Biomedical Research in Urology
The Biomedical Research in Urology group is interested in the study of hormone-dependent cancers, in particular prostate cancer (but not limited to it).
Our efforts are focused on finding, on the one hand, tools that help us in the early diagnosis of the disease, in the best differentiation of tumors according to their aggressiveness and their response to therapy, and finally in finding effective therapies against it.
From a molecular point of view, we focus our studies mainly on cell signaling processes related to the cell cycle and mitosis (with kinesins, kinases and ubiquitin ligases as main targets).
Our multidisciplinary group is made up of molecular biologists and urologists, and we collaborate with oncologists, pathologists and specialists in other diseases when required.
We work with in silico data obtained with different "omics" techniques, samples and clinical data from patients, in vitro and in vivo models, to answer the questions raised.
Publications
A Diagnostic Accuracy Study of Targeted and Systematic Biopsies to Detect Clinically Significant Prostate Cancer, including a Model for the Partial Omission of Systematic Biopsies.
PMID: 37760511
Journal: Cancers
Year: 2023
Reference: Cancers (Basel). 2023 Sep 13;15(18):4543. doi: 10.3390/cancers15184543.
Impact factor:
Publication type: Paper in international publication
Authors: Abascal, Jose M; Abascal, Jose M; Aisian, Ignacio; Celma, Anna; Celma, Anna; Manuel, Gemma Garcia-de; Morote, Juan; Morote, Juan; Munoz-Rivero, Marta V; Munoz-Rodriguez, Jesus et al.
DOI: 10.3390/cancers15184543
Proclarix, A New Biomarker for the Diagnosis of Clinically Significant Prostate Cancer: A Systematic Review.
PMID: 35471698
Journal: Molecular Diagnosis & Therapy
Year: 2022
Reference: Mol Diagn Ther. 2022 May;26(3):273-281. doi: 10.1007/s40291-022-00584-4. Epub 2022 Apr 26.
Impact factor:
Publication type: Review in international publication
Authors: Campistol, Miriam; Celma, Ana; Morote, Juan; Planas, Jacques; Regis, Lucas; Trilla, Enrique et al.
DOI: 10.1007/s40291-022-00584-4
Overcoming Paradoxical Kinase Priming by a Novel MNK1 Inhibitor.
PMID: 35417652
Journal: JOURNAL OF MEDICINAL CHEMISTRY
Year: 2022
Reference: J Med Chem. 2022 Apr 28;65(8):6070-6087. doi: 10.1021/acs.jmedchem.1c01941. Epub 2022 Apr 13.
Impact factor:
Publication type: Paper in international publication
Authors: Alarcon, Helena; Borrell, Jose I; Bou-Petit, Elisabeth; Cano-Galietero, Marta; Estrada-Tejedor, Roger; Fuentes, Pedro; Guijarro, Pedro J; Hummer, Stefan; Munoz, Maria Jose; Ramon Y Cajal, Santiago et al.
DOI: 10.1021/acs.jmedchem.1c01941
Multiparametric Magnetic Resonance Imaging Grades the Aggressiveness of Prostate Cancer.
PMID: 35406600
Journal: Cancers
Year: 2022
Reference: Cancers (Basel). 2022 Apr 5;14(7). pii: cancers14071828. doi: 10.3390/cancers14071828.
Impact factor:
Publication type: Paper in international publication
Authors: Borque-Fernando, Angel; Celma, Anna; de Torres, Ines M; Esteban, Luis M; Mast, Richard; Morote, Juan; Planas, Jacques; Regis, Lucas; Santamaria, Anna; Semidey, Maria E et al.
DOI: 10.3390/cancers14071828
Application of One-Step Nucleic Acid Amplification (OSNA) in different cancer entities and usefulness in prostate cancer: a systematic review.
PMID: 35366849
Journal: BMC CANCER
Year: 2022
Reference: BMC Cancer. 2022 Apr 2;22(1):357. doi: 10.1186/s12885-022-09355-0.
Impact factor:
Publication type: Review in international publication
Authors: Celma, Ana; Cuadras, Merce; de Torres, Ines M; Morote, Juan; Planas, Jacques; Regis, Lucas; Semidey, M Eugenia; Trilla, Enrique et al.
DOI: 10.1186/s12885-022-09355-0
Loss of microRNA-135b Enhances Bone Metastasis in Prostate Cancer and Predicts Aggressiveness in Human Prostate Samples.
PMID: 34944822
Journal: Cancers
Year: 2021
Reference: Cancers (Basel). 2021 Dec 9;13(24). pii: cancers13246202. doi: 10.3390/cancers13246202.
