Skip to main content

Microbiology

The Microbiology research group of the Vall d'Hebron Research Institute (VHIR) focuses on the study of microbiological aspects —in basic, translational and clinical research— that could improve the outcome of patients with infectious diseases.

Our priority research areas are:

  • Microbiological surveillance of emerging and re-emerging infectious diseases.
    • Diseases due to viral infections of the respiratory tract
    • Microorganisms that cause vaccine-preventable diseases
    • Infectious diseases of sexual transmission
  • Antimicrobial resistance
  • Sepsis
  • Development and validation of rapid microbiological diagnostic devices.
  • International Health
  • Hepatitis 

We actively collaborate with other microbiology laboratories, health services, national and international centres and organizations, as well as with the different research networks of the Carlos III Health Institute in Spain.

In addition, we carry out an important activity in the surveillance of the genotypic and phenotypic evolution of microorganisms present in the community in terms of their virulence, transmissibility, antigenic escape and antimicrobial resistance, in collaboration with public administrations, both at the national and international level.
 

Publications

Epidemiological and clinical profile of adult patients with diarrhoea after international travel attended in an International Health referral center.

PMID: 34839009
Journal: Travel Medicine and Infectious Disease
Year: 2022
Reference: Travel Med Infect Dis. 2022 Jan-Feb;45:102216. doi: 10.1016/j.tmaid.2021.102216. Epub 2021 Nov 25.
Impact factor:
Publication type: Paper in international publication
Authors: Aznar, Maria Luisa; Bosch-Nicolau, Pau; Espana-Cueto, Sergio; Espinosa-Pereiro, Juan; Goterris, Lidia; Molina, Israel; Oliveira, Ines; Pou, Diana; Rodriguez, Virginia; Salvador, Fernando et al.
DOI: 10.1016/j.tmaid.2021.102216

Label-Free Plasmonic Biosensor for Rapid, Quantitative, and Highly Sensitive COVID-19 Serology: Implementation and Clinical Validation.

PMID: 34971311
Journal: ANALYTICAL CHEMISTRY
Year: 2022
Reference: Anal Chem. 2022 Jan 18;94(2):975-984. doi: 10.1021/acs.analchem.1c03850. Epub 2021 Dec 31.
Impact factor:
Publication type: Paper in international publication
Authors: Attoumani, Sarah; Bueno, Leticia; Calvo-Lozano, Olalla; Charrel, Remi; Chiscano-Camon, Luis; Coutard, Bruno; Esperalba, Juliana; Estevez, Maria Carmen; Fernandez-Barat, Laia; Fernandez-Naval, Candela et al.
DOI: 10.1021/acs.analchem.1c03850

Letter to the Editor: standardization of HBV RNA assay for the different phases of chronic hepatitis B is essential.

PMID: 34758113
Journal: HEPATOLOGY
Year: 2022
Reference: Hepatology. 2022 Feb;75(2):501-502. doi: 10.1002/hep.32227. Epub 2021 Dec 18.
Impact factor:
Publication type: Letter or abstract
Authors: Buti, Maria; Cortese, Maria Francesca; Rando-Segura, Ariadna; Rodriguez-Frias, Francisco; Tabernero, David et al.
DOI: 10.1002/hep.32227

Effectiveness of Fosfomycin for the Treatment of Multidrug-Resistant Escherichia coli Bacteremic Urinary Tract Infections: A Randomized Clinical Trial.

PMID: 35024838
Journal: JAMA Network Open
Year: 2022
Reference: JAMA Netw Open. 2022 Jan 4;5(1):e2137277. doi: 10.1001/jamanetworkopen.2021.37277.
Impact factor:
Publication type: Paper in international publication
Authors: Agea-Duran, Ivan; Almirante, Benito; Amador-Prous, Concha; Ardanuy, Carmen; Belles-Belles, Alba; Bereciartua, Elena; Blazquez-Abellan, Ana; Boix-Martinez, Vicente; Boix-Palop, Lucia; Borreguero, Irene et al.
DOI: 10.1001/jamanetworkopen.2021.37277

Neisseria gonorrhoeae antimicrobial resistance in Spain: a prospective multicentre study.

PMID: 33569588
Journal: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Year: 2021
Reference: J Antimicrob Chemother. 2021 May 12;76(6):1523-1531. doi: 10.1093/jac/dkab037.
Impact factor:
Publication type: Paper in international publication
Authors: Alcoceba, Eva; Arando, Maider; Bernal, Samuel; Colomina, Javier; Idigoras, Pedro; Leal-Negredo, Alvaro; Martin-Saco, Gloria; Martinez, Olalla; Menendez, Blanca; Romero, Beatriz et al.
DOI: 10.1093/jac/dkab037

Reflex viral load testing in dried blood spots generated by plasma separation card allows the screening and diagnosis of chronic viral hepatitis.

