado Fernandez, Ampuero, Javier et al. DOI: 10.1016/j.jhep.2017.01.028
PMID: 28288829 Journal: CLINICAL MICROBIOLOGY AND INFECTION Year: 2017 Reference: Clin Microbiol Infect. 2017 Nov;23(11):860-867. doi: 10.1016/j.cmi.2017.03.003. Epub 2017 Mar 11. Impact factor: 5.292 Publication type: Paper in international publication Authors: Riveiro-Barciela, Mar, Bes, Marta, Rodriguez-Frias, Francisco, Tabernero, David, Ruiz, Alicia, Casillas, Rosario, Vidal, Judith, Homs, Maria, Nieto, Leonardo, Sauleda, Silvia et al. DOI: 10.1016/j.cmi.2017.03.003
PMID: 28248445 Journal: JOURNAL OF VIRAL HEPATITIS Year: 2017 Reference: J Viral Hepat. 2017 Sep;24(9):725-732. doi: 10.1111/jvh.12700. Epub 2017 Apr 10. Impact factor: 4.122 Publication type: Paper in international publication Authors: Navarro, Daniel, Rodriguez Frias, Francisco, Viciana, Isabel, Martinez-Sapina, Ana Maria, Rodriguez, Mario Jose, Martro, Elisa, Del Carmen Lozano, Maria, Coletta, Eleda, Cardenoso, Laura, Suarez, Avelina et al. DOI: 10.1111/jvh.12700
Preliminary study results confirm that the drug resmetirom reduces the presence of fat, inflammation, cell damage and fibrosis in the liver.
The European project, in which Vall d'Hebron participates, will favor personalized diagnosis and innovative therapeutic strategies in patients with the disease.
The research team used nanotechnology to deliver the drug directly to liver cells, which eliminated side effects without reducing effectiveness.
Des de Vall d'Hebron estem buscant 200 persones voluntàries sanes d'entre 18 i 30 anys per a participar en un estudi sobre els patrons de consum habitual de l'alcohol en població jove, en el marc del projecte StopALD.
