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Growth and Development

Our group is dedicated to paediatric research. We are interested in rare respiratory and endocrinological diseases, and also in common paediatric problems such as normal growth, asthma, neonatal pathology and imaging diagnosis, as well as minority diseases. Our goal is to transfer the findings of clinical and genetic studies to the widespread clinical practice and the general population, with the long-term objective of obtaining better diagnoses, implementing better therapeutic practices and improving the health of children.

Our group is part of CIBERER (Biomedical Research Networking Centre on Rare Diseases) (CIBERER U712) and European Reference Networks (ERN) for rare diseases ERN LUNG and Endo-ERN.

Team

Isabel Ramos Soriano

Isabel Ramos Soriano

Growth and Development
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Karina Alicia Gonzalez

Karina Alicia Gonzalez

Research technician
Growth and Development
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Laura Gonzalez Garcia

Laura Gonzalez Garcia

Growth and Development
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Laura Soler Colomer

Laura Soler Colomer

Predoctoral researcher
Growth and Development
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Maria Carmen Soto Perez

Maria Carmen Soto Perez

Research technician
Growth and Development
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Maria Clemente Leon

Maria Clemente Leon

Growth and Development
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Isabel Ramos Soriano

Isabel Ramos Soriano

Growth and Development
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Karina Alicia Gonzalez

Karina Alicia Gonzalez

Research technician
Growth and Development
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Laura Gonzalez Garcia

Laura Gonzalez Garcia

Growth and Development
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Laura Soler Colomer

Laura Soler Colomer

Predoctoral researcher
Growth and Development
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Maria Carmen Soto Perez

Maria Carmen Soto Perez

Research technician
Growth and Development
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Maria Clemente Leon

Maria Clemente Leon

Growth and Development
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Publications

New-onset heart failure in infants: when the aetiological diagnosis becomes a challenge.

PMID: 37843615
Journal: EUROPEAN JOURNAL OF PEDIATRICS
Year: 2023
Reference: Eur J Pediatr. 2023 Oct 16. doi: 10.1007/s00431-023-05286-5.
Impact factor:
Publication type: Paper in international publication
Authors: Adriaansen, Bas P H; Ahmed, S Faisal; Ali, Salma R; Amr, Nermine Hussein; Bachega, Tania A S S; Baronio, Federico; Birkebaek, Niels Holtum; Bonfig, Walter; Bryce, Jillian; Claahsen-van der Grinten, Hedi L et al.
DOI: 10.1007/s00431-023-05286-5

Impact of hepatitis D reflex testing on the future disease burden: A modelling analysis.

PMID: 37916574
Journal: LIVER INTERNATIONAL
Year: 2023
Reference: Liver Int. 2023 Nov 2. doi: 10.1111/liv.15776.
Impact factor:
Publication type: Paper in international publication
Authors: Aguilar-Riera, Cristina; Biagetti, Betina; Buti, Maria; Campos-Martorell, Ariadna; Casado, Miguel Angel; Clemente, Maria; Dominguez-Hernandez, Raquel; Esteban, Rafael; Fabregas, Anna; Gonzalez-Llorens, Nuria et al.
DOI: 10.1111/liv.15776

Correction: Efficacy and safety assessment of different dosage of benznidazol for the treatment of Chagas disease in chronic phase in adults (MULTIBENZ study): study protocol for a multicenter randomized Phase II non-inferiority clinical trial.

PMID: 37964376
Journal: Trials
Year: 2023
Reference: Trials. 2023 Nov 14;24(1):726. doi: 10.1186/s13063-023-07659-5.
Impact factor:
Publication type: Other (letters to the editor, abstracts, corrigendum, etc.)
Authors: Abdulai, Raolat M; Abdulai, Raolat M; Akinlade, Bolanle; Akinlade, Bolanle; Bacharier, Leonard B; Bacharier, Leonard B; Bangher, M; Bosch-Nicolau, P; Correa-Oliveira, R; de Mir, Ines et al.
DOI: 10.1186/s13063-023-07659-5

Biofeedback and Digitalized Motivational Interviewing to Increase Daily Physical Activity: Series of Factorial N-of-1 Randomized Controlled Trials Piloting the Precious App.

