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Nanopartícules Farmacocinètiques

El grup de Nanopartícules Farmacocinètiques del Vall d’Hebron Institut de Recerca es centra en la síntesi, caracterització i aplicacions de nanopartícules inorgàniques en el camp de la medicina. En controlar el nucli inorgànic (mida, estructura i forma) i la unió de molècules a la seva superfície, dissenyem nanopartícules que interactuen amb els sistemes biològics d'una manera específica. També posem especial èmfasi en la seguretat, viabilitat, ampliació, aplicabilitat i altres aspectes del disseny de nanopartícules per a la medicina.

El nostre grup està dirigit pel professor Víctor Puntes, qui té una Càtedra d'Investigació ICREA. Atès que una gran part del nostre treball exigeix una experiència altament multidisciplinària, mantenim col·laboracions amb físics, biòlegs, immunòlegs, oncòlegs i altres, d'Europa, la Xina i els EUA. El treball del grup ha donat lloc a diverses patents i a la creació d’empreses derivades (spin-off) com Nanotargeting i Applied nanoparticles.

Equip

Joan Comenge Farré

Joan Comenge Farré

Investigador/a postdoctoral
Nanopartícules farmacocinètiques
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Ramon Gonzalez Rioja

Ramon Gonzalez Rioja

Investigador/a predoctoral
Nanopartícules farmacocinètiques
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Joana Ramis Garcia

Joana Ramis Garcia

Tècnic de recerca
Nanopartícules farmacocinètiques
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Lena Nerea Montaña Ernst

Lena Nerea Montaña Ernst

Tècnic de recerca
Nanopartícules farmacocinètiques
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Victor Franco Puntes

Victor Franco Puntes

Cap de grup
Nanopartícules farmacocinètiques
Llegir més
Joan Comenge Farré

Joan Comenge Farré

Investigador/a postdoctoral
Nanopartícules farmacocinètiques
Llegir més
Ramon Gonzalez Rioja

Ramon Gonzalez Rioja

Investigador/a predoctoral
Nanopartícules farmacocinètiques
Llegir més
Joana Ramis Garcia

Joana Ramis Garcia

Tècnic de recerca
Nanopartícules farmacocinètiques
Llegir més
Lena Nerea Montaña Ernst

Lena Nerea Montaña Ernst

Tècnic de recerca
Nanopartícules farmacocinètiques
Llegir més
Victor Franco Puntes

Victor Franco Puntes

Cap de grup
Nanopartícules farmacocinètiques
Llegir més

Línies de recerca

Design of nanoparticles for useful applications

Getting advantages from the accumulated experience, I will study the most problematic points related to the growth of multi-component materials and hollow structures. We are preparing complex multifunctional environment responsive NPs comprising different families: i) metallic, ii) metal oxide, iii) semiconductor and iv) oxides of semiconductor. Beyond synthesis, I will focus on the precise characterization of the obtained NPs in terms of their reactivity and physico-chemical properties to precisely correlate morphology with activity. The synthesis of advanced NPs will be carry out, primarily, following seeding-growth approaches or by combining the simultaneous or sequential injection of precursor solutions, surfactant mixtures. The temperature of the solution will be adjusted in order to kinetically control the formation of the NPs and reaction times will be controlled to induce digestion processes and re-crystallizations/controlled sintering when required.  I will use mixtures of surfactants or reducing agents and coordinating complexes under controlled atmospheres, intending to independently modify the solubility of the monomer, the nucleation radii, the growing rate and the morphology of the growing structure (by stabilizing different crystals phases and therefore lowering their energy and accelerating selected competing reactions). Hollow metal structures will be synthesized following a multi-step procedure. In the first step, Ag nanocubes are synthesized by known techniques (such as polyol synthesis). Polymetallic hollow NPs with very different morphology  and composition, will be obtained by the simultaneous or sequential action of galvanic replacement and the Kirkendall effect in order to control the number and morphology of void spaces inside a single NP, and the chemical transformation of NPs such as cation release/exchange. This allows the production of, among other, monodisperse single- and double-walled nanoboxes or noble metal fullerenes, in high yields and scalable synthesis.


a. APPLICATION ON MEDICINE.

Nanotechnology’s ability to shape matter at the scale of molecules is opening the door to a new generation of diagnostics, imaging agents and drugs/therapies for detecting and treating disease. But perhaps more important,  it is allowing to combine a series of advances, creating nanosized particles that may for example contain drugs designed to kill damaged cells together with targeting compounds designed to home-in on malignancies, and imaging agents designed to light up even the earliest stage of disease. For example NPs are perfect candidates to be used in anticancer therapy since they showed passive accumulation in solid tumours due to the Enhanced Permeation and Retention effect (EPR). Is in this context that nanotechnology emerges as a “disruptive technology” with a great potential to contribute to improve treatment by generating new diagnostic and therapeutic products. Its fields of action can be classified in diagnosis, imaging, drug delivery, hyperthermia, theranostics, the simultaneous diagnosis and therapy, and therapy monitoring.


