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Neurotraumatology and Neurosurgery Research Unit (UNINN)

The Neurotraumatology and Neurosurgery Research Unit (UNINN) is a translational research group fully integrated into the European research community and accredited as a Consolidated Research Group since 2005.

The UNINN conduct both basic and clinical research, with the aim of transferring benchside discoveries to the bedside. We have robust intramural synergies, national collaborations with basic scientists, and international collaborations and alliances with researchers from multiple countries and institutions with whom we share common research goals.

Our research unit participates in multinational clinical trials funded by the pharmaceutical industry and the European Union (EU). Our research unit is highly focused on developing and using new technologies to improve the assessment of clinical outcomes, incorporating quality of life measures, and patient-reported outcomes. We also maintain an important collection of brain tissue samples, serum, LCR, and microdialysates from the cerebral extracellular space of neurocritical patients. 

Publications

Sleep increases leaks and asynchronies during home noninvasive ventilation: a polysomnographic study.

PMID: 34314351
Journal: Journal of Clinical Sleep Medicine
Year: 2022
Reference: J Clin Sleep Med. 2022 Jan 1;18(1):225-233. doi: 10.5664/jcsm.9546.
Impact factor:
Publication type: Paper in international publication
Authors: Ferre, Alex; Ferrer, Jaume; Marti, Sergi; Pallero, Mercedes; Romero, Odile; Sampol, Gabriel; Sampol, Julia et al.
DOI: 10.5664/jcsm.9546

Magnetic resonance imaging findings in focal onset status epilepticus.

PMID: 34390102
Journal: EUROPEAN JOURNAL OF NEUROLOGY
Year: 2022
Reference: Eur J Neurol. 2022 Jan;29(1):3-11. doi: 10.1111/ene.15065. Epub 2021 Sep 3.
Impact factor:
Publication type: Paper in international publication
Authors: Auger, C; Pareto, D; Quintana, M; Rovira, A; Santamarina, E; Sarria-Estrada, S; Sueiras, M; Toledo, M et al.
DOI: 10.1111/ene.15065

Study protocol for an observational cohort evaluating incidence and clinical relevance of perioperative elevation of high-sensitivity troponin I and N-terminal pro-brain natriuretic peptide in patients undergoing lung resection.

PMID: 36600389
Journal: BMJ Open
Year: 2022
Reference: BMJ Open. 2022 Dec 8;12(12):e063778. doi: 10.1136/bmjopen-2022-063778.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, Maria; Candela-Toha, Angel; Cladellas-Gutierrez, Esther; de Miguel, Marcos; de Nadal, Miriam; de Pablo, Angelica; Gajate, Luis; Gonzalez-Tallada, Anna; Martin-Grande, Ascencion; Martinez-Tellez, Elisabeth et al.
DOI: 10.1136/bmjopen-2022-063778

Sleep increases leaks and asynchronies during home noninvasive ventilation: a polysomnographic study.

PMID: 34314351
Journal: Journal of Clinical Sleep Medicine
Year: 2022
Reference: J Clin Sleep Med. 2022 Jan 1;18(1):225-233. doi: 10.5664/jcsm.9546.
Impact factor: 4.062
Publication type: Paper in international publication
Authors: Marti, Sergi; Ferre, Alex; Sampol, Gabriel; Pallero, Mercedes; Romero, Odile; Ferrer, Jaume; Sampol, Julia et al.
DOI: 10.5664/jcsm.9546

Frequency of fatigue and its changes in the first 6 months after traumatic brain injury: results from the CENTER-TBI study.

PMID: 32676767
Journal: JOURNAL OF NEUROLOGY
Year: 2021
Reference: J Neurol. 2021 Jan;268(1):61-73. doi: 10.1007/s00415-020-10022-2. Epub 2020 Jul 16.
Impact factor:
Publication type: Paper in international publication
Authors: Akerlund, Cecilia; Amrein, Krisztina; Andelic, Nada; Andelic, Nada; Andreassen, Lasse; Anke, Audny; Antoni, Anna; Ao, Braden Te; Audibert, Gerard; Azouvi, Philippe et al.
DOI: 10.1007/s00415-020-10022-2

Cortical Spreading Depression Phenomena Are Frequent in Ischemic and Traumatic Penumbra: A Prospective Study in Patients With Traumatic Brain Injury and Large Hemispheric Ischemic Stroke.

