Skip to main content

Microbiology

The Microbiology research group of the Vall d'Hebron Research Institute (VHIR) focuses on the study of microbiological aspects —in basic, translational and clinical research— that could improve the outcome of patients with infectious diseases.

Our priority research areas are:

  • Microbiological surveillance of emerging and re-emerging infectious diseases.
    • Diseases due to viral infections of the respiratory tract
    • Microorganisms that cause vaccine-preventable diseases
    • Infectious diseases of sexual transmission
  • Antimicrobial resistance
  • Sepsis
  • Development and validation of rapid microbiological diagnostic devices.
  • International Health
  • Hepatitis 

We actively collaborate with other microbiology laboratories, health services, national and international centres and organizations, as well as with the different research networks of the Carlos III Health Institute in Spain.

In addition, we carry out an important activity in the surveillance of the genotypic and phenotypic evolution of microorganisms present in the community in terms of their virulence, transmissibility, antigenic escape and antimicrobial resistance, in collaboration with public administrations, both at the national and international level.
 

Publications

Humoral and Cellular Responses to SARS-CoV-2 in Convalescent COVID-19 Patients With Multiple Sclerosis.

PMID: 35105687
Journal: Neurology-Neuroimmunology & Neuroinflammation
Year: 2022
Reference: Neurol Neuroimmunol Neuroinflamm. 2022 Feb 1;9(2). pii: 9/2/e1143. doi: 10.1212/NXI.0000000000001143. Print 2022 Mar.
Impact factor:
Publication type: Paper in international publication
Authors: Arrambide, Georgina; Beltran, Jordina; Bonastre, Merce; Carbonell-Mirabent, Pere; Cardenas-Robledo, Simon; Castillo, Joaquin; Castillo, Mireia; Cobo-Calvo, Alvaro; Comabella, Manuel; Espejo, Carmen et al.
DOI: 10.1212/NXI.0000000000001143

Cellular and humoral immunogenicity of the mRNA-1273 SARS-CoV-2 vaccine in patients with hematologic malignancies.

PMID: 34844263
Journal: Blood Advances
Year: 2022
Reference: Blood Adv. 2022 Feb 8;6(3):774-784. doi: 10.1182/bloodadvances.2021006101.
Impact factor:
Publication type: Paper in international publication
Authors: Abrisqueta, Pau; Barba, Pere; Bosch, Francesc; Cabirta, Alba; Campins, Magda; Catala, Eva; Crespo, Marta; Esperalba, Juliana; Fernandez-Naval, Candela; Fox, Maria Laura et al.
DOI: 10.1182/bloodadvances.2021006101

Study protocol for monitoring SARS-CoV-2 infection and its determinants in Catalonia (Spain): an observational and participatory research approach in a Sentinel Network of Schools.

PMID: 35078847
Journal: BMJ Open
Year: 2022
Reference: BMJ Open. 2022 Jan 25;12(1):e055649. doi: 10.1136/bmjopen-2021-055649.
Impact factor:
Publication type: Paper in international publication
Authors: Aceiton, Jordi; Alonso, Lucia; Andres, Cristina; Anton, Andres; Anton, Andres; Aulet, Lidia; Basora, Josep; Blanco, Albert; Blanco, Ignacio; Blanco, Ignacio et al.
DOI: 10.1136/bmjopen-2021-055649

Dynamics of SARS-CoV-2 Alpha (B.1.1.7) variant spread: The wastewater surveillance approach.

PMID: 35074352
Journal: ENVIRONMENTAL RESEARCH
Year: 2022
Reference: Environ Res. 2022 May 15;208:112720. doi: 10.1016/j.envres.2022.112720. Epub 2022 Jan 22.
Impact factor:
Publication type: Paper in international publication
Authors: Andres, Cristina; Anton, Andres; Borrego, Carles M; Bosch, Albert; Carcereny, Albert; Chacon-Villanueva, Carme; Garcia-Cehic, Damir; Garcia-Pedemonte, David; Gregori, Josep; Guix, Susana et al.
DOI: 10.1016/j.envres.2022.112720

Detection of Plasmodium falciparum malaria in 1 h using a simplified enzyme-linked immunosorbent assay.

PMID: 33648654
Journal: ANALYTICA CHIMICA ACTA
Year: 2021
Reference: Anal Chim Acta. 2021 Apr 1;1152:338254. doi: 10.1016/j.aca.2021.338254. Epub 2021 Jan 30.
Impact factor:
Publication type: Paper in international publication
Authors: Arias-Alpizar, Kevin; Baldrich, Eva; Borgheti-Cardoso, Livia Neves; Bosch-Nicolau, Pau; de la Serna, Erica; Fernandez-Busquets, Xavier; Molina, Israel; Ramirez, Miriam; Salvador, Fernando; Sanchez-Cano, Ana et al.
DOI: 10.1016/j.aca.2021.338254

Does Routine Abdominal Drain Tip Culture Anticipate Post-Operative Infection in Liver Transplantation?