It has been acknowledged that one of the most promising societal impacts of nanotechnology is in the area of nanomedicine. Personalized health care, rational drug design and targeted drug delivery are some of the proposed benefits of a nanomedicine-based approach to therapy. On this subject, my lines of work are: i) Nanooncology, the use of nanoparticles for diagnosis and treatment of cancer. Here I am developing NP-Biomolecule (as AuNP-Antibody) for detection (as lung cancer in breath or circulating cancer cells) and AuNP and Fe3O4 NP for diagnosis/imaging. I continue my work carrying antitumoral drugs with AuNPs (as cisplatin, oxaliplatin, carboplatin, doxorubicin, and sorafenib) and their use as radiotherapy enhancers or hyperthermia agents. ii) Immunology. Significantly important is the interaction of NPs with the immune system. Because one cannot put stuff inside the body without asking the immune system for permission, I am studying the effect of NP on antigen presentation, to then avoid immune detection (for a drug delivery vehicle) or design prophylactic and therapeutic vaccines (for molecular scaffolds). This includes as much AuNPs decorated with antigens as redox active anti-inflammatory CeO2 NPs. iii) Antimicrobial NPs. The emergence of antibiotic resistant strains of common pathogens is a major threat to health and is already putting tremendous pressure on health services worldwide. It has been shown that positive (cationic) nanoparticles show toxic effects to prokaryote, as defensines do. Also, silver, iron or cerium NPs, yield ions that are toxic for prokaryote cells (but well tolerated in eukaryote), acting as disinfectant and bacteriostatic agents. iv) Nanosafety: the prevention of unwanted effects produced by nanoparticles. This is one of our core-expertise areas and I have been working on it, developing NP models for toxicity and ecotoxicity testing, since FP06. My job is to understand which features of NPs poses health threats and then modify the NPs and the way they are used, to avoid the related hazards or exposure (risks) while maintaining the parental desired NP properties.


All this efforts have been translated into the creation of a spin-off company to exploit this knowledge: Nanotargeting (www.nanotargeeting.com), who is actually performing the regulatory preclinical studies and preparing the phase I clinical trials of Aurocis (cisplatin bounded AuNPs).



b. APPLICATION ON ENERGY.

We are facing energy and environmental threats that challenge our world: decrease/consumption of the fossil fuel reserves, global increase in energy demand, increasing pollution and the need to improve the processing of organic waste into a sustainable waste management, since damage to the environment is sooner or later translated into an energy cost. I am working on the design of advanced catalyst (multimetallic and heterodimer NPs) that are able to improve energy-chemical processes. Interestingly, energy harvesting and energy transfer processes are based on physic-chemical principles (electromagnetism) at the scale of few nm, from photosynthesis to electrical transport. I am also working on the design of a new generation of NPs for the production of hydrogen (with CdSe-Pt NPs) for reduction process and transform biomass and produce biofuels. Also I work on the use of iron oxide NPs to boost Biogas production thanks to the fact that iron ions are essential for the bacterial consortia responsible for the degradation and transformation of organic matter into methane. Our approach consists on the use of small concentrations of iron oxide nanoparticles designed and functionalized such that they progressively dispensing active iron ions at the necessary dose (not too low, not too high) for the bacteria, in analogy to sustained drug delivery, boosting methane production up to 300%. This work has been patent and it has received funds from the Bill and Melinda Gates foundation. This project has been granted the second SEGIB international prize and received support from the Programa Emprendedores of the REPSOL foundation leading to the creation of a Spin-Off, Applied Nanoparticles, dedicated to nanotechnology and energy/environment solutions which has, among other, the mission to exploit our Biogas enhanced production patent. I would like to stress that to me energy and environment are closely linked, while indeed, health and environment, are also extremely connected, since the health of the environment determine our morbidity. Regarding environment we address two issues, environmental toxicity of NPs and environmental remediation with NPs. I also focus on the electrochemical oxidation of molecules with our hollow Pt NPs where we are observing also important reactivity (and efficiency) boosts. Finally, I started in collaboration with the chemical engineering department of the UAB, with funding from the Fundación Ramón Areces, the study of nanostructures for the absorption of CO2, in such a way that in the future, the photocatalysis will reduce CO2 to other C species (CO, CH4, CH3OH, CHOOH) and it will be oxydized to recover energy and absorbed to avoid emissions and be transformed into a raw material in a close carbon cycle (note that 75% of south Africa gasoline is synthetic).


My work has position me as a privileged observer of the development of nanotechnology allowing me to advise and communicate to a broad audience. This is translated in participating as Project (e.g.: serenade-labex) or Industry (Nanonica) Scientific Advisor or communicating Science to Society, I am specially proud about the ebook “Nanoparticles before Nanotechnology” with more than 14.000 downloads. Also, the  reporting of my activities in international media, as the BBC or The Guardian also indicates the societal the impact of my work.