PMID: 37995122
Journal: JMIR formative research
Year: 2023
Reference: JMIR Form Res. 2023 Nov 23;7:e34232. doi: 10.2196/34232.
Impact factor:
Publication type: Paper in international publication
Authors: Castellano-Tejedor, Carmina; Gartner, Silvia; Ginchev, Todor; Haukkala, Ari; Iglesias Serrano, Ignacio; Izquierdo, Ana Diez; Khattak, Fida; Knittle, Keegan; Lusilla-Palacios, Pilar; Messa, Ines Mir et al.
DOI: 10.2196/34232

Incidence and Prevalence of Children's Diffuse Lung Disease in Spain.

PMID: 35249699
Journal: ARCHIVOS DE BRONCONEUMOLOGIA
Year: 2022
Reference: Arch Bronconeumol. 2022 Jan;58(1):22-29. doi: 10.1016/j.arbres.2021.06.001. Epub 2021 Jun 17.
Impact factor: 4.872
Publication type: Paper in national publication
Authors: Pastor-Vivero, Maria Dolores, Torrent-Vernetta, Alba, Gaboli, Mirella, Castillo-Corullon, Silvia, Mondejar-Lopez, Pedro, Sanz Santiago, Veronica, Costa-Colomer, Jordi, Osona, Borja, Torres-Borrego, Javier, de la Serna-Blazquez, Olga et al.
DOI: 10.1016/j.arbres.2021.06.001

Epigenetic regulation of inflammation by microRNAs in post-infectious bronchiolitis obliterans.

PMID: 35228871
Journal: Clinical & Translational Immunology
Year: 2022
Reference: Clin Transl Immunology. 2022 Feb 21;11(2):e1376. doi: 10.1002/cti2.1376. eCollection 2022.
Impact factor: 6.161
Publication type: Paper in international publication
Authors: Kreyenberg, Hermann, Duecker, Ruth P, De Mir Messa, Ines, Jerkic, Silvija-Pera, Kochems, Annalena, Gottwald, Gabriele, Moreno-Galdo, Antonio, Rosewich, Martin, Gronau, Lucia, Zielen, Stefan et al.
DOI: 10.1002/cti2.1376

Prenatal dexamethasone treatment for classic 21-hydroxylase deficiency in Europe.

PMID: 35235536
Journal: EUROPEAN JOURNAL OF ENDOCRINOLOGY
Year: 2022
Reference: Eur J Endocrinol. 2022 Mar 23;186(5):K17-K24. doi: 10.1530/EJE-21-0554.
Impact factor: 6.664
Publication type: Paper in international publication
Authors: Nowotny, Hanna, Neumann, Uta, Tardy-Guidollet, Veronique, Ahmed, S Faisal, Baronio, Federico, Battelino, Tadej, Phylactou, Leonidas A, Rohayem, Julia, Russo, Gianni, Scaroni, Carla et al.
DOI: 10.1530/EJE-21-0554

Prevalence of genetic variants in pediatric pulmonary arterial hypertension associated with corrected D-transposition of the great arteries. The REHIPED registry.

PMID: 35058221
Journal: REVISTA ESPANOLA DE CARDIOLOGIA
Year: 2022
Reference: Rev Esp Cardiol (Engl Ed). 2022 May;75(5):448-450. doi: 10.1016/j.rec.2021.12.006. Epub 2022 Jan 17.
Impact factor: 4.753
Publication type: Letter whit IF
Authors: Cruz-Utrilla, Alejandro, Gallego, Natalia, Torrent-Vernetta, Alba, Guillen, Inmaculada, Escribano Subias, Maria Pilar, Del Cerro Marin, Maria Jesus et al.
DOI: 10.1016/j.rec.2021.12.006

Gene expression signatures predict response to therapy with growth hormone.

PMID: 34045667
Journal: PHARMACOGENOMICS JOURNAL
Year: 2021
Reference: Pharmacogenomics J. 2021 Oct;21(5):594-607. doi: 10.1038/s41397-021-00237-5. Epub 2021 May 27.
Impact factor: 3.55
Publication type: Paper in international publication
Authors: Hagenas, Lars, Dahlgren, Jovanna, Deal, Cheri, Chatelain, Pierre, Clayton, Peter, Vangsoy-Hansen, Eirik, Coutant, Regis, Belgorosky, Alicia, Stevens, Adam, Murray, Philip et al.
DOI: 10.1038/s41397-021-00237-5

Intralymphatic Glutamic Acid Decarboxylase With Vitamin D Supplementation in Recent-Onset Type 1 Diabetes: A Double-Blind, Randomized, Placebo-Controlled Phase IIb Trial.