PMID: 32429799
Journal: Surgical Infections
Year: 2021
Reference: Surg Infect (Larchmt). 2021 Mar;22(2):222-226. doi: 10.1089/sur.2020.031. Epub 2020 May 20.
Impact factor:
Publication type: Paper in international publication
Authors: Castells, Lluis; Gomez-Gavara, Concepcion; Hidalgo, Ernesto; Len, Oscar; Los-Arcos, Ibai; Lung, Mayli; Nuvials, Xavier; Perez-Cameo, Cristina; Vargas, Victor et al.
DOI: 10.1089/sur.2020.031

Screening for asymptomatic STIs in HIV-infected men who have sex with men.

PMID: 32753480
Journal: SEXUALLY TRANSMITTED INFECTIONS
Year: 2021
Reference: Sex Transm Infect. 2021 Mar;97(2):170-171. doi: 10.1136/sextrans-2020-054560. Epub 2020 Aug 4.
Impact factor:
Publication type: Paper in international publication
Authors: Burgos, Joaquin; Caballero, Estrella; Curran, Adrian; Esperalba, Juliana; Falco, Vicenc; Martin, Mario; Miguel, Lucia; Navarro, Jordi; Ribera, Esteban; Sanchez, Irene et al.
DOI: 10.1136/sextrans-2020-054560

Sophisticated viral quasispecies with a genotype-related pattern of mutations in the hepatitis B X gene of HBeAg-ve chronically infected patients.

PMID: 33603102
Journal: Scientific Reports
Year: 2021
Reference: Sci Rep. 2021 Feb 18;11(1):4215. doi: 10.1038/s41598-021-83762-4.
Impact factor:
Publication type: Paper in international publication
Authors: Buti, Maria; Carioti, Luca; Casillas, Rosario; Cortese, Maria Francesca; Esteban-Mur, Rafael; Garcia-Garcia, Selene; Godoy, Cristina; Gonzalez, Carolina; Gregori, Josep; Guerrero-Murillo, Mercedes et al.
DOI: 10.1038/s41598-021-83762-4

Rapid and Digital Detection of Inflammatory Biomarkers Enabled by a Novel Portable Nanoplasmonic Imager.

PMID: 31830370
Journal: Small
Year: 2020
Reference: Small. 2020 Jan;16(3):e1906108. doi: 10.1002/smll.201906108. Epub 2019 Dec 12.
Impact factor:
Publication type: Paper in international publication
Authors: Altug, Hatice; Belushkin, Alexander; Fabrega, Anna; Ferrer, Ricard; Gonzalez-Lopez, Juan Jose; Ruiz-Rodriguez, Juan Carlos; Yesilkoy, Filiz et al.
DOI: 10.1002/smll.201906108

Characterisation of the sewage virome: comparison of NGS tools and occurrence of significant pathogens.

PMID: 31955099
Journal: SCIENCE OF THE TOTAL ENVIRONMENT
Year: 2020
Reference: Sci Total Environ. 2020 Apr 15;713:136604. doi: 10.1016/j.scitotenv.2020.136604. Epub 2020 Jan 8.
Impact factor:
Publication type: Paper in international publication
Authors: Abril, Josep F; Andres, Cristina; Anton, Andres; Bofill-Mas, Silvia; Fernandez-Cassi, Xavier; Girones, Rosina; Itarte, Marta; Martinez-Puchol, Sandra; Rusinol, Marta; Timoneda, Natalia et al.
DOI: 10.1016/j.scitotenv.2020.136604

Single-locus-sequence-based typing of the mgpB gene reveals transmission dynamics in Mycoplasma genitalium.

PMID: 31941694
Journal: JOURNAL OF CLINICAL MICROBIOLOGY
Year: 2020
Reference: J Clin Microbiol. 2020 Mar 25;58(4). pii: JCM.01886-19. doi: 10.1128/JCM.01886-19. Print 2020 Mar 25.
Impact factor:
Publication type: Paper in international publication
Authors: Aparicio, David; Barbera, Maria-Jesus; Espasa, Mateu; Esperalba, Juliana; Fernandez-Huerta, Miguel; Fernandez-Naval, Candela; Jensen, Jorgen S; Moreno-Mingorance, Albert; Pich, Oscar Q; Pumarola, Tomas et al.
DOI: 10.1128/JCM.01886-19

Biomarkers and clinical scores to aid the identification of disease severity and intensive care requirement following activation of an in-hospital sepsis code.