Impact factor: 6.639
Publication type: Paper in international publication
Authors: Santamaria, Anna, Rodriguez-Barrueco, Ruth, Morote, Juan, de la Cruz, Xavier, Olivan, Mireia, Garcia, Marta, Suarez, Leticia, Guiu, Marc, Gros, Laura, Mendez, Olga et al.
DOI: 10.3390/cancers13246202
The position of urethrovesical anastomosis after robotic radical prostatectomy assessed by MRI predicts early functional recovery: A cohort analyses from a randomized clinical trial.
PMID: 33607371
Journal: EUROPEAN JOURNAL OF RADIOLOGY
Year: 2021
Reference: Eur J Radiol. 2021 Apr;137:109589. doi: 10.1016/j.ejrad.2021.109589. Epub 2021 Feb 12.
Impact factor: 3.528
Publication type: Paper in international publication
Authors: Salazar, Aina, Planas, Jacques, Celma, Ana, Cuadras, Merce, Roche, Sarai, Mast, Richard, Morote, Juan, Trilla, Enrique, Regis, Lucas et al.
DOI: 10.1016/j.ejrad.2021.109589
Analysis of the nuclear expression of pSer727-STAT3 as a prognostic factor in patients with clear cell renal carcinoma.
PMID: 32247519
Journal: Actas Urologicas Espanolas
Year: 2020
Reference: Actas Urol Esp. 2020 May;44(4):245-250. doi: 10.1016/j.acuro.2019.11.006. Epub 2020 Apr 1.
Impact factor:
Publication type: Paper in national publication
Authors: Arevalo, J; de Torres, I; Lorente, D; Meseguer, A; Morote, J; Salcedo, M T; Trilla, E et al.
DOI: 10.1016/j.acuro.2019.11.006
The future of bladder cancer therapy: Optimizing the inhibition of the fibroblast growth factor receptor.
PMID: 32203842
Journal: CANCER TREATMENT REVIEWS
Year: 2020
Reference: Cancer Treat Rev. 2020 Jun;86:102000. doi: 10.1016/j.ctrv.2020.102000. Epub 2020 Mar 13.
Impact factor:
Publication type: Review in international publication
Authors: Carles, Joan; Gonzalez, Macarena; Maldonado, Xavier; Mateo, Joaquin; Morales-Barrera, Rafael; Morote, Juan; Raventos, Carles; Serra, Ester; Suarez, Cristina; Valverde, Claudia et al.
DOI: 10.1016/j.ctrv.2020.102000
Comparison of standard vs. palliative management for bladder cancer in patients older than 85 years: multicenter study of 317 de novo tumors.
PMID: 31586544
Journal: UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
Year: 2020
Reference: Urol Oncol. 2020 Feb;38(2):40.e9-40.e15. doi: 10.1016/j.urolonc.2019.09.007. Epub 2019 Oct 2.
Impact factor:
Publication type: Paper in international publication
Authors: Ajami, Tarek; Bonet, Xavier; Carrion, Albert; Diaz, Fernando; Dominguez, Arturo; Freixa, Roger; Huguet, Jorge; Lozano, Fernando; Mayordomo, Olga; Morote, Juan et al.
DOI: 10.1016/j.urolonc.2019.09.007
Re: Frank-Jan H. Drost, Daniel Osses, Daan Nieboer, et al. Prostate Magnetic Resonance Imaging, with or Without Magnetic Resonance Imaging-targeted Biopsy, and Systematic Biopsy for Detecting Prostate Cancer: A Cochrane Systematic Review and Meta-analysis. Eur Urol 2020;77:78-94: Are Targeted Prostate Biopsies Enough in Men with a Previous Negative Biopsy?
PMID: 32089360
Journal: EUROPEAN UROLOGY
Year: 2020
Reference: Eur Urol. 2020 May;77(5):e138-e139. doi: 10.1016/j.eururo.2020.02.010. Epub 2020 Feb 20.
Impact factor:
Publication type: Letter or abstract
Authors: Celma, Anna; Morote, Juan; Planas, Jacques et al.
DOI: 10.1016/j.eururo.2020.02.010
Preoperative magnetic resonance imaging in predicting early continence recovery after robotic radical prostatectomy.
PMID: 30420112
Journal: Actas Urologicas Espanolas
Year: 2019
Reference: Actas Urol Esp. 2019 Apr;43(3):137-142. doi: 10.1016/j.acuro.2018.07.003. Epub 2018 Nov 9.
