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Biomedical Research in Urology

The Biomedical Research in Urology group is interested in the study of hormone-dependent cancers, in particular prostate cancer (but not limited to it).

Our efforts are focused on finding, on the one hand, tools that help us in the early diagnosis of the disease, in the best differentiation of tumors according to their aggressiveness and their response to therapy, and finally in finding effective therapies against it.

From a molecular point of view, we focus our studies mainly on cell signaling processes related to the cell cycle and mitosis (with kinesins, kinases and ubiquitin ligases as main targets).

Our multidisciplinary group is made up of molecular biologists and urologists, and we collaborate with oncologists, pathologists and specialists in other diseases when required.

We work with in silico data obtained with different "omics" techniques, samples and clinical data from patients, in vitro and in vivo models, to answer the questions raised.

Publications

BRCA1 mutations in high-grade serous ovarian cancer are associated with proteomic changes in DNA repair, splicing, transcription regulation and signaling.

PMID: 35292711
Journal: Scientific Reports
Year: 2022
Reference: Sci Rep. 2022 Mar 15;12(1):4445. doi: 10.1038/s41598-022-08461-0.
Impact factor:
Publication type: Paper in international publication
Authors: Borras, Eva; Bradbury, Melissa; Castellvi, Josep; Gil-Moreno, Antonio; Mendez, Olga; Perez-Benavente, Assumpcio; Sabido, Eduard; Sanchez-Iglesias, Jose Luis; Santamaria, Anna et al.
DOI: 10.1038/s41598-022-08461-0

Continence definition and prognostic factors for early urinary continence recovery in posterior rhabdosphincter reconstruction after robot-assisted radical prostatectomy. Post-hoc analysis of a randomised controlled trial.

PMID: 35272967
Journal: Actas Urologicas Espanolas
Year: 2022
Reference: Actas Urol Esp (Engl Ed). 2022 Apr;46(3):159-166. doi: 10.1016/j.acuroe.2021.06.012. Epub 2022 Mar 7.
Impact factor:
Publication type: Paper in national publication
Authors: Celma, A; Morote, J; Planas, J; Regis, L; Salazar, A; Trilla, E et al.
DOI: 10.1016/j.acuroe.2021.06.012

Improving the Early Detection of Clinically Significant Prostate Cancer in Men in the Challenging Prostate Imaging-Reporting and Data System 3 Category.

PMID: 35243388
Journal: European Urology Open Science
Year: 2022
Reference: Eur Urol Open Sci. 2022 Jan 23;37:38-44. doi: 10.1016/j.euros.2021.12.009. eCollection 2022 Mar.
Impact factor:
Publication type: Paper in international publication
Authors: Campistol, Miriam; Celma, Anna; de Torres, Ines; Mast, Richard; Morote, Juan; Planas, Jacques; Regis, Lucas; Santamaria, Anna; Semidey, Maria E; Trilla, Enrique et al.
DOI: 10.1016/j.euros.2021.12.009

Who with suspected prostate cancer can benefit from Proclarix after multiparametric magnetic resonance imaging?

PMID: 35200058
Journal: INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS
Year: 2022
Reference: Int J Biol Markers. 2022 Jun;37(2):218-223. doi: 10.1177/03936155221081537. Epub 2022 Feb 24.
Impact factor:
Publication type: Paper in international publication
Authors: Campistol, Miriam; Celma, Anna; de Torres, Ines; Mast, Richard; Morote, Juan; Planas, Jacques; Regis, Lucas; Roche, Sarai; Santamaria, Anna; Semidey, Maria E et al.
DOI: 10.1177/03936155221081537

Clinical Implications of Extracellular HMGA1 in Breast Cancer.

PMID: 31779212
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2019
Reference: Int J Mol Sci. 2019 Nov 26;20(23):5950. doi: 10.3390/ijms20235950.
Impact factor:
Publication type: Paper in international publication
Authors: Cortes, Javier; Mendez, Olga; Perez, Jose; Racca, Fabricio; Soberino, Jesus; Villanueva, Josep et al.
DOI: 10.3390/ijms20235950

A Novel Saliva-Based miRNA Signature for Colorectal Cancer Diagnosis.

PMID: 31757017
Journal: Journal of Clinical Medicine
Year: 2019
Reference: J Clin Med. 2019 Nov 20;8(12). pii: jcm8122029. doi: 10.3390/jcm8122029.
Impact factor: 5.688
Publication type: Paper in international publication
Authors: Rapado-Gonzalez, Oscar, Majem, Blanca, Alvarez-Castro, Ana, Diaz-Pena, Roberto, Abalo, Alicia, Suarez-Cabrera, Leticia, Gil-Moreno, Antonio, Santamaria, Anna, Lopez-Lopez, Rafael, Suarez-Cunqueiro, Maria Mercedes et al.
DOI: 10.3390/jcm8122029

MicroRNA-654-5p suppresses ovarian cancer development impacting on MYC, WNT and AKT pathways.

PMID: 31278368
Journal: ONCOGENE
Year: 2019
Reference: Oncogene. 2019 Aug;38(32):6035-6050. doi: 10.1038/s41388-019-0860-0. Epub 2019 Jul 5.
Impact factor: 6.634
Publication type: Paper in international publication
Authors: Majem, Blanca, Parrilla, Alfonso, Jimenez, Carlos, Suarez-Cabrera, Leticia, Barber, Marta, Marin, Andrea, Castellvi, Josep, Tamayo, Gabriel, Moreno-Bueno, Gema, Ponce, Jordi et al.
DOI: 10.1038/s41388-019-0860-0

Blog

News

On World Cancer Research Day, we highlight research aimed at improving treatments for both pediatric and adult cancers through innovative techniques.

The work led by Dr. Regis demonstrates that performing robotic reconstruction after radical prostatectomy is associated with better urinary control.

A clinical trial with the prototype of the device shows that the use of this technology improves patient monitoring by nurses and reduces post-surgical complications.