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Infectious Diseases

The VHIR Infectious Diseases research group is made up of medical professionals, with healthcare and clinical or basic translational research activities; of Biomedicine dedicated to basic research; and Nursing, with activities to support clinical research.

The group's lines of research are mainly focused on four areas:

Infections related to immunosuppression. Includes infectious diseases related to immunocompromised patients, solid organ or hematopoietic stem cell transplant recipients and recipients of biological therapies.

Sexually transmitted diseases, including HIV infection and other highly prevalent infections in our country (syphilis, gonorrhea, lymphogranuloma venere or infections caused by the human papillomavirus).

Infections related to health care, with special emphasis on those difficult to treat (cardiovascular infections or infections related to prosthetic materials) or caused by multi-resistant pathogens (MDRO) or affecting vulnerable populations.

Global Health and Tropical Diseases with special emphasis on prevalent diseases in our environment that affect the immigrant or displaced population.

Publications

Early outcomes in adults hospitalized with severe SARS-CoV-2 infection receiving tocilizumab.

PMID: 34544604
Journal: MEDICINA CLINICA
Year: 2022
Reference: Med Clin (Barc). 2022 Jun 10;158(11):509-518. doi: 10.1016/j.medcli.2021.06.012. Epub 2021 Jun 18.
Impact factor: 1.725
Publication type: Paper in national publication
Authors: Espinosa-Pereiro, Juan, Fernandez-Hidalgo, Nuria, Perez-Hoyos, Santiago, Salvador, Fernando, Dura, Xavier, Miarons, Marta, Anton, Andres, Eremiev-Eremiev, Simeon, Sempere-Gonzalez, Abiu, Monforte-Pallares, Arnau et al.
DOI: 10.1016/j.medcli.2021.06.012

Outcomes of the SARS-CoV-2 omicron (B.1.1.529) variant outbreak among vaccinated and unvaccinated patients with cancer in Europe: results from the retrospective, multicentre, OnCovid registry study.

PMID: 35660139
Journal: LANCET ONCOLOGY
Year: 2022
Reference: Lancet Oncol. 2022 Jul;23(7):865-875. doi: 10.1016/S1470-2045(22)00273-X. Epub 2022 Jun 2.
Impact factor: 41.316
Publication type: Paper in international publication
Authors: Earnshaw, Irina, Handford, Jasmine, Sita-Lumsden, Ailsa, Apthorp, Eleanor, Vincenzi, Bruno, Bertuzzi, Alexia, Brunet, Joan, Lambertini, Matteo, Maluquer, Clara, Pedrazzoli, Paolo et al.
DOI: 10.1016/S1470-2045(22)00273-X

Cytokine response as a biomarker for early diagnosis and outcome prediction of stem cell transplant recipients and acute leukemia patients with invasive aspergillosis.

PMID: 35652817
Journal: MEDICAL MYCOLOGY
Year: 2022
Reference: Med Mycol. 2022 Jun 2. pii: 6598867. doi: 10.1093/mmy/myac038.
Impact factor: 4.076
Publication type: Paper in international publication
Authors: Puerta-Alcalde, Pedro, Ruiz-Camps, Isabel, Gudiol, Carlota, Salavert, Miquel, Barba, Pere, Morandeira, Francisco, Jarque, Isidro, Cuervo, Guillermo, Ayats, Josefina, Carratala, Jordi et al.
DOI: 10.1093/mmy/myac038

Pilot hepatitis C micro-elimination strategy in Pakistani migrants in Catalonia through a community intervention.

PMID: 35635535
Journal: LIVER INTERNATIONAL
Year: 2022
Reference: Liver Int. 2022 May 30. doi: 10.1111/liv.15327.
Impact factor: 5.828
Publication type: Paper in international publication
Authors: Martro, Elisa, Ouaarab, Hakima, Saludes, Veronica, Buti, Maria, Trevino, Begona, Roade, Luisa, Egea-Cortes, Laia, Reyes-Urena, Juliana, Not, Anna, Majo, Xavier et al.
DOI: 10.1111/liv.15327

Redefining therapeutic success in HIV patients: an expert view.

PMID: 34077524
Journal: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Year: 2021
Reference: J Antimicrob Chemother. 2021 Sep 15;76(10):2501-2518. doi: 10.1093/jac/dkab168.
Impact factor: 5.79
Publication type: Review in international publication
Authors: Antela, Antonio, Rivero, Antonio, Llibre, Josep M, Moreno, Santiago, Antela, Antonio, Llibre, Josep M, Moreno, Santiago, Rivero, Antonio, Alonso Montero, Marta, Bernal, Enrique et al.
DOI: 10.1093/jac/dkab168

Incidence and predictive biomarkers of Clostridioides difficile infection in hospitalized patients receiving broad-spectrum antibiotics.

