About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The group of design and pharmacodynamics of nanoparticles at the Vall d’Hebron Research Institute focuses on the synthesis, characterization, and applications of engineered inorganic nanoparticles in the field of medicine. By mastering the inorganic core (size, structure, and shape) and understanding and controlling the linking of molecules to the nanoparticle surface, we engineer nanoparticles that can interact with biological systems in a specific way. We also put particular emphasis on safety, feasibility, scale-up, applicability, and other aspects of nanoparticle design.
Our group is led by Prof. Víctor Puntes, who holds an ICREA Research Professorship. Since a great part of our work demands highly multidisciplinary expertise, we maintain several strong collaborations with biologists, immunologists, oncologists, physicists, environmentalists, and more, from all over Europe, China and the US. The work of the group has resulted in several patents and the creation of several spin-offs such as Nanotargeting and Applied nanoparticles.
Getting advantages from the accumulated experience, I will study the most problematic points related to the growth of multi-component materials and hollow structures. We are preparing complex multifunctional environment responsive NPs comprising different families: i) metallic, ii) metal oxide, iii) semiconductor and iv) oxides of semiconductor. Beyond synthesis, I will focus on the precise characterization of the obtained NPs in terms of their reactivity and physico-chemical properties to precisely correlate morphology with activity. The synthesis of advanced NPs will be carry out, primarily, following seeding-growth approaches or by combining the simultaneous or sequential injection of precursor solutions, surfactant mixtures. The temperature of the solution will be adjusted in order to kinetically control the formation of the NPs and reaction times will be controlled to induce digestion processes and re-crystallizations/controlled sintering when required. I will use mixtures of surfactants or reducing agents and coordinating complexes under controlled atmospheres, intending to independently modify the solubility of the monomer, the nucleation radii, the growing rate and the morphology of the growing structure (by stabilizing different crystals phases and therefore lowering their energy and accelerating selected competing reactions). Hollow metal structures will be synthesized following a multi-step procedure. In the first step, Ag nanocubes are synthesized by known techniques (such as polyol synthesis). Polymetallic hollow NPs with very different morphology and composition, will be obtained by the simultaneous or sequential action of galvanic replacement and the Kirkendall effect in order to control the number and morphology of void spaces inside a single NP, and the chemical transformation of NPs such as cation release/exchange. This allows the production of, among other, monodisperse single- and double-walled nanoboxes or noble metal fullerenes, in high yields and scalable synthesis.
a. APPLICATION ON MEDICINE.
Nanotechnology’s ability to shape matter at the scale of molecules is opening the door to a new generation of diagnostics, imaging agents and drugs/therapies for detecting and treating disease. But perhaps more important, it is allowing to combine a series of advances, creating nanosized particles that may for example contain drugs designed to kill damaged cells together with targeting compounds designed to home-in on malignancies, and imaging agents designed to light up even the earliest stage of disease. For example NPs are perfect candidates to be used in anticancer therapy since they showed passive accumulation in solid tumours due to the Enhanced Permeation and Retention effect (EPR). Is in this context that nanotechnology emerges as a “disruptive technology” with a great potential to contribute to improve treatment by generating new diagnostic and therapeutic products. Its fields of action can be classified in diagnosis, imaging, drug delivery, hyperthermia, theranostics, the simultaneous diagnosis and therapy, and therapy monitoring.
