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Estudio en Fase 3, de 12 meses de tratamiento abierto con Lasmiditan en pacientes pediátricos con migraña

  • Protocol code: H8H-MC-LAHW
  • EudraCT code: 2019-004379-38
  • Pathology: Migraña
  • Pharmac: Lasmiditan
  • Promoter: Eli Lilly
  • Principal investigator:  Pozo Rosich, Patricia
  • Research group:  Cefalea i dolor neurològic
  • Service: Neurologia
  • Phase: Fase III
  • Recruiting: Open
  • Status: Activo

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Opciones para el alivio de la migraña en pediatría: Estudio aleatorizado, doble ciego de Lasmiditan frente a placebo para tratar el episodio agudo de migraña..

  • Protocol code: H8H-MC-LAHV
  • EudraCT code: 2019-004378-24
  • Pathology: Migraña
  • Pharmac: Lasmiditan
  • Promoter: Eli Lilly
  • Principal investigator:  Pozo Rosich, Patricia
  • Research group:  Headache and Neurological Pain
  • Service: Neurology
  • Phase: Phase III
  • Recruiting: Open
  • Status: Activo

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Estudio de fase III para evaluar la seguridad y la eficacia de PF-06939926en el tratamiento de la distrofia muscular de Duchenne (CIFFREO)

  • Protocol code: C3391003
  • EudraCT code: 2019-002921-31
  • Pathology: Distrofia muscular de Duchenne
  • Pharmac: PF-06939926
  • Promoter: Pfizer
  • Principal investigator:  Munell Casadesus, Francina
  • Research group:  Neurologia infantil
  • Service: Neurologia pediàtrica
  • Phase: Phase III
  • Recruiting: Closed
  • Status: Finalizado

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Estudio doble ciego, aleatorizado y controlado con placebo para evaluar la eficacia y la seguridad de odevixibat (A4250) en niños con atresia biliar que se han sometido a hepatoportoenterostomía de Kasai (BOLD)

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Escalating Dose and Randomized, Controlled Study of Nusinersen (BIIB058) in Participants With Spinal Muscular Atrophy

  • Protocol code: 232SM203
  • EudraCT code: 2019-002663-10
  • Pathology: Atrofia muscular espinal
  • Pharmac: Nusinersen (BIIB058)
  • Promoter: Biogen
  • Principal investigator:  Munell Casadesus, Francina
  • Research group:  Neurologia infantil
  • Service: Neurologia pediàtrica
  • Phase: Fase II
  • Recruiting: Closed
  • Status: Cerrado

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Estudio de fase 1 en el que se evalúa LY3295668 (un inhibidor de lacinasa Aurora A) en monoterapia y en politerapia en pacientes con neuroblastomarecidivante o resistente al tratamiento.

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Estudio de fase II, aleatorizado, abierto y multicéntrico para evaluar la reactogenicidad, seguridad e inmunogenicidad de la vacuna pediátrica candidata de subunidades de herpes zóster (PED-HZ/su) de GSK tras su administración intramuscular con una pauta de dos dosis a niños inmunodeprimidos receptores de trasplante renal de 1-17 años de edad.

  • Protocol code: ZOSTER-47 (200075)
  • EudraCT code: 2019-000607-33
  • Pathology: Herpes zóster en sujetos inmunodeprimidos
  • Pharmac: subunit candidate vaccine (PED-HZ/su)
  • Promoter: GlaxoSmithKline
  • Principal investigator:  Martínez Gómez, Xavier
  • Research group:  Epidemologia i salut pública
  • Service: Medicina Preventiva
  • Phase: Phase II
  • Recruiting: Open
  • Status: Activo

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Estudio de fase 1/2 del inhibidor de RET oral LOXO 292 en pacientes pediátricos con tumores sólidos avanzados o tumores primarios del sistema nervioso central ambos con alteración de RET.

