Matilde Lleonart Pajarin Institutions of which they are part Head of group Biomedical Research in Cancer Stem Cells Vall Hebron Institut de Recerca Email Matilde Lleonart Pajarin Email Institutions of which they are part Head of group Biomedical Research in Cancer Stem Cells Vall Hebron Institut de Recerca
Research lines Study of new genes involved in proliferation Searching for new proliferative genes/tumor suppressor genes is being performed at our laboratory by carring out genetic screens. By the use of retroviral vectors as carriers of a cDNA libraries (formed by mRNA from murine embryonic stem cells), primary cells are infected and screening for those clones able to bypass senescence are selected for further characterization. The marked morphological heterogeneity observed in several tumorigenic process, support the hypothesis that several cancers have their origin in a stem cell. It is believed that genes expressed by embryonic stem cells, may play an important role in the tumorigenic mechanism.This project unravels the effect of immortal genes existing in embryonic stem cells, when are forced to be expressed in primary and thereby mortal cells. These immortal genes are future candidate markers in tumors with potential prognosis value. The novel genes discovered, are being analyzed in the biopsies from patients with different kinds of tumors collected at the Pathology Department of the Vall d´Hebrón Hospital. IP: Matilde Lleonart Pajarin Identificación y caracterización de genes/microRNAs en tumores humanos asociados a mal pronóstico En base a arrays de microRNAs y mRNAs efectuados a partir de tumores humanos, identificamos los más desregulados entre tejidos normales y tumorales para caracterizarlos a nivel molecular. IP: Matilde Lleonart Pajarin Identificación y caracterización de poblaciones de CSCs ("cancer stem cells") en tumores A partir de diversos tipos de cánceres que incluyen desde mama, pulmón, cabeza y cuello, en particular los más letales (faringe y laringe), aislamos poblaciones de CSCs para determinar su caracterización completa e implicación en la clínica. IP: Matilde Lleonart Pajarin Detección precoz de cáncer mamario antes de que éste se manifieste A partir de datos preliminares de arrays, hemos caracterizado algunos microRNAs/mRNAs relevantes en tumores. Actualmente los estamos analizando a nivel de pacientes con cáncer en sangre como posible método predictivo antes de la aparición del tumor. IP: Matilde Lleonart Pajarin Pagination Current page 1 Page 2 Next page › Last page » Projects Degradadores moleculares de SFN para sensibilizar células tumorales de cabeza y cuello (HNSCC) resistentes a terapias convencionales (ANTCANRES) IP: Matilde Lleonart Pajarin Collaborators: - Funding agency: Fundació Institut Bioenginyeria de Catalunya Funding: Reference: K9086 Duration: 24/07/2023 - 24/07/2024 Beca VHIR PhD IP: Matilde Lleonart Pajarin Collaborators: Sira Rodrigo Bosch, Laia Perez Lasarte, Marina Bataller Fernández Funding agency: Fundació Institut de Recerca HUVH Funding: 69188.74 Reference: VPHD/MARINA_B Duration: 01/04/2023 - 31/03/2026 New compounds targeting head and neck cancer as Trojan horses against chemoresistant cells IP: Matilde Lleonart Pajarin Collaborators: Yoelsis Garcia Mayea, Marina Bataller Fernández, Gabriela Isabel Fuentes Llopis, Almudena Sanchez Garcia Funding agency: Agència Gestió Ajuts Universitaris i de Recerca Funding: 20000 Reference: 2023 LLAV 00102 Duration: 01/02/2024 - 31/07/2024 Therapeutical approaches against chemoresistant cancers IP: Matilde Lleonart Pajarin Collaborators: Yoelsis Garcia Mayea, Fco. Xavier De la Cruz Montserrat, Juan Lorente Guerrero, Natalia Padilla Sirera, Marina Bataller Fernández, Almudena Sanchez Garcia, Selen Ozkan Funding agency: Agència Gestió Ajuts Universitaris i de Recerca Funding: 0.01 Reference: 2021 SGR 01205 Duration: 01/01/2022 - 31/12/2024 Pagination Current page 1 Page 2 Page 3 Page 4 Page 5 … Next page › Last page »