IP: Victor Franco Puntes

Projectes

Next generation serology: Immune profiling via graphene-enhanced DNA scaffold sensors – SerDNA

IP: Victor Franco Puntes
Col·laboradors: -
Entitat finançadora: Ministerio de Ciencia e Innovación-MICINN
Finançament: 66250
Referència: CPP2023-010774
Durada: 01/11/2024 - 31/10/2027

Ministerio de Ciencia

Buscando el camino para la autosuficiencia: preservación corneal con nuevos antioxidantes minerales (nanopartículas de óxido de cerio). Proyecto PRE-CO-CE.

IP: Anna Vilarrodona Serrat
Col·laboradors: Alberto Sandiumenge Camps, Joan Comenge Farré, Victor Franco Puntes, Elisabeth Navas Moya
Entitat finançadora: Fundación Invest. Médica Mutua Madrileña
Finançament: 109998
Referència: FMM24VILARODONA
Durada: 16/09/2024 - 15/09/2027

Nanopartículas de CeO2 para la Regulación Metabólica y el Tratamiento del Estrés Oxidativo y Enfermedades (TRANSCERIA)

IP: Victor Franco Puntes
Col·laboradors: Joan Comenge Farré, Lena Nerea Montaña Ernst
Entitat finançadora: Ministerio de Ciencia e Innovación-MICINN
Finançament: 187500
Referència: PID2023-148967OB-C21
Durada: 01/09/2024 - 31/12/2028

Ministerio de Ciencia

A new formulation of cerium oxide nanoparticles as adjuvant for retinal anti-angiogenesis therapy.

IP: Victor Franco Puntes
Col·laboradors: -
Entitat finançadora: Agència Gestió Ajuts Universitaris i de Recerca
Finançament: 150000
Referència: 2023 PROD 00200
Durada: 01/02/2024 - 31/07/2025

Publicacions

Long-Term Intracellular Tracking of Label-Free Nanoparticles in Live Cells and Tissues with Confocal Microscopy.

PMID: 38564783
Revista: Small Methods
Any: 2024
Referència: Small Methods. 2024 Apr 2:e2301713. doi: 10.1002/smtd.202301713.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Bastus, Neus G; Ernst, Lena M; Gusta, Muriel F; Moriones, Oscar H; Piella, Jordi; Puntes, Victor; Valeri, Marta et al.
DOI: 10.1002/smtd.202301713

Repeated Topical Administration of 3 nm Cerium Oxide Nanoparticles Reverts Disease Atrophic Phenotype and Arrests Neovascular Degeneration in AMD Mouse Models.

PMID: 36596252
Revista: ACS Nano
Any: 2023
Referència: ACS Nano. 2023 Jan 3. doi: 10.1021/acsnano.2c05447.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Badia, Anna; Casals, Eudald; Duarri, Anna; Garcia-Arumi, Josep; Gusta, Muriel Freixanet; Puntes, Victor; Ramis, Joana; Rosell, Jordi; Salas, Anna; Zapata, Miguel A et al.
DOI: 10.1021/acsnano.2c05447

Toxicokinetics and bioaccumulation of silver sulfide nanoparticles in benthic invertebrates in an indoor stream mesocosm.

PMID: 36775152
Revista: Science of The Total Environment
Any: 2023
Referència: Sci Total Environ. 2023 May 15;873:162160. doi: 10.1016/j.scitotenv.2023.162160. Epub 2023 Feb 11.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Baccaro, Marta; Busquets-Fite, Marti; Clark, Nathaniel J; Ferreira, Abel; Grgic, Magdalena; Handy, Richard D; Jurkschat, Kerstin; Loureiro, Susana; Lynch, Iseult; Medvescek, Neja et al.
DOI: 10.1016/j.scitotenv.2023.162160

The development of highly dense highly protected surfactant ionizable lipid RNA loaded nanoparticles.

PMID: 36923400
Revista: Frontiers in Immunology
Any: 2023
Referència: Front Immunol. 2023 Feb 27;14:1129296. doi: 10.3389/fimmu.2023.1129296. eCollection 2023.
Factor d'impacte:
Tipus de publicació: Revisió en revista internacional
Autors: Bastus, Neus G; Gonzalez-Rioja, Ramon; Puntes, Victor; Salazar, Vivian A et al.
DOI: 10.3389/fimmu.2023.1129296

Exploring the Long-Term Tissue Accumulation and Excretion of 3 nm Cerium Oxide Nanoparticles after Single Dose Administration.

PMID: 36979013
Revista: Antioxidants
Any: 2023
Referència: Antioxidants (Basel). 2023 Mar 21;12(3):765. doi: 10.3390/antiox12030765.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Bastus, Neus G; Casals, Eudald; Casals, Gregori; Ernst, Lena M; Fernandez-Varo, Guillermo; Gusta, Muriel F; Jimenez, Wladimiro; Mondragon, Laura; Puntes, Victor; Ramis, Joana et al.
DOI: 10.3390/antiox12030765

Induction of Innate Memory in Human Monocytes Exposed to Mixtures of Bacterial Agents and Nanoparticles.