It has been acknowledged that one of the most promising societal impacts of nanotechnology is in the area of nanomedicine. Personalized health care, rational drug design and targeted drug delivery are some of the proposed benefits of a nanomedicine-based approach to therapy. On this subject, my lines of work are: i) Nanooncology, the use of nanoparticles for diagnosis and treatment of cancer. Here I am developing NP-Biomolecule (as AuNP-Antibody) for detection (as lung cancer in breath or circulating cancer cells) and AuNP and Fe3O4 NP for diagnosis/imaging. I continue my work carrying antitumoral drugs with AuNPs (as cisplatin, oxaliplatin, carboplatin, doxorubicin, and sorafenib) and their use as radiotherapy enhancers or hyperthermia agents. ii) Immunology. Significantly important is the interaction of NPs with the immune system. Because one cannot put stuff inside the body without asking the immune system for permission, I am studying the effect of NP on antigen presentation, to then avoid immune detection (for a drug delivery vehicle) or design prophylactic and therapeutic vaccines (for molecular scaffolds). This includes as much AuNPs decorated with antigens as redox active anti-inflammatory CeO2 NPs. iii) Antimicrobial NPs. The emergence of antibiotic resistant strains of common pathogens is a major threat to health and is already putting tremendous pressure on health services worldwide. It has been shown that positive (cationic) nanoparticles show toxic effects to prokaryote, as defensines do. Also, silver, iron or cerium NPs, yield ions that are toxic for prokaryote cells (but well tolerated in eukaryote), acting as disinfectant and bacteriostatic agents. iv) Nanosafety: the prevention of unwanted effects produced by nanoparticles. This is one of our core-expertise areas and I have been working on it, developing NP models for toxicity and ecotoxicity testing, since FP06. My job is to understand which features of NPs poses health threats and then modify the NPs and the way they are used, to avoid the related hazards or exposure (risks) while maintaining the parental desired NP properties.
All this efforts have been translated into the creation of a spin-off company to exploit this knowledge: Nanotargeting (www.nanotargeeting.com), who is actually performing the regulatory preclinical studies and preparing the phase I clinical trials of Aurocis (cisplatin bounded AuNPs).
b. APPLICATION ON ENERGY.
We are facing energy and environmental threats that challenge our world: decrease/consumption of the fossil fuel reserves, global increase in energy demand, increasing pollution and the need to improve the processing of organic waste into a sustainable waste management, since damage to the environment is sooner or later translated into an energy cost. I am working on the design of advanced catalyst (multimetallic and heterodimer NPs) that are able to improve energy-chemical processes. Interestingly, energy harvesting and energy transfer processes are based on physic-chemical principles (electromagnetism) at the scale of few nm, from photosynthesis to electrical transport. I am also working on the design of a new generation of NPs for the production of hydrogen (with CdSe-Pt NPs) for reduction process and transform biomass and produce biofuels. Also I work on the use of iron oxide NPs to boost Biogas production thanks to the fact that iron ions are essential for the bacterial consortia responsible for the degradation and transformation of organic matter into methane. Our approach consists on the use of small concentrations of iron oxide nanoparticles designed and functionalized such that they progressively dispensing active iron ions at the necessary dose (not too low, not too high) for the bacteria, in analogy to sustained drug delivery, boosting methane production up to 300%. This work has been patent and it has received funds from the Bill and Melinda Gates foundation. This project has been granted the second SEGIB international prize and received support from the Programa Emprendedores of the REPSOL foundation leading to the creation of a Spin-Off, Applied Nanoparticles, dedicated to nanotechnology and energy/environment solutions which has, among other, the mission to exploit our Biogas enhanced production patent. I would like to stress that to me energy and environment are closely linked, while indeed, health and environment, are also extremely connected, since the health of the environment determine our morbidity. Regarding environment we address two issues, environmental toxicity of NPs and environmental remediation with NPs. I also focus on the electrochemical oxidation of molecules with our hollow Pt NPs where we are observing also important reactivity (and efficiency) boosts. Finally, I started in collaboration with the chemical engineering department of the UAB, with funding from the Fundación Ramón Areces, the study of nanostructures for the absorption of CO2, in such a way that in the future, the photocatalysis will reduce CO2 to other C species (CO, CH4, CH3OH, CHOOH) and it will be oxydized to recover energy and absorbed to avoid emissions and be transformed into a raw material in a close carbon cycle (note that 75% of south Africa gasoline is synthetic).
My work has position me as a privileged observer of the development of nanotechnology allowing me to advise and communicate to a broad audience. This is translated in participating as Project (e.g.: serenade-labex) or Industry (Nanonica) Scientific Advisor or communicating Science to Society, I am specially proud about the ebook “Nanoparticles before Nanotechnology” with more than 14.000 downloads. Also, the reporting of my activities in international media, as the BBC or The Guardian also indicates the societal the impact of my work.