PMID: 33854064
Journal: Nature Communications
Year: 2021
Reference: Nat Commun. 2021 Apr 14;12(1):2240. doi: 10.1038/s41467-021-22269-y.
Impact factor: 14.919
Publication type: Paper in international publication
Authors: Mentre, France, van Werkhoven, Cornelis H, Ducher, Annie, Berkell, Matilda, Mysara, Mohamed, Lammens, Christine, Torre-Cisneros, Julian, Rodriguez-Bano, Jesus, Herghea, Delia, Cornely, Oliver A et al.
DOI: 10.1038/s41467-021-22269-y

Microbiota-based markers predictive of development of Clostridioides difficile infection.

PMID: 33854066
Journal: Nature Communications
Year: 2021
Reference: Nat Commun. 2021 Apr 14;12(1):2241. doi: 10.1038/s41467-021-22302-0.
Impact factor: 14.919
Publication type: Paper in international publication
Authors: Berkell, Matilda, Mysara, Mohamed, Xavier, Basil Britto, van Werkhoven, Cornelis H, Monsieurs, Pieter, Lammens, Christine, Ducher, Annie, Vehreschild, Maria J G T, Goossens, Herman, de Gunzburg, Jean et al.
DOI: 10.1038/s41467-021-22302-0

Natural influenza infection produces a greater diversity of humoral responses than vaccination in immunosuppressed transplant recipients.

PMID: 33484237
Journal: AMERICAN JOURNAL OF TRANSPLANTATION
Year: 2021
Reference: Am J Transplant. 2021 Aug;21(8):2709-2718. doi: 10.1111/ajt.16503. Epub 2021 Feb 18.
Impact factor: 8.086
Publication type: Paper in international publication
Authors: Hirzel, Cedric, Chruscinski, Andrzej, Ferreira, Victor H, L'Huillier, Arnaud G, Natori, Yochiro, Han, Sang H, Cordero, Elisa, Humar, Atul, Kumar, Deepali, Influenza in Transplant Study Group et al.
DOI: 10.1111/ajt.16503

Executive summary of the Consensus Statement of the Transplant Infection Study Group (GESITRA) of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) and the National Transplant Organization (ONT) on the Selection Criteria of Donors of Solid Organs in relation to Infectious Diseases.

PMID: 31870646
Journal: ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
Year: 2020
Reference: Enferm Infecc Microbiol Clin. 2020 Oct;38(8):379-389. doi: 10.1016/j.eimc.2019.10.016. Epub 2019 Dec 24.
Impact factor: 1.654
Publication type: Paper in national publication
Authors: Dominguez-Gil, Beatriz, Vidal, Elisa, San-Juan, Rafael, Pumarola, Tomas, Los-Arcos, Ibai, Aguado, Jose Maria, Blanes, Marino, Bodro, Marta, Carratala, Jordi, Cordero, Elisa et al.
DOI: 10.1016/j.eimc.2019.10.016

Reducing infectious complications after allogeneic stem cell transplant.

PMID: 32996342
Journal: Expert Review of Hematology
Year: 2020
Reference: Expert Rev Hematol. 2020 Nov;13(11):1235-1251. doi: 10.1080/17474086.2020.1831382. Epub 2020 Nov 3.
Impact factor: 2.573
Publication type: Review in international publication
Authors: Bacigalupo, Andrea, Metafuni, Elisabetta, Amato, Viviana, Marquez Algaba, Ester, Pagano, Livio et al.
DOI: 10.1080/17474086.2020.1831382

Comparison of DNA extraction methods and real-time PCR assays for the molecular diagnostics of chronic Chagas disease.

PMID: 32954845
Journal: Future Microbiology
Year: 2020
Reference: Future Microbiol. 2020 Aug;15:1139-1145. doi: 10.2217/fmb-2020-0023.
Impact factor: 2.907
Publication type: Paper in international publication
Authors: Silgado, Aroa, Moure, Zaira, de Oliveira, Maykon T, Serre-Delcor, Nuria, Salvador, Fernando, Oliveira, Ines, Molina, Israel, Pumarola, Tomas, Ramirez, Juan C, Sulleiro, Elena et al.
DOI: 10.2217/fmb-2020-0023

Primary resistance to integrase strand transfer inhibitors in Spain using ultrasensitive HIV-1 genotyping.