PMID: 36498992
Revista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Any: 2022
Referència: Int J Mol Sci. 2022 Nov 24;23(23):14655. doi: 10.3390/ijms232314655.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Boraschi, Diana; Della Camera, Giacomo; Gioria, Sabrina; Italiani, Paola; Li, Yang; Liu, Tinghao; Puntes, Victor F; Yang, Wenjie et al.
DOI: 10.3390/ijms232314655

Nanoceria dissolution at acidic pH by breaking off the catalytic loop.

PMID: 36125109
Revista: Nanoscale
Any: 2022
Referència: Nanoscale. 2022 Oct 6;14(38):14223-14230. doi: 10.1039/d2nr03586c.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Bastus, Neus G; Ernst, Lena M; Fito-Parera, Aina; Galyamin, Dmitry; Mira-Vidal, Guillem; Puntes, Victor; Sabate, Neus et al.
DOI: 10.1039/d2nr03586c

Nucleation and growth of gold nanoparticles in the presence of different surfactants. A dissipative particle dynamics study.

PMID: 35977997
Revista: Scientific Reports
Any: 2022
Referència: Sci Rep. 2022 Aug 17;12(1):13926. doi: 10.1038/s41598-022-18155-2.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Bastus, Neus G; Herves, Carmen; Jaime, Carlos; Puntes, Victor F; Suarez-Lopez, Rosa et al.
DOI: 10.1038/s41598-022-18155-2

Metal transfer to sediments, invertebrates and fish following waterborne exposure to silver nitrate or silver sulfide nanoparticles in an indoor stream mesocosm.

PMID: 35952886
Revista: Science of the Total Environment
Any: 2022
Referència: Sci Total Environ. 2022 Dec 1;850:157912. doi: 10.1016/j.scitotenv.2022.157912. Epub 2022 Aug 8.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Baccaro, Marta; Busquets-Fite, Marti; Clark, Nathaniel; Ferreira, Abel; Grgic, Magdalena; Handy, Richard D; Jurkschat, Kerstin; Loureiro, Susana; Lynch, Iseult; Medvescek, Neja et al.
DOI: 10.1016/j.scitotenv.2022.157912

Growth-Promoting Gold Nanoparticles Decrease Stress Responses in Arabidopsis Seedlings.

PMID: 34947510
Revista: Nanomaterials
Any: 2021
Referència: Nanomaterials (Basel). 2021 Nov 23;11(12). pii: nano11123161. doi: 10.3390/nano11123161.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Barbero, Francesco; Busquets-Fite, Marti; Ferrari, Eleonora; Franz-Wachtel, Mirita; Kemmerling, Birgit; Kohler, Heinz-R; Puntes, Victor et al.
DOI: 10.3390/nano11123161

The Interactions between Nanoparticles and the Innate Immune System from a Nanotechnologist Perspective.

PMID: 34835755
Revista: Nanomaterials
Any: 2021
Referència: Nanomaterials (Basel). 2021 Nov 6;11(11). pii: nano11112991. doi: 10.3390/nano11112991.
Factor d'impacte:
Tipus de publicació: Revisió en revista internacional
Autors: Boraschi, Diana; Casals, Eudald; Ernst, Lena M; Italiani, Paola; Puntes, Victor et al.
DOI: 10.3390/nano11112991

Innate Memory Reprogramming by Gold Nanoparticles Depends on the Microbial Agents That Induce Memory.

PMID: 34804037
Revista: Frontiers in Immunology
Any: 2021
Referència: Front Immunol. 2021 Nov 4;12:751683. doi: 10.3389/fimmu.2021.751683. eCollection 2021.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Barbero, Francesco; Boraschi, Diana; De Luca, Anna Chiara; Duschl, Albert; Frauenlob, Tobias; Horejs-Hoeck, Jutta; Italiani, Paola; Michelini, Sara; Puntes, Victor; Swartzwelter, Benjamin J et al.
DOI: 10.3389/fimmu.2021.751683

Immunomodulatory Function of Polyvinylpyrrolidone (PVP)-Functionalized Gold Nanoparticles in Vibrio-Stimulated Sea Urchin Immune Cells.