PMID: 31702708
Journal: JOURNAL OF CLINICAL NEUROPHYSIOLOGY
Year: 2021
Reference: J Clin Neurophysiol. 2021 Jan 1;38(1):47-55. doi: 10.1097/WNP.0000000000000648.
Impact factor:
Publication type: Paper in international publication
Authors: Poca, Maria A; Quintana, Manuel; Riveiro, Marilyn; Sahuquillo, Juan; Sanchez-Guerrero, Angela; Santamarina, Estevo; Sueiras, Maria; Thonon, Vanessa et al.
DOI: 10.1097/WNP.0000000000000648

Considerations in the Use of Gravitational Valves in the Management of Hydrocephalus. Some Lessons Learned with the Dual-Switch Valve.

PMID: 33445418
Journal: Journal of Clinical Medicine
Year: 2021
Reference: J Clin Med. 2021 Jan 12;10(2). pii: jcm10020246. doi: 10.3390/jcm10020246.
Impact factor:
Publication type: Review in international publication
Authors: Alcina, Aloma; Gandara, Dario F; Lopez-Bermeo, Diego; Poca, Maria A; Rosas, Katiuska; Sahuquillo, Juan et al.
DOI: 10.3390/jcm10020246

Association between Physiological Signal Complexity and Outcomes in Moderate and Severe Traumatic Brain Injury: A CENTER-TBI Exploratory Analysis of Multi-Scale Entropy.

PMID: 32814492
Journal: JOURNAL OF NEUROTRAUMA
Year: 2021
Reference: J Neurotrauma. 2021 Jan 15;38(2):272-282. doi: 10.1089/neu.2020.7249. Epub 2020 Sep 23.
Impact factor:
Publication type: Paper in international publication
Authors: Anke, Audny; Beer, Ronny; Bellander, Bo Michael; Beqiri, Erta; Buki, Andras; Cabeleira, Manuel; Carbonara, Marco; Chieregato, Arturo; Citerio, Giuseppe; Clusmann, Hans et al.
DOI: 10.1089/neu.2020.7249

Optimizing Organ Donation: Expert Opinion from Austria, Germany, Spain and the U.K.

PMID: 32179731
Journal: Annals of Transplantation
Year: 2020
Reference: Ann Transplant. 2020 Mar 17;25:e921727. doi: 10.12659/AOT.921727.
Impact factor:
Publication type: Paper in international publication
Authors: Amelung, Volker; Bayliss, Janice; Becker, Fabian; Castellana, Teresa Pont; Kaltenborn, Alexander; Kellner, Christian; Krauth, Christian; Murphy, Nick; Nadal, Miriam de; Pemberger, Sonja et al.
DOI: 10.12659/AOT.921727

Variability of Clinical and Angiographic Results based on the Treatment Preference (Endovascular or Surgical) of Centers Participating in the Subarachnoid Hemorrhage Database of the Working Group of the Spanish Society of Neurosurgery.

PMID: 31811967
Journal: World Neurosurgery
Year: 2020
Reference: World Neurosurg. 2020 Mar;135:e339-e349. doi: 10.1016/j.wneu.2019.11.163. Epub 2019 Dec 5.
Impact factor:
Publication type: Paper in international publication
Authors: Arikan, Fuat; Arrese, Ignacio; Bano-Ruiz, Elena; Brell, Marta; de Asis Lorente-Munoz, Francisco; Delgado-Lopez, Pedro D; Dominguez, Jaime; Errando, Nacho; Fernandez-Alen, Jose A; Gabarros, Andreu et al.
DOI: 10.1016/j.wneu.2019.11.163

Quality indicators for patients with traumatic brain injury in European intensive care units: a CENTER-TBI study.

PMID: 32131882
Journal: CRITICAL CARE
Year: 2020
Reference: Crit Care. 2020 Mar 4;24(1):78. doi: 10.1186/s13054-020-2791-0.
Impact factor:
Publication type: Paper in international publication
Authors: Akerlund, Cecilia; Amrein, Krisztina; Andelic, Nada; Andreassen, Lasse; Audibert, Gerard; Azouvi, Philippe; Azzolini, Maria Luisa; Bartels, Ronald; Beer, Ronny; Bellander, Bo-Michael et al.
DOI: 10.1186/s13054-020-2791-0

Myocardial Injury After Noncardiac Surgery: Incidence, Predictive Factors, and Outcome in High-Risk Patients Undergoing Thoracic Surgery: An Observational Study.