PMID: 32929472
Journal: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Year: 2020
Reference: J Antimicrob Chemother. 2020 Dec 1;75(12):3517-3524. doi: 10.1093/jac/dkaa349.
Impact factor: 5.439
Publication type: Paper in international publication
Authors: Del, Maria, Paredes, R, Santos, Jose R, Bravo, Isabel, Chamorro, Anna, Miranda, Cristina, Mican, Rafael, Gonzalez, Juan, Antela, Antonio, Diez, Marcos et al.
DOI: 10.1093/jac/dkaa349

External validation of the INCREMENT-CPE mortality score in a carbapenem-resistant Klebsiella pneumoniae bacteraemia cohort: the prognostic significance of colistin resistance.

PMID: 31377343
Journal: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
Year: 2019
Reference: Int J Antimicrob Agents. 2019 Oct;54(4):442-448. doi: 10.1016/j.ijantimicag.2019.07.017. Epub 2019 Aug 1.
Impact factor: 4.615
Publication type: Paper in international publication
Authors: Paterson, David, Pascual, Alvaro, Martinez-Martinez, Luis, Rodriguez-Bano, Jesus, Torre-Cisneros, Julian, Almirante Gragera, Benito, Larrosa Escartin, María Nieves, Puig Asensio, Mireia, REIPI ESGBIS INCREMENT Grp, Carmeli, Yehuda et al.
DOI: 10.1016/j.ijantimicag.2019.07.017

Molecular diagnosis of Pneumocystis jirovecii pneumonia using oral wash samples in immunocompromised patients: usefulness and importance of the DNA target.

PMID: 31578265
Journal: JOURNAL OF CLINICAL MICROBIOLOGY
Year: 2019
Reference: J Clin Microbiol. 2019 Nov 22;57(12). pii: JCM.01287-19. doi: 10.1128/JCM.01287-19. Print 2019 Dec.
Impact factor: 4.959
Publication type: Paper in international publication
Authors: Goterris, Lidia, Fernandez, M A Mancebo, Aguilar-Company, Juan, Falco, Vicenc, Ruiz-Camps, Isabel, Martin-Gomez, M Teresa et al.
DOI: 10.1128/JCM.01287-19

Executive summary of clinical practice guideline for the management of invasive diseases caused by Aspergillus: 2018 Update by the GEMICOMED-SEIMC/REIPI.

PMID: 29960829
Journal: ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
Year: 2019
Reference: Enferm Infecc Microbiol Clin. 2019 Oct;37(8):535-541. doi: 10.1016/j.eimc.2018.03.018. Epub 2018 Jun 28.
Impact factor: 1.685
Publication type: Paper in national publication
Authors: Gavalda, Joan, Gudiol, Carlota, Guinea, Jesus, Gomez-Lopez, Alicia, Munoz, Patricia, Peman, Javier, Rovira, Montserrat, Ruiz-Camps, Isabel, Cuenca-Estrella, Manuel, Garnacho-Montero, Jose et al.
DOI: 10.1016/j.eimc.2018.03.018

Switching from a protease inhibitor-based regimen to a dolutegravir-based regimen: a randomized clinical trial to determine the effect on peripheral blood and ileum biopsies from ART-suppressed HIV-infected individuals.

PMID: 30590412
Journal: CLINICAL INFECTIOUS DISEASES
Year: 2019
Reference: Clin Infect Dis. 2019 Sep 27;69(8):1320-1328. doi: 10.1093/cid/ciy1095.
Impact factor: 9.055
Publication type: Paper in international publication
Authors: Martinez-Picado, Javier, Moron-Lopez, Sara, Navarro, Jordi, Jimenez, Montse, Rutsaert, Sofie, Urrea, Victor, Puertas, Maria C, Torrella, Ariadna, Clercq, Laura De, Ribas, Bibiana Planas et al.
DOI: 10.1093/cid/ciy1095

Effectiveness of a Double-Carbapenem Regimen in a KPC-Producing Klebsiella pneumoniae Infection in an Immunocompromised Patient.