PMID: 34685085
Revista: Nanomaterials
Any: 2021
Referència: Nanomaterials (Basel). 2021 Oct 8;11(10). pii: nano11102646. doi: 10.3390/nano11102646.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Alijagic, Andi; Barbero, Francesco; Bonura, Angela; Gervasi, Francesco; Pinsino, Annalisa; Puntes, Victor F et al.
DOI: 10.3390/nano11102646

Understanding galvanic replacement reactions: the case of Pt and Ag

PMID: NOPMID0088
Revista: Materials Today Advances
Any: 2020
Referència: Materials Today Advances. 2020 Mar;5:100037
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: ; ; ; ; ; ; ; et al.
DOI: 10.1016/j.mtadv.2019.100037

Probing the immune responses to nanoparticles across environmental species. A perspective of the EU Horizon 2020 project PANDORA

PMID: NOPMID0089
Revista: Environmental Science-Nano
Any: 2020
Referència: Environmental Science: Nano. 2020;7(11):3216-32
Factor d'impacte:
Tipus de publicació: Revisió en revista internacional
Autors: Bastús, Neus G.; Boraschi, Diana; Busquets-Fité, Martí; Canesi, Laura; Cesaroni, Paola; Drobne, Damjana; Duschl, Albert; Ewart, Marie-Ann; Gispert, Ignasi; Horejs-Hoeck, Jutta et al.
DOI: 10.1039/d0en00732c

Nanocrystal-molecular hybrids for the photocatalytic oxidation of water

PMID: NOPMID0084
Revista: ACS Applied Energy Materials
Any: 2020
Referència: ACS Applied Energy Materials. 2020 Oct 26;3(10):10008-14. doi: 10.1021/acsaem.0c01685
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: ; ; ; ; ; Puntes, Victor et al.
DOI: 10.1021/acsaem.0c01685

Epigenetics in Breast Cancer Therapy-New Strategies and Future Nanomedicine Perspectives.

PMID: 33287297
Revista: Cancers
Any: 2020
Referència: Cancers (Basel). 2020 Dec 3;12(12). pii: cancers12123622. doi: 10.3390/cancers12123622.
Factor d'impacte:
Tipus de publicació: Revisió en revista internacional
Autors: Buocikova, Verona; Chatziioannou, Aristotelis; Cimpan, Mihaela Roxana; Dusinska, Maria; Freixanet, Muriel; Gabelova, Alena; Longhin, Eleonora Marta; Mego, Michal; Miklikova, Svetlana; Pajuste, Karlis et al.
DOI: 10.3390/cancers12123622

Hollow PdAg-CeO2 heterodimer nanocrystals as highly structured heterogeneous catalysts.

PMID: 31827146
Revista: Scientific Reports
Any: 2019
Referència: Sci Rep. 2019 Dec 11;9(1):18776. doi: 10.1038/s41598-019-55105-x.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Arbiol, Jordi; Bastus, Neus G; Claver, Carmen; Delgado, Jorge A; Genc, Aziz; Godard, Cyril; Llorca, Jordi; Merkoci, Florind; Patarroyo, Javier; Puntes, Victor et al.
DOI: 10.1038/s41598-019-55105-x

Cerium Oxide Nanoparticles Protect against Oxidant Injury and Interfere with Oxidative Mediated Kinase Signaling in Human-Derived Hepatocytes.

PMID: 31783479
Revista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Any: 2019
Referència: Int J Mol Sci. 2019 Nov 27;20(23). pii: ijms20235959. doi: 10.3390/ijms20235959.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Carvajal, Silvia; Casado, Pedro; Casals, Eudald; Casals, Gregori; Cutillas, Pedro; Fernandez-Varo, Guillermo; Jimenez, Wladimiro; Melgar-Lesmes, Pedro; Morales-Ruiz, Manuel; Oro, Denise et al.
DOI: 10.3390/ijms20235959

Robust one-pot synthesis of citrate-stabilized Au@CeO2 hybrid nanocrystals with different thickness and dimensionality

PMID: NOPMID0065
Revista: Applied Materials Today
Any: 2019
Referència: Applied Materials Today. 2019 Jun;15:445-52. doi:10.1016/j.apmt.2019.03.003
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Arbiol, Jordi; Bastus, Neus G.; Genc, Aziz; Patarroyo, Javier; Perez, Sara; Piella, Jordi; Puntes, Victor et al.
DOI: 10.1016/j.apmt.2019.03.003

Cerium oxide nanoparticles improve liver regeneration after acetaminophen-induced liver injury and partial hepatectomy in rats.

PMID: 31672158
Revista: JOURNAL OF NANOBIOTECHNOLOGY
Any: 2019
Referència: J Nanobiotechnology. 2019 Oct 31;17(1):112. doi: 10.1186/s12951-019-0544-5.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Arce-Cerezo, Altamira; Casals, Eudald; Casals, Gregori; Cordoba-Jover, Bernat; Fernandez-Varo, Guillermo; Jimenez, Wladimiro; Morales-Ruiz, Manuel; Oro, Denise; Pauta, Montse; Puntes, Victor et al.
DOI: 10.1186/s12951-019-0544-5

Nanosafety: Towards Safer Nanoparticles by Design.

PMID: 28412902
Revista: CURRENT MEDICINAL CHEMISTRY
Any: 2018
Referència: Curr Med Chem. 2018;25(35):4587-4601. doi: 10.2174/0929867324666170413124915.
Factor d'impacte:
Tipus de publicació: Revisió en revista internacional
Autors: Bastus, Neus G; Puntes, Victor et al.
DOI: 10.2174/0929867324666170413124915

Influence of Soil Pore Water Properties on the Fate and Toxicity of Silver Nanoparticles to C. elegans.

