About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The work of the Biomedical Research in Cancer Stem Cell group focuses mainly on senescence (replicative or stress-induced oncoge). In our laboratory, we carry out several genetic screens based on the detection of new genes / small interfering RNA (siRNA) / microRNAs related to cell proliferation, which have a role in cancer. Therefore, we use different cell models: murine cells, human primary cells or immortalized cells capable of entering senescence.
The objectives of the group are:
PMID: 34979155 Journal: BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER Year: 2022 Reference: Biochim Biophys Acta Rev Cancer. 2022 Jan;1877(1):188674. doi: 10.1016/j.bbcan.2021.188674. Epub 2021 Dec 31. Impact factor: 10.68 Publication type: Review in international publication Authors: Mir, Cristina; Carballo, Laia; Sanchez-Garcia, Almudena; Bataller, Marina; LLeonart, Matilde E; Garcia-Mayea, Yoelsis et al. DOI: 10.1016/j.bbcan.2021.188674
PMID: 35124196 Journal: SEMINARS IN CANCER BIOLOGY Year: 2022 Reference: Semin Cancer Biol. 2022 Feb 3. pii: S1044-579X(22)00020-7. doi: 10.1016/j.semcancer.2022.01.010. Impact factor: 15.707 Publication type: Paper in international publication Authors: LLeonart, M E; Kondoh, H; Garcia-Mayea, Y; Zhao, Y; Mir, C; Paciucci, R et al. DOI: 10.1016/j.semcancer.2022.01.010
PMID: 35772609 Journal: SEMINARS IN CANCER BIOLOGY Year: 2022 Reference: Semin Cancer Biol. 2022 Jun 27. pii: S1044-579X(22)00152-3. doi: 10.1016/j.semcancer.2022.06.008. Impact factor: 15.707 Publication type: Review in international publication Authors: Garcia-Mayea, Y; LLeonart, M E; Mir, C et al. DOI: 10.1016/j.semcancer.2022.06.008
PMID: 33090711 Journal: FEBS Journal Year: 2021 Reference: FEBS J. 2021 Apr;288(7):2184-2202. doi: 10.1111/febs.15588. Epub 2020 Nov 3. Impact factor: Publication type: Paper in international publication Authors: Abad, Etna; Civit, Laia; Lyakhovich, Alex; Potesil, David; Zdrahal, Zbynek et al. DOI: 10.1111/febs.15588
PMID: 33316348 Journal: CANCER LETTERS Year: 2021 Reference: Cancer Lett. 2021 Apr 10;503:185-196. doi: 10.1016/j.canlet.2020.12.010. Epub 2020 Dec 11. Impact factor: Publication type: Paper in international publication Authors: Abad, Etna; Graifer, Dmitry; Grodzicki, Robert L; Lyakhovich, Alex; OscarYanes; Pagano, Giovanni; Potesil, David; Samino, Sara; Trifuoggi, Marco; Zdrahal, Zbynek et al. DOI: 10.1016/j.canlet.2020.12.010
PMID: 33634751 Journal: Autophagy Year: 2021 Reference: Autophagy. 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280. Epub 2021 Feb 8. Impact factor: Publication type: Review in international publication Authors: Abdel-Aziz, Amal Kamal; Abdelfatah, Sara; Abdellatif, Mahmoud; Abdoli, Asghar; Abel, Steffen; Abeliovich, Hagai; Abildgaard, Marie H; Abudu, Yakubu Princely; Acevedo-Arozena, Abraham; Adamopoulos, Iannis E et al. DOI: 10.1080/15548627.2020.1797280
PMID: 33346851 Journal: INFLAMMATION RESEARCH Year: 2021 Reference: Inflamm Res. 2021 Feb;70(2):159-170. doi: 10.1007/s00011-020-01423-0. Epub 2020 Dec 21. Impact factor: Publication type: Review in international publication Authors: Lyakhovich, Alex; Manfredi, Carla; Pagano, Giovanni; Pallardo, Federico V; Tiano, Luca; Trifuoggi, Marco et al. DOI: 10.1007/s00011-020-01423-0
PMID: 33167355 Journal: Cancers Year: 2020 Reference: Cancers (Basel). 2020 Nov 5;12(11). pii: cancers12113269. doi: 10.3390/cancers12113269. Impact factor: 6.126 Publication type: Paper in international publication Authors: Garcia-Mayea, Yoelsis, Mir, Cristina, Carballo, Laia, Castellvi, Josep, Temprana-Salvador, Jordi, Lorente, Juan, Benavente, Sergi, Garcia-Pedrero, Juana M, Allonca, Eva, Rodrigo, Juan P et al. DOI: 10.3390/cancers12113269
