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Neurotraumatology and Neurosurgery Research Unit (UNINN)

The Neurotraumatology and Neurosurgery Research Unit (UNINN) is a translational research group fully integrated into the European research community and accredited as a Consolidated Research Group since 2005.

The UNINN conduct both basic and clinical research, with the aim of transferring benchside discoveries to the bedside. We have robust intramural synergies, national collaborations with basic scientists, and international collaborations and alliances with researchers from multiple countries and institutions with whom we share common research goals.

Our research unit participates in multinational clinical trials funded by the pharmaceutical industry and the European Union (EU). Our research unit is highly focused on developing and using new technologies to improve the assessment of clinical outcomes, incorporating quality of life measures, and patient-reported outcomes. We also maintain an important collection of brain tissue samples, serum, LCR, and microdialysates from the cerebral extracellular space of neurocritical patients. 

Publications

Prevalence of common origin of the innominate and left carotid artery (CILCA) or bovine arch configuration in patients with blunt aortic injury.

PMID: 35112824
Journal: INTERNATIONAL ANGIOLOGY
Year: 2022
Reference: Int Angiol. 2022 Apr;41(2):170-176. doi: 10.23736/S0392-9590.22.04793-9. Epub 2022 Feb 3.
Impact factor: 2.789
Publication type: Paper in international publication
Authors: Tello-Diaz, Cristina; Alvarez Garcia, Beatriz; Gil-Sala, Daniel; Riveiro Vilaboa, Marilyn; Tenezaca-Sari, Xavier; Bellmunt, Sergi et al.
DOI: 10.23736/S0392-9590.22.04793-9

Planning for the assistance of critically ill patients in a Pandemic Situation: The experience of Vall d'Hebron University Hospital.

PMID: 34872890
Journal: ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
Year: 2022
Reference: Enferm Infecc Microbiol Clin (Engl Ed). 2022 Feb;40(2):71-77. doi: 10.1016/j.eimce.2021.11.003. Epub 2021 Nov 26.
Impact factor: 1.731
Publication type: Paper in international publication
Authors: Ferrer, Ricard; Baguena, Marcelino; Balcells, Joan; Baneras, Jordi; Biarnes, Alfons; de Nadal, Miriam; Gracia, Rosa Maria; Martinez, Jesus; Nuvials, Xavier; Riera, Jordi et al.
DOI: 10.1016/j.eimce.2021.11.003

Epileptic seizures in the emergency room: clinical and electroencephalographic findings associated with brain perfusion patterns on computed tomography.

PMID: 35152335
Journal: JOURNAL OF NEUROLOGY
Year: 2022
Reference: J Neurol. 2022 Jul;269(7):3761-3769. doi: 10.1007/s00415-022-11005-1. Epub 2022 Feb 13.
Impact factor: 4.849
Publication type: Paper in international publication
Authors: Coscojuela, P; Fonseca, E; Quintana, M; Sarria-Estrada, S; Santamarina, E; Abraira, L; Sueiras, M; Thonon, V; Alvarez-Sabin, J; Toledo, M et al.
DOI: 10.1007/s00415-022-11005-1

Tailoring Multi-Dimensional Outcomes to Level of Functional Recovery after Traumatic Brain Injury.

PMID: 35607855
Journal: JOURNAL OF NEUROTRAUMA
Year: 2022
Reference: J Neurotrauma. 2022 Jun 24. doi: 10.1089/neu.2022.0013.
Impact factor: 5.269
Publication type: Paper in international publication
Authors: Clusmann, Hans; Berardino, Maurizio; Beretta, Luigi; Blaabjerg, Morten; Bragge, Peter; Brazinova, Alexandra; Brinck, Vibeke; Brooker, Joanne; Brorsson, Camilla; Buki, Andras et al.
DOI: 10.1089/neu.2022.0013

Association between Physiological Signal Complexity and Outcomes in Moderate and Severe Traumatic Brain Injury: A CENTER-TBI Exploratory Analysis of Multi-Scale Entropy.

PMID: 32814492
Journal: JOURNAL OF NEUROTRAUMA
Year: 2021
Reference: J Neurotrauma. 2021 Jan 15;38(2):272-282. doi: 10.1089/neu.2020.7249. Epub 2020 Sep 23.
Impact factor:
Publication type: Paper in international publication
Authors: Anke, Audny; Beer, Ronny; Bellander, Bo Michael; Beqiri, Erta; Buki, Andras; Cabeleira, Manuel; Carbonara, Marco; Chieregato, Arturo; Citerio, Giuseppe; Clusmann, Hans et al.
DOI: 10.1089/neu.2020.7249

Prediction of Global Functional Outcome and Post-Concussive Symptoms after Mild Traumatic Brain Injury: External Validation of Prognostic Models in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Study.