PMID: 31940096
Journal: Annals of Intensive Care
Year: 2020
Reference: Ann Intensive Care. 2020 Jan 15;10(1):7. doi: 10.1186/s13613-020-0625-5.
Impact factor:
Publication type: Paper in international publication
Authors: Baldira, Jaume; Chiscano, Luis; Comas, Inma; Cortes, Alejandro; Fabrega, Anna; Ferrer, Ricard; Ferrer-Costa, Roser; Gonzalez-Lopez, Juan Jose; Larrosa, Nieves; Ruiz-Rodriguez, Juan Carlos et al.
DOI: 10.1186/s13613-020-0625-5

Teicoplanin for treating enterococcal infective endocarditis: a retrospective observational study from a referral center.

PMID: 30315920
Journal: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
Year: 2019
Reference: Int J Antimicrob Agents. 2019 Feb;53(2):165-170. doi: 10.1016/j.ijantimicag.2018.10.003. Epub 2018 Oct 10.
Impact factor:
Publication type: Paper in international publication
Authors: Almirante, Benito; Bartolome, Rosa; Escola-Verge, Laura; Fernandez-Hidalgo, Nuria; Gonzalez-Lopez, Juan Jose; Pigrau, Carlos; Rodriguez-Pardo, Dolors et al.
DOI: 10.1016/j.ijantimicag.2018.10.003

Simultaneous CMV and Listeria infection following alemtuzumab treatment for multiple sclerosis.

PMID: 30587519
Journal: NEUROLOGY
Year: 2019
Reference: Neurology. 2019 Feb 5;92(6):296-298. doi: 10.1212/WNL.0000000000006801. Epub 2018 Dec 26.
Impact factor:
Publication type: Paper in international publication
Authors: Arrambide, Georgina; Boix Rodriguez, Claudia P; Camps, Isabel Ruiz; Castillo, Joaquin; Comabella, Manuel; Galan, Ingrid; Lung, Maiylyi; Midaglia, Luciana; Montalban, Xavier; Mulero, Patricia et al.
DOI: 10.1212/WNL.0000000000006801

Prevention and treatment of sexually transmitted infections in high-risk individuals, including patients with HIV infection.

PMID: 30591390
Journal: ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
Year: 2019
Reference: Enferm Infecc Microbiol Clin. 2019 Feb;37(2):117-126. doi: 10.1016/j.eimc.2018.11.008. Epub 2018 Dec 24.
Impact factor:
Publication type: Paper in national publication
Authors: Del Romero, Jorge; Espasa-Soley, Mateu; Garcia-Perez, Jorge N et al.
DOI: 10.1016/j.eimc.2018.11.008

Mycoplasma genitalium and antibiotic resistance in Spain; the need for an effective response against an emerging problem.

PMID: 29853280
Journal: ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
Year: 2019
Reference: Enferm Infecc Microbiol Clin. 2019 Feb;37(2):144-145. doi: 10.1016/j.eimc.2018.04.008. Epub 2018 May 28.
Impact factor:
Publication type: Letter or abstract
Authors: Barbera, Maria-Jesus; Espasa, Mateu; Fernandez-Huerta, Miguel; Serra-Pladevall, Judit et al.
DOI: 10.1016/j.eimc.2018.04.008

Drug Resistance of Mycobacterium tuberculosis Complex in a Rural Setting, Angola.

PMID: 29460748
Journal: EMERGING INFECTIOUS DISEASES
Year: 2018
Reference: Emerg Infect Dis. 2018 Mar;24(3):569-572. doi: 10.3201/eid2403.171562.
Impact factor: 7.422
Publication type: Paper in international publication
Authors: Rando-Segura, Ariadna, Aznar, Maria Luisa, Moreno, Maria Milagros, Espasa, Mateu, Sulleiro, Elena, Bocanegra, Cristina, Gil, Eva, Eugenio, Arlete N E, Escartin, Carlos, Zacarias, Adriano et al.
DOI: 10.3201/eid2403.171562

Recommendations for enterovirus diagnostics and characterisation within and beyond Europe.