PMID: 31515189
Journal: JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
Year: 2020
Reference: J Cardiothorac Vasc Anesth. 2020 Feb;34(2):426-432. doi: 10.1053/j.jvca.2019.08.014. Epub 2019 Aug 16.
Impact factor:
Publication type: Paper in international publication
Authors: Borrell-Vega, Jaume; Coronado, Carolina; de Miguel, Marcos; de Nadal, Miriam; Ferreira-Gonzalez, Ignacio; Gonzalez-Tallada, Anna; Morales, Paula et al.
DOI: 10.1053/j.jvca.2019.08.014

Correction to: Variation in neurosurgical management of traumatic brain injury: a survey in 68 centers participating in the CENTER-TBI study.

PMID: 30715604
Journal: ACTA NEUROCHIRURGICA
Year: 2019
Reference: Acta Neurochir (Wien). 2019 Mar;161(3):451-455. doi: 10.1007/s00701-019-03815-6.
Impact factor:
Publication type: Letter or abstract
Authors: Ackerlund, Cecilia; Adams, Hadie; Agnoletti, Vanni; Allanson, Judith; Amrein, Krisztina; Andaluz, Norberto; Andelic, Nada; Andreassen, Lasse; Anke, Audny; Antoni, Anna et al.
DOI: 10.1007/s00701-019-03815-6

Maternal anaesthesia in open and fetoscopic surgery of foetal open spinal neural tube defects: A 6-year observational study.

PMID: 30507621
Journal: EUROPEAN JOURNAL OF ANAESTHESIOLOGY
Year: 2019
Reference: Eur J Anaesthesiol. 2019 Mar;36(3):175-184. doi: 10.1097/EJA.0000000000000930.
Impact factor:
Publication type: Paper in international publication
Authors: Arevalo, Silvia; Blanco, Domingo; Carreras, Elena; de Nadal, Miriam; Garcia, Irene; Gine, Carles; Lopez, Manuel; Maiz, Nerea; Manrique, Susana; Molino, Jose Andres et al.
DOI: 10.1097/EJA.0000000000000930

Practical document on the management of hyponatremia in critically ill patients.

PMID: 30678998
Journal: Medicina Intensiva
Year: 2019
Reference: Med Intensiva. 2019 Jun - Jul;43(5):302-316. doi: 10.1016/j.medin.2018.12.002. Epub 2019 Jan 22.
Impact factor:
Publication type: Paper in national publication
Authors: Alvarez Rocha, L; Ballesteros Sanz, M A; Broch Porcar, M J; Cervera Montes, M; Chico Fernandez, M; de Gea Garcia, J H; Dominguez-Roldan, J M; Enriquez Giraudo, P; Garcia de Lorenzo Y Mateos, A; Gomez Lopez, R et al.
DOI: 10.1016/j.medin.2018.12.002

A Conditional Inference Tree Model for Predicting Sleep-Related Breathing Disorders in Patients With Chiari Malformation Type 1: Description and External Validation.

PMID: 30621833
Journal: Journal of Clinical Sleep Medicine
Year: 2019
Reference: J Clin Sleep Med. 2019 Jan 15;15(1):89-99. doi: 10.5664/jcsm.7578.
Impact factor:
Publication type: Paper in international publication
Authors: de la Calzada, Maria Dolore; Ferre, Alex; Moncho, Dulce; Poca, Maria A; Romero, Odile; Sahuquillo, Juan; Sampol, Gabriel; Urbizu, Aintzane et al.
DOI: 10.5664/jcsm.7578

Blog

News

The goal is to test a low-cost, easy-to-use and non-invasive monitor, which will serve to control intracranial pressure (PICO) values, which will help to control and treat different acute brain pathologies.

The new tool will improve patient care and allow early detection of complications, as the hospital previously did not have a specific form.

Entre els projectes es troben 12 investigacions on participen investigadors i investigadores de Vall d’Hebron.

Rates

Check the current rates for the LUMINEX MAGPIX service offered by the Neurotraumatology and Neurosurgery Research Unit (UNINN).