PMID: 30003578
Revista: ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
Any: 2018
Referència: Environ Toxicol Chem. 2018 Oct;37(10):2609-2618. doi: 10.1002/etc.4220. Epub 2018 Aug 6.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Crossley, Alison; Lahive, Elma; Lawlor, Alan; Puntes, Victor; Schultz, Carolin L; Spurgeon, David J; Svendsen, Claus; Unrine, Jason M et al.
DOI: 10.1002/etc.4220

Effects of systematic variation in size and surface coating of silver nanoparticles on their in vitro toxicity to macrophage RAW 264.7 cells.

PMID: 29106689
Revista: TOXICOLOGICAL SCIENCES
Any: 2018
Referència: Toxicol Sci. 2018 Mar 1;162(1):79-88. doi: 10.1093/toxsci/kfx228.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: de Ruijter, Norbert C A; Kloet, Samantha K; Makama, Sunday; Piella, Jordi; Puntes, Victor F; Rietjens, Ivonne M C M; van den Berg, Hans; van den Brink, Nico W et al.
DOI: 10.1093/toxsci/kfx228

Size-Dependent Protein-Nanoparticle Interactions in Citrate-Stabilized Gold Nanoparticles: The Emergence of the Protein Corona.

PMID: 27997136
Revista: BIOCONJUGATE CHEMISTRY
Any: 2017
Referència: Bioconjug Chem. 2017 Jan 18;28(1):88-97. doi: 10.1021/acs.bioconjchem.6b00575. Epub 2016 Dec 20.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Bastus, Neus G; Piella, Jordi; Puntes, Victor et al.
DOI: 10.1021/acs.bioconjchem.6b00575

One-Pot Synthesis of Cationic Gold Nanoparticles by Differential Reduction

PMID: NOPMID009
Revista: ZEITSCHRIFT FUR PHYSIKALISCHE CHEMIE-INTERNATIONAL JOURNAL OF RESEARCH IN PHYSICAL CHEMISTRY & CHEMICAL PHYSICS
Any: 2017
Referència: doi.org/10.1515/zpch-2016-0864
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Bastús, N.G.; Franco Puntes, V; García-Fernandez, L; Ojea-Jimenez, I; Piella, J; Sperlin, R.A. et al.
DOI: 10.1515/zpch-2016-0864

Seeded Growth Synthesis of Au–Fe3O4 Heterostructured Nanocrystals: Rational Design and Mechanistic Insights

PMID: NOPMID010
Revista: CHEMISTRY OF MATERIALS
Any: 2017
Referència: 10.1021/acs.chemmater.7b00608
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Bastús, N.G.; Coy, E; Estradé, S; Fantechi, E; Franco Puntes, V; Jurga, S; Nogues, J; Peiró, F; Roca, A.E.; Sepúlveda, B et al.
DOI: 10.1021/acs.chemmater.7b00608

Assembly of Plasmonic Nanoparticles on Nanopatterns of Polymer Brushes Fabricated by Electrospin Nanolithography

PMID: NOPMID0003
Revista: ACS Macro Letters
Any: 2017
Referència: 10.1021/acsmacrolett.7b00288
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Burak Kiremitler, N; Franco Puntes, Victor; Karabel, Sema; Onses, M Serdar; Patarroyo, Javier; Pekdemir, Sami; Torun, Ilker et al.
DOI: 10.1021/acsmacrolett.7b00288

Galvanic Replacement onto Complex Metal-Oxide Nanoparticles: Impact of Water or Other Oxidizers in the Formation of either Fully Dense Onion-like or Multicomponent Hollow MnOx/FeOx Structures

PMID: SensePMID
Revista: CHEMISTRY OF MATERIALS
Any: 2016
Referència: Chem. Mater., 2016, 28 (21), pp 8025–8031
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: ; ; ; ; ; ; ; et al.
DOI: 10.1021/acs.chemmater.6b03765

Cerium oxide nanoparticles reduce steatosis, portal hypertension and display anti-inflammatory properties in rats with liver fibrosis.

PMID: 26519601
Revista: JOURNAL OF HEPATOLOGY
Any: 2016
Referència: J Hepatol. 2016 Mar;64(3):691-8. doi: 10.1016/j.jhep.2015.10.020. Epub 2015 Oct 28.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Carvajal, Silvia; Casals, Eudald; Casals, Gregori; Fernandez-Varo, Guillermo; Gonzalez de la Presa, Bernardino; Jimenez, Wladimiro; Oro, Denise; Puntes, Victor; Reichenbach, Vedrana; Sandalinas, Silvia et al.
DOI: 10.1016/j.jhep.2015.10.020

Toxicity of nickel in the marine calanoid copepod Acartia tonsa: Nickel chloride versus nanoparticles.