PMID: 33338545
Journal: JOURNAL OF VIROLOGICAL METHODS
Year: 2021
Reference: J Virol Methods. 2021 Mar;289:114039. doi: 10.1016/j.jviromet.2020.114039. Epub 2020 Dec 15.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez-Lopez, Patricia; Barbosa, Gisela; Barreira-Diaz, Ana; Buti, Maria; Esteban, Rafael; Ferreira, Vicelma; Ferrer-Costa, Roser; Kuchta, Alison; Lopez, Eva; Martinez-Camprecios, Joan et al.
DOI: 10.1016/j.jviromet.2020.114039

Severe SARS-CoV-2 placenta infection can impact neonatal outcome in the absence of vertical transmission.

PMID: 33497369
Journal: JOURNAL OF CLINICAL INVESTIGATION
Year: 2021
Reference: J Clin Invest. 2021 Mar 15;131(6). pii: 145427. doi: 10.1172/JCI145427.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, Lidia; Anton, Andres; Cribiu, Fulvia Milena; Croci, Giorgio A; Erra, Roberta; Fagnani, Anna Maria; Ferrazzi, Enrico; Ferrero, Stefano; Iurlaro, Enrico; Lunghi, Giovanna et al.
DOI: 10.1172/JCI145427

Antifungal stewardship in a tertiary care paediatric hospital: the PROAFUNGI study.

PMID: 33482749
Journal: BMC INFECTIOUS DISEASES
Year: 2021
Reference: BMC Infect Dis. 2021 Jan 22;21(1):100. doi: 10.1186/s12879-021-05774-9.
Impact factor:
Publication type: Paper in international publication
Authors: Fernandez-Polo, Aurora; Garcia-Palop, Beatriz; Martin, Maria Teresa; Melendo, Susana; Mendoza-Palomar, Natalia; Renedo-Miro, Berta; Soler-Palacin, Pere et al.
DOI: 10.1186/s12879-021-05774-9

Taking a look on fungi in cystic fibrosis: More questions than answers.

PMID: 31928888
Journal: REVISTA IBEROAMERICANA DE MICOLOGIA
Year: 2020
Reference: Rev Iberoam Micol. 2020 Jan - Mar;37(1):17-23. doi: 10.1016/j.riam.2019.10.004. Epub 2020 Jan 9.
Impact factor:
Publication type: Review in national publication
Authors: Martin-Gomez, M Teresa et al.
DOI: 10.1016/j.riam.2019.10.004

Serum IL-10 Levels and Its Relationship with Parasitemia in Chronic Chagas Disease Patients.

PMID: 31701864
Journal: AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
Year: 2020
Reference: Am J Trop Med Hyg. 2020 Jan;102(1):159-163. doi: 10.4269/ajtmh.19-0550.
Impact factor:
Publication type: Paper in international publication
Authors: Bosch-Nicolau, Pau; Franco-Jarava, Clara; Martinez-Gallo, Monica; Molina, Israel; Moure, Zaira; Salvador, Fernando; Sanchez-Montalva, Adrian; Sao Aviles, Augusto; Silgado, Aroa; Sulleiro, Elena et al.
DOI: 10.4269/ajtmh.19-0550

Mycoplasma genitalium and fluoroquinolone resistance: From genotype to phenotype.

PMID: 31122671
Journal: ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
Year: 2020
Reference: Enferm Infecc Microbiol Clin. 2020 Jan;38(1):44-45. doi: 10.1016/j.eimc.2019.04.007. Epub 2019 May 20.
Impact factor:
Publication type: Letter or abstract
Authors: Espasa, Mateu; Esperalba, Juliana; Fernandez-Huerta, Miguel; Serra-Pladevall, Judit et al.
DOI: 10.1016/j.eimc.2019.04.007

Infectivity of Norovirus GI and GII from Bottled Mineral Water during a Waterborne Outbreak, Spain.

PMID: 31855546
Journal: EMERGING INFECTIOUS DISEASES
Year: 2020
Reference: Emerg Infect Dis. 2020 Jan;26(1):134-137. doi: 10.3201/eid2601.190778.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, Manuel; Anfruns-Estrada, Eduard; Bartolome, Rosa; Blanco, Albert; Bosch, Albert; Cornejo, Thais; Fuentes, Cristina; Garrido, Virginia Rodriguez; Guix, Susana; Pinto, Rosa M et al.
DOI: 10.3201/eid2601.190778

Risk factors for antimicrobial-resistant Neisseria gonorrhoeae and characteristics of patients infected with gonorrhea.

PMID: 30100098
Journal: ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
Year: 2019
Reference: Enferm Infecc Microbiol Clin. 2019 Feb;37(2):145-146. doi: 10.1016/j.eimc.2018.07.004. Epub 2018 Aug 9.
Impact factor:
Publication type: Letter or abstract
Authors: Andreu, Antonia; Barbera, Maria-Jesus; Espasa, Mateu; Serra-Pladevall, Judit et al.
DOI: 10.1016/j.eimc.2018.07.004

Cutaneous infections by dematiaceous opportunistic fungi: diagnosis and management in 11 solid organ transplant recipients.

