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Microbiology

The Microbiology research group of the Vall d'Hebron Research Institute (VHIR) focuses on the study of microbiological aspects —in basic, translational and clinical research— that could improve the outcome of patients with infectious diseases.

Our priority research areas are:

  • Microbiological surveillance of emerging and re-emerging infectious diseases.
    • Diseases due to viral infections of the respiratory tract
    • Microorganisms that cause vaccine-preventable diseases
    • Infectious diseases of sexual transmission
  • Antimicrobial resistance
  • Sepsis
  • Development and validation of rapid microbiological diagnostic devices.
  • International Health
  • Hepatitis 

We actively collaborate with other microbiology laboratories, health services, national and international centres and organizations, as well as with the different research networks of the Carlos III Health Institute in Spain.

In addition, we carry out an important activity in the surveillance of the genotypic and phenotypic evolution of microorganisms present in the community in terms of their virulence, transmissibility, antigenic escape and antimicrobial resistance, in collaboration with public administrations, both at the national and international level.
 

Publications

Safety and Effectiveness of Isavuconazole Treatment for Fungal Infections in Solid Organ Transplant Recipients (ISASOT Study).

PMID: 35171022
Journal: Microbiology Spectrum
Year: 2022
Reference: Microbiol Spectr. 2022 Feb 23;10(1):e0178421. doi: 10.1128/spectrum.01784-21. Epub 2022 Feb 16.
Impact factor:
Publication type: Paper in international publication
Authors: Berastegui, Cristina; Bravo, Carles; Campany-Herrero, David; Castells, Lluis; Deu, Maria; Gavalda, Joan; Len, Oscar; Los-Arcos, Ibai; Marquez-Algaba, Ester; Martin-Gomez, Maria Teresa et al.
DOI: 10.1128/spectrum.01784-21

Monitoring of SARS-CoV-2 seroprevalence among primary healthcare patients in the Barcelona Metropolitan Area: the SeroCAP sentinel network protocol.

PMID: 35140153
Journal: BMJ Open
Year: 2022
Reference: BMJ Open. 2022 Feb 9;12(2):e053237. doi: 10.1136/bmjopen-2021-053237.
Impact factor:
Publication type: Paper in international publication
Authors: Aceiton, Jordi; Agusti, Cristina; Alonso, Lucia; Angel, Miguel; Anton, Andres; Basora, Josep; Bordas, Anna; Calatayud, Laura; Casabona, Jordi; Dacosta-Aguayo, Rosalia et al.
DOI: 10.1136/bmjopen-2021-053237

A comprehensive assessment of long-term SARS-CoV-2-specific adaptive immune memory in convalescent COVID-19 Solid Organ Transplant recipients.

PMID: 35124011
Journal: KIDNEY INTERNATIONAL
Year: 2022
Reference: Kidney Int. 2022 May;101(5):1027-1038. doi: 10.1016/j.kint.2021.12.029. Epub 2022 Feb 4.
Impact factor:
Publication type: Paper in international publication
Authors: Ardanuy, Carmen; Bestard, Oriol; Cabanas, Nuria Serra; Cachero, Alba; Calatayud, Laura; Couceiro, Carlos; Crespo, Elena; Crespo, Marta; Cruzado, Josep Maria; Donadeu, Laura et al.
DOI: 10.1016/j.kint.2021.12.029

Reconciling short-term clinical and Immunological outcomes of SARS-CoV-2 vaccination in Solid Organ Transplant recipients.

PMID: 34554648
Journal: AMERICAN JOURNAL OF TRANSPLANTATION
Year: 2022
Reference: Am J Transplant. 2022 Feb;22(2):673-675. doi: 10.1111/ajt.16855. Epub 2021 Oct 5.
Impact factor:
Publication type: Letter or abstract
Authors: Bestard, Oriol; Campins, Magda; Campos-Varela, Isabel; Castells, Lluis; Crespo, Elena; Esperalba, Juliana; Jouve, Thomas; Len, Oscar; Lopez, Manuel; Moreso, Francesc et al.
DOI: 10.1111/ajt.16855

Evaluation of the performance of Loopamp Trypanosoma cruzi Detection Kit for the diagnosis of Chagas disease in a non-endemic area, Spain.