PMID: 28708458
Journal: Microbial Drug Resistance
Year: 2018
Reference: Microb Drug Resist. 2018 Mar;24(2):199-202. doi: 10.1089/mdr.2017.0129. Epub 2017 Jul 14.
Impact factor: 2.344
Publication type: Paper in international publication
Authors: Piedra-Carrasco, Nuria, Miguel, Lucia, Fabrega, Anna, Vinado, Belen, Campany, David, Mir, Alba, Fox, Maria Laura, Almirante, Benito, Larrosa, Nieves, Ruiz-Camps, Isabel et al.
DOI: 10.1089/mdr.2017.0129

A Five-year Prospective Multi-center Evaluation of Influenza Infection in Transplant Recipients.

PMID: 29635437
Journal: CLINICAL INFECTIOUS DISEASES
Year: 2018
Reference: Clin Infect Dis. 2018 Oct 15;67(9):1322-1329. doi: 10.1093/cid/ciy294.
Impact factor: 9.117
Publication type: Paper in international publication
Authors: Montejo, Miguel, Lopez-Medrano, Francisco, Farinas, Maria Carmen, Gavalda, Joan, Moreno, Asuncion, Levi, Marilyn, Fortun, Jesus, Torre-Cisneros, Julian, Englund, Janet A, Natori, Yoichiro et al.
DOI: 10.1093/cid/ciy294

Comparison of Predictors and Mortality Between Bloodstream Infections Caused by ESBL-Producing Escherichia coli and ESBL-Producing Klebsiella pneumoniae.

PMID: 29618394
Journal: INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
Year: 2018
Reference: Infect Control Hosp Epidemiol. 2018 Jun;39(6):660-667. doi: 10.1017/ice.2018.63. Epub 2018 Apr 5.
Impact factor: 3.084
Publication type: Paper in international publication
Authors: Scheuerman, Oded, Schechner, Vered, Carmeli, Yehuda, Gutierrez-Gutierrez, Belen, Calbo, Esther, Almirante, Benito, Viale, Pier-Luigy, Oliver, Antonio, Ruiz-Garbajosa, Patricia, Gasch, Oriol et al.
DOI: 10.1017/ice.2018.63

Ceftolozane/tazobactam for the treatment of XDR Pseudomonas aeruginosa infections.

PMID: 29594953
Journal: INFECTION
Year: 2018
Reference: Infection. 2018 Aug;46(4):461-468. doi: 10.1007/s15010-018-1133-5. Epub 2018 Mar 28.
Impact factor: 2.773
Publication type: Paper in international publication
Authors: Escola-Verge, Laura, Pigrau, Carles, Los-Arcos, Ibai, Arevalo, Angel, Vinado, Belen, Campany, David, Larrosa, Nieves, Nuvials, Xavier, Ferrer, Ricard, Len, Oscar et al.
DOI: 10.1007/s15010-018-1133-5

Assessment of the influence of direct tobacco smoke on infection and active TB management.

PMID: 28837570
Journal: PLoS One
Year: 2017
Reference: PLoS One. 2017 Aug 24;12(8):e0182998. doi: 10.1371/journal.pone.0182998. eCollection 2017.
Impact factor: 2.806
Publication type: Paper in international publication
Authors: Latorre, Irene, Altet, Neus, Jimenez-Fuentes, Maria Angeles, Maldonado, Jose, Molina, Israel, Gonzalez-Diaz, Yoel, Mila, Celia, Garcia-Garcia, Esther, Muriel, Beatriz, Villar-Hernandez, Raquel et al.
DOI: 10.1371/journal.pone.0182998

Prevalence of Strongyloides stercoralis and Other Intestinal Parasite Infections in School Children in a Rural Area of Angola: A Cross-Sectional Study.

PMID: 28820707
Journal: AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
Year: 2017
Reference: Am J Trop Med Hyg. 2017 Oct;97(4):1226-1231. doi: 10.4269/ajtmh.17-0159. Epub 2017 Aug 18.
Impact factor: 2.549
Publication type: Paper in international publication
Authors: Moreno, Milagros, de Alegria Aznar, Maria Luisa Ruiz, Colmenares, Karen, Espasa, Mateu, Amor, Arancha, Lopez, Isabel, Ninda, Arlette, Kanjala, Joaquina, Guilherme, Domingas, Sulleiro, Elena et al.
DOI: 10.4269/ajtmh.17-0159

18F-FDG-PET/CT angiography in the diagnosis of infective endocarditis and cardiac device infection in adult patients with congenital heart disease and prosthetic material.