PMID: 30230044
Journal: MYCOSES
Year: 2019
Reference: Mycoses. 2019 Feb;62(2):121-127. doi: 10.1111/myc.12853. Epub 2018 Oct 17.
Impact factor:
Publication type: Paper in international publication
Authors: Aparicio, G; Ferrandiz-Pulido, C; Ferrer, B; Garcia-Patos, V; Gonzalez-Cruz, C; Juarez, C; Lopez-Lerma, I; Martin-Gomez, M T; Moreso, F; Repiso, T et al.
DOI: 10.1111/myc.12853

Label-free Bacteria Quantification in Blood Plasma by a Bioprinted Microarray Based Interferometric Point-of-Care Device.

PMID: 30525470
Journal: ACS Sensors
Year: 2019
Reference: ACS Sens. 2019 Jan 25;4(1):52-60. doi: 10.1021/acssensors.8b00789. Epub 2018 Dec 20.
Impact factor:
Publication type: Paper in international publication
Authors: Altug, Hatice; Belushkin, Alexander; Calvo-Lozano, Olalla; Dey, Priyanka; Estevez, Maria Carmen; Fabrega, Anna; Fabri-Faja, Nuria; Ferrer, Ricard; Gonzalez-Lopez, Juan Jose; Lechuga, Laura M et al.
DOI: 10.1021/acssensors.8b00789

Evidence for positive selection of hepatitis A virus antigenic variants in vaccinated men-having-sex-with men patients: Implications for immunization policies.

PMID: 30472089
Journal: EBioMedicine
Year: 2019
Reference: EBioMedicine. 2019 Jan;39:348-357. doi: 10.1016/j.ebiom.2018.11.023. Epub 2018 Nov 22.
Impact factor:
Publication type: Paper in international publication
Authors: Bosch, Albert; Cayla, Joan A; Garcia-Cehic, Damir; Gregori, Josep; Guix, Susana; Manzanares-Laya, Sandra; Pinto, Rosa M; Pumarola, Tomas; Quer, Josep; Sabria, Aurora et al.
DOI: 10.1016/j.ebiom.2018.11.023

Prevalence and molecular characterization of Strongyloides stercoralis, Giardia duodenalis, Cryptosporidium spp., and Blastocystis spp. isolates in school children in Cubal, Western Angola.

PMID: 29378626
Journal: Parasites & Vectors
Year: 2018
Reference: Parasit Vectors. 2018 Jan 29;11(1):67. doi: 10.1186/s13071-018-2640-z.
Impact factor: 3.163
Publication type: Paper in international publication
Authors: Aznar-Ruiz-de-Alegria, Maria L, Espasa, Mateu, Ninda, Arlette, Gandasegui, Javier, Sulleiro, Elena, Moreno, Milagros, Salvador, Fernando, Molina, Israel, Rodriguez, Esperanza, Carmena, David et al.
DOI: 10.1186/s13071-018-2640-z

Health Status of Asylum Seekers, Spain.

PMID: 29165223
Journal: AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
Year: 2018
Reference: Am J Trop Med Hyg. 2018 Jan;98(1):300-307. doi: 10.4269/ajtmh.17-0438. Epub 2018 Jan 1.
Impact factor: 2.564
Publication type: Paper in international publication
Authors: Romero, Israel Molina, Serre-Delcor, Nuria, Ascaso, Carlos, Soriano-Arandes, Antoni, Sanchez, Francisco Collazos, Maruri, Begona Trevino, Sulleiro, Elena, Ciruelo, Diana Pou, Garcia, Cristina Bocanegra et al.
DOI: 10.4269/ajtmh.17-0438

Acute periprosthetic joint infection due to Fusobacterium nucleatum in a non-immunocompromised patient. Failure using a Debridement, Antibiotics + Implant retention approach.

PMID: 29307651
Journal: ANAEROBE
Year: 2018
Reference: Anaerobe. 2018 Feb;49:116-120. doi: 10.1016/j.anaerobe.2017.12.010. Epub 2018 Jan 5.
Impact factor: 2.742
Publication type: Paper in international publication
Authors: Corona, Pablo S, Lung, Mayli, Pigrau, Carles, Soldado, Francisco, Amat, Carles, Carrera, Luis, Rodriguez-Pardo, Dolors et al.
DOI: 10.1016/j.anaerobe.2017.12.010

Zika virus dynamics in body fluids and risk of sexual transmission in a non-endemic area.

PMID: 29194880
Journal: TROPICAL MEDICINE & INTERNATIONAL HEALTH
Year: 2018
Reference: Trop Med Int Health. 2018 Jan;23(1):92-100. doi: 10.1111/tmi.13019. Epub 2017 Dec 21.
Impact factor: 2.541
Publication type: Paper in international publication
Authors: Molina, Israel, Almirante, Benito, Pumarola, Tomas, Serre, Nuria, Rando, Ariadna, Sanchez-Montalva, Adrian, Pou, Diana, Sulleiro, Elena, Salvador, Fernando, Bocanegra, Cristina et al.
DOI: 10.1111/tmi.13019

Blog

News

The collaboration will focus on several key areas of mutual interest in microbiology in particular antimicrobial resistance and stewardship.

On European Antibiotic Awareness Day, we highlight the importance of using these medications responsibly and finding innovative solutions to combat this issue.

The new diagnostic method, designed for use in endemic regions, combines a mobile application with a low-cost robotic microscope.