  • Protocol code: LOXO-RET-18036 (292036) J2G-OX-JZJJ
  • EudraCT code: 2019-000212-28
  • Pathology: Tumores sólidos o primarios del sistema nervioso central con alteración avanzada de RET
  • Pharmac: Oral RET Inhibitor LOXO-292
  • Promoter: Eli Lilly
  • Principal investigator:  Hladun Alvaro, Raquel
  • Research group:  Childhood Cancer and Blood Disorders
  • Service: Pediatric Oncohematology
  • Phase: Phase I
  • Recruiting: Closed
  • Status: Finalizado

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A Phase 2 Open-Label Study of Continuation Treatment With Combination Pyrimidine Nucleosides in Patients With Thymidine Kinase 2 Deficiency (TK2)

  • Protocol code: MT-1621-102
  • EudraCT code: 2018-004277-27
  • Pathology: Deficiencia de timidina quinasa 2
  • Pharmac: Combination pyrimidine nucleos(t)ides
  • Promoter: UCB Biosciences Inc. (United States)
  • Principal investigator:  Munell Casadesus, Francina
  • Research group:  Neurologia infantil
  • Service: Neurologia pediàtrica
  • Phase: Phase II
  • Recruiting: Closed
  • Status: Finalizado

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Estudio global, multicéntrico, abierto, comparativo con controles históricos equiparables, de SHP611 intratecal en sujetos con leucodistrofia metacromática infantil tardía

  • Protocol code: SHP611-201
  • EudraCT code: 2018-003291-12
  • Pathology: Leucodistrofia metacromática tardía
  • Pharmac: Intrathecal SHP611
  • Promoter: Takeda
  • Principal investigator:  Del Toro Riera, Mireia
  • Research group:  Neurologia infantil
  • Service: Neurologia pediàtrica
  • Phase: Phase II
  • Recruiting: Closed
  • Status: Finalizado

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Estudio abierto, de seguridad a largo plazo, de tolerabilidad y de eficacia de GIVINOSTAT en todos los pacientes con DMD que hayan sido tratadospreviamente en uno de los estudios de GIVINOSTAT.

  • Protocol code: DSC/14/2357/51
  • EudraCT code: 2017-000397-10
  • Pathology: Distrofia muscular de Duchenne
  • Pharmac: GIVINOSTAT
  • Promoter: ITALFARMACO
  • Principal investigator:  Munell Casadesus, Francina
  • Research group:  Neurologia infantil
  • Service: Neurologia pediàtrica
  • Phase: Phase III
  • Recruiting: Open
  • Status: Activo

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Seguimiento a largo plazo (LTFU) de pacientes tratados con la terapia celularCART dirigida a CD19 basada en vectores lentivirales

  • Protocol code: CCTL019A2205B
  • EudraCT code: 2014-001673-14
  • Pathology: Patologías del sistema immunitario. Seguimiento a largo plazo de pacientes expuestos a la terapia lentiviral con células CAR-T
  • Pharmac: Lentiviral-Based CD19 directed CAR T-Cell Therapy
  • Promoter: Novartis
  • Principal investigator:  Díaz de Heredia Rubio, Maria Cristina
  • Research group:  Childhood Cancer and Blood Disorders
  • Service: Pediatric Oncohematology
  • Phase: Phase II
  • Recruiting: Open
  • Status: Activo

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A phase 2, multicenter, open-label study to assess appropriate dosing and to evaluate safety ofcrizanlizumab, with or without hydroxyurea/hydroxycarbamide, in sequential,descending age groups of pediatric sickle cell disease patients with vaso-occlusive crisis.

  • Protocol code: CSEG101B2201
  • EudraCT code: 2017-001747-12
  • Pathology: Células Falciformes con crisis vaso-oclusivas.
  • Pharmac: Crizanlizumab, with or without Hydroxyurea/Hydroxycarbamide
  • Promoter: Novartis
  • Principal investigator:  Díaz de Heredia Rubio, Maria Cristina
  • Research group:  Childhood Cancer and Blood Disorders
  • Service: Pediatric Oncohematology
  • Phase: Phase II
  • Recruiting: Closed
  • Status: Cerrado

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Estudio multicéntrico, aleatorizado, con doble enmascaramiento y controlado con placebo de la eficacia y la seguridad de LJPC-501 en pacientes pediátricos de >2 a 17 años de edad con hipotensión resistente a las catecolaminas asociada a shockdistributivo.

