Matilde Lleonart Pajarin

I am group leader of "Biomedical Research in Cancer Stem Cells" at VHIR. I arrived at VHIR 21 years ago after having worked in different prestigious international research centers: World Health Organization (WHO) at the International Agency for Research on Cancer (IARC) (Lyon, France), the Wolfson Institute for Biomedical Research (WIBR) in London and the Queen´s Mary University of London.

Instituciones de las que forman parte

Jefe de grupo
Cáncer de cabeza y cuello: Investigación biomédica en células madre tumorales

Vall Hebron Institut de Recerca

Matilde Lleonart Pajarin

Instituciones de las que forman parte

Jefe de grupo
Cáncer de cabeza y cuello: Investigación biomédica en células madre tumorales

Vall Hebron Institut de Recerca

My Research Group was recognized as an Emerging Research Group in 2009 by the Generalitat de Catalunya and later in 2014 as a Consolidated Research Group.
Throughout my career I have been involved in cancer research from a more molecular point of view correlating key mutations in oncogenes and tumor suppressor genes with anatomical, pathological and clinical features of patients' tumors and also through cell culture studies to determine important key cell signaling pathways in tumorigenesis.
Currently, the main lines of research of my Research Group focus on the identification and characterization of biological mechanisms in resistant cancer cells, including cancer stem cells, to unravel the pathways responsible for their resistance in breast, lung and head and neck cancer models.
In addition, we are particularly focused on identifying molecular targets in resistant cancer cells and cancer stem cells affecting particularly aggressive tumors. The aim is to attack them pharmacologically in order to propose new cancer therapies: new drugs and/or drug combinations to combat resistant tumors in mouse models.

Proyectos

Genetic screen for detecting genes expressed in embryonic stem cells that bypass immortalisation in primary cells

IP: Matilde Lleonart Pajarin
Colaboradores: -
Entidad financiadora: EUROPEAN COMMISSION
Financiación: 31959
Referencia: MERG-510300
Duración: 01/02/2004 - 31/01/2005

Desarrollo de dianas terapéuticas basadas en micro-RNAs sobreexpresados en cáncer

IP: Matilde Lleonart Pajarin
Colaboradores: -
Entidad financiadora: Fundación Caja Navarra
Financiación: 9463.18
Referencia: CAN2009-16708
Duración: 01/01/2010 - 31/12/2010

Identificación de nuevas dianas terapéuticas basadas en micro-RNAs sobreexpresados en cáncer

IP: Matilde Lleonart Pajarin
Colaboradores: Marc Pellicer Sarasa, Carmela Iglesias i Felip
Entidad financiadora: Instituto de Salud Carlos III
Financiación: 147015
Referencia: PI09/02193
Duración: 01/01/2010 - 30/04/2013

Oncología y Patología Molecular

IP: Matilde Lleonart Pajarin
Colaboradores: -
Entidad financiadora: Agència Gestió Ajuts Universitaris i de Recerca
Financiación: 39520
Referencia: 2009 SGR 604
Duración: 01/01/2010 - 30/04/2014