PMID: 29414181
Journal: JOURNAL OF CLINICAL VIROLOGY
Year: 2018
Reference: J Clin Virol. 2018 Apr;101:11-17. doi: 10.1016/j.jcv.2018.01.008. Epub 2018 Feb 6.
Impact factor: 3.101
Publication type: Review in international publication
Authors: Wolthers, Katja, Harvala, Heli, Broberg, Eeva, Benschop, Kimberley, Berginc, Natasa, Ladhani, Shamez, Susi, Petri, Christiansen, Claus, McKenna, James, Allen, David et al.
DOI: 10.1016/j.jcv.2018.01.008

Preservation of Neisseria gonorrhoeae: should swabs be refrigerated or not?: Neisseria gonorrhoeae preservation.

PMID: 29292202
Journal: JOURNAL OF MICROBIOLOGICAL METHODS
Year: 2018
Reference: J Microbiol Methods. 2018 Feb;145:37-39. doi: 10.1016/j.mimet.2017.12.012. Epub 2017 Dec 29.
Impact factor: 1.701
Publication type: Paper in international publication
Authors: Serra-Pladevall, Judit, Gulin Blanco, Carlos, Vila Olmo, Neus, Arjona Camacho, Pilar, Andreu Domingo, Antonia et al.
DOI: 10.1016/j.mimet.2017.12.012

Prevalence of Chagas Disease among Solid Organ-Transplanted Patients in a Nonendemic Country.

PMID: 29405102
Journal: AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
Year: 2018
Reference: Am J Trop Med Hyg. 2018 Mar;98(3):742-746. doi: 10.4269/ajtmh.17-0735. Epub 2018 Feb 1.
Impact factor: 2.564
Publication type: Paper in international publication
Authors: Salvador, Fernando, Sanchez-Montalva, Adrian, Sulleiro, Elena, Moreso, Francesc, Berastegui, Cristina, Caralt, Mireia, Pinazo, Maria-Jesus, Moure, Zaira, Los-Arcos, Ibai, Len, Oscar et al.
DOI: 10.4269/ajtmh.17-0735

Differences in Neisseria gonorrhoeae population structure and antimicrobial resistance pattern between men who have sex with men and heterosexuals.

PMID: 27758727
Journal: EPIDEMIOLOGY AND INFECTION
Year: 2017
Reference: Epidemiol Infect. 2017 Jan;145(2):379-385. Epub 2016 Oct 19.
Impact factor: 2.075
Publication type: Paper in international publication
Authors: Bartolome-Comas, R, Andreu, A, Callarisa, A E, Barbera, M J, Serra-Pladevall, J et al.
DOI: 10.1017/S095026881600234X

Infections in intensive care unit adult patients harboring multidrug-resistant Pseudomonas aeruginosa: implications for prevention and therapy.

PMID: 28093651
Journal: EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
Year: 2017
Reference: Eur J Clin Microbiol Infect Dis. 2017 Jul;36(7):1097-1104. doi: 10.1007/s10096-016-2894-3. Epub 2017 Jan 16.
Impact factor: 2.727
Publication type: Paper in international publication
Authors: Borgatta, B, Lagunes, L, Imbiscuso, A T, Larrosa, M N, Lujan, M, Rello, J et al.
DOI: 10.1007/s10096-016-2894-3

Centrality in the host-pathogen interactome is associated with pathogen fitness during infection.

PMID: 28090086
Journal: Nature Communications
Year: 2017
Reference: Nat Commun. 2017 Jan 16;8:14092. doi: 10.1038/ncomms14092.
Impact factor: 12.124
Publication type: Paper in international publication
Authors: Crua Asensio, Nuria, Munoz Giner, Elisabet, de Groot, Natalia Sanchez, Torrent Burgas, Marc et al.
DOI: 10.1038/ncomms14092

Sentinel surveillance of imported dengue via travellers to Europe 2012 to 2014: TropNet data from the DengueTools Research Initiative.

PMID: 28080959
Journal: Eurosurveillance
Year: 2017
Reference: Euro Surveill. 2017 Jan 5;22(1). pii: 30433. doi: 10.2807/1560-7917.ES.2017.22.1.30433.
Impact factor: 7.202
Publication type: Paper in international publication
Authors: Castelli, Francesco, Van Esbroeck, Marjan, Matteelli, Alberto, Rochat, Laurence, Sulleiro, Elena, Kurth, Florian, Gobbi, Federico, Norman, Francesca, Torta, Ilaria, Clerinx, Jan et al.
DOI: 10.2807/1560-7917.ES.2017.22.1.30433

Blog

News

The collaboration will focus on several key areas of mutual interest in microbiology in particular antimicrobial resistance and stewardship.

On European Antibiotic Awareness Day, we highlight the importance of using these medications responsibly and finding innovative solutions to combat this issue.

The new diagnostic method, designed for use in endemic regions, combines a mobile application with a low-cost robotic microscope.