PMID: 33692137
Journal: JOURNAL OF CLINICAL MICROBIOLOGY
Year: 2021
Reference: J Clin Microbiol. 2021 Apr 20;59(5). pii: JCM.01860-20. doi: 10.1128/JCM.01860-20. Print 2021 Apr 20.
Impact factor:
Publication type: Paper in international publication
Authors: Abras, Alba; Ballart, Cristina; Cruz, Israel; Flores-Chavez, Maria D; Gallego, Montserrat; Garcia Diez, Emilia; Ibanez Perez, Ismael; Moure, Zaira; Munoz, Carmen; Nieto, Javier et al.
DOI: 10.1128/JCM.01860-20

Prescription quality of prolonged antibiotherapy in pediatrics. Impact of ASP program interventions.

PMID: 32229130
Journal: ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
Year: 2021
Reference: Enferm Infecc Microbiol Clin. 2021 Mar;39(3):134-138. doi: 10.1016/j.eimc.2020.02.015. Epub 2020 Mar 27.
Impact factor:
Publication type: Paper in national publication
Authors: Alonso Garcia, Laura; Barnes-Mayolas, Meritxell; Castellnou Asens, Ivette; Castilla Fernandez, Yolanda; Estrella Barcelo, Maria; Fernandez Polo, Aurora; Fernandez-Polo, Aurora; Lopez Fernandez, Sergio; Melendo Perez, Susana; Melendo, Susana et al.
DOI: 10.1016/j.eimc.2020.02.015

A new pleosporalean fungus isolated from superficial to deep human clinical specimens.

PMID: 32717745
Journal: MEDICAL MYCOLOGY
Year: 2021
Reference: Med Mycol. 2021 Mar 4;59(3):278-288. doi: 10.1093/mmy/myaa055.
Impact factor:
Publication type: Paper in international publication
Authors: Cano-Lira, Jose F; Guarro, Josep; Los-Arcos, Ibai; Martin-Gomez, M Teresa; Stchigel, Alberto M; Valenzuela-Lopez, Nicomedes et al.
DOI: 10.1093/mmy/myaa055

Comment on: Lower mgpB diversity in macrolide-resistant Mycoplasma genitalium infecting men visiting two sexually transmitted infection clinics in Montpellier, France.

PMID: 33657213
Journal: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Year: 2021
Reference: J Antimicrob Chemother. 2021 May 12;76(6):1649-1650. doi: 10.1093/jac/dkab041.
Impact factor:
Publication type: Letter or abstract
Authors: Espasa, Mateu; Fernandez-Huerta, Miguel; Pich, Oscar Q; Pumarola, Tomas; Serra-Pladevall, Judit et al.
DOI: 10.1093/jac/dkab041

A Spanish case-control study in <5 year-old children reveals the lack of association between MLB and VA astrovirus and diarrhea.

PMID: 32020041
Journal: Scientific Reports
Year: 2020
Reference: Sci Rep. 2020 Feb 4;10(1):1760. doi: 10.1038/s41598-020-58691-3.
Impact factor:
Publication type: Paper in international publication
Authors: Aregall, Nuria; Bosch, Albert; Goterris, Lidia; Guix, Susana; Michl, Kristina; Pinto, Rosa Maria; Rodriguez Garrido, Virginia; Sabria, Aurora; Sabria, Jaume; Vu, Diem-Lan et al.
DOI: 10.1038/s41598-020-58691-3

Selection criteria of solid organ donors in relation to infectious diseases: A Spanish consensus.

PMID: 32001103
Journal: Transplantation Reviews
Year: 2020
Reference: Transplant Rev (Orlando). 2020 Apr;34(2):100528. doi: 10.1016/j.trre.2020.100528. Epub 2020 Jan 13.
Impact factor:
Publication type: Review in international publication
Authors: Aguado, Jose Maria; Blanes, Marino; Bodro, Marta; Carratala, Jordi; Cordero, Elisa; Dominguez-Gil, Beatriz; Farinas, Maria Carmen; Fernandez-Ruiz, Mario; Fortun, Jesus; Gavalda, Joan et al.
DOI: 10.1016/j.trre.2020.100528

Mycoplasma genitalium and antimicrobial resistance in Europe: a comprehensive review.

PMID: 32000587
Journal: INTERNATIONAL JOURNAL OF STD & AIDS
Year: 2020
Reference: Int J STD AIDS. 2020 Mar;31(3):190-197. doi: 10.1177/0956462419890737. Epub 2020 Jan 30.
Impact factor:
Publication type: Paper in international publication
Authors: Barbera, Maria J; Centeno, Cristina; Espasa, Mateu; Esperalba, Juliana; Fernandez-Huerta, Miguel; Martinez-Gomez, Xavier; Pich, Oscar Q; Pumarola, Tomas; Serra-Pladevall, Judit et al.
DOI: 10.1177/0956462419890737

Re: A Case of Rectal Ureaplasma Infection and Implications for Testing in Young Men Who Have Sex with Men: The P18 Cohort Study, by Abbott et al. (LGBT Health 2017;4:161-163).

