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Microbiology

The Microbiology research group of the Vall d'Hebron Research Institute (VHIR) focuses on the study of microbiological aspects —in basic, translational and clinical research— that could improve the outcome of patients with infectious diseases.

Our priority research areas are:

  • Microbiological surveillance of emerging and re-emerging infectious diseases.
    • Diseases due to viral infections of the respiratory tract
    • Microorganisms that cause vaccine-preventable diseases
    • Infectious diseases of sexual transmission
  • Antimicrobial resistance
  • Sepsis
  • Development and validation of rapid microbiological diagnostic devices.
  • International Health
  • Hepatitis 

We actively collaborate with other microbiology laboratories, health services, national and international centres and organizations, as well as with the different research networks of the Carlos III Health Institute in Spain.

In addition, we carry out an important activity in the surveillance of the genotypic and phenotypic evolution of microorganisms present in the community in terms of their virulence, transmissibility, antigenic escape and antimicrobial resistance, in collaboration with public administrations, both at the national and international level.
 

Publications

Clinical evaluation of the Procleix SARS-CoV-2 assay, a sensitive, high-throughput test that runs on an automated system.

PMID: 34688036
Journal: DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
Year: 2022
Reference: Diagn Microbiol Infect Dis. 2022 Jan;102(1):115560. doi: 10.1016/j.diagmicrobio.2021.115560. Epub 2021 Sep 25.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso-Hernandez, Lorena; Anton, Andres; Bes, Marta; Bres, Vanessa; Entrena, Edurne; Gurrola, Adrian; Linnen, Jeffrey M; Marimon, Jose Maria; Minguez-Micolau, Antonio M; Palacios, Lourdes et al.
DOI: 10.1016/j.diagmicrobio.2021.115560

The frequency of defective genomes in Omicron differs from that of the Alpha, Beta and Delta variants.

PMID: 36581627
Journal: Scientific Reports
Year: 2022
Reference: Sci Rep. 2022 Dec 29;12(1):22571. doi: 10.1038/s41598-022-24918-8.
Impact factor:
Publication type: Paper in international publication
Authors: Adombi, Caroline Melanie; Andres, Cristina; Anton, Andres; Borras, Blanca; Campos, Carolina; Codina, Maria Gema; Colomer-Castell, Sergi; Esperalba, Juliana; Esteban, Juan Ignacio; Garcia-Cehic, Damir et al.
DOI: 10.1038/s41598-022-24918-8

Molecular Diagnosis of Endemic Mycoses.

PMID: 36675880
Journal: Journal of Fungi
Year: 2022
Reference: J Fungi (Basel). 2022 Dec 30;9(1):59. doi: 10.3390/jof9010059.
Impact factor:
Publication type: Review in international publication
Authors: Buitrago, Maria Jose; Martin-Gomez, Maria Teresa; Valero, Clara et al.
DOI: 10.3390/jof9010059

Chimeric Human Papillomavirus-16 Virus-like Particles Presenting P18I10 and T20 Peptides from HIV-1 Envelope Induce HPV16 and HIV-1-Specific Humoral and T Cell-Mediated Immunity in BALB/c Mice.

PMID: 36679860
Journal: Vaccines
Year: 2022
Reference: Vaccines (Basel). 2022 Dec 21;11(1):15. doi: 10.3390/vaccines11010015.
Impact factor:
Publication type: Paper in international publication
Authors: Chen, Chun-Wei; Joseph-Munne, Joan; Kilpelainen, Athina; Saubi, Narcis et al.
DOI: 10.3390/vaccines11010015

COVID-19 in Solid Organ Transplantation: A Matched Retrospective Cohort Study and Evaluation of Immunosuppression Management.

PMID: 32941394
Journal: TRANSPLANTATION
Year: 2021
Reference: Transplantation. 2021 Jan 1;105(1):138-150. doi: 10.1097/TP.0000000000003460.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso-Martinez, Carla; Anton, Andres; Berastegui, Cristina; Castells, Lluis; Del-Rio-Gutierrez, Jose-Manuel; Domenech, Laura; Garcia-Garcia, Sonia; Garcia-Ortega, Patricia; Gomez-Ganda, Laura; Gorgas-Torner, Maria-Queralt et al.
DOI: 10.1097/TP.0000000000003460

Sarilumab in patients admitted to hospital with severe or critical COVID-19: a randomised, double-blind, placebo-controlled, phase 3 trial.