PMID: 32977737
Journal: JOURNAL OF NEUROTRAUMA
Year: 2021
Reference: J Neurotrauma. 2021 Jan 15;38(2):196-209. doi: 10.1089/neu.2020.7074. Epub 2020 Oct 19.
Impact factor:
Publication type: Paper in international publication
Authors: Akerlund, Cecilia; Amrein, Krisztina; Andelic, Nada; Andreassen, Lasse; Anke, Audny; Antoni, Anna; Audibert, Gerard; Azouvi, Philippe; Azzolini, Maria Luisa; Bartels, Ronald et al.
DOI: 10.1089/neu.2020.7074

Prediction model for intracranial hypertension demonstrates robust performance during external validation on the CENTER-TBI dataset.

PMID: 33001234
Journal: INTENSIVE CARE MEDICINE
Year: 2021
Reference: Intensive Care Med. 2021 Jan;47(1):124-126. doi: 10.1007/s00134-020-06247-4. Epub 2020 Oct 1.
Impact factor:
Publication type: Letter whit IF
Authors: Anke, Audny; Beer, Ronny; Bellander, Bo-Michael; Beqiri, Erta; Buki, Andras; Cabeleira, Manuel; Carbonara, Marco; Carra, Giorgia; Chieregato, Arturo; Citerio, Giuseppe et al.
DOI: 10.1007/s00134-020-06247-4

Acute Kidney Injury in Traumatic Brain Injury Patients: Results From the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury Study.

PMID: 33060506
Journal: CRITICAL CARE MEDICINE
Year: 2021
Reference: Crit Care Med. 2021 Jan 1;49(1):112-126. doi: 10.1097/CCM.0000000000004673.
Impact factor:
Publication type: Paper in international publication
Authors: Akerlund, Cecilia; Amrein, Krisztina; Andelic, Nada; Andreassen, Lasse; Anke, Audny; Audibert, Gerard; Azouvi, Philippe; Azzolini, Maria Luisa; Banzato, Erika; Bartels, Ronald et al.
DOI: 10.1097/CCM.0000000000004673

Prognostic Validation of the NINDS Common Data Elements for the Radiologic Reporting of Acute Traumatic Brain Injuries: A CENTER-TBI Study.

PMID: 31813313
Journal: JOURNAL OF NEUROTRAUMA
Year: 2020
Reference: J Neurotrauma. 2020 Jun 1;37(11):1269-1282. doi: 10.1089/neu.2019.6710. Epub 2020 Feb 25.
Impact factor:
Publication type: Paper in international publication
Authors: Akerlund, Cecilia; Amrein, Krisztina; Andelic, Nada; Andreassen, Lasse; Anke, Audny; Antoni, Anna; Audibert, Gerard; Azouvi, Philippe; Azzolini, Maria Luisa; Bartels, Ronald et al.
DOI: 10.1089/neu.2019.6710

Correction to: Efficacy of Ronopterin (VAS203) in Patients with Moderate and Severe Traumatic Brain Injury (NOSTRA phase III trial): study protocol of a confirmatory, placebocontrolled, randomised, double blind, multi-centre study.

PMID: 32051020
Journal: Trials
Year: 2020
Reference: Trials. 2020 Feb 12;21(1):172. doi: 10.1186/s13063-020-4107-8.
Impact factor:
Publication type: Letter or abstract
Authors: Andrews, Peter; Beer, Ronny; Belli, Antonio; Bulters, Diederik; Fluh, Charlotte; Ibanez, Javier; Lagares, Alfonso; LeFrant, Jean-Yves; Mokry, Michael; Sahuquillo, Joan et al.
DOI: 10.1186/s13063-020-4107-8

Tracheostomy practice and timing in traumatic brain-injured patients: a CENTER-TBI study.