Impact factor:
Publication type: Paper in national publication
Authors: Celma, A; Cuadras, M; Lorente, D; Miret, E; Morote, J; Placer, J; Planas, J; Regis, L; Roche, S; Salazar, A et al.
DOI: 10.1016/j.acuro.2018.07.003
Comparison of Outcomes between Standard and Palliative Management for High Grade Non-Muscle Invasive Bladder Cancer in Patients Older than 85 Years.
PMID: 30844807
Journal: UROLOGIA INTERNATIONALIS
Year: 2019
Reference: Urol Int. 2019;102(3):277-283. doi: 10.1159/000496802. Epub 2019 Mar 7.
Impact factor:
Publication type: Paper in international publication
Authors: Carrion, Albert; Diaz, Fernando; Lozano, Fernando; Morote, Juan; Pinero, Adria; Raventos, Carles et al.
DOI: 10.1159/000496802
A novel DNA-binding motif in Prostate Tumor Overexpressed-1 (PTOV1) required for the expression of ALDH1A1 and CCNG2 in cancer cells.
PMID: 30922918
Journal: CANCER LETTERS
Year: 2019
Reference: Cancer Lett. 2019 Jun 28;452:158-167. doi: 10.1016/j.canlet.2019.03.019. Epub 2019 Mar 25.
Impact factor:
Publication type: Paper in international publication
Authors: Canovas, Veronica; Ciudad, Carlos J; de Torres, Ines; Felix, Alex J; Gomez, Valenti; Maggio, Valentina; Morote, Juan; Noe, Veronique; Paciucci, Rosanna; Semidey, Maria Eugenia et al.
DOI: 10.1016/j.canlet.2019.03.019
Reversal Unilateral Ureteral Obstruction: A Mice Experimental Model.
PMID: 30783029
Journal: NEPHRON
Year: 2019
Reference: Nephron. 2019;142(2):125-134. doi: 10.1159/000497119. Epub 2019 Feb 15.
Impact factor:
Publication type: Paper in international publication
Authors: Cruzado, Josep M; Guiteras, Roser; Manonelles, Anna; Morote, Juan; Narvaez Barros, Alonso; Sola, Anna et al.
DOI: 10.1159/000497119
Large-Scale Mitotic Cell Synchronization.
PMID: 27815896
Journal: Methods in molecular biology (Clifton, N.J.)
Year: 2017
Reference: Methods Mol Biol. 2017;1524:65-74.
Impact factor:
Publication type: Paper in international publication
Authors: Dulla, Kalyan; Margalef, Anna Santamaria et al.
DOI: 10.1007/978-1-4939-6603-5_4
Regulation of protein translation and c-Jun expression by prostate tumor overexpressed 1.
PMID: 23455324
Journal: ONCOGENE
Year: 2014
Reference: Oncogene. 2014 Feb 27;33(9):1124-34. doi: 10.1038/onc.2013.51. Epub 2013 Mar 4.
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, I; Bermudo, R; Canovas, V; Castellon, E; Celia-Terrassa, T; Contreras, H; de Torres, I; Fernandez, P L; Fernandez, Y; Marques, N et al.
DOI: 10.1038/onc.2013.51
Native ureteropyelostomy in the treatment of obstructive uropathy in adult renal transplant.
PMID: 24636074
Journal: Actas Urologicas Espanolas
Year: 2014
Reference: Actas Urol Esp. 2014 Oct;38(8):552-6. doi: 10.1016/j.acuro.2014.02.004. Epub 2014 Mar 11.
Impact factor:
Publication type: Paper in national publication
Authors: Cantarell, C; Celma, A; Lorente, D; Moreso, F; Morote, J; Placer, J; Planas, J; Salvador, C; Seron, D; Trilla, E et al.
DOI: 10.1016/j.acuro.2014.02.004
Current significance of the finding of high grade prostatic intraepithelial neoplasia in the prostate biopsy.
PMID: 24529539
Journal: Actas Urologicas Espanolas
Year: 2014
Reference: Actas Urol Esp. 2014 May;38(4):270-5. doi: 10.1016/j.acuro.2013.10.001. Epub 2014 Feb 14.
Impact factor:
Publication type: Paper in national publication
Authors: Bastaros, J; Celma, A; Morote, J; Placer, J; Planas, J et al.
DOI: 10.1016/j.acuro.2013.10.001
Role of Immunotherapy in Castration-Resistant Prostate Cancer (CRPC).
