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Headache and Neurological Pain

Our research group is focused on studying the pathophysiology of migraine and other primary headaches using preclinical, translational and clinical research.

Migraine will allow us to define the brain’s adaptive, sensory/cognitive functions, through genetics, epigenetics, neurophysiology, neuromolecular and neuroanatomical information with an interest in developing clinical therapeutic solutions, with the goal on having an impact on suffering and increasing the well-being.

Publications

Post-COVID-19 persistent headache: A multicentric 9-months follow-up study of 905 patients.

PMID: 35166156
Journal: CEPHALALGIA
Year: 2022
Reference: Cephalalgia. 2022 Jul;42(8):804-809. doi: 10.1177/03331024211068074. Epub 2022 Feb 15.
Impact factor: 6.295
Publication type: Paper in international publication
Authors: Pozo-Rosich, Patricia; de Lorenzo, Inigo; Garcia-Azorin, David; Layos-Romero, Almudena; Porta-Etessam, Jesus; Membrilla, Javier A; Caronna, Edoardo; Gonzalez-Martinez, Alicia; Mencia, Alvaro Sierra; Segura, Tomas et al.
DOI: 10.1177/03331024211068074

Safety and efficacy of eptinezumab for migraine prevention in patients with two-to-four previous preventive treatment failures (DELIVER): a multi-arm, randomised, double-blind, placebo-controlled, phase 3b trial.

PMID: 35716692
Journal: LANCET NEUROLOGY
Year: 2022
Reference: Lancet Neurol. 2022 Jul;21(7):597-607. doi: 10.1016/S1474-4422(22)00185-5.
Impact factor: 44.182
Publication type: Paper in international publication
Authors: Lanteri-Minet, Michel; Pozo-Rosich, Patricia; Ettrup, Anders; Christoffersen, Cecilie Laurberg; Josiassen, Mette Krog; Phul, Ravinder; Sperling, Bjorn; Ashina, Messoud et al.
DOI: 10.1016/S1474-4422(22)00185-5

Migraine-attributed burden, impact and disability, and migraine-impacted quality of life: Expert consensus on definitions from a Delphi process.

PMID: 35791285
Journal: CEPHALALGIA
Year: 2022
Reference: Cephalalgia. 2022 Jul 5:3331024221110102. doi: 10.1177/03331024221110102.
Impact factor: 6.295
Publication type: Paper in international publication
Authors: Steiner, Timothy J; Terwindt, Gisela M; Katsarava, Zaza; Pozo-Rosich, Patricia; Gantenbein, Andreas R; Roche, Sarah L; Dell'Agnello, Grazia; Tassorelli, Cristina et al.
DOI: 10.1177/03331024221110102

Avoidance behaviour modulates but does not condition phonophobia in migraine.

PMID: 35815637
Journal: CEPHALALGIA
Year: 2022
Reference: Cephalalgia. 2022 Jul 9:3331024221111772. doi: 10.1177/03331024221111772.
Impact factor: 6.295
Publication type: Paper in international publication
Authors: Pozo-Rosich, Patricia, Gallardo, Victor Jose, Caronna, Edoardo, Vila-Ballo, Adria, Marti-Marca, Angela, Cerda-Company, Xim, Ikumi, Nara et al.
DOI: 10.1177/03331024221111772

Document of revision and updating of medication overuse headache (MOH).

PMID: 32917437
Journal: NEUROLOGIA
Year: 2021
Reference: Neurologia. 2021 Apr;36(3):229-240. doi: 10.1016/j.nrl.2020.04.029. Epub 2020 Sep 9.
Impact factor:
Publication type: Review in international publication
Authors: Belvis, R; Cuadrado, M L; Diaz-Insa, S; Gonzalez-Oria, C; Guerrero-Peral, A L; Huerta, M; Irimia, P; Lainez, J M; Latorre, G; Leira, R et al.
DOI: 10.1016/j.nrl.2020.04.029

Partial and non responders to onabotulinumtoxinA can benefit from anti-CGRP monoclonal preventive treatment: a real-world evidence study.

PMID: 33730441
Journal: EUROPEAN JOURNAL OF NEUROLOGY
Year: 2021
Reference: Eur J Neurol. 2021 Jul;28(7):2378-2382. doi: 10.1111/ene.14828. Epub 2021 Apr 5.
Impact factor:
Publication type: Letter whit IF
Authors: Alpuente, Alicia; Caronna, Edoardo; Gallardo, Victor J; Pozo-Rosich, Patricia; Torres-Ferrus, Marta et al.
DOI: 10.1111/ene.14828

Comments on <<Headache: Pregnancy and breastfeeding. Recommendations of the Spanish Society of Neurology's Headache Study Group>>.

PMID: 32444176
Journal: NEUROLOGIA
Year: 2021
Reference: Neurologia. 2021 Mar;36(2):176. doi: 10.1016/j.nrl.2020.01.005. Epub 2020 May 20.
Impact factor:
Publication type: Letter or abstract
Authors: Gonzalez-Garcia, N; Pozo-Rosich, P et al.
DOI: 10.1016/j.nrl.2020.01.005

Headache during COVID-19: Lessons for all, implications for the International Classification of Headache Disorders.

PMID: 33522600
Journal: HEADACHE
Year: 2021
Reference: Headache. 2021 Feb;61(2):385-386. doi: 10.1111/head.14059. Epub 2021 Feb 1.
Impact factor:
Publication type: Letter or abstract
Authors: Caronna, Edoardo; Pozo-Rosich, Patricia et al.
DOI: 10.1111/head.14059

Have the IHS Guidelines for controlled trials of acute treatment of migraine attacks been followed? Laying the ground for the 4th edition.

PMID: 32056459
Journal: CEPHALALGIA
Year: 2020
Reference: Cephalalgia. 2020 Jul;40(8):778-787. doi: 10.1177/0333102420906843. Epub 2020 Feb 14.
Impact factor: 4.868
Publication type: Review in international publication
Authors: Alpuente, Alicia, Tassorelli, Cristina, Diener, Hans-Christoph, Silberstein, Stephen D, Pozo-Rosich, Patricia et al.
DOI: 10.1177/0333102420906843

Blog

News

Two international studies led by Vall d'Hebron recommend early administration of specific drugs to prevent migraine to achieve a better response to therapy.

On World Clinical Trials Day, we highlight some of the studies we have participated in that confirm the efficacy of new drugs, allowing their approval by regulatory agencies.

The study, conducted in more than 770 people, concludes that atogepant reduces the frequency of migraine attacks and the need to take medication.