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Liver Diseases

The Liver Diseases group is a referent at the local, national and international level in research, and is one of the most active groups in clinical research at VHIR. The group's prominent involvement in clinical trials is a clear indication of our professionals' commitment to ensuring that patients have access to state-of-the-art therapies. Our participation and collaboration in international projects and consortiums are also a fundamental characteristic of the group. The main objective of the group is to become one of the best translational research groups in liver diseases. It is essential to be able to apply all the findings of basic research to clinical research to improve the health of patients with liver disease.

Team

Juan Bañares Sanchez

Juan Bañares Sanchez

Administration and Management
Liver Diseases
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Juan Ignacio Esteban Mur

Juan Ignacio Esteban Mur

Main researcher
Liver Diseases
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Juan Manuel Pericàs Pulido

Juan Manuel Pericàs Pulido

Main researcher
Liver Diseases
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Judit Vico Romero

Judit Vico Romero

Research technician
Liver Diseases
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Laura Puente Ramo

Laura Puente Ramo

Liver Diseases
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Lluis Castells Fusté

Lluis Castells Fusté

Liver Diseases
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Juan Bañares Sanchez

Juan Bañares Sanchez

Administration and Management
Liver Diseases
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Juan Ignacio Esteban Mur

Juan Ignacio Esteban Mur

Main researcher
Liver Diseases
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Juan Manuel Pericàs Pulido

Juan Manuel Pericàs Pulido

Main researcher
Liver Diseases
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Judit Vico Romero

Judit Vico Romero

Research technician
Liver Diseases
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Laura Puente Ramo

Laura Puente Ramo

Liver Diseases
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Lluis Castells Fusté

Lluis Castells Fusté

Liver Diseases
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Projects

Impact of HLA haplotypes and HDV viremia in developing of clinical events and quality of life of patients with chronic hepatitis delta.

IP: Maria Buti Ferret
Collaborators: Maria Jose Herrero Mata, Ana Barreira Diaz, Maria del Mar Riveiro Barciela, Jordi Llaneras Artigues, Adriana Palom Agusti
Funding agency: Instituto de Salud Carlos III
Funding: 117370
Reference: PI20/01692
Duration: 01/01/2021 - 30/06/2025

OPTIMIZACIÓN DE NUEVOS TRATAMIENTOS EN LA ENFERMEDAD HEPÁTICA CRÓNICA-NASH

IP: Joan Genescà Ferrer
Collaborators: Immaculada Raurell Saborit, Maria Nieves Martell Pérez-Alcalde, Mònica Pons Delgado
Funding agency: Instituto de Salud Carlos III
Funding: 268620
Reference: PI21/00691
Duration: 01/01/2022 - 30/06/2026

Determinación de biomarcadores de lesión neuronal y astrocitaria en suero de paciente con encefalopatía hepática

IP: Macarena Simon-Talero Horga
Collaborators: Joaquin Castillo Justribo, Mònica Pons Delgado
Funding agency: Instituto de Salud Carlos III
Funding: 60500
Reference: PI21/00312
Duration: 01/01/2022 - 30/06/2026

Aislamiento y caracterización molecular de Células Tumorales Circulantes (CTCs): potenciales biomarcadores en Carcinoma Hepatocelular

IP: Beatriz Minguez Rosique
Collaborators: Itxarone Izaskun Bilbao Aguirre, Elena Vargas Accarino, Maria Teresa Salcedo Allende, Monica Higuera Urbano
Funding agency: Instituto de Salud Carlos III
Funding: 183920
Reference: PI21/00714
Duration: 01/01/2022 - 31/12/2025

Publications

In-Host Flat-like Quasispecies: Characterization Methods and Clinical Implications.

PMID: 38792840
Journal: Microorganisms
Year: 2024
Reference: Microorganisms. 2024 May 17;12(5):1011. doi: 10.3390/microorganisms12051011.
Impact factor:
Publication type: Paper in international publication
Authors: Andres, Cristina; Anton, Andres; Buti, Maria; Campos, Carolina; Colomer-Castell, Sergi; Cortese, Maria Francesca; Esteban, Juan Ignacio; Garcia-Cehic, Damir; Gonzalez-Sanchez, Alejandra; Gregori, Josep et al.
DOI: 10.3390/microorganisms12051011

Genotyping Hepatitis B virus by Next-Generation Sequencing: Detection of Mixed Infections and Analysis of Sequence Conservation.

PMID: 38791519
Journal:
Year: 2024
Reference: Int J Mol Sci. 2024 May 17;25(10):5481. doi: 10.3390/ijms25105481.
Impact factor:
Publication type: Paper in international publication
Authors: Anton, Andres; Buti, Maria; Cortese, Maria Francesca; Costa, Josep; Dopico, Eva; Ferrer-Costa, Roser; Gonzalez-Sanchez, Alejandra; Gregori, Josep; Guerrero, Laura; Martinez, Miguel J et al.
DOI: 10.3390/ijms25105481

Hepatic venous pressure gradient predicts risk of hepatic decompensation and liver-related mortality in patients with MASLD.

PMID: 38823501
Journal: JOURNAL OF HEPATOLOGY
Year: 2024
Reference: J Hepatol. 2024 May 30:S0168-8278(24)00368-4. doi: 10.1016/j.jhep.2024.05.033.
Impact factor:
Publication type: Paper in international publication
Authors: Albillos, Agustin; Alvarado, Edilmar; Ardevol, Alba; Bagdadi, Ali; Banares, Rafael; Berzigotti, Annalisa; Bureau, Christophe; Fortea, Jose Ignacio; Francque, Sven; Garcia-Pagan, Juan Carlos et al.
DOI: 10.1016/j.jhep.2024.05.033

Frailty and sarcopenia in patients with acute-on-chronic liver failure: assessment and risk in the liver transplant setting.