PMID: 23650874
Journal: BJU INTERNATIONAL
Year: 2014
Reference: BJU Int. 2014 Mar;113(3):367-75. doi: 10.1111/bju.12110. Epub 2013 Apr 12.
Impact factor:
Publication type: Paper in international publication
Authors: Carles, Joan; Maldonado, Xavier; Morales-Barrera, Rafael; Morote, Juan; Nunez, Isaac; Planas, Jacques; Ramos, Victor; Suarez, Cristina; Valverde, Claudia et al.
DOI: 10.1111/bju.12110
Current Status of Pediatric Donor en Bloc Kidney Transplantation to Young Adult Recipients.
PMID: 23411068
Journal: Actas Urologicas Espanolas
Year: 2013
Reference: Actas Urol Esp. 2013 Jun;37(6):383-6. doi: 10.1016/j.acuro.2012.11.008. Epub 2013 Feb 12.
Impact factor:
Publication type: Paper in national publication
Authors: Lorente, D; Moreso, J; Morote, J; Seron, D; Trilla, E et al.
DOI: 10.1016/j.acuro.2012.11.008
Hepatitis A virus cellular receptor 1/kidney injury molecule-1 is a susceptibility gene for clear cell renal cell carcinoma and hepatitis A virus cellular receptor/kidney injury molecule-1 ectodomain shedding a predictive biomarker of tumour progression.
PMID: 23352434
Journal: EUROPEAN JOURNAL OF CANCER
Year: 2013
Reference: Eur J Cancer. 2013 May;49(8):2034-47. doi: 10.1016/j.ejca.2012.12.020. Epub 2013 Jan 23.
Impact factor:
Publication type: Paper in international publication
Authors: Blanco, Albert; Cuadros, Thais; de Torres, Ines; Itarte, Emilio; Lopez-Hellin, Joan; Meseguer, Anna; Messaoud, Nabil Ben; Mir, Carmen; Morote, Juan; Ramon Y Cajal, Santiago et al.
DOI: 10.1016/j.ejca.2012.12.020
Analysis of the Lipid Profile and Atherogenic Risk during Androgen Deprivation Therapy in Prostate Cancer Patients.
PMID: 23235105
Journal: UROLOGIA INTERNATIONALIS
Year: 2013
Reference: Urol Int. 2013;90(1):41-4. doi: 10.1159/000342814. Epub 2012 Dec 12.
Impact factor:
Publication type: Paper in international publication
Authors: Agreda, F; Lopez, M A; Morote, J; Placer, J; Planas, J; Salvador, C; Trilla, E et al.
DOI: 10.1159/000342814
Identification and genotyping of human papillomavirus in a Spanish cohort of penile squamous cell carcinomas: Correlation with pathologic subtypes, p16(INK4a) expression, and prognosis.
PMID: 22863066
Journal: JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
Year: 2013
Reference: J Am Acad Dermatol. 2013 Jan;68(1):73-82. doi: 10.1016/j.jaad.2012.05.029. Epub 2012 Aug 3.
Impact factor:
Publication type: Paper in international publication
Authors: de Torres, Ines; Ferrandiz-Pulido, Carla; Garcia-Patos, Vicente; Hernandez-Losa, Javier; Lloveras, Belen; Masferrer, Emili; Mojal, Sergio; Morote, Juan; Pujol, Ramon M; Ramon Y Cajal, Santiago et al.
DOI: 10.1016/j.jaad.2012.05.029
Preoperative Prediction of Pathologically Insignificant Prostate Cancer in Radical Prostatectomy Specimens: The Role of Prostate Volume and the Number of Positive Cores.
PMID: 20215818
Journal: UROLOGIA INTERNATIONALIS
Year: 2010
Reference: Urol Int. 2010;84(2):153-158. Epub 2010 Mar 4.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; et al.
DOI: 10.1159/000277591
Urothelial Carcinoma of the Bladder, Lipid Cell Variant: Clinicopathologic Findings and LOH Analysis.
PMID: 20139762
Journal: AMERICAN JOURNAL OF SURGICAL PATHOLOGY
Year: 2010
Reference: Am J Surg Pathol. 2010 Mar;34(3):371-6.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1097/PAS.0b013e3181cd385b
News
On World Cancer Research Day, we highlight research aimed at improving treatments for both pediatric and adult cancers through innovative techniques.
The work led by Dr. Regis demonstrates that performing robotic reconstruction after radical prostatectomy is associated with better urinary control.
A clinical trial with the prototype of the device shows that the use of this technology improves patient monitoring by nurses and reduces post-surgical complications.