IP: Victor Franco Puntes
IP: Victor Franco Puntes Collaborators: - Funding agency: Ministerio de Ciencia e Innovación-MICINN Funding: 66250 Reference: CPP2023-010774 Duration: 01/11/2024 - 31/10/2027
IP: Anna Vilarrodona Serrat Collaborators: Alberto Sandiumenge Camps, Joan Comenge Farré, Victor Franco Puntes, Elisabeth Navas Moya Funding agency: Fundación Invest. Médica Mutua Madrileña Funding: 109998 Reference: FMM24VILARODONA Duration: 16/09/2024 - 15/09/2027
IP: Victor Franco Puntes Collaborators: Joan Comenge Farré, Lena Nerea Montaña Ernst Funding agency: Ministerio de Ciencia e Innovación-MICINN Funding: 187500 Reference: PID2023-148967OB-C21 Duration: 01/09/2024 - 31/12/2028
IP: Victor Franco Puntes Collaborators: - Funding agency: Agència Gestió Ajuts Universitaris i de Recerca Funding: 150000 Reference: 2023 PROD 00200 Duration: 01/02/2024 - 31/07/2025
PMID: 38564783 Journal: Small Methods Year: 2024 Reference: Small Methods. 2024 Apr 2:e2301713. doi: 10.1002/smtd.202301713. Impact factor: Publication type: Paper in international publication Authors: Bastus, Neus G; Ernst, Lena M; Gusta, Muriel F; Moriones, Oscar H; Piella, Jordi; Puntes, Victor; Valeri, Marta et al. DOI: 10.1002/smtd.202301713
PMID: 36596252 Journal: ACS Nano Year: 2023 Reference: ACS Nano. 2023 Jan 3. doi: 10.1021/acsnano.2c05447. Impact factor: Publication type: Paper in international publication Authors: Badia, Anna; Casals, Eudald; Duarri, Anna; Garcia-Arumi, Josep; Gusta, Muriel Freixanet; Puntes, Victor; Ramis, Joana; Rosell, Jordi; Salas, Anna; Zapata, Miguel A et al. DOI: 10.1021/acsnano.2c05447
PMID: 36775152 Journal: Science of The Total Environment Year: 2023 Reference: Sci Total Environ. 2023 May 15;873:162160. doi: 10.1016/j.scitotenv.2023.162160. Epub 2023 Feb 11. Impact factor: Publication type: Paper in international publication Authors: Baccaro, Marta; Busquets-Fite, Marti; Clark, Nathaniel J; Ferreira, Abel; Grgic, Magdalena; Handy, Richard D; Jurkschat, Kerstin; Loureiro, Susana; Lynch, Iseult; Medvescek, Neja et al. DOI: 10.1016/j.scitotenv.2023.162160
PMID: 36923400 Journal: Frontiers in Immunology Year: 2023 Reference: Front Immunol. 2023 Feb 27;14:1129296. doi: 10.3389/fimmu.2023.1129296. eCollection 2023. Impact factor: Publication type: Review in international publication Authors: Bastus, Neus G; Gonzalez-Rioja, Ramon; Puntes, Victor; Salazar, Vivian A et al. DOI: 10.3389/fimmu.2023.1129296
PMID: 36979013 Journal: Antioxidants Year: 2023 Reference: Antioxidants (Basel). 2023 Mar 21;12(3):765. doi: 10.3390/antiox12030765. Impact factor: Publication type: Paper in international publication Authors: Bastus, Neus G; Casals, Eudald; Casals, Gregori; Ernst, Lena M; Fernandez-Varo, Guillermo; Gusta, Muriel F; Jimenez, Wladimiro; Mondragon, Laura; Puntes, Victor; Ramis, Joana et al. DOI: 10.3390/antiox12030765