PMID: 38851394
Journal: Annals of Hepatology
Year: 2024
Reference: Ann Hepatol. 2024 Jun 6:101515. doi: 10.1016/j.aohep.2024.101515.
Impact factor:
Publication type: Paper in international publication
Authors: Campos-Varela, Isabel; Castells, Lluis; Quiroga, Sergi; Simon-Talero, Macarena; Vargas, Victor et al.
DOI: 10.1016/j.aohep.2024.101515

Retreatment with Checkpoint inhibitors after a severe immune-related hepatitis: Results from a prospective multicenter study.

PMID: 35487453
Journal: Clinical Gastroenterology and Hepatology
Year: 2023
Reference: Clin Gastroenterol Hepatol. 2023 Mar;21(3):732-740. doi: 10.1016/j.cgh.2022.03.050. Epub 2022 Apr 26.
Impact factor:
Publication type: Paper in international publication
Authors: Barreira-Diaz, Ana; Buti, Maria; Callejo-Perez, Ana; Diaz-Gonzalez, Alvaro; Diaz-Mejia, Nely; Londono, Maria-Carlota; Munoz-Couselo, Eva; Riveiro-Barciela, Mar; Salcedo, Maria-Teresa et al.
DOI: 10.1016/j.cgh.2022.03.050

Long-term follow-up of HCV-infected patients with end-stage chronic kidney disease after sustained virological response with direct-acting antiviral therapy.

PMID: 36584754
Journal: Gastroenterologia y Hepatologia
Year: 2023
Reference: Gastroenterol Hepatol. 2023 Oct;46(8):594-602. doi: 10.1016/j.gastrohep.2022.12.004. Epub 2022 Dec 27.
Impact factor:
Publication type: Paper in national publication
Authors: Azancot, Maria A; Azancot, Maria A; Buti, Maria; Carmona, Isabel; Delgado, Manuel; Escudero-Garcia, Desamparados; Garcia-Samaniego, Javier; Gutierrez, Maria L; Londono, Maria-Carlota; Losa-Garcia, Juan E et al.
DOI: 10.1016/j.gastrohep.2022.12.004

Clinical and Patient-Reported Outcome Profile of Patients with Hepatitis B Viral Infection from the Global Liver Registry.

PMID: 36601668
Journal: JOURNAL OF VIRAL HEPATITIS
Year: 2023
Reference: J Viral Hepat. 2023 Apr;30(4):335-344. doi: 10.1111/jvh.13800. Epub 2023 Jan 11.
Impact factor:
Publication type: Paper in international publication
Authors: Ahmed, Aijaz; Alqahtani, Saleh; Alswat, Khalid Aida; Buti, Maria; Chan, Wah Kheong; Duseja, Ajay K; Eguchi, Yuichiro; El-Kassas, Mohamed; Fan, Jian-Gao; Fernandez, Marlen Ivon Castellanos et al.
DOI: 10.1111/jvh.13800

Remdesivir and survival outcomes in critically ill patients with COVID-19: A multicentre observational cohort study.

PMID: 36596315
Journal: JOURNAL OF INFECTION
Year: 2023
Reference: J Infect. 2023 Mar;86(3):256-308. doi: 10.1016/j.jinf.2022.12.027. Epub 2022 Dec 31.
Impact factor:
Publication type: Letter whit IF
Authors: Adell-Serrano, Berta; Adrio, Sabela Vara; Agrifoglio, Alexander; Aguilera, Luciano; Albaiceta, Guillermo M; Alcaraz-Serrano, Victoria; Aldecoa, Cesar; Alegre, Cynthia; Almansa, Raquel; Alvarez, Juan I Lazo et al.
DOI: 10.1016/j.jinf.2022.12.027

WITHDRAWN: Validation of IDSA/ATS Guidelines for ICU Admission in Adults Over 80 Years Old With Community-acquired Pneumonia.

PMID: 36163305
Journal: ARCHIVOS DE BRONCONEUMOLOGIA
Year: 2022
Reference: Arch Bronconeumol. 2022 Sep 15:S0300-2896(22)00528-2. doi: 10.1016/j.arbres.2022.08.010.
Impact factor:
Publication type: Paper in national publication
Authors: Cilloniz, Catia; Ferrer, Miquel; Gabarrus, Albert; Mendez, Raul; Menendez, Rosario; Pericas, Juan M; Peroni, Hector Jose; Ruiz, Luis Alberto; Serrano, Leyre; Torres, Antoni et al.
DOI: 10.1016/j.arbres.2022.08.010

Risk of infections in patients with NAFLD and Type 2 Diabetes under treatment with SGLT2 inhibitors and relationship with liver outcomes: A retrospective case-control study.

PMID: 36093073
Journal: Frontiers in Endocrinology
Year: 2022
Reference: Front Endocrinol (Lausanne). 2022 Aug 24;13:945626. doi: 10.3389/fendo.2022.945626. eCollection 2022.
Impact factor:
Publication type: Paper in international publication
Authors: Banares, Juan; Camps-Relats, Laura; Ciudin, Andreea; Genesca, Joan; Manzano-Nunez, Ramiro; Pericas, Juan M; Pons, Monica; Prio, Alba; Rivera-Esteban, Jesus; Ruiz-Ortega, Lourdes et al.
DOI: 10.3389/fendo.2022.945626

High frequency of acute decompensation and cancer in patients with compensated cirrhosis due to nonalcoholic fatty liver disease: A retrospective cohort study.