PMID: 34021020
Journal: DIABETES CARE
Year: 2021
Reference: Diabetes Care. 2021 Jul;44(7):1604-1612. doi: 10.2337/dc21-0318. Epub 2021 May 21.
Impact factor: 19.112
Publication type: Paper in international publication
Authors: Hanas, Ragnar, Hernandez, Cristina, Clemente Leon, Maria, Gomez-Gila, Ana, Lind, Marcus, Lozano, Marta Ferrer, Sas, Theo, Samuelsson, Ulf, Pruhova, Stepanka, Dietrich, Fabricia et al.
DOI: 10.2337/dc21-0318

Onset of nut allergy in a pediatric cohort: clinical and molecular patterns. AFRUSEN study.

PMID: 33884956
Journal: JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
Year: 2021
Reference: J Investig Allergol Clin Immunol. 2021 Apr 22:0. doi: 10.18176/jiaci.0696.
Impact factor: 7.033
Publication type: Paper in international publication
Authors: Vila, L, Ibanez-Sandin, M D, Rodriguez Del Rio, P, Alvarado, M I, Garcia, B E, Garriga-Baraut, T, Reche Frutos, M, Escudero, C, Ramirez, A, Marchan-Martin, E et al.
DOI: 10.18176/jiaci.0696

Development of a core outcome set for congenital pulmonary airway malformations: study protocol of an international Delphi survey.

PMID: 33846152
Journal: BMJ Open
Year: 2021
Reference: BMJ Open. 2021 Apr 12;11(4):e044544. doi: 10.1136/bmjopen-2020-044544.
Impact factor: 2.692
Publication type: Paper in international publication
Authors: Rikkers-Mutsaerts, N, Ertresvag, Kjetil, Tiddens, Harm A W M, Wijnen, Rene M H, Schnater, Marco, Hermelijn, S M, Kersten, C M, Schnater, J M, Wijnen, R M H, Tiddens, H A W M et al.
DOI: 10.1136/bmjopen-2020-044544

Primary endovascular treatment for acute ischemic stroke in teenage patients: a short case series.

PMID: 32307558
Journal: NEURORADIOLOGY
Year: 2020
Reference: Neuroradiology. 2020 Jul;62(7):851-860. doi: 10.1007/s00234-020-02421-z. Epub 2020 Apr 19.
Impact factor: 2.238
Publication type: Paper in international publication
Authors: Parra-Farinas, Carmen, Dmytriw, Adam A, Delgado-Alvarez, Ignacio, Sanchez-Montanez, Angel, de Miquel, Maria Angeles, Sola, Teresa, Felipe-Rucian, Ana, Macaya, Alfons, Tomasello, Alejandro, Ribo, Marc et al.
DOI: 10.1007/s00234-020-02421-z

Hypophosphatasia: Novel Mutation Associated With An Atypical Newborn Presentation

PMID: 30929401
Journal: Journal of Clinical Research in Pediatric Endocrinology
Year: 2020
Reference: J Clin Res Pediatr Endocrinol. 2020 Mar 19;12(1):104-108. doi: 10.4274/jcrpe.galenos.2019.2018.0263. Epub 2019 Apr 1.
Impact factor: 1.803
Publication type: Paper in international publication
Authors: Castillo, Felix, Esmel-Vilomara, Roger, Hernandez, Susana, Campos-Martorell, Ariadna, Gonzalez-Roca, Eva, Yeste, Diego et al.
DOI: 10.4274/jcrpe.galenos.2019.2018.0263

The effectiveness of interventions to improve self-management for adolescents and young adults with allergic conditions: a systematic review.

PMID: 32159856
Journal: ALLERGY
Year: 2020
Reference: Allergy. 2020 Aug;75(8):1880-1897. doi: 10.1111/all.14269.
Impact factor: 8.706
Publication type: Review in international publication
Authors: Knibb, Rebecca C, Alviani, Cherry, Garriga-Baraut, Teresa, Mortz, Charlotte G, Vazquez-Ortiz, Marta, Angier, Elizabeth, Blumchen, Katerina, Comberiati, Pasquale, Duca, Bettina, DunnGalvin, Audrey et al.
DOI: 10.1111/all.14269

Understanding the challenges faced by adolescents and young adults with allergic conditions: a systematic review.