PMID: 36498992 Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Year: 2022 Reference: Int J Mol Sci. 2022 Nov 24;23(23):14655. doi: 10.3390/ijms232314655. Impact factor: Publication type: Paper in international publication Authors: Boraschi, Diana; Della Camera, Giacomo; Gioria, Sabrina; Italiani, Paola; Li, Yang; Liu, Tinghao; Puntes, Victor F; Yang, Wenjie et al. DOI: 10.3390/ijms232314655
PMID: 36125109 Journal: Nanoscale Year: 2022 Reference: Nanoscale. 2022 Oct 6;14(38):14223-14230. doi: 10.1039/d2nr03586c. Impact factor: Publication type: Paper in international publication Authors: Bastus, Neus G; Ernst, Lena M; Fito-Parera, Aina; Galyamin, Dmitry; Mira-Vidal, Guillem; Puntes, Victor; Sabate, Neus et al. DOI: 10.1039/d2nr03586c
PMID: 35977997 Journal: Scientific Reports Year: 2022 Reference: Sci Rep. 2022 Aug 17;12(1):13926. doi: 10.1038/s41598-022-18155-2. Impact factor: Publication type: Paper in international publication Authors: Bastus, Neus G; Herves, Carmen; Jaime, Carlos; Puntes, Victor F; Suarez-Lopez, Rosa et al. DOI: 10.1038/s41598-022-18155-2
PMID: 35952886 Journal: Science of the Total Environment Year: 2022 Reference: Sci Total Environ. 2022 Dec 1;850:157912. doi: 10.1016/j.scitotenv.2022.157912. Epub 2022 Aug 8. Impact factor: Publication type: Paper in international publication Authors: Baccaro, Marta; Busquets-Fite, Marti; Clark, Nathaniel; Ferreira, Abel; Grgic, Magdalena; Handy, Richard D; Jurkschat, Kerstin; Loureiro, Susana; Lynch, Iseult; Medvescek, Neja et al. DOI: 10.1016/j.scitotenv.2022.157912
PMID: 34947510 Journal: Nanomaterials Year: 2021 Reference: Nanomaterials (Basel). 2021 Nov 23;11(12). pii: nano11123161. doi: 10.3390/nano11123161. Impact factor: Publication type: Paper in international publication Authors: Barbero, Francesco; Busquets-Fite, Marti; Ferrari, Eleonora; Franz-Wachtel, Mirita; Kemmerling, Birgit; Kohler, Heinz-R; Puntes, Victor et al. DOI: 10.3390/nano11123161
PMID: 34835755 Journal: Nanomaterials Year: 2021 Reference: Nanomaterials (Basel). 2021 Nov 6;11(11). pii: nano11112991. doi: 10.3390/nano11112991. Impact factor: Publication type: Review in international publication Authors: Boraschi, Diana; Casals, Eudald; Ernst, Lena M; Italiani, Paola; Puntes, Victor et al. DOI: 10.3390/nano11112991
PMID: 34804037 Journal: Frontiers in Immunology Year: 2021 Reference: Front Immunol. 2021 Nov 4;12:751683. doi: 10.3389/fimmu.2021.751683. eCollection 2021. Impact factor: Publication type: Paper in international publication Authors: Barbero, Francesco; Boraschi, Diana; De Luca, Anna Chiara; Duschl, Albert; Frauenlob, Tobias; Horejs-Hoeck, Jutta; Italiani, Paola; Michelini, Sara; Puntes, Victor; Swartzwelter, Benjamin J et al. DOI: 10.3389/fimmu.2021.751683
PMID: 34685085 Journal: Nanomaterials Year: 2021 Reference: Nanomaterials (Basel). 2021 Oct 8;11(10). pii: nano11102646. doi: 10.3390/nano11102646. Impact factor: Publication type: Paper in international publication Authors: Alijagic, Andi; Barbero, Francesco; Bonura, Angela; Gervasi, Francesco; Pinsino, Annalisa; Puntes, Victor F et al. DOI: 10.3390/nano11102646