PMID: 31174844 Journal: Acta otorrinolaringologica espanola Year: 2020 Reference: Acta Otorrinolaringol Esp. 2020 Sep-Oct;71(5):316-320. doi: 10.1016/j.otorri.2019.02.007. Epub 2019 Jun 4. Impact factor: 0 Publication type: Paper in national publication Authors: Carrasco Llatas, Marina, Martinez Ruiz de Apodaca, Paula, Baptista Jardin, Peter, O'Connor Reina, Carlos, Plaza Mayor, Guillermo, Vicente Gonzalez, Eugenio, Vilaseca Gonzalez, Isabel, Navazo Egia, Ana Isabel, Samara Pinol, Laura, Alvarez Garcia, Irene et al. DOI: 10.1016/j.otorri.2019.02.007
PMID: 32769030 Journal: SLEEP MEDICINE Year: 2020 Reference: Sleep Med. 2020 Sep;73:29-37. doi: 10.1016/j.sleep.2020.04.016. Epub 2020 Apr 30. Impact factor: 3.038 Publication type: Paper in international publication Authors: Garcia, Marcos, Cabrera, Juan A, Bataller, Alex, Vila, Javier, Mayoral, Pedro et al. DOI: 10.1016/j.sleep.2020.04.016
PMID: 31369817 Journal: SEMINARS IN CANCER BIOLOGY Year: 2020 Reference: Semin Cancer Biol. 2020 Feb;60:166-180. doi: 10.1016/j.semcancer.2019.07.022. Epub 2019 Jul 29. Impact factor: 11.09 Publication type: Review in international publication Authors: Garcia-Mayea, Y, Mir, C, Masson, F, Paciucci, R, LLeonart, M E et al. DOI: 10.1016/j.semcancer.2019.07.022
PMID: 30616837 Journal: Acta otorrinolaringologica espanola Year: 2019 Reference: Acta Otorrinolaringol Esp. 2019 Nov - Dec;70(6):364-372. doi: 10.1016/j.otorri.2018.06.008. Epub 2019 Jan 5. Impact factor: 0 Publication type: Paper in national publication Authors: Esteller, Eduard, Carrasco, Marina, Diaz-Herrera, Miguel Angel, Sampol, Gabriel, Juvanteny, Joan, Sieira, Ramon, Farre, Alex, Vilaseca, Isabel, Vila, Javier et al. DOI: 10.1016/j.otorri.2018.06.008
PMID: 28683561 Journal: ANTIOXIDANTS & REDOX SIGNALING Year: 2018 Reference: Antioxidants & Redox Signaling. 2018 Apr 10;28(11):1066-79. doi:10.1089/ars.2017.7223 Impact factor: 6.53 Publication type: Review in international publication Authors: Lleonart Pajarin, Matilde, Abad Cortel, Etna, Graifer, Dmitry, Lyakhovich, Alex et al. DOI: 10.1089/ars.2017.7223
PMID: 30228363 Journal: Scientific Reports Year: 2018 Reference: Sci Rep. 2018 Sep 18;8(1):13978. doi: 10.1038/s41598-018-32264-x. Impact factor: 4.122 Publication type: Paper in international publication Authors: Gonzalez, Diana Abigail, Leone, Paola E, Paz-Y-Mino, Cesar, Guevara-Ramirez, Patricia, Cabrera-Andrade, Alejandro, Garcia-Cardenas, Jennyfer M, Guerrero, Santiago, Lopez-Cortes, Andres, Indacochea, Alberto, Zambrano, Ana Karina et al. DOI: 10.1038/s41598-018-32264-x
PMID: 28464404 Journal: BIOLOGICAL REVIEWS Year: 2018 Reference: Biol Rev Camb Philos Soc. 2018 Feb;93(1):152-165. doi: 10.1111/brv.12337. Epub 2017 May 2. Impact factor: 11.7 Publication type: Paper in international publication Authors: Lorente, Juan, Velandia, Carolina, Leal, Jose A, Garcia-Mayea, Yoelsis, Lyakhovich, Alex, Kondoh, Hiroshi, LLeonart, Matilde E et al. DOI: 10.1111/brv.12337
PMID: 28763470 Journal: PLoS One Year: 2017 Reference: PLoS One. 2017 Aug 1;12(8):e0182044. doi: 10.1371/journal.pone.0182044. eCollection 2017. Impact factor: Publication type: Paper in international publication Authors: Borrero-Palacios, Aurea; Cebrian, Arancha; Celdran, Angel; Del Puerto-Nevado, Laura; Fernandez-Acenero, Maria Jesus; Garcia-Foncillas, Jesus; Gebauer, Fatima; Georgiev-Hristov, Tihomir; Gomez Del Pulgar, Teresa; Guerrero, Santiago et al. DOI: 10.1371/journal.pone.0182044
PMID: 28757873 Journal: International journal of otolaryngology Year: 2017 Reference: Int J Otolaryngol. 2017;2017:5185268. doi: 10.1155/2017/5185268. Epub 2017 Jul 3. Impact factor: Publication type: Paper in international publication Authors: Brana, I; Garcia-Vaquero, C; Graterol, D; LLeonart, M E; Lorente, J; Lyakhovich, A; Mir, C; Pardo, A N; Rochera-Villach, M I et al. DOI: 10.1155/2017/5185268