PMID: 28807509
Journal: INTERNATIONAL JOURNAL OF CARDIOLOGY
Year: 2017
Reference: Int J Cardiol. 2017 Dec 1;248:396-402. doi: 10.1016/j.ijcard.2017.08.008. Epub 2017 Aug 9.
Impact factor: 6.189
Publication type: Paper in international publication
Authors: Pizzi, Maria N, Dos-Subira, L, Roque, Albert, Fernandez-Hidalgo, Nuria, Cuellar-Calabria, Hug, Pijuan Domenech, Antonia, Gonzalez-Alujas, Maria T, Subirana-Domenech, M T, Miranda-Barrio, B, Ferreira-Gonzalez, Ignacio et al.
DOI: 10.1016/j.ijcard.2017.08.008

Outbreak of intestinal amoebiasis among men who have sex with men, Barcelona (Spain), October 2016 and January 2017.

PMID: 28797327
Journal: Eurosurveillance
Year: 2017
Reference: Euro Surveill. 2017 Jul 27;22(30). pii: 30581. doi: 10.2807/1560-7917.ES.2017.22.30.30581.
Impact factor: 7.202
Publication type: Paper in international publication
Authors: Sulleiro, Elena, Escola-Verge, Laura, Arando, Maider, Vall, Marti, Rovira, Roger, Espasa, Mateu, Barbera, Maria-Jesus, Zarzuela, Francesc, Armengol, Pere et al.
DOI: 10.2807/1560-7917.ES.2017.22.30.30581

Reduced darunavir dose is as effective in maintaining HIV suppression as the standard dose in virologically suppressed HIV-infected patients: a randomized clinical trial.

PMID: 25525195
Journal: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Year: 2015
Reference: J Antimicrob Chemother. 2015 Apr;70(4):1139-45. doi: 10.1093/jac/dku516. Epub 2014 Dec 18.
Impact factor: 5.313
Publication type: Paper in international publication
Authors: Molto, Jose, Valle, Marta, Ferrer, Elena, Domingo, Pere, Curran, Adrian, Santos, Jose Ramon, Mateo, Maria Gracia, Di Yacovo, Maria Silvana, Miranda, Cristina, Podzamczer, Daniel et al.
DOI: 10.1093/jac/dku516

Impact of influenza season and environmental factors on the clinical presentation and outcome of invasive pneumococcal disease.

PMID: 25109886
Journal: EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
Year: 2015
Reference: Eur J Clin Microbiol Infect Dis. 2015 Jan;34(1):177-86. doi: 10.1007/s10096-014-2221-9. Epub 2014 Aug 12.
Impact factor: 2.668
Publication type: Paper in international publication
Authors: Burgos, J, Larrosa, M N, Martinez, A, Belmonte, J, Gonzalez-Lopez, J, Rello, J, Pumarola, T, Pahissa, A, Falco, V et al.
DOI: 10.1007/s10096-014-2221-9

Influence of Virulence Genotype and Resistance Profile in the Mortality of Pseudomonas aeruginosa Bloodstream Infections.

PMID: 25378459
Journal: CLINICAL INFECTIOUS DISEASES
Year: 2015
Reference: Clin Infect Dis. 2015 Feb 15;60(4):539-48. doi: 10.1093/cid/ciu866. Epub 2014 Nov 6.
Impact factor: 8.886
Publication type: Paper in international publication
Authors: Rodriguez-Bano, Jesus, Rodriguez-Lopez, Fernando, Tubau, Fe, Martinez-Martinez, Luis, Oliver, Antonio, Calbo, Esther, Granados, Ana, Pomar, Virginia, Pena, Carmen, Cabot, Gabriel et al.
DOI: 10.1093/cid/ciu866

Ventilator-associated respiratory infection following lung transplantation.

PMID: 25359351
Journal: EUROPEAN RESPIRATORY JOURNAL
Year: 2015
Reference: Eur Respir J. 2015 Mar;45(3):726-37. doi: 10.1183/09031936.00095214. Epub 2014 Oct 30.
Impact factor: 7.636
Publication type: Paper in international publication
Authors: Riera, Jordi, Caralt, Berta, Lopez, Iker, Augustin, Salvador, Roman, Antonio, Gavalda, Joan, Rello, Jordi et al.
DOI: 10.1183/09031936.00095214

Blog

News

The meeting was an opportunity to get to know projects from both institutions and to promote interaction between professionals.

On European Antibiotic Awareness Day, we highlight the importance of using these medications responsibly and finding innovative solutions to combat this issue.

Vall d'Hebron has coordinated this initiative that has carried out numerous training and community awareness activities aimed at empowering young people in sexual and reproductive health issues.