PMID: NOPMID0088 Journal: Materials Today Advances Year: 2020 Reference: Materials Today Advances. 2020 Mar;5:100037 Impact factor: Publication type: Paper in international publication Authors: ; ; ; ; ; ; ; et al. DOI: 10.1016/j.mtadv.2019.100037
PMID: NOPMID0089 Journal: Environmental Science-Nano Year: 2020 Reference: Environmental Science: Nano. 2020;7(11):3216-32 Impact factor: Publication type: Review in international publication Authors: Bastús, Neus G.; Boraschi, Diana; Busquets-Fité, Martí; Canesi, Laura; Cesaroni, Paola; Drobne, Damjana; Duschl, Albert; Ewart, Marie-Ann; Gispert, Ignasi; Horejs-Hoeck, Jutta et al. DOI: 10.1039/d0en00732c
PMID: NOPMID0084 Journal: ACS Applied Energy Materials Year: 2020 Reference: ACS Applied Energy Materials. 2020 Oct 26;3(10):10008-14. doi: 10.1021/acsaem.0c01685 Impact factor: Publication type: Paper in international publication Authors: ; ; ; ; ; Puntes, Victor et al. DOI: 10.1021/acsaem.0c01685
PMID: 33287297 Journal: Cancers Year: 2020 Reference: Cancers (Basel). 2020 Dec 3;12(12). pii: cancers12123622. doi: 10.3390/cancers12123622. Impact factor: Publication type: Review in international publication Authors: Buocikova, Verona; Chatziioannou, Aristotelis; Cimpan, Mihaela Roxana; Dusinska, Maria; Freixanet, Muriel; Gabelova, Alena; Longhin, Eleonora Marta; Mego, Michal; Miklikova, Svetlana; Pajuste, Karlis et al. DOI: 10.3390/cancers12123622
PMID: 31827146 Journal: Scientific Reports Year: 2019 Reference: Sci Rep. 2019 Dec 11;9(1):18776. doi: 10.1038/s41598-019-55105-x. Impact factor: Publication type: Paper in international publication Authors: Arbiol, Jordi; Bastus, Neus G; Claver, Carmen; Delgado, Jorge A; Genc, Aziz; Godard, Cyril; Llorca, Jordi; Merkoci, Florind; Patarroyo, Javier; Puntes, Victor et al. DOI: 10.1038/s41598-019-55105-x
PMID: 31783479 Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Year: 2019 Reference: Int J Mol Sci. 2019 Nov 27;20(23). pii: ijms20235959. doi: 10.3390/ijms20235959. Impact factor: Publication type: Paper in international publication Authors: Carvajal, Silvia; Casado, Pedro; Casals, Eudald; Casals, Gregori; Cutillas, Pedro; Fernandez-Varo, Guillermo; Jimenez, Wladimiro; Melgar-Lesmes, Pedro; Morales-Ruiz, Manuel; Oro, Denise et al. DOI: 10.3390/ijms20235959
PMID: NOPMID0065 Journal: Applied Materials Today Year: 2019 Reference: Applied Materials Today. 2019 Jun;15:445-52. doi:10.1016/j.apmt.2019.03.003 Impact factor: Publication type: Paper in international publication Authors: Arbiol, Jordi; Bastus, Neus G.; Genc, Aziz; Patarroyo, Javier; Perez, Sara; Piella, Jordi; Puntes, Victor et al. DOI: 10.1016/j.apmt.2019.03.003
PMID: 31672158 Journal: JOURNAL OF NANOBIOTECHNOLOGY Year: 2019 Reference: J Nanobiotechnology. 2019 Oct 31;17(1):112. doi: 10.1186/s12951-019-0544-5. Impact factor: Publication type: Paper in international publication Authors: Arce-Cerezo, Altamira; Casals, Eudald; Casals, Gregori; Cordoba-Jover, Bernat; Fernandez-Varo, Guillermo; Jimenez, Wladimiro; Morales-Ruiz, Manuel; Oro, Denise; Pauta, Montse; Puntes, Victor et al. DOI: 10.1186/s12951-019-0544-5