PMID: 32141620
Journal: ALLERGY
Year: 2020
Reference: Allergy. 2020 Aug;75(8):1849-1879. doi: 10.1111/all.14258.
Impact factor: 8.706
Publication type: Review in international publication
Authors: Comberiati, Pasquale, Vazquez-Ortiz, Marta, Angier, Elizabeth, Blumchen, Katharina, Gore, Claudia, Hox, Valerie, Jensen, Britt, Pite, Helena, Santos, Alexandra F, Sanchez, Silvia et al.
DOI: 10.1111/all.14258

Mutations in the mitochondrial complex I assembly factor NDUFAF6 cause isolated bilateral striatal necrosis and progressive dystonia in childhood.

PMID: 30642748
Journal: MOLECULAR GENETICS AND METABOLISM
Year: 2019
Reference: Mol Genet Metab. 2019 Mar;126(3):250-258. doi: 10.1016/j.ymgme.2019.01.001. Epub 2019 Jan 5.
Impact factor: 3.61
Publication type: Paper in international publication
Authors: Baide-Mairena, Heidy, Gaudo, Paula, Marti-Sanchez, Laura, Emperador, Sonia, Sanchez-Montanez, Angel, Alonso-Luengo, Olga, Correa, Marta, Grau, Anna Marce, Artuch, Rafael, Vazquez, Elida et al.
DOI: 10.1016/j.ymgme.2019.01.001

Safety outcomes during pediatric GH therapy: final results from the prospective GeNeSIS observational program.

PMID: 30219920
Journal: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
Year: 2019
Reference: J Clin Endocrinol Metab. 2019 Feb 1;104(2):379-389. doi: 10.1210/jc.2018-01189.
Impact factor: 5.605
Publication type: Paper in international publication
Authors: Blum, Werner F, Child, Christopher J, Zimmermann, Alan G, Chrousos, George P, Cummings, Elisabeth, Deal, Cheri L, Hasegawa, Tomonobu, Jia, Nan, Lawrence, Sarah, Linglart, Agnes et al.
DOI: 10.1210/jc.2018-01189

A rare cause of primary adrenal insufficiency due to a homozygous Arg188Cys mutation in the STAR gene.

PMID: 29576868
Journal: Endocrinology, diabetes & metabolism case repo
Year: 2018
Reference: Endocrinol Diabetes Metab Case Rep. 2018 Mar 21;2018. pii: EDM180003. doi: 10.1530/EDM-18-0003. eCollection 2018.
Impact factor: 0
Publication type: Paper in international publication
Authors: Henzen, Christoph, Burget, Lukas, Parera, Laura Audi, Fernandez-Cancio, Monica, Grani, Rolf, Fluck, Christa E et al.
DOI: 10.1530/EDM-18-0003

Attention deficit hyperactivity disorder symptoms in patients with cystic fibrosis.

PMID: 29269187
Journal: Journal of Cystic Fibrosis
Year: 2018
Reference: J Cyst Fibros. 2018 Mar;17(2):281-285. doi: 10.1016/j.jcf.2017.11.020. Epub 2017 Dec 19.
Impact factor: 3.858
Publication type: Paper in international publication
Authors: Breuer, Oded, Blau, Hannah, Mussaffi, Huda, Kadosh, Diana, Gartner, Silvia, Salinas, Alma, Bentur, Lea, Nir, Vered, Gur, Michal, Reiter, Joel et al.
DOI: 10.1016/j.jcf.2017.11.020

Development of Laboratory Investigations in Disorders of Sex Development.

PMID: 28898878
Journal: Sexual Development
Year: 2018
Reference: Sex Dev. 2018;12(1-3):7-18. doi: 10.1159/000479719. Epub 2017 Sep 13.
Impact factor: 1.913
Publication type: Paper in international publication
Authors: Granada, Maria L, Camats, Nuria, Audi, Laura, Fernandez-Cancio, Monica et al.
DOI: 10.1159/000479719

[Body mass index and tri-ponderal mass index of 1,453 healthy non-obese, non-undernourished millennial children. The Barcelona longitudinal growth study].