PMID: 36073343
Journal: Hepatology Communications
Year: 2022
Reference: Hepatol Commun. 2022 Nov;6(11):3212-3222. doi: 10.1002/hep4.2056. Epub 2022 Sep 8.
Impact factor:
Publication type: Paper in international publication
Authors: Aracil, Carles; Augustin, Salvador; Bassegoda, Octavi; Broquetas, Teresa; Carrion, Jose A; Gines, Pere; Graupera, Isabel; Morillas, Rosa; Pardo, Albert; Pericas, Juan M et al.
DOI: 10.1002/hep4.2056

Effectiveness of entecavir vs tenofovir disoproxil fumarate for functional cure of chronic hepatitis B in an international cohort.

PMID: 36070123
Journal: Hepatology International
Year: 2022
Reference: Hepatol Int. 2022 Dec;16(6):1297-1307. doi: 10.1007/s12072-022-10411-x. Epub 2022 Sep 7.
Impact factor:
Publication type: Paper in international publication
Authors: Accarino, Elena Vargas; Ahn, Sang Bong; Buti, Maria; Chen, Chien-Hung; Cheung, Ramsey; Cho, Yong Kyun; Chuang, Wan-Long; Dai, Chia-Yen; Enomoto, Masaru; Gadano, Adrian et al.
DOI: 10.1007/s12072-022-10411-x

Trans-arterial chemoembolization as a loco-regional inducer of immunogenic cell death in hepatocellular carcinoma: implications for immunotherapy.

PMID: 34593621
Journal: Journal for ImmunoTherapy of Cancer
Year: 2021
Reference: J Immunother Cancer. 2021 Sep;9(9). pii: jitc-2021-003311. doi: 10.1136/jitc-2021-003311.
Impact factor:
Publication type: Paper in international publication
Authors: Akarca, Ayse U; Altmann, Daniel M; Avellini, Claudio; Bhoori, Sherrie; Boyton, Rosemary J; Cacciato, Valentina; Casagrande, Edoardo; Diaz, Alba; Fessas, Petros; Forner, Alejandro et al.
DOI: 10.1136/jitc-2021-003311

Treatment of Chronic Hepatitis B Virus with Oral Anti-Viral Therapy.

PMID: 34593150
Journal: Clinics in Liver Disease
Year: 2021
Reference: Clin Liver Dis. 2021 Nov;25(4):725-740. doi: 10.1016/j.cld.2021.06.003. Epub 2021 Jul 29.
Impact factor:
Publication type: Review in international publication
Authors: Buti, Maria; Esteban, Rafael; Riveiro-Barciela, Mar et al.
DOI: 10.1016/j.cld.2021.06.003

Association between circulating alpha-1 antitrypsin polymers and lung and liver disease.

PMID: 34526035
Journal: RESPIRATORY RESEARCH
Year: 2021
Reference: Respir Res. 2021 Sep 15;22(1):244. doi: 10.1186/s12931-021-01842-5.
Impact factor:
Publication type: Paper in international publication
Authors: Barrecheguren, Miriam; Belmonte, Irene; Esquinas, Cristina; Farago, Georgina; Gabriel-Medina, Pablo; Genesca, Joan; Loeb, Eduardo; Miranda, Elena; Miravitlles, Marc; Nunez, Alexa et al.
DOI: 10.1186/s12931-021-01842-5

Naive hepatitis B e antigen-negative chronic hepatitis B patients are at risk of carotid atherosclerosis: A prospective study.

PMID: 34497439
Journal: WORLD JOURNAL OF GASTROENTEROLOGY
Year: 2021
Reference: World J Gastroenterol. 2021 Aug 14;27(30):5112-5125. doi: 10.3748/wjg.v27.i30.5112.
Impact factor:
Publication type: Paper in international publication
Authors: Bronte, Fabrizio; Buti, Maria; Craxi, Antonio; Esteban, Rafael; Marcos-Fosch, Cristina; Martinez-Valle, Fernando; Orozco, Olimpia; Petta, Salvatore; Riveiro-Barciela, Mar; Salcedo, Maria-Teresa et al.
DOI: 10.3748/wjg.v27.i30.5112

Temporal Trends and Outcomes in Liver Transplantation for Recipients With HIV Infection in Europe and United States.

PMID: 32969987
Journal: TRANSPLANTATION
Year: 2020
Reference: Transplantation. 2020 Oct;104(10):2078-2086. doi: 10.1097/TP.0000000000003107.
Impact factor:
Publication type: Paper in international publication
Authors: Adam, Rene; Belli, Luca S; Berenguer, Marina; Campos-Varela, Isabel; Di Benedetto, Fabrizio; Dodge, Jennifer L; Duvoux, Christophe; Karam, Vincent; Samuel, Didier; Terrault, Norah A et al.
DOI: 10.1097/TP.0000000000003107

Management of chronic liver disease-associated severe thrombocytopenia in Spain: a view from the experts.

PMID: 32954777
Journal: REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
Year: 2020
Reference: Rev Esp Enferm Dig. 2020 Oct;112(10):778-783. doi: 10.17235/reed.2020.6895/2020.
Impact factor:
Publication type: Paper in international publication
Authors: Andrade, Raul J; Banares, Rafael; Bentley, Roy; Calleja-Panero, Jose Luis; Crespo, Javier; Esteban, Rafael; Gil Aguirre, Alicia; Jarque, Isidro; Mingot-Castellano, Maria Eva; Munoz-Penin, Rocio et al.
DOI: 10.17235/reed.2020.6895/2020

Covert hepatic encephalopathy and spontaneous portosystemic shunts increase the risk of developing overt hepatic encephalopathy.