PMID: 28412902 Journal: CURRENT MEDICINAL CHEMISTRY Year: 2018 Reference: Curr Med Chem. 2018;25(35):4587-4601. doi: 10.2174/0929867324666170413124915. Impact factor: Publication type: Review in international publication Authors: Bastus, Neus G; Puntes, Victor et al. DOI: 10.2174/0929867324666170413124915
PMID: 30003578 Journal: ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY Year: 2018 Reference: Environ Toxicol Chem. 2018 Oct;37(10):2609-2618. doi: 10.1002/etc.4220. Epub 2018 Aug 6. Impact factor: Publication type: Paper in international publication Authors: Crossley, Alison; Lahive, Elma; Lawlor, Alan; Puntes, Victor; Schultz, Carolin L; Spurgeon, David J; Svendsen, Claus; Unrine, Jason M et al. DOI: 10.1002/etc.4220
PMID: 29106689 Journal: TOXICOLOGICAL SCIENCES Year: 2018 Reference: Toxicol Sci. 2018 Mar 1;162(1):79-88. doi: 10.1093/toxsci/kfx228. Impact factor: Publication type: Paper in international publication Authors: de Ruijter, Norbert C A; Kloet, Samantha K; Makama, Sunday; Piella, Jordi; Puntes, Victor F; Rietjens, Ivonne M C M; van den Berg, Hans; van den Brink, Nico W et al. DOI: 10.1093/toxsci/kfx228
PMID: 27997136 Journal: BIOCONJUGATE CHEMISTRY Year: 2017 Reference: Bioconjug Chem. 2017 Jan 18;28(1):88-97. doi: 10.1021/acs.bioconjchem.6b00575. Epub 2016 Dec 20. Impact factor: Publication type: Paper in international publication Authors: Bastus, Neus G; Piella, Jordi; Puntes, Victor et al. DOI: 10.1021/acs.bioconjchem.6b00575
PMID: NOPMID009 Journal: ZEITSCHRIFT FUR PHYSIKALISCHE CHEMIE-INTERNATIONAL JOURNAL OF RESEARCH IN PHYSICAL CHEMISTRY & CHEMICAL PHYSICS Year: 2017 Reference: doi.org/10.1515/zpch-2016-0864 Impact factor: Publication type: Paper in international publication Authors: Bastús, N.G.; Franco Puntes, V; García-Fernandez, L; Ojea-Jimenez, I; Piella, J; Sperlin, R.A. et al. DOI: 10.1515/zpch-2016-0864
PMID: NOPMID010 Journal: CHEMISTRY OF MATERIALS Year: 2017 Reference: 10.1021/acs.chemmater.7b00608 Impact factor: Publication type: Paper in international publication Authors: Bastús, N.G.; Coy, E; Estradé, S; Fantechi, E; Franco Puntes, V; Jurga, S; Nogues, J; Peiró, F; Roca, A.E.; Sepúlveda, B et al. DOI: 10.1021/acs.chemmater.7b00608
PMID: NOPMID0003 Journal: ACS Macro Letters Year: 2017 Reference: 10.1021/acsmacrolett.7b00288 Impact factor: Publication type: Paper in international publication Authors: Burak Kiremitler, N; Franco Puntes, Victor; Karabel, Sema; Onses, M Serdar; Patarroyo, Javier; Pekdemir, Sami; Torun, Ilker et al. DOI: 10.1021/acsmacrolett.7b00288
PMID: SensePMID Journal: CHEMISTRY OF MATERIALS Year: 2016 Reference: Chem. Mater., 2016, 28 (21), pp 8025–8031 Impact factor: Publication type: Paper in international publication Authors: ; ; ; ; ; ; ; et al. DOI: 10.1021/acs.chemmater.6b03765
