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Systemic Diseases

The Systemic Diseases group performs translational research based on at least 300 patients with systemic lupus erytomatosus (SLE), antiphospholipid syndrome (APS), systemic sclerosis, vasculitis, dermatomyitis, Sjörgen syndrome or autoinflammatory syndromes in order to better understand their pathogenesis (both at the immunological and genetic regulation level), study their clinical and biological expression (through the detection of new markers that help characterize each of the autoimmune diseases), study morbimortality (through epidemiological studies) and analyse patients' response to medications. With these goals in mind, we seek to improve the diagnosis, clinical monitoring, and prognosis of our patients.

Publications

Myo-Spain: Spanish Registry of Patients with Idiopathic Inflammatory Myopathy. Methodology.

PMID: 33867271
Journal: Reumatologia clinica
Year: 2021
Reference: Reumatol Clin (Engl Ed). 2021 Apr 15. pii: S1699-258X(21)00065-6. doi: 10.1016/j.reuma.2021.01.007.
Impact factor: 0
Publication type: Paper in national publication
Authors: Barbadillo, Carmen, Sivera, Francisca, Belzunegui, Joaquin, Perez Gomez, Ana, Gomez Gomez, Alejandro, Delgado-Frias, Esmeralda, Pego-Reigosa, Jose Maria, Joven, Beatriz, Ibanez, Monica, Martinez-Gonzalez, Olga et al.
DOI: 10.1016/j.reuma.2021.01.007

Nanotechnology-based approaches for treating lysosomal storage disorders, a focus on Fabry disease.

PMID: 33314628
Journal: Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology
Year: 2021
Reference: Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2021 May;13(3):e1684. doi: 10.1002/wnan.1684. Epub 2020 Dec 13.
Impact factor: 9.182
Publication type: Review in international publication
Authors: Abasolo, Ibane, Seras-Franzoso, Joaquin, Molto-Abad, Marc, Diaz-Riascos, Vanessa, Corchero, Jose Luis, Pintos-Morell, Guillem, Schwartz, Simo Jr et al.
DOI: 10.1002/wnan.1684

Accumulation of autophagosome cargo protein p62 is common in idiopathic inflammatory myopathies.

PMID: 32896253
Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
Year: 2021
Reference: Clin Exp Rheumatol. 2021 Mar-Apr;39(2):351-356. Epub 2020 Sep 1.
Impact factor: 4.473
Publication type: Paper in international publication
Authors: Milisenda, Jose C, Pinal-Fernandez, Iago, Lloyd, Thomas E, Grau, Josep Maria, Miller, Frederick W, Selva-O'Callaghan, Albert, Christopher-Stine, Lisa, Stenzel, Werner, Mammen, Andrew L, Corse, Andrea M et al.
DOI:

The ovarian reserve as measured by the anti-Mullerian hormone is not diminished in patients with rheumatoid arthritis compared to the healthy population.

PMID: 32896242
Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
Year: 2021
Reference: Clin Exp Rheumatol. 2021 Mar-Apr;39(2):337-343. Epub 2020 Sep 3.
Impact factor: 4.473
Publication type: Paper in international publication
Authors: Lopez-Corbeto, Mireia, Martinez-Mateu, Sergio, Pluma, Andrea, Ferrer, Roser, Lopez-Lasanta, Maria, De Agustin, Juan Jose, Barcelo, Mireia, Julia, Antonio, Marsal, Sara et al.
DOI:

MicroRNA expression profiling identifies miR-31 and miR-485-3p as regulators in the pathogenesis of Discoid Cutaneous Lupus.

PMID: 30130620
Journal: JOURNAL OF INVESTIGATIVE DERMATOLOGY
Year: 2019
Reference: J Invest Dermatol. 2019 Jan;139(1):51-61. doi: 10.1016/j.jid.2018.07.026. Epub 2018 Aug 18.
Impact factor: 6.29
Publication type: Paper in international publication
Authors: Sole, Cristina, Domingo, Sandra, Ferrer, Berta, Moline, Teresa, Ordi-Ros, Josep, Cortes-Hernandez, Josefina et al.
DOI: 10.1016/j.jid.2018.07.026

Blog

News

The new technology allows more sensitive detection of scleroderma patients' autoantibodies, which are related to the severity and progression of the disease.

Researchers have used an innovative protocol to identify people with this autoimmune disease who have a higher risk of cancer.

It will allow the promotion of research on systemic autoimmune-based diseases that especially affect women of childbearing age and, therefore, can also appear during pregnancy.