PMID: 28682452 Journal: MEDICINAL RESEARCH REVIEWS Year: 2017 Reference: Med Res Rev. 2017 Nov;37(6):1275-1298. doi: 10.1002/med.21459. Epub 2017 Jul 6. Impact factor: Publication type: Review in international publication Authors: Graifer, Dmitri M; Grodzicki, Robert; Lleonart, Matilde E; Lyakhovich, Alex et al. DOI: 10.1002/med.21459
PMID: 27918383 Journal: PEDIATRIC INFECTIOUS DISEASE JOURNAL Year: 2017 Reference: Pediatr Infect Dis J. 2017 Mar;36(3):274-281. doi: 10.1097/INF.0000000000001420. Impact factor: Publication type: Paper in international publication Authors: Al-Mazrou, Khalid; Cohen, Robert; Grevers, Gerhard; Hausdorff, William P; Lopez, Pio; Macias Parra, Mercedes; Madhi, Shabir A; Naranjo, Laura; Pircon, Jean-Yves; Pumarola, Felix et al. DOI: 10.1097/INF.0000000000001420
PMID: 27517150 Journal: Oncotarget Year: 2016 Reference: Oncotarget. 2016 Sep 6;7(36):58065-58074. doi: 10.18632/oncotarget.11161. Impact factor: 5.008 Publication type: Paper in international publication Authors: Shyamsunder, Pavithra, Esner, Milan, Barvalia, Maunish, Wu, Yu Jun, Loja, Tomas, Verma, Rama S, Krejci, Lumir, Lyakhovich, Alex, Lleonart, Matilde E, Boon, Huat Bay et al. DOI: 10.18632/oncotarget.11161
PMID: 26697128 Journal: Oxidative Medicine and Cellular Longevity Year: 2016 Reference: Oxid Med Cell Longev. 2016;2016:1716341. doi: 10.1155/2016/1716341. Epub 2015 Nov 30. Impact factor: 4.492 Publication type: Review in national publication Authors: Lyakhovich, Alex, Lleonart, Matilde E et al. DOI: 10.1155/2016/1716341
PMID: 25609364 Journal: CELL MOL LIFE SCI Year: 2015 Reference: Cell Mol Life Sci. 2015 May;72(10):1881-92. doi: 10.1007/s00018-015-1840-3. Epub 2015 Jan 22. Impact factor: Publication type: Paper in international publication Authors: Inagaki, Nobuya; Kondoh, Hiroshi; LLeonart, Matilde E; Mikawa, Takumi; Takaori-Kondo, Akifumi; Yokode, Masayuki et al. DOI: 10.1007/s00018-015-1840-3
PMID: 27775292 Journal: Cirugia pediatrica : organo oficial de la Sociedad Year: 2015 Reference: Cir Pediatr. 2015 Oct 10;28(4):165-171. Impact factor: 0 Publication type: Letter or abstract Authors: Lloret, J, Seidler, L, Lopez-Fernandez, S, Santiago-Martinez, S, Lain, A, Guillen, G, Gander, R, Pumarola, F et al. DOI:
PMID: 25446794 Journal: ANALES DE PEDIATRIA Year: 2015 Reference: An Pediatr (Barc). 2015 Jun;82(6):388-96. doi: 10.1016/j.anpedi.2014.09.008. Epub 2014 Oct 29. Impact factor: 0.722 Publication type: Paper in national publication Authors: Morgenstern Isaak, A, Bach Faig, A, Martinez, S, Martin-Nalda, A, Vazquez Mendez, E, Pumarola Segura, F, Soler-Palacin, P et al. DOI: 10.1016/j.anpedi.2014.09.008
PMID: 26219394 Journal: CURRENT MEDICINAL CHEMISTRY Year: 2015 Reference: Curr Med Chem. 2015;22(26):3040-53. Impact factor: 3.853 Publication type: Review in national publication Authors: Lyakhovich, Alex, Graifer, Dmitri et al. DOI:
PMID: 21040949 Journal: HUMAN PATHOLOGY Year: 2011 Reference: Hum Pathol. 2011 Feb;42(2):194-203. Epub 2010 Oct 30. Impact factor: Publication type: Paper in international publication Authors: ; ; ; ; ; et al. DOI: 10.1016/j.humpath.2010.04.020
PMID: 21297668 Journal: ONCOGENE Year: 2011 Reference: Oncogene. 2011 May 5;30(18):2087-97. Epub 2011 Feb 7. Impact factor: Publication type: Review in international publication Authors: ; ; ; ; ; ; et al. DOI: 10.1038/onc.2010.614
The sessions were aimed at establishing new collaborations to advance the prevention and treatment of this type of tumour.
On World Cancer Research Day, we highlight research aimed at improving treatments for both pediatric and adult cancers through innovative techniques.
The Biomedical Research in Cancer Stem Cells group at VHIR has identified a new therapeutic target and is working to find new therapies for this type of tumor.