PMID: 27388915 Journal: JOURNAL OF NANOBIOTECHNOLOGY Year: 2016 Reference: J Nanobiotechnology. 2016 Jul 7;14(1):55. doi: 10.1186/s12951-016-0210-0. Impact factor: Publication type: Paper in international publication Authors: Czeh, Arpad; Kenesei, Kata; Madarasz, Emilia; Murali, Kumarasamy; Piella, Jordi; Puntes, Victor et al. DOI: 10.1186/s12951-016-0210-0
PMID: 26519601 Journal: JOURNAL OF HEPATOLOGY Year: 2016 Reference: J Hepatol. 2016 Mar;64(3):691-8. doi: 10.1016/j.jhep.2015.10.020. Epub 2015 Oct 28. Impact factor: Publication type: Paper in international publication Authors: Carvajal, Silvia; Casals, Eudald; Casals, Gregori; Fernandez-Varo, Guillermo; Gonzalez de la Presa, Bernardino; Jimenez, Wladimiro; Oro, Denise; Puntes, Victor; Reichenbach, Vedrana; Sandalinas, Silvia et al. DOI: 10.1016/j.jhep.2015.10.020
PMID: 26562184 Journal: AQUATIC TOXICOLOGY Year: 2016 Reference: Aquat Toxicol. 2016 Jan;170:1-12. doi: 10.1016/j.aquatox.2015.11.003. Epub 2015 Nov 4. Impact factor: Publication type: Paper in international publication Authors: Benvenuto, G; Buttino, I; Casals, E; Changwen, W; Iamunno, F; Pellegrini, D; Puntes, V F; Vitiello, V; Zhou, C et al. DOI: 10.1016/j.aquatox.2015.11.003
PMID: 26416297 Journal: SCI REP-UK Year: 2015 Reference: Sci Rep. 2015 Sep 29;5:14536. doi: 10.1038/srep14536. Impact factor: Publication type: Paper in international publication Authors: Beleggia, Marco; Frandsen, Cathrine; Jordanovic, Jelena; Kasama, Takeshi; Puntes, Victor F; Schiotz, Jakob; Varon, Miriam et al. DOI: 10.1038/srep14536
PMID: 25119419 Journal: NANOTOXICOLOGY Year: 2015 Reference: Nanotoxicology. 2015 May;9(4):462-73. doi: 10.3109/17435390.2014.948090. Epub 2014 Aug 14. Impact factor: Publication type: Paper in international publication Authors: Boraschi, Diana; Casals, Eudald; Italiani, Paola; Li, Yang; Puntes, Victor F; Tran, Ngoc et al. DOI: 10.3109/17435390.2014.948090
PMID: 91000024 Journal: CHEMISTRY OF MATERIALS Year: 2014 Reference: 1 Impact factor: Publication type: Paper in international publication Authors: Bastús, NG; Merkoçi, F; Piella, J; Puntes, V. F. et al. DOI:
PMID: 91000026 Journal: HEPATOLOGY Year: 2014 Reference: 1 Impact factor: Publication type: Paper in international publication Authors: Casals,E; Casals,G; Fernandez,G; Gonzalez,B; Jimenez,W; Oro,D; Puntes, V. F; Reichenbach,V; Yudina,T et al. DOI:
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PMID: 22428999 Journal: LANGMUIR Year: 2012 Reference: Langmuir. 2012 Apr 17;28(15):6461-7. doi: 10.1021/la3003993. Epub 2012 Apr 5. Impact factor: Publication type: Paper in international publication Authors: Alvaro, Gregorio; Ardao, Ines; Benaiges, M Dolors; Comenge, Joan; Puntes, Victor F et al. DOI: 10.1021/la3003993
PMID: 22744679 Journal: WATER SCIENCE AND TECHNOLOGY Year: 2012 Reference: Water Sci Technol. 2012;66(3):503-9. doi: 10.2166/wst.2012.185. Impact factor: Publication type: Paper in international publication Authors: Casals, Eudald; Font, Xavier; Garcia, Ana; Gonzalez, Edgar; Puntes, Victor; Recillas, Sonia; Sanchez, Antoni et al. DOI: 10.2166/wst.2012.185