PMID: 32890428
Journal: LIVER INTERNATIONAL
Year: 2020
Reference: Liver Int. 2020 Dec;40(12):3093-3102. doi: 10.1111/liv.14660.
Impact factor:
Publication type: Paper in international publication
Authors: Genesca, Joan; Greinert, Robin; Hohne, Kevin; Ludwig, Christiane; Praktiknjo, Michael; Ripoll, Cristina; Simon-Talero, Macarena; Stangl, Franz; Trebicka, Jonel; Wienke, Andreas et al.
DOI: 10.1111/liv.14660

Toxicities from immunotherapy: From clinical trials to real-world clinical practice.

PMID: 32868034
Journal: MEDICINA CLINICA
Year: 2020
Reference: Med Clin (Barc). 2020 Dec 24;155(12):541-547. doi: 10.1016/j.medcli.2020.06.057. Epub 2020 Aug 28.
Impact factor:
Publication type: Review in national publication
Authors: Barreira-Diaz, Ana; Martinez-Valle, Fernando; Munoz-Couselo, Eva; Riveiro-Barciela, Mar; Roca-Herrera, Maria; Trallero-Araguas, Ernesto; Zamora, Ester et al.
DOI: 10.1016/j.medcli.2020.06.057

Too many people with viral hepatitis are diagnosed late - with dire consequences.

PMID: 31320742
Journal: Nature Reviews Gastroenterology & Hepatology
Year: 2019
Reference: Nat Rev Gastroenterol Hepatol. 2019 Aug;16(8):451-452. doi: 10.1038/s41575-019-0177-z.
Impact factor:
Publication type: Review in international publication
Authors: Buti, Maria; Dillon, John F; Lazarus, Jeffrey V; Picchio, Camila; Rockstroh, Jurgen K; Weis, Nina et al.
DOI: 10.1038/s41575-019-0177-z

Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis.

PMID: 31311938
Journal: Nature Communications
Year: 2019
Reference: Nat Commun. 2019 Jul 16;10(1):3126. doi: 10.1038/s41467-019-11004-3.
Impact factor:
Publication type: Paper in international publication
Authors: Altamirano, Jose; Arab, Juan P; Aragon, Tomas; Argemi, Josepmaria; Atkinson, Stephen R; Avila, Matias A; Bataller, Ramon; Bell, Aaron; Berasain, Carmen; Blokhin, Ilya O et al.
DOI: 10.1038/s41467-019-11004-3

The Critical Role of Codon Composition on the Translation Efficiency Robustness of the Hepatitis A Virus Capsid.

PMID: 31290967
Journal: Genome Biology and Evolution
Year: 2019
Reference: Genome Biol Evol. 2019 Sep 1;11(9):2439-2456. doi: 10.1093/gbe/evz146.
Impact factor:
Publication type: Paper in international publication
Authors: Bosch, Albert; D'Andrea, Lucia; de Castellarnau, Montserrat; Gregori, Josep; Guix, Susana; Perez-Rodriguez, Francisco-Javier; Pinto, Rosa M; Quer, Josep; Ribes, Enric et al.
DOI: 10.1093/gbe/evz146

Effectiveness and Safety of Sofosbuvir/Velpatasvir/ Voxilaprevir in Patients with Chronic Hepatitis C Previously Treated with DAAs.

PMID: 31203153
Journal: JOURNAL OF HEPATOLOGY
Year: 2019
Reference: J Hepatol. 2019 Oct;71(4):666-672. doi: 10.1016/j.jhep.2019.06.002. Epub 2019 Jun 14.
Impact factor:
Publication type: Paper in international publication
Authors: Antonio Carrion, Jose; Arenas, Juan; Arencibia, Ana; Badia, Ester; Bernal, Vanesa; Buti, Maria; Cachero, Alba; Carmona, Isabel; Conde, Isabel; Delgado, Manuel et al.
DOI: 10.1016/j.jhep.2019.06.002

Extracellular HMGA1 promotes tumor Invasion and Metastasis in Triple-Negative Breast Cancer.

PMID: 30135148
Journal: CLINICAL CANCER RESEARCH
Year: 2018
Reference: Clin Cancer Res. 2018 Dec 15;24(24):6367-6382. doi: 10.1158/1078-0432.CCR-18-0517. Epub 2018 Aug 22.
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, Ibane; Arribas, Joaquin; Cortes, Javier; Fernandez, Yolanda; Gregori, Josep; Matres, Ana; Mendez, Olga; Peg, Vicente; Perez, Jose; Pujals, Mireia et al.
DOI: 10.1158/1078-0432.CCR-18-0517

Hepatitis B Surface Antigen Loss with Tenofovir Disoproxil Fumarate Plus Peginterferon Alfa-2a: Week 120 Analysis.

PMID: 30136045
Journal: DIGESTIVE DISEASES AND SCIENCES
Year: 2018
Reference: Dig Dis Sci. 2018 Dec;63(12):3487-3497. doi: 10.1007/s10620-018-5251-9. Epub 2018 Aug 22.
Impact factor:
Publication type: Paper in international publication
Authors: Ahn, Sang Hoon; Buti, Maria; Caruntu, Florin A; Chan, Alain; Chan, Henry L Y; Chuang, Wan-Long; Crans, Gerald; Elkhashab, Magdy; Flisiak, Robert; Fung, Scott et al.
DOI: 10.1007/s10620-018-5251-9

Resistance of high fitness hepatitis C virus to lethal mutagenesis.