PMID: 26562184
Revista: AQUATIC TOXICOLOGY
Any: 2016
Referència: Aquat Toxicol. 2016 Jan;170:1-12. doi: 10.1016/j.aquatox.2015.11.003. Epub 2015 Nov 4.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Benvenuto, G; Buttino, I; Casals, E; Changwen, W; Iamunno, F; Pellegrini, D; Puntes, V F; Vitiello, V; Zhou, C et al.
DOI: 10.1016/j.aquatox.2015.11.003

Tuning the Plasmonic Response up: Hollow Cuboid Metal Nanostructures

PMID: NO PMID
Revista: ACS Photonics
Any: 2016
Referència: ACS Photonics, 2016, 3 (5), pp 770–779
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Aziz Genç; Edgar E. Gonzalez; Javier Patarroyo; Jordi Arbiol; Jordi Sancho-Parramon; Luc Henrard; Martial Duchamp; Neus G Bastus; Rafael E. Dunin-Borkowski; Raul Arenal et al.
DOI: 10.1021/acsphotonics.5b00667

Longitudinal domain wall formation in elongated assemblies of ferromagnetic nanoparticles.

PMID: 26416297
Revista: SCI REP-UK
Any: 2015
Referència: Sci Rep. 2015 Sep 29;5:14536. doi: 10.1038/srep14536.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Beleggia, Marco; Frandsen, Cathrine; Jordanovic, Jelena; Kasama, Takeshi; Puntes, Victor F; Schiotz, Jakob; Varon, Miriam et al.
DOI: 10.1038/srep14536

Optimising the use of commercial LAL assays for the analysis of endotoxin contamination in metal colloids and metal oxide nanoparticles.

PMID: 25119419
Revista: NANOTOXICOLOGY
Any: 2015
Referència: Nanotoxicology. 2015 May;9(4):462-73. doi: 10.3109/17435390.2014.948090. Epub 2014 Aug 14.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Boraschi, Diana; Casals, Eudald; Italiani, Paola; Li, Yang; Puntes, Victor F; Tran, Ngoc et al.
DOI: 10.3109/17435390.2014.948090

Synthesis of Highly Monodisperse Citrate-Stabilized Silver Nanoparticles of up to 200 nm: Kinetic Control and Catalytic Properties

PMID: 91000024
Revista: CHEMISTRY OF MATERIALS
Any: 2014
Referència: 1
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Bastús, NG; Merkoçi, F; Piella, J; Puntes, V. F. et al.
DOI:

Cerium Oxide Nanoparticles Reduce Portal Hypertension and Show Antiinflammatory Properties in CCl4-Treated Rats

PMID: 91000026
Revista: HEPATOLOGY
Any: 2014
Referència: 1
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Casals,E; Casals,G; Fernandez,G; Gonzalez,B; Jimenez,W; Oro,D; Puntes, V. F; Reichenbach,V; Yudina,T et al.
DOI:

Effect of cerium dioxide, titanium dioxide, silver, and gold nanoparticles on the activity of microbial communities intended in wastewater treatment.

PMID: 22088500
Revista: JOURNAL OF HAZARDOUS MATERIALS
Any: 2012
Referència: J Hazard Mater. 2012 Jan 15;199-200:64-72. doi: 10.1016/j.jhazmat.2011.10.057. Epub 2011 Oct 25.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Carrera, Julian; Casals, Eudald; Delgado, Lucia; Font, Xavier; Garcia, Ana; Gonzalez, Edgar; Puntes, Victor; Sanchez, Antoni; Tora, Josep A et al.
DOI: 10.1016/j.jhazmat.2011.10.057

Rational nanoconjugation improves biocatalytic performance of enzymes: aldol addition catalyzed by immobilized rhamnulose-1-phosphate aldolase.

PMID: 22428999
Revista: LANGMUIR
Any: 2012
Referència: Langmuir. 2012 Apr 17;28(15):6461-7. doi: 10.1021/la3003993. Epub 2012 Apr 5.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Alvaro, Gregorio; Ardao, Ines; Benaiges, M Dolors; Comenge, Joan; Puntes, Victor F et al.
DOI: 10.1021/la3003993

Preliminary study of phosphate adsorption onto cerium oxide nanoparticles for use in water purification; nanoparticles synthesis and characterization.

PMID: 22744679
Revista: WATER SCIENCE AND TECHNOLOGY
Any: 2012
Referència: Water Sci Technol. 2012;66(3):503-9. doi: 10.2166/wst.2012.185.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Casals, Eudald; Font, Xavier; Garcia, Ana; Gonzalez, Edgar; Puntes, Victor; Recillas, Sonia; Sanchez, Antoni et al.
DOI: 10.2166/wst.2012.185

Problems and challenges in the development and validation of human cell-based assays to determine nanoparticle-induced immunomodulatory effects.

