Neurodegenerative Diseases
The research conducted in our group is geared toward elucidating the cause and molecular mechanisms of neurodegeneration in Parkinson's disease (PD), a disabling, currently incurable common neurodegenerative disorder. To this end, we perform clinical and pre-clinical translational research in both PD patients and in human-relevant experimental in vitro and in vivo PD-related models.
Elucidating the molecular mechanisms underlying neurodegeneration in PD should allow to:
- Identify biomarkers for PD diagnosis, early detection, patient stratification, disease progression, prognosis or response to treatment. This is the objective of the VHIP Project that the team is carrying out.
- Identify new molecular targets for potential therapeutic intervention and prevention.
- Develop novel therapeutic strategies with disease-modifying potential.
- Unravel molecular pathways common to other neurodegenerative diseases and, in a broader sense, brain aging.
Publications
Efficacy and Safety of Pea Protein and Xyloglucan Versus Simethicone in Functional Abdominal Bloating and Distension.
PMID: 37923826
Journal: DIGESTIVE DISEASES AND SCIENCES
Year: 2023
Reference: Dig Dis Sci. 2023 Nov 3. doi: 10.1007/s10620-023-08155-1.
Impact factor:
Publication type: Paper in international publication
Authors: Belohlavek, Jan; Dimitrova, Emiliya; Elenski, Kiril; Etropolska, Zlatka; Jung, Christian; Petrisor, Diana Corina; Riera, Jordi; Santos, Javier et al.
DOI: 10.1007/s10620-023-08155-1
Anticoagulation and Bleeding during Veno-Venous Extracorporeal Membrane Oxygenation: Insights from the PROTECMO Study.
PMID: 37943110
Journal: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
Year: 2023
Reference: Am J Respir Crit Care Med. 2023 Nov 9. doi: 10.1164/rccm.202305-0896OC.
Impact factor:
Publication type: Paper in international publication
Authors: Agerstrand, Cara; Ait Hssain, Ali; Arcadipane, Antonio; Balik, Martin; Beggs, Alan; Ben Yaou, Rabah; Bertini, Enrico Silvio; Bloch, Adrien; Boespflug-Tanguy, Odile; Bonne, Gisele et al.
DOI: 10.1164/rccm.202305-0896OC
International Guideline for Idiopathic Inflammatory Myopathy-Associated Cancer Screening: an International Myositis Assessment and Clinical Studies Group (IMACS) initiative.
PMID: 37945774
Journal: Nature Reviews Rheumatology
Year: 2023
Reference: Nat Rev Rheumatol. 2023 Nov 9. doi: 10.1038/s41584-023-01045-w.
Impact factor:
Publication type: Paper in international publication
Authors: Aggarwal, Rohit; Alonso Losada, Maria G; Alonso Redondo, Ruben; Alvarado, Maria Cristina Iniguez; Alvarez Sauco, Maria; Avila Rivera, Maria A; Borrue, Carmen; Buongiorno, Maria Teresa; Caballol, Nuria; Cabo, Iria et al.
DOI: 10.1038/s41584-023-01045-w
Prophylactic mesh does not prevent parastomal hernia in long-term: Meta-analysis and trial sequential analysis.
PMID: 37949696
Journal: SURGERY
Year: 2023
Reference: Surgery. 2023 Nov 8:S0039-6060(23)00708-0. doi: 10.1016/j.surg.2023.09.038.
Impact factor:
Publication type: Paper in international publication
Authors: Agerstrand, Cara; Ait Hssain, Ali; Arcadipane, Antonio; Balik, Martin; Brodie, Daniel; Broman, Lars Mikael; Buabbas, Sara; Buscher, Hergen; Chico, Juan I; Combes, Alain et al.
DOI: 10.1016/j.surg.2023.09.038
Depression is Associated with Impulse-compulsive Behaviors in Parkinson's disease.
PMID: 33242731
Journal: JOURNAL OF AFFECTIVE DISORDERS
Year: 2021
Reference: J Affect Disord. 2021 Feb 1;280(Pt B):77-89. doi: 10.1016/j.jad.2020.11.075. Epub 2020 Nov 13.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso Losada, M G; Borrue, C; Caballol, N; Cabo-Lopez, I; Carrillo Padilla, F; Cores Bartolome, C; Cubo, E; de Deus Fonticoba, T; Garcia Caldentey, J; Gonzalez Aramburu, I et al.
DOI: 10.1016/j.jad.2020.11.075
Present and Future Therapeutic Approaches to Barrier Dysfunction.
PMID: 34778332
Journal: Frontiers in Nutrition
Year: 2021
Reference: Front Nutr. 2021 Oct 28;8:718093. doi: 10.3389/fnut.2021.718093. eCollection 2021.
Impact factor: 6.576
Publication type: Review in international publication
Authors: Fortea, Marina, Albert-Bayo, Merce, Abril-Gil, Mar, Ganda Mall, John-Peter, Serra-Ruiz, Xavier, Henao-Paez, Alejandro, Exposito, Elba, Gonzalez-Castro, Ana Maria, Guagnozzi, Danila, Lobo, Beatriz et al.
DOI: 10.3389/fnut.2021.718093
Serum metabolic biomarkers for synucleinopathy conversion in isolated REM sleep behavior disorder.
PMID: 33986284
Journal: npj Parkinsons Disease
Year: 2021
Reference: NPJ Parkinsons Dis. 2021 May 13;7(1):40. doi: 10.1038/s41531-021-00184-9.
Impact factor: 8.651
Publication type: Paper in international publication
Authors: Yanes, Oscar, Laguna, Ariadna, Xicoy, Helena, Tolosa, Eduardo, Serradell, Monica, Vilas, Dolores, Gaig, Carles, Fernandez, Manel, Iranzo, Alex, Vila, Miquel et al.
DOI: 10.1038/s41531-021-00184-9
Corticobasal syndrome: A case of discordance between the clinical findings and the imaging biomarkers.
PMID: 33875401
Journal: Revista Espanola de Medicina Nuclear e Imagen Molecular
Year: 2021
Reference: Rev Esp Med Nucl Imagen Mol (Engl Ed). 2021 Apr 16. pii: S2253-654X(21)00057-3. doi: 10.1016/j.remn.2021.02.015.
Impact factor: 1.359
Publication type: Letter or abstract
Authors: Hernandez-Vara, J, Martinez-Saez, E, Lucas Del Pozo, S, Cardozo-Saavedra, A, Carrillo-Villamizar, E, Lorenzo-Bosquet, C et al.
DOI: 10.1016/j.remn.2021.02.015
News
The initiative seeks to raise awareness of the disease and promote the well-being of those affected, while fostering empathy and scientific vocations among young people.
On World Clinical Trials Day, we highlight some of the studies we have participated in that confirm the efficacy of new drugs, allowing their approval by regulatory agencies.
Vall d'Hebron has participated in a phase III clinical trial which confirmed the efficacy and safety of subcutaneous infusion of levodopa therapy.
Coneix i participa al projecte VHIP
Vall d'Hebron Iniciativa per al Parkinson (VHIP) is a research project aimed at the development of biochemical markers for the early detection of Parkinson's disease. This study is carried out in people at high risk of having this disease, because they carry genetic mutations that predispose to the development of Parkinson's or because they present non-motor symptoms that manifest themselves years before motor symptoms.