PMID: 30107298
Journal: VIROLOGY
Year: 2018
Reference: Virology. 2018 Oct;523:100-109. doi: 10.1016/j.virol.2018.07.030. Epub 2018 Aug 11.
Impact factor:
Publication type: Paper in international publication
Authors: Domingo, Esteban; Esteban, Juan Ignacio; Gallego, Isabel; Garcia-Alvarez, Monica; Garcia-Crespo, Carlos; Gomez, Jordi; Gomez-Gonzalez, Alfonso; Gregori, Josep; Perales, Celia; Quer, Josep et al.
DOI: 10.1016/j.virol.2018.07.030

Characterization of intra- and inter-host norovirus P2 genetic variability in linked individuals by amplicon sequencing.

PMID: 30092071
Journal: PLoS One
Year: 2018
Reference: PLoS One. 2018 Aug 9;13(8):e0201850. doi: 10.1371/journal.pone.0201850. eCollection 2018.
Impact factor:
Publication type: Paper in international publication
Authors: Bosch, Albert; Carol, Monica; Dominguez, Angela; Garcia-Cehic, Damir; Gregori, Josep; Guix, Susana; Pinto, Rosa M; Quer, Josep; Sabria, Aurora; Sala-Farre, Maria-Rosa et al.
DOI: 10.1371/journal.pone.0201850

Evolution of acute hepatitis C virus infection in a large European city: Trends and new patterns.

PMID: 29135988
Journal: PLoS One
Year: 2017
Reference: PLoS One. 2017 Nov 14;12(11):e0187893. doi: 10.1371/journal.pone.0187893. eCollection 2017.
Impact factor:
Publication type: Paper in international publication
Authors: Barbera, Maria-Jesus; Cayla, Joan A; de Andres, Anna; Garcia de Olalla, Patricia; Garriga, Cesar; Gorrindo, Pilar; Gurgui, Merce; Laguno, Montserrat; Lens, Sabela; Manzanares-Laya, Sandra et al.
DOI: 10.1371/journal.pone.0187893

Identification of sapovirus GV.2, astrovirus VA3 and novel anelloviruses in serum from patients with acute hepatitis of unknown aetiology.

PMID: 28982120
Journal: PLoS One
Year: 2017
Reference: PLoS One. 2017 Oct 5;12(10):e0185911. doi: 10.1371/journal.pone.0185911. eCollection 2017.
Impact factor:
Publication type: Paper in international publication
Authors: Abril, J F; Buti, M; Caballero, A; Fernandez-Cassi, X; Girones, R; Gonzales-Gustavson, Eloy; Rodriguez-Frias, F; Timoneda, N et al.
DOI: 10.1371/journal.pone.0185911

Randomized prospective study evaluating tenofovir disoproxil fumarate prophylaxis against hepatitis B virus reactivation in anti-HBc-positive patients with rituximab-based regimens to treat hematologic malignancies: The Preblin study.

PMID: 28898281
Journal: PLoS One
Year: 2017
Reference: PLoS One. 2017 Sep 12;12(9):e0184550. doi: 10.1371/journal.pone.0184550. eCollection 2017.
Impact factor:
Publication type: Paper in international publication
Authors: Buti, Maria; Calleja, Jose L; Castillo, Pilar; Esteban, Rafael; Garcia-Retortillo, Montserrat; Gomez Rubio, Mariano; Gutierrez, Maria L; Lopez, Javier; Manzano, Maria L; Martin, Leticia et al.
DOI: 10.1371/journal.pone.0184550

Clinical outcomes of patients undergoing antiviral therapy while awaiting liver transplantation.

PMID: 28842296
Journal: JOURNAL OF HEPATOLOGY
Year: 2017
Reference: J Hepatol. 2017 Dec;67(6):1168-1176. doi: 10.1016/j.jhep.2017.08.008. Epub 2017 Aug 24.
Impact factor:
Publication type: Paper in international publication
Authors: Castells, Lluis; Colmenero, Jordi; Ferrer, Maria Teresa; Forns, Xavier; Giraldez, Alvaro; Gonzalez-Dieguez, Luisa; Herrero, Jose Ignacio; Londono, Maria-Carlota; Lorente, Sara; Manzano, Maria Luisa et al.
DOI: 10.1016/j.jhep.2017.08.008

Distance effects during polyprotein processing in the complementation between defective FMDV RNAs.

PMID: 27073008
Journal: JOURNAL OF GENERAL VIROLOGY
Year: 2016
Reference: J Gen Virol. 2016 Jul;97(7):1575-83. doi: 10.1099/jgv.0.000480. Epub 2016 Apr 12.
Impact factor:
Publication type: Paper in international publication
Authors: Moreno, Elena; Perales, Celia et al.
DOI: 10.1099/jgv.0.000480

Kinase analysis in alcoholic hepatitis identifies p90RSK as a potential mediator of liver fibrogenesis.

PMID: 25652085
Journal: GUT
Year: 2016
Reference: Gut. 2016 May;65(5):840-51. doi: 10.1136/gutjnl-2014-307979. Epub 2015 Feb 4.
Impact factor:
Publication type: Paper in international publication
Authors: Affo, Silvia; Altamirano, Jose; Arroyo, Vicente; Bataller, Ramon; Blaya, Delia; Caballeria, Juan; Coll, Mar; Gines, Pere; Knorpp, Thomas; Millan, Cristina et al.
DOI: 10.1136/gutjnl-2014-307979

Heavy daily alcohol intake at the population level predicts the weight of alcohol in cirrhosis burden worldwide.

PMID: 27392424
Journal: JOURNAL OF HEPATOLOGY
Year: 2016
Reference: J Hepatol. 2016 Nov;65(5):998-1005. doi: 10.1016/j.jhep.2016.06.018. Epub 2016 Jul 5.
Impact factor:
Publication type: Paper in international publication
Authors: Abraldes, Juan G; Altamirano, Jose; Bataller, Ramon; Couper, David; Cruz-Lemini, Monica; Ndugga, Nambi; Stein, Eva et al.
DOI: 10.1016/j.jhep.2016.06.018

Validation of prognostic scores for clinical outcomes in cirrhotic patients with acute variceal bleeding.

