Matilde Lleonart Pajarin

I am group leader of "Biomedical Research in Cancer Stem Cells" at VHIR. I arrived at VHIR 21 years ago after having worked in different prestigious international research centers: World Health Organization (WHO) at the International Agency for Research on Cancer (IARC) (Lyon, France), the Wolfson Institute for Biomedical Research (WIBR) in London and the Queen´s Mary University of London.

Instituciones de las que forman parte

Jefe de grupo
Investigación biomédica con Células Madre de Cáncer

Vall Hebron Institut de Recerca

Matilde Lleonart Pajarin

Instituciones de las que forman parte

Jefe de grupo
Investigación biomédica con Células Madre de Cáncer

Vall Hebron Institut de Recerca

My Research Group was recognized as an Emerging Research Group in 2009 by the Generalitat de Catalunya and later in 2014 as a Consolidated Research Group.
Throughout my career I have been involved in cancer research from a more molecular point of view correlating key mutations in oncogenes and tumor suppressor genes with anatomical, pathological and clinical features of patients' tumors and also through cell culture studies to determine important key cell signaling pathways in tumorigenesis.
Currently, the main lines of research of my Research Group focus on the identification and characterization of biological mechanisms in resistant cancer cells, including cancer stem cells, to unravel the pathways responsible for their resistance in breast, lung and head and neck cancer models.
In addition, we are particularly focused on identifying molecular targets in resistant cancer cells and cancer stem cells affecting particularly aggressive tumors. The aim is to attack them pharmacologically in order to propose new cancer therapies: new drugs and/or drug combinations to combat resistant tumors in mouse models.

Proyectos

RedOx status of cancer stem cells and their resistance to chemo- and radio-therapy

IP: Matilde Lleonart Pajarin
Colaboradores: -
Entidad financiadora: EUROPEAN COMMISSION
Financiación: 40986
Referencia: INCOMED - FELLOW 6
Duración: 08/06/2016 - 28/02/2018

RNA binding proteins : Future markers for cancer progression

IP: Matilde Lleonart Pajarin
Colaboradores: -
Entidad financiadora: Fundació Institut de Recerca HUVH
Financiación: 197196
Referencia: PHD4MD/LLEONART/2015
Duración: 08/07/2015 - 08/07/2018

Oncologia i Patologia Molecular

IP: Matilde Lleonart Pajarin
Colaboradores: Juan Lorente Guerrero, Margarita Alberola Ferranti, Marc Pellicer Sarasa
Entidad financiadora: Agència Gestió Ajuts Universitaris i de Recerca
Financiación:
Referencia: 2014 SGR 1617
Duración: 01/01/2014 - 31/12/2016

Relevancia terapéutica de las Células Madre de Cáncer en carcinoma epidermoide Faringo-Laríngeo

IP: Matilde Lleonart Pajarin
Colaboradores: Yoelsis Garcia Mayea
Entidad financiadora: Fundació Institut de Recerca HUVH
Financiación: 46800
Referencia: PRED-VHIR-2014-12
Duración: 01/06/2015 - 31/05/2018