PMID: 21879030 Journal: ANALYST Year: 2011 Reference: Analyst. 2011 Nov 7;136(21):4402-8. doi: 10.1039/c1an15313g. Epub 2011 Aug 30. Impact factor: Publication type: Paper in international publication Authors: Candeloro, Patrizio; Casals, Eudald; Coluccio, Maria Laura; Das, Gobind; De Angelis, Francesco; Di Fabrizio, Enzo; Fregola, Annalisa; Gentile, Francesco; Liberale, Carlo; Malara, Natalia et al. DOI: 10.1039/c1an15313g
PMID: 21306632 Journal: Particle and Fibre Toxicology Year: 2011 Reference: Part Fibre Toxicol. 2011 Feb 9;8(1):8. doi: 10.1186/1743-8977-8-8. Impact factor: Publication type: Paper in international publication Authors: Boraschi, Diana; Casals, Eudald; Colognato, Renato; Duschl, Albert; Favilli, Flavia; Italiani, Paola; Kohl, Yvonne; Leppens, Hilde; Lucchesi, Davide; Nelissen, Inge et al. DOI: 10.1186/1743-8977-8-8
PMID: 21167967 Journal: ANALYTICA CHIMICA ACTA Year: 2011 Reference: Anal Chim Acta. 2011 Jan 10;683(2):170-7. doi: 10.1016/j.aca.2010.10.014. Epub 2010 Oct 30. Impact factor: Publication type: Paper in international publication Authors: Amigo, Jose Manuel; Bastus, Neus G; Hoen, Rob; Puntes, Victor; Royo, Miriam; Varon, Miriam; Vazquez-Campos, Socorro et al. DOI: 10.1016/j.aca.2010.10.014
PMID: 22158813 Journal: SCIENCE Year: 2011 Reference: Science. 2011 Dec 9;334(6061):1377-80. doi: 10.1126/science.1212822. Impact factor: Publication type: Paper in international publication Authors: Arbiol, Jordi; Gonzalez, Edgar; Puntes, Victor F et al. DOI: 10.1126/science.1212822
PMID: 20038165 Journal: LANGMUIR Year: 2010 Reference: Langmuir. 2010 Jan 5;26(1):109-16. doi: 10.1021/la902169s. Impact factor: Publication type: Paper in international publication Authors: Balcells, Lluis; Pena, Luis; Puntes, Victor; Skumryev, Vassil; Varon, Miriam et al. DOI: 10.1021/la902169s
PMID: 20485835 Journal: CHEMICAL COMMUNICATIONS Year: 2010 Reference: Chem Commun (Camb). 2010 Jul 14;46(26):4737-9. doi: 10.1039/c003084h. Epub 2010 May 20. Impact factor: Publication type: Paper in international publication Authors: Garcia, Francisca; Garcia-Fernandez, Lorena; Hernando, Jordi; Imaz, Inhar; Maspoch, Daniel; Puntes, Victor; Rubio-Martinez, Marta; Ruiz-Molina, Daniel et al. DOI: 10.1039/c003084h
PMID: 20795902 Journal: Nanotoxicology Year: 2010 Reference: Nanotoxicology. 2010 Mar;4(1):52-72. doi: 10.3109/17435390903374001. Impact factor: Publication type: Paper in international publication Authors: Boraschi, Diana; Casals, Eudald; Colognato, Renato; Duschl, Albert; Favilli, Flavia; Leppens, Hilde; Nelissen, Inge; Ooms, Daniella; Oostingh, Gertie J; Pfaller, Tobias et al. DOI: 10.3109/17435390903374001
PMID: 20143792 Journal: NANO LETTERS Year: 2010 Reference: Nano Lett. 2010 Mar 10;10(3):964-73. doi: 10.1021/nl100032c. Impact factor: Publication type: Paper in international publication Authors: Arbiol, Jordi; Casals, Eudald; Lim, Stephanie I; Ojea-Jimenez, Isaac; Puntes, Victor; Varon, Miriam et al. DOI: 10.1021/nl100032c
PhD student: Joan Comenge Farré Director/s: Victor Franco Puntes University: Universidad Autònoma de Barcelona Year: 2013