PMID: 27740523
Journal: Annals of Hepatology
Year: 2016
Reference: Ann Hepatol. 2016 Nov-Dec 2016;15(6):895-901.
Impact factor:
Publication type: Paper in international publication
Authors: Aguilar-Olivos, Nancy; Altamirano, Jose; Chavez-Tapia, Norberto C; Escobedo-Arzate, Angelica; Gonzalez-Angulo, Alberto; Motola-Kuba, Miguel; Tellez-Avila, Felix; Uribe, Misael; Zamarripa-Dorsey, Felipe et al.
DOI: 10.5604/16652681.1222107

Fat-Specific Protein 27/CIDEC Promotes Development of Alcoholic Steatohepatitis in Mice and Humans.

PMID: 26099526
Journal: GASTROENTEROLOGY
Year: 2015
Reference: Gastroenterology. 2015 Oct;149(4):1030-1041.e6. doi: 10.1053/j.gastro.2015.06.009. Epub 2015 Jun 20.
Impact factor:
Publication type: Paper in international publication
Authors: Altamirano, Jose; Bataller, Ramon; Bertola, Adeline; Cai, Yan; Chang, Binxia; Gao, Bin; Gonzalez, Frank J; Kimura, Shioko; Lu, Jim; Matsubara, Tsutomu et al.
DOI: 10.1053/j.gastro.2015.06.009

Impact of anticoagulation on upper-gastrointestinal bleeding in cirrhosis. A retrospective multicenter study.

PMID: 25773591
Journal: HEPATOLOGY
Year: 2015
Reference: Hepatology. 2015 Aug;62(2):575-83. doi: 10.1002/hep.27783. Epub 2015 Apr 27.
Impact factor:
Publication type: Paper in international publication
Authors: ; Albillos, Agustin; Ardevol, Alba; Augustin, Salvador; Banares, Rafael; Berenguer, Marina; Bosch, Jaume; Casas, Meritxell; Cerini, Federica; de la Pena, Joaquin et al.
DOI: 10.1002/hep.27783

Benefit of Treating Hepatocellular Carcinoma Recurrence after Liver Transplantation and Analysis of Prognostic Factors for Survival in a Large Euro-American Series.

PMID: 25472651
Journal: ANN SURG ONCOL
Year: 2015
Reference: Ann Surg Oncol. 2015 Jul;22(7):2286-94. doi: 10.1245/s10434-014-4273-6. Epub 2014 Dec 4.
Impact factor:
Publication type: Paper in international publication
Authors: Astete, S; Bilbao, I; Caralt, M; Castells, L; Cattral, M S; Charco, R; Davidson, D; Dopazo, C; Ghanekar, A; Goldaracena, N et al.
DOI: 10.1245/s10434-014-4273-6

Fine-mapping butyrophilin family genes revealed several polymorphisms influencing viral genotype selection in hepatitis C infection.

PMID: 25928882
Journal: GENES IMMUN
Year: 2015
Reference: Genes Immun. 2015 Jul-Aug;16(5):297-300. doi: 10.1038/gene.2015.14. Epub 2015 Apr 30.
Impact factor:
Publication type: Paper in international publication
Authors: Ampuero, J; Andrade, R; Buti, M; Calleja, J L; del Campo, J A; Diago, M; Forns, X; Garcia-Lozano, R J; Garcia-Samaniego, J; Garcia-Valdecasas, M et al.
DOI: 10.1038/gene.2015.14

Clinical Application of Estimating Hepatitis B Virus Quasispecies Complexity by Massive Sequencing: Correlation between Natural Evolution and On-Treatment Evolution.

PMID: 25393280
Journal: PLoS One
Year: 2014
Reference: PLoS One. 2014 Nov 13;9(11):e112306. doi: 10.1371/journal.pone.0112306. eCollection 2014.
Impact factor:
Publication type: Paper in international publication
Authors: Buti, Maria; Caballero, Andrea; Esteban, Rafael; Gregori, Josep; Homs, Maria; Nieto, Leonardo; Quer, Josep; Rodriguez-Frias, Francisco; Tabernero, David et al.
DOI: 10.1371/journal.pone.0112306

[Cost-utility analysis of triple therapy with telaprevir in treatment-naive hepatitis C patients].

PMID: 25344136
Journal: Farmacia hospitalaria
Year: 2014
Reference: Farm Hosp. 2014 Sep 16;38(5):418-29. doi: 10.7399/fh.2014.38.5.7640.
Impact factor:
Publication type: Letter or abstract
Authors: Andrade, Raul J; Buti, Maria; Casado, Miguel A; Gros, Blanca; Oyaguez, Itziar; Serra, Miguel A; Turnes, Juan et al.
DOI: 10.7399/fh.2014.38.5.7640

Inhibition of neuronal apoptosis and axonal regression ameliorates sympathetic atrophy and hemodynamic alterations in portal hypertensive rats.

PMID: 24400086
Journal: PLoS One
Year: 2014
Reference: PLoS One. 2014 Jan 6;9(1):e84374. doi: 10.1371/journal.pone.0084374. eCollection 2014.
Impact factor:
Publication type: Paper in international publication
Authors: Esteban, Rafael; Ezkurdia, Nahia; Genesca, Joan; Gonzalez, Antonio; Martell, Maria; Raurell, Imma; Rodriguez, Sarai et al.
DOI: 10.1371/journal.pone.0084374

Detection of early portal hypertension with routine data and liver stiffness in patients with asymptomatic liver disease: a prospective study.