PMID: 31985335
Journal: LGBT Health
Year: 2020
Reference: LGBT Health. 2020 Feb/Mar;7(2):119-120. doi: 10.1089/lgbt.2019.0211. Epub 2020 Jan 27.
Impact factor:
Publication type: Letter or abstract
Authors: Espasa, Mateu; Esperalba, Juliana; Fernandez-Huerta, Miguel; Garcia-Perez, Jorge N; Pich, Oscar Q; Serra-Pladevall, Judit et al.
DOI: 10.1089/lgbt.2019.0211

Clinical experience with integrase inhibitors in HIV-2-infected individuals in Spain.

PMID: 30753573
Journal: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Year: 2019
Reference: J Antimicrob Chemother. 2019 May 1;74(5):1357-1362. doi: 10.1093/jac/dkz007.
Impact factor:
Publication type: Paper in international publication
Authors: Aguilera, A; Aldamiz, T; Barreiro, P; Benitez-Gutierrez, L; Benito, R; Caballero, E; Caballero, E; Cabrera, J; Cifuentes, C; Cilla, G et al.
DOI: 10.1093/jac/dkz007

Gonococcal infection: An unresolved problem.

PMID: 30732970
Journal: ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
Year: 2019
Reference: Enferm Infecc Microbiol Clin. 2019 Aug - Sep;37(7):458-466. doi: 10.1016/j.eimc.2018.12.008. Epub 2019 Feb 4.
Impact factor:
Publication type: Paper in national publication
Authors: Barbera, Maria Jesus; Serra-Pladevall, Judit et al.
DOI: 10.1016/j.eimc.2018.12.008

A case report of proctitis associated with Mycoplasma genitalium in a man who has sex with men.

PMID: 30722752
Journal: INTERNATIONAL JOURNAL OF STD & AIDS
Year: 2019
Reference: Int J STD AIDS. 2019 May;30(6):623-625. doi: 10.1177/0956462419825896. Epub 2019 Feb 5.
Impact factor:
Publication type: Paper in international publication
Authors: Esperalba-Esquerra, Juliana; Isabel Lazaro-Simo, Anna; Vall-Mayans, Marti et al.
DOI: 10.1177/0956462419825896

Does the economic recession influence the incidence of pertussis in a cosmopolitan European city?

PMID: 30717741
Journal: BMC PUBLIC HEALTH
Year: 2019
Reference: BMC Public Health. 2019 Feb 4;19(1):144. doi: 10.1186/s12889-019-6448-3.
Impact factor:
Publication type: Paper in international publication
Authors: Avellanes, Ingrid; Brio, Sonia; Brugueras, Silvia; Calsina, Marta; Casals, Marti; Cayla, Joan A; Clos, Roser; Codina, Gema; Cunille, Montse; de Andres, Anna et al.
DOI: 10.1186/s12889-019-6448-3

Secular trends in the epidemiology of Clostridium difficile infection (CDI) at a tertiary care hospital in Barcelona, 2006-2015: A prospective observational study.

PMID: 29655966
Journal: ANAEROBE
Year: 2018
Reference: Anaerobe. 2018 Jun;51:54-60. doi: 10.1016/j.anaerobe.2018.04.002. Epub 2018 Apr 12.
Impact factor: 2.742
Publication type: Paper in international publication
Authors: Larrainzar-Coghen, Thais, Rodriguez-Pardo, Dolors, Fernandez-Hidalgo, Nuria, Puig-Asensio, Mireia, Pigrau, Carles, Ferrer, Carmen, Rodriguez, Virginia, Bartolome, Rosa, Campany, David, Almirante, Benito et al.
DOI: 10.1016/j.anaerobe.2018.04.002

Descriptive study of severe hospitalized cases of laboratory-confirmed influenza during five epidemic seasons (2010-2015).