PMID: 21306632
Revista: Particle and Fibre Toxicology
Any: 2011
Referència: Part Fibre Toxicol. 2011 Feb 9;8(1):8. doi: 10.1186/1743-8977-8-8.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Boraschi, Diana; Casals, Eudald; Colognato, Renato; Duschl, Albert; Favilli, Flavia; Italiani, Paola; Kohl, Yvonne; Leppens, Hilde; Lucchesi, Davide; Nelissen, Inge et al.
DOI: 10.1186/1743-8977-8-8

Analysis of time-dependent conjugation of gold nanoparticles with an antiparkinsonian molecule by using curve resolution methods.

PMID: 21167967
Revista: ANALYTICA CHIMICA ACTA
Any: 2011
Referència: Anal Chim Acta. 2011 Jan 10;683(2):170-7. doi: 10.1016/j.aca.2010.10.014. Epub 2010 Oct 30.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Amigo, Jose Manuel; Bastus, Neus G; Hoen, Rob; Puntes, Victor; Royo, Miriam; Varon, Miriam; Vazquez-Campos, Socorro et al.
DOI: 10.1016/j.aca.2010.10.014

Nanoparticle microinjection and Raman spectroscopy as tools for nanotoxicology studies.

PMID: 21879030
Revista: ANALYST
Any: 2011
Referència: Analyst. 2011 Nov 7;136(21):4402-8. doi: 10.1039/c1an15313g. Epub 2011 Aug 30.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Candeloro, Patrizio; Casals, Eudald; Coluccio, Maria Laura; Das, Gobind; De Angelis, Francesco; Di Fabrizio, Enzo; Fregola, Annalisa; Gentile, Francesco; Liberale, Carlo; Malara, Natalia et al.
DOI: 10.1039/c1an15313g

Carving at the nanoscale: sequential galvanic exchange and Kirkendall growth at room temperature.

PMID: 22158813
Revista: SCIENCE
Any: 2011
Referència: Science. 2011 Dec 9;334(6061):1377-80. doi: 10.1126/science.1212822.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Arbiol, Jordi; Gonzalez, Edgar; Puntes, Victor F et al.
DOI: 10.1126/science.1212822

The suitability of different cellular in vitro immunotoxicity and genotoxicity methods for the analysis of nanoparticle-induced events.

PMID: 20795902
Revista: Nanotoxicology
Any: 2010
Referència: Nanotoxicology. 2010 Mar;4(1):52-72. doi: 10.3109/17435390903374001.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Boraschi, Diana; Casals, Eudald; Colognato, Renato; Duschl, Albert; Favilli, Flavia; Leppens, Hilde; Nelissen, Inge; Ooms, Daniella; Oostingh, Gertie J; Pfaller, Tobias et al.
DOI: 10.3109/17435390903374001

Synthesis of platinum cubes, polypods, cuboctahedrons, and raspberries assisted by cobalt nanocrystals.

PMID: 20143792
Revista: NANO LETTERS
Any: 2010
Referència: Nano Lett. 2010 Mar 10;10(3):964-73. doi: 10.1021/nl100032c.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Arbiol, Jordi; Casals, Eudald; Lim, Stephanie I; Ojea-Jimenez, Isaac; Puntes, Victor; Varon, Miriam et al.
DOI: 10.1021/nl100032c

Exploring the binding of Pt drugs to gold nanoparticles for controlled passive release of cisplatin.

PMID: 21529607
Revista: JOURNAL OF CONTROLLED RELEASE
Any: 2010
Referència: J Control Release. 2010 Nov 20;148(1):e31-2. doi: 10.1016/j.jconrel.2010.07.041.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Comenge, Joan; Dominguez, Fernando; Puntes, Victor; Romero, Francisco M; Sotelo, Carmen et al.
DOI: 10.1016/j.jconrel.2010.07.041

Dipolar driven spontaneous self assembly of superparamagnetic Co nanoparticles into micrometric rice-grain like structures.

PMID: 20038165
Revista: LANGMUIR
Any: 2010
Referència: Langmuir. 2010 Jan 5;26(1):109-16. doi: 10.1021/la902169s.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Balcells, Lluis; Pena, Luis; Puntes, Victor; Skumryev, Vassil; Varon, Miriam et al.
DOI: 10.1021/la902169s

Tesis

Gold Nanoparticles as Drug Delivery Agents: Detoxifying the Chemotherapeutic Drug Cisplatin

Doctorand: Joan Comenge Farré
Director/s: Victor Franco Puntes
Universitat: Universidad Autònoma de Barcelona
Any: 2013

Actualitat

Notícies

Els estudis permetran estudiar noves estratègies terapèutiques per a diferents tipus tumorals.

Una jornada organitzada en el marc del Dia Mundial contra el Càncer posa el focus en les últimes innovacions en el camp.

El treball busca una nova estratègia terapèutica més efectiva per tractar les malformacions arteriovenoses cerebrals, una de les causes principals d’ictus en infants i joves.