PMID: 24211744
Journal: JOURNAL OF HEPATOLOGY
Year: 2014
Reference: J Hepatol. 2014 Mar;60(3):561-9. doi: 10.1016/j.jhep.2013.10.027. Epub 2013 Nov 6.
Impact factor:
Publication type: Paper in international publication
Authors: Augustin, Salvador; Esteban, Rafael; Gelabert, Arantzazu; Genesca, Joan; Gonzalez, Antonio; Martell, Maria; Millan, Laura; Segarra, Antoni; Serres, Xavier et al.
DOI: 10.1016/j.jhep.2013.10.027

Soluble CD40 ligand in morbidly obese patients: effect of body mass index on recovery to normal levels after gastric bypass surgery.

PMID: 23426590
Journal: ARCHIVES OF SURGERY
Year: 2013
Reference: JAMA Surg. 2013 Feb;148(2):151-6. doi: 10.1001/jamasurgery.2013.419.
Impact factor:
Publication type: Paper in international publication
Authors: Baena-Fustegueras, Juan A; Balada, Eva; Casals, Isidre; Catalan, Roberto; Ferrer, Roser; Fort, Jose M; Lecube, Albert; Pardina, Eva; Peinado-Onsurbe, Julia; Rivero, Joaquin et al.
DOI: 10.1001/jamasurgery.2013.419

Embolization of large spontaneous portosystemic shunts for refractory hepatic encephalopathy : A multi-center survey on safety & efficacy.

PMID: 23401201
Journal: HEPATOLOGY
Year: 2013
Reference: Hepatology. 2013 Jun;57(6):2448-57. doi: 10.1002/hep.26314. Epub 2013 May 1.
Impact factor:
Publication type: Paper in international publication
Authors: Ameloot, Koen; Barrufet, Marta; Brookes, Jocelyn; Burroughs, Andrew K; Cordoba, Juan; Garcia-Pagan, Juan-Carlos; Jalan, Rajiv; Laleman, Wim; Maleux, Geert; Nevens, Frederik et al.
DOI: 10.1002/hep.26314

The alpha7beta0 Isoform of the Complement Regulator C4b-Binding Protein Induces a Semimature, Anti-Inflammatory State in Dendritic Cells.

PMID: 23390292
Journal: JOURNAL OF IMMUNOLOGY
Year: 2013
Reference: J Immunol. 2013 Mar 15;190(6):2857-72. doi: 10.4049/jimmunol.1200503. Epub 2013 Feb 6.
Impact factor:
Publication type: Paper in international publication
Authors: Aran, Josep M; Blom, Anna M; Borras, Francesc E; Garcia de Frutos, Pablo; Luque, Ana; Naranjo-Gomez, Mar; Olivar, Rut; Quer, Josep; Rodriguez de Cordoba, Santiago et al.
DOI: 10.4049/jimmunol.1200503

Cost effectiveness of first-line oral antiviral therapies for chronic hepatitis B : a systematic review.

PMID: 23329593
Journal: PHARMACOECONOMICS
Year: 2013
Reference: Pharmacoeconomics. 2013 Jan;31(1):63-75. doi: 10.1007/s40273-012-0009-2.
Impact factor:
Publication type: Review in international publication
Authors: Buti, Maria; Casado, Miguel A; Lozano, Virginia; Oyaguez, Itziar et al.
DOI: 10.1007/s40273-012-0009-2

[Quantification of hepatitis B virus HBsAg: clinical implications.]

PMID: 21719049
Journal: MEDICINA CLINICA
Year: 2012
Reference: Med Clin (Barc). 2012 Apr 28;138(11):483-8. Epub 2011 Jun 29.
Impact factor:
Publication type: Review in national publication
Authors: Buti Ferret, Maria; Esteban Mur, Rafael; Rodríguez Frias, Francisco et al.
DOI: 10.1016/j.medcli.2011.04.024

Outcome of HCV/HIV-Coinfected Liver Transplant Recipients: A Prospective and Multicenter Cohort Study.

PMID: 22471341
Journal: AMERICAN JOURNAL OF TRANSPLANTATION
Year: 2012
Reference: Am J Transplant. 2012 Jul;12(7):1866-76. doi: 10.1111/j.1600-6143.2012.04028.x. Epub 2012 Apr 4.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1111/j.1600-6143.2012.04028.x

[New agents for the treatment of Hepatitis C.]

PMID: 22118805
Journal: ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
Year: 2012
Reference: Enferm Infecc Microbiol Clin. 2012 Mar;30(3):147-50. Epub 2011 Nov 25.
Impact factor:
Publication type: Review in national publication
Authors: ; et al.
DOI: 10.1016/j.eimc.2011.09.012

Reversal of nonstructural protein 3-specific CD4(+) T cell dysfunction in patients with persistent hepatitis C virus infection.

PMID: 22404727
Journal: JOURNAL OF VIRAL HEPATITIS
Year: 2012
Reference: J Viral Hepat. 2012 Apr;19(4):283-94. doi: 10.1111/j.1365-2893.2011.01549.x. Epub 2011 Nov 24.
Impact factor:
Publication type: Paper in international publication
Authors: Bes, M; Campos-Varela, I; Casamitjana, N; Cubero, M; Esteban, J I; Guardia, J; Piron, M; Puig, L; Quer, J; Sauleda, S et al.
DOI: 10.1111/j.1365-2893.2011.01549.x

Evolution and management of de novo neoplasm post-liver transplantation: a 20-year experience from a single European centre.

PMID: 21484107
Journal: Hepatology International
Year: 2011
Reference: Hepatol Int. 2011 Jun;5(2):707-15. Epub 2010 Dec 28.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1007/s12072-010-9231-1

Safety of liver transplantation performed with Chagas seropositive donors to seronegative recipients.