  • Protocol code: LJ501-CRH04
  • EudraCT code: 2017-005153-37
  • Pathology: Hipotensión resistente a las catecolaminas asociada a shock distributivo
  • Pharmac: LJPC-501
  • Promoter: La Jolla Pharmaceutical
  • Principal investigator:  Balcells Ramirez, Joan
  • Research group:  Recerca clínica/Innovació en la pneumònia i sèpsia
  • Service: UCI Pediatria
  • Phase: Phase II
  • Recruiting: Closed
  • Status: Cerrado

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Ensayo internacional pediátrico en tumor hepático

  • Protocol code: RG_15-114
  • EudraCT code: 2016-002828-85
  • Pathology: Hepatoblastoma y carcinoma hepatocelular
  • Pharmac: C5VD, SIOPEL-3 high risk, cisplatin monotherapy, GEMOX
  • Promoter: University of Birmingham
  • Principal investigator:  Sábado Álvarez, Constantino
  • Research group:  Childhood Cancer and Blood Disorders
  • Service: Pediatric Oncohematology
  • Phase: Phase III
  • Recruiting: Closed
  • Status: Finalizado

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Segundo estudio internacional intergrupo para el linfoma de Hodgkin clásico en niños y adolescentes. Estudio EuroNet-PHL-C2.

  • Protocol code: EURONET-PHL-C2
  • EudraCT code: 2012-004053-88
  • Pathology: Linfoma de Hodgkin
  • Pharmac: DECOPDAC-21 protocol +/- radiation
  • Promoter: Justus Liebig University of Giessen
  • Principal investigator:  Sábado Álvarez, Constantino
  • Research group:  Childhood Cancer and Blood Disorders
  • Service: Pediatric Oncohematology
  • Phase: Phase III
  • Recruiting: Closed
  • Status: Cerrado

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Estudio prospectivo internacional de meduloblastoma riesgo estándar clínico en niños mayores de 3 a 5 años, con perfil bajo de riesgo biológico (PNET 5 MB - LR) o perfil medio de riesgo biológico (PNET 5 - SR MB).Estudio SIOP

  • Protocol code: SIOP-PNET5MB
  • EudraCT code: 2011-004868-30
  • Pathology: Medulloblastoma
  • Pharmac: neuraxis irradiation + chemotherapy
  • Promoter: Sociedad Española de Hematología y Oncología Pediátricas
  • Principal investigator:  Llort Sales, Anna
  • Research group:  Childhood Cancer and Blood Disorders
  • Service: Pediatric Oncohematology
  • Phase: Phase III
  • Recruiting: Open
  • Status: Activo

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Estudio aleatorizado de fase IIb con bevacizumab asociado a temozolomida ± irinotecán en niños y jóvenes con neuroblastoma resistente o recidivan.

  • Protocol code: RG_11-087
  • EudraCT code: 2012-000072-42
  • Pathology: Neuroblastoma
  • Pharmac:  bevacizumab added to temozolomide ± irinotecan
  • Promoter: The University of Birmingham
  • Principal investigator:  Moreno Martín-Retortillo, Lucas
  • Research group:  Childhood Cancer and Blood Disorders
  • Service: Pediatric Oncohematology
  • Phase: Phase II
  • Recruiting: Closed
  • Status: Finalizado

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Year
2026
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Acuerdo Marco para la homologación de un total de 4 empresas, especializadas en consultoría regulatoria en ciencias de la vida, destinadas a ofrecer servicios a los proyectos de R+D+i de la Fundació Hospital Universitari Vall Hebron-Institut de Recerca (VHIR).
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24988877
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Year
2026
Títol Complet
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