PMID: 29655370
Journal: BMC research notes
Year: 2018
Reference: BMC Res Notes. 2018 Apr 14;11(1):244. doi: 10.1186/s13104-018-3349-y.
Impact factor: 0
Publication type: Paper in international publication
Authors: Carol, Monica, Torner, Nuria, Martinez, Ana, Basile, Luca, Mosquera, MMar, Anton, Andres, Rius, Cristina, Sala, M Rosa, Minguell, Sofia, Plasencia, Elsa et al.
DOI: 10.1186/s13104-018-3349-y

Effectiveness of a Double-Carbapenem Regimen in a KPC-Producing Klebsiella pneumoniae Infection in an Immunocompromised Patient.

PMID: 28708458
Journal: Microbial Drug Resistance
Year: 2018
Reference: Microb Drug Resist. 2018 Mar;24(2):199-202. doi: 10.1089/mdr.2017.0129. Epub 2017 Jul 14.
Impact factor: 2.344
Publication type: Paper in international publication
Authors: Piedra-Carrasco, Nuria, Miguel, Lucia, Fabrega, Anna, Vinado, Belen, Campany, David, Mir, Alba, Fox, Maria Laura, Almirante, Benito, Larrosa, Nieves, Ruiz-Camps, Isabel et al.
DOI: 10.1089/mdr.2017.0129

Ceftolozane/tazobactam for the treatment of XDR Pseudomonas aeruginosa infections.

PMID: 29594953
Journal: INFECTION
Year: 2018
Reference: Infection. 2018 Aug;46(4):461-468. doi: 10.1007/s15010-018-1133-5. Epub 2018 Mar 28.
Impact factor: 2.773
Publication type: Paper in international publication
Authors: Escola-Verge, Laura, Pigrau, Carles, Los-Arcos, Ibai, Arevalo, Angel, Vinado, Belen, Campany, David, Larrosa, Nieves, Nuvials, Xavier, Ferrer, Ricard, Len, Oscar et al.
DOI: 10.1007/s15010-018-1133-5

Carbapenemase-producing enterobacteriaceae recovered from a Spanish river ecosystem.

PMID: 28380016
Journal: PLoS One
Year: 2017
Reference: PLoS One. 2017 Apr 5;12(4):e0175246. doi: 10.1371/journal.pone.0175246. eCollection 2017.
Impact factor: 2.806
Publication type: Paper in international publication
Authors: Piedra-Carrasco, Nuria, Fabrega, Anna, Calero-Caceres, William, Cornejo-Sanchez, Thais, Brown-Jaque, Maryury, Mir-Cros, Alba, Muniesa, Maite, Gonzalez-Lopez, Juan Jose et al.
DOI: 10.1371/journal.pone.0175246

Detection of cytomegalovirus drug resistance mutations in solid organ transplant recipients with suspected resistance.

PMID: 28359845
Journal: JOURNAL OF CLINICAL VIROLOGY
Year: 2017
Reference: J Clin Virol. 2017 May;90:57-63. doi: 10.1016/j.jcv.2017.03.014. Epub 2017 Mar 21.
Impact factor: 3.051
Publication type: Paper in international publication
Authors: Marcos, M Angeles, Len, Oscar, Montejo, Miguel, Aranzamendi, Maitane, Lopez-Aladid, Ruben, Guiu, Alba, Sanclemente, Gemma, Lopez-Medrano, Francisco, Cofan, Frederic, Mosquera, M Mar et al.
DOI: 10.1016/j.jcv.2017.03.014

Infectious encephalitis: utility of a rational approach to aetiological diagnosis in daily clinical practice.

PMID: 27888402
Journal: EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
Year: 2017
Reference: Eur J Clin Microbiol Infect Dis. 2017 Apr;36(4):641-648. doi: 10.1007/s10096-016-2840-4. Epub 2016 Nov 25.
Impact factor: 2.727
Publication type: Paper in international publication
Authors: Lopez-Sanchez, C, Sulleiro, E, Bocanegra, C, Romero, S, Codina, G, Sanz, I, Esperalba, J, Serra, J, Pigrau, C, Burgos, J et al.
DOI: 10.1007/s10096-016-2840-4

Periprosthetic joint infection by Propionibacterium acnes: Clinical differences between monomicrobial versus polymicrobial infection.

PMID: 28285096
Journal: ANAEROBE
Year: 2017
Reference: Anaerobe. 2017 Apr;44:143-149. doi: 10.1016/j.anaerobe.2017.03.008. Epub 2017 Mar 8.
Impact factor: 2.278
Publication type: Paper in international publication
Authors: Gomez, Lucia, Matamala, A, Lung, Mayli, Cuchi, Eva, Corona, Pablo S, Muneton, David, Figa, Raul et al.
DOI: 10.1016/j.anaerobe.2017.03.008

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