PMID: 21618698
Journal: LIVER TRANSPLANTATION
Year: 2011
Reference: Liver Transpl. 2011 Nov;17(11):1304-8. doi: 10.1002/lt.22346.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1002/lt.22346

Pretransplant Liver Function Impacts on the Outcome of Allogeneic Hematopoietic Stem Cell Transplantation: A Study of 455 Patients.

PMID: 21586334
Journal: BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
Year: 2011
Reference: Biol Blood Marrow Transplant. 2011 Nov;17(11):1653-61. Epub 2011 Apr 27.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1016/j.bbmt.2011.04.009

Entecavir treatment for chronic hepatitis B: Adaptation is not needed for the majority of naive patients with a partial virological response.

PMID: 21563196
Journal: HEPATOLOGY
Year: 2011
Reference: Hepatology. 2011 Aug;54(2):443-51. doi: 10.1002/hep.24406.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1002/hep.24406

Quality of life in cirrhosis is related to potentially treatable factors.

PMID: 19794311
Journal: EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
Year: 2010
Reference: Eur J Gastroenterol Hepatol. 2010 Feb;22(2):221-7.
Impact factor:
Publication type: Paper in international publication
Authors: Cardenas, Guillermo; Cordoba, Juan; Doval, Eduardo; Esteban, Rafael; Flavia, Montserrat; Guardia, Jaime; Jacas, Carlos; Jacas, Carlos; Les, Inigo et al.
DOI: 10.1097/MEG.0b013e3283319975

A Long-Term Study of Changes in the Volume of Brain Ventricles and White Matter Lesions After Successful Liver Transplantation.

PMID: 20118844
Journal: TRANSPLANTATION
Year: 2010
Reference: Transplantation. 2010 Mar 15;89(5):589-94.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; et al.
DOI: 10.1097/TP.0b013e3181ca7bb3

Are recipients of solid organ transplantation a high-risk population for hepatitis E virus infection?

PMID: 20035519
Journal: LIVER TRANSPLANTATION
Year: 2010
Reference: Liver Transpl. 2010 Jan;16(1):106-7; author reply 108.
Impact factor:
Publication type: Letter or abstract
Authors: Buti, Maria; Cabrera, Cecilia; Castells, Luis; Esteban, Rafael; Jardi, Rosendo et al.
DOI: 10.1002/lt.21925

Validation of the INNO-LiPA HBV DR v2 assay in HBV-infected patients under nucleoside analog treatment.

PMID: 20065049
Journal: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Year: 2010
Reference: Antimicrob Agents Chemother. 2010 Mar;54(3):1283-9. Epub 2010 Jan 11.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; et al.
DOI: 10.1128/AAC.00970-09

Clinical outcome of lamivudine-resistant chronic hepatitis B patients with compensated cirrhosis under adefovir salvage treatment. Importance of HCC surveillance.

PMID: 19712848
Journal: European Journal of Internal Medicine
Year: 2009
Reference: Eur J Intern Med. 2009 Sep;20(5):478-81.
Impact factor:
Publication type: Paper in international publication
Authors: Buti, M; Elefsiniotis, I; Esteban, R; Jardi, R; Vezali, E et al.
DOI: 10.1016/j.ejim.2008.12.013

Severe rhabdomyolysis and acute renal failure secondary to concomitant use of simvastatin with rapamycin plus tacrolimus in liver transplant patient.

PMID: 19376416
Journal: TRANSPLANTATION PROCEEDINGS
Year: 2009
Reference: Transplant Proc. 2009 Apr;41(3):1021-4.
Impact factor:
Publication type: Paper in international publication
Authors: Bilbao, I; Blanco, L; Caralt, M; Castells, L; Charco, R; Dopazo, C; Lazaro, J L; Sapisochin, G et al.
DOI: 10.1016/j.transproceed.2009.02.019

Clinically relevant differences in the model for end-stage liver disease and model for end-stage liver disease-sodium scores determined at three university-based laboratories of the same area.

PMID: 19242993
Journal: LIVER TRANSPLANTATION
Year: 2009
Reference: Liver Transpl. 2009 Mar;15(3):300-5.
Impact factor:
Publication type: Paper in international publication
Authors: Castellote, Jose; Castells, Lluis; Deulofeu, Roser; Fuentes-Arderiu, Xavier; Gines, Pere; Navasa, Miquel; Ribalta, Alba; Rodriguez, Santiago; Twose, Jorge; Xiol, Xavier et al.
DOI: 10.1002/lt.21688

[Hepatitis B vaccine and inflammatory bowel disease]

PMID: 19268979
Journal: MEDICINA CLINICA
Year: 2009
Reference: Med Clin (Barc). 2009 Mar 14;132(9):348-50.
Impact factor:
Publication type: Editorail in international publication
Authors: Castells, Lluis et al.
DOI: 10.1016/j.medcli.2008.10.031

Blog

News

The consensus establishes recommendations that could correct the current disparities related to muscle mass, weight and height and would allow for more precise prioritization of patients who require transplants more urgently.

Using computed tomography (CT), with or without contrast, it is possible to perform an accurate and safe detection of the disease without the need for biopsies and avoiding the limitations of other non-invasive diagnostic tools.

On World Clinical Trials Day, we highlight some of the studies we have participated in that confirm the efficacy of new drugs, allowing their approval by regulatory agencies.

Estudi sobre els patrons de consum habitual de l'alcohol en població jove

Des de Vall d'Hebron estem buscant 200 persones voluntàries sanes d'entre 18 i 30 anys per a participar en un estudi sobre els patrons de consum habitual de l'alcohol en població jove, en el marc del projecte StopALD.

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