PMID: 33676590
Journal: Lancet Respiratory Medicine
Year: 2021
Reference: Lancet Respir Med. 2021 May;9(5):522-532. doi: 10.1016/S2213-2600(21)00099-0. Epub 2021 Mar 4.
Impact factor: 30.7
Publication type: Paper in international publication
Authors: Silvio, Javier P, Scublinsky, Dario G, Bales, Alessandra, Catarino, Daniela, Fiss, Elie, Mohrbacher, Sara, Sato, Victor, Baylao, Antonio, Cavalcante, Adilson, Correa, Francini et al.
DOI: 10.1016/S2213-2600(21)00099-0

Acute bronchiolitis and respiratory syncytial virus seasonal transmission during the COVID-19 pandemic in Spain: A national perspective from the pediatric Spanish Society (AEP).

PMID: 34781241
Journal: JOURNAL OF CLINICAL VIROLOGY
Year: 2021
Reference: J Clin Virol. 2021 Dec;145:105027. doi: 10.1016/j.jcv.2021.105027. Epub 2021 Nov 9.
Impact factor: 3.168
Publication type: Paper in international publication
Authors: Torres-Fernandez, David, Casellas, Aina, Mellado, Maria Jose, Calvo, Cristina, Bassat, Quique, Vila Soler, Jorgina, Antón Pagarolas, Andres et al.
DOI: 10.1016/j.jcv.2021.105027

Rhinovirus prevalence as indicator for efficacy of measures against SARS-CoV-2.

PMID: 34154549
Journal: BMC PUBLIC HEALTH
Year: 2021
Reference: BMC Public Health. 2021 Jun 21;21(1):1178. doi: 10.1186/s12889-021-11178-w.
Impact factor: 3.295
Publication type: Paper in international publication
Authors: Respiratory Virus Network, Kitanovski, Simo, Horemheb-Rubio, Gibran, Adams, Ortwin, Gartner, Barbara, Lengauer, Thomas, Hoffmann, Daniel, Kaiser, Rolf, et al.
DOI: 10.1186/s12889-021-11178-w

The value of the continuous genotyping of multi-drug resistant tuberculosis over 20 years in Spain.

PMID: 33235225
Journal: Scientific Reports
Year: 2020
Reference: Sci Rep. 2020 Nov 24;10(1):20433. doi: 10.1038/s41598-020-77249-x.
Impact factor: 3.998
Publication type: Paper in international publication
Authors: Aldea, M J, Ruiz, I, Garcia, P, Lopez, M D, Cardenoso, L, de la Calle, I Jesus, Ruiz, P, Alados, J C, Roman, J, Villa-Real, R et al.
DOI: 10.1038/s41598-020-77249-x

Efficacy and safety of hydroxychloroquine in healthcare professionals with mild SARS-CoV-2 infection: Prospective, non-randomized trial.

PMID: 33413989
Journal: ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
Year: 2020
Reference: Enferm Infecc Microbiol Clin (Engl Ed). 2020 Dec 9. pii: S0213-005X(20)30413-4. doi: 10.1016/j.eimc.2020.10.023.
Impact factor: 1.654
Publication type: Paper in national publication
Authors: Alonso, Manuel, Espuga, Meritxell, Esperalba, Juliana, Gorgas, M feminine Queralt, Almirante, Benito, Ribera, Esteban, Andres, Cristina, Vidal, Xavier, Anton, Andres, Agusti, Antonia et al.
DOI: 10.1016/j.eimc.2020.10.023

Zika Virus Infection in Tourists Travelling to Thailand: Case Series Report.

PMID: 33379281
Journal: Tropical medicine and infectious disease
Year: 2020
Reference: Trop Med Infect Dis. 2020 Dec 28;6(1). pii: tropicalmed6010003. doi: 10.3390/tropicalmed6010003.
Impact factor: 0
Publication type: Letter or abstract
Authors: Espiau, Maria, Pou, Diana, Silgado, Aroa, Suy, Anna, Pumarola, Tomas, Soler-Palacin, Pere, Soriano-Arandes, Antoni, Rodo, Carlota, Sulleiro, Elena, Romani, Natalia et al.
DOI: 10.3390/tropicalmed6010003

[Serogroup C invasive meningococcal disease in the post-vaccine era and vaccine failures authors reply].

PMID: 33390356
Journal: ANALES DE PEDIATRIA
Year: 2020
Reference: An Pediatr (Barc). 2020 Dec 31. pii: S1695-4033(20)30477-X. doi: 10.1016/j.anpedi.2020.10.018.
Impact factor: 1.313
Publication type: Letter or abstract
Authors: Iglesias, Tamara, Esperalba, Juliana, Moraga-Llop, Fernando A, Soler-Palacin, Pere, Fernandez-San Jose, Carolina, Lung, Mayli, Rius, Neus et al