PMID: 32025780
Journal: INTENSIVE CARE MEDICINE
Year: 2020
Reference: Intensive Care Med. 2020 May;46(5):983-994. doi: 10.1007/s00134-020-05935-5. Epub 2020 Feb 5.
Impact factor:
Publication type: Paper in international publication
Authors: Akerlund, Cecilia; Amrein, Krisztina; Andelic, Nada; Andreassen, Lasse; Anke, Audny; Audibert, Gerard; Azouvi, Philippe; Azzolini, Maria Luisa; Bartels, Ronald; Beer, Ronny et al.
DOI: 10.1007/s00134-020-05935-5

Nighttime hypoxia affects global cognition, memory, and executive function in community-dwelling individuals with hypertension.

PMID: 31992414
Journal: Journal of Clinical Sleep Medicine
Year: 2020
Reference: J Clin Sleep Med. 2020 Feb 15;16(2):243-250. doi: 10.5664/jcsm.8174. Epub 2020 Jan 13.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez-Sabin, Jose; Delgado, Pilar; Ferre, Alex; Maisterra, Olga; Montaner, Joan; Quintana, Manuel; Riba-Llena, Iolanda; Romero, Odile; Sampol, Gabriel; Santamarina, Estevo et al.
DOI: 10.5664/jcsm.8174

Soluble Suppression of Tumorigenicity-2 Predicts Hospital Mortality in Burn Patients: An Observational Prospective Cohort Pilot Study.

PMID: 29642231
Journal: SHOCK
Year: 2019
Reference: Shock. 2019 Feb;51(2):194-199. doi: 10.1097/SHK.0000000000001155.
Impact factor:
Publication type: Paper in international publication
Authors: Baena, Jacinto; Barret, Juan P; Bosacoma, Pau; Dos Santos, Bruce; Guilabert, Patricia; Marin-Corral, Judith; Masclans, Joan R; Roca, Oriol; Ruiz-Castilla, Mireia et al.
DOI: 10.1097/SHK.0000000000001155

Actively personalized vaccination trial for newly diagnosed glioblastoma.

PMID: 30568303
Journal: NATURE
Year: 2019
Reference: Nature. 2019 Jan;565(7738):240-245. doi: 10.1038/s41586-018-0810-y. Epub 2018 Dec 19.
Impact factor:
Publication type: Paper in international publication
Authors: Admon, Arie; Britten, Cedrik M; Bukur, Valesca; Bunse, Lukas; Capper, David; Castle, John C; Derhovanessian, Evelyna; Dietrich, Pierre-Yves; Dorner, Sonja; Dutoit, Valerie et al.
DOI: 10.1038/s41586-018-0810-y

Forewarning of hypotensive events using a Bayesian artificial neural network in neurocritical care.

PMID: 29799079
Journal: JOURNAL OF CLINICAL MONITORING AND COMPUTING
Year: 2019
Reference: J Clin Monit Comput. 2019 Feb;33(1):39-51. doi: 10.1007/s10877-018-0139-y. Epub 2018 May 24.
Impact factor:
Publication type: Paper in international publication
Authors: Chambers, I; Chambers, I R; Chambers, Iain; Citerio, G; Citerio, Giuseppe; Corte, Della; Cruickshank, Garth; de Jong, Dirk; Donald, Rob; Dunn et al.
DOI: 10.1007/s10877-018-0139-y

Bilateral suprazygomatic maxillary nerve blocks vs. infraorbital and palatine nerve blocks in cleft lip and palate repair: A double-blind prospective, randomised study.

PMID: 30308523
Journal: EUROPEAN JOURNAL OF ANAESTHESIOLOGY
Year: 2019
Reference: Eur J Anaesthesiol. 2019 Jan;36(1):40-47. doi: 10.1097/EJA.0000000000000900.
Impact factor:
Publication type: Paper in international publication
Authors: Bora, Pranjal; Borah, Nabamallika; Bosenberg, Adrian; Ciarallo, Christopher; De Miguel, Marcos; de Nadal, Miriam; Echaniz, Gaston; Ing, Richard J; Merritt, Glenn; Sierra, Plinio et al.
DOI: 10.1097/EJA.0000000000000900

Blog

News

The goal is to test a low-cost, easy-to-use and non-invasive monitor, which will serve to control intracranial pressure (PICO) values, which will help to control and treat different acute brain pathologies.

The new tool will improve patient care and allow early detection of complications, as the hospital previously did not have a specific form.

Entre els projectes es troben 12 investigacions on participen investigadors i investigadores de Vall d’Hebron.

Rates

Check the current rates for the LUMINEX MAGPIX service offered by the Neurotraumatology and Neurosurgery Research Unit (UNINN).