PMID: 29478880
Journal: ANALES DE PEDIATRIA
Year: 2018
Reference: An Pediatr (Barc). 2018 Sep;89(3):137-143. doi: 10.1016/j.anpedi.2017.12.016. Epub 2018 Feb 22.
Impact factor: 1.318
Publication type: Paper in national publication
Authors: Carrascosa, Antonio, Yeste, Diego, Gussinye, Miquel, Ferrandez, Angel, Clemente, Maria, Fernandez-Cancio, Monica, Moreno-Galdo, Antonio et al.
DOI: 10.1016/j.anpedi.2017.12.016

[Recommendations for respiratory support in the newborn (IV). High frequency ventilation, ex-utero intrapartum treatment (EXIT), extracorporeal membrane oxygenation (ECMO)].

PMID: 28571898
Journal: ANALES DE PEDIATRIA
Year: 2017
Reference: An Pediatr (Barc). 2017 Nov;87(5):295.e1-295.e7. doi: 10.1016/j.anpedi.2017.04.003. Epub 2017 May 29.
Impact factor: 1.14
Publication type: Paper in national publication
Authors: Castillo Salinas, Felix, Elorza Fernandez, Dolores, Gutierrez Laso, Antonio, Moreno Hernando, Julio, Bustos Lozano, Gerardo, Gresa Munoz, Manuel, Miracle Echegoyen, Xavier et al.
DOI: 10.1016/j.anpedi.2017.04.003

Health-Care Associated Mycobacterium bovis-BCG Infection in Cancer Patients without prior BCG Instillation.

PMID: 28575173
Journal: CLINICAL INFECTIOUS DISEASES
Year: 2017
Reference: Clin Infect Dis. 2017 Oct 1;65(7):1136-1143. doi: 10.1093/cid/cix496.
Impact factor: 8.216
Publication type: Paper in international publication
Authors: Montes, M, Ayestaran, A, Carratala, J, Orcau, A, Lopez-Sanchez, C, Ruiz-Camps, I, Vaque, M, Calsina, M, Martinez-Montauti, J, Cayla, J A et al.
DOI: 10.1093/cid/cix496

Component-Resolved Diagnosis of Dog Allergy.

PMID: 28570224
Journal: JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
Year: 2017
Reference: J Investig Allergol Clin Immunol. 2017 Jun;27(3):185-187. doi: 10.18176/jiaci.0150.
Impact factor: 3.094
Publication type: Paper in international publication
Authors: Basagana, M, Luengo, O, Labrador, M, Garriga, T, Mattsson, L, Lidholm, J, Cardona, V et al.
DOI: 10.18176/jiaci.0150

Hyperinsulinaemic hypoglycaemia, renal Fanconi syndrome and liver disease due to a mutation in the HNF4A gene.

PMID: 28458902
Journal: Endocrinology, diabetes & metabolism case repo
Year: 2017
Reference: Endocrinol Diabetes Metab Case Rep. 2017 Mar 16;2017. pii: 16-0133. doi: 10.1530/EDM-16-0133. eCollection 2017.
Impact factor: 0
Publication type: Paper in international publication
Authors: Clemente, Maria, Vargas, Alejandro, Ariceta, Gema, Martinez, Rosa, Campos, Ariadna, Yeste, Diego et al.
DOI: 10.1530/EDM-16-0133

[Determining asthma treatment in children by monitoring fractional exhaled nitric oxide, sputum eosinophils and leukotriene B]

PMID: 24857428
Journal: ANALES DE PEDIATRIA
Year: 2015
Reference: An Pediatr (Barc). 2015 Jan;82(1):e21-5. doi: 10.1016/j.anpedi.2014.03.012. Epub 2014 May 22.
Impact factor: 0.833
Publication type: Paper in national publication
Authors: Vizmanos-Lamotte, G, Cruz, M J, Gomez-Olles, S, Munoz, X, de Mir Messa, I, Moreno-Galdo, A et al.
DOI: 10.1016/j.anpedi.2014.03.012

Blog

News

The study, in which Vall d'Hebron participates, helps to understand the variability among patients with retinitis pigmentosa.

Es va reconèixer la tasca de més de 70 professionals dedicades a aquesta malaltia pulmonar, tant assistencial com de recerca.

The two studies awarded has been the research for a the ciliary dyskinesia diagnosis led by the VHIR’s Growth and Development Group and the EPISCAN II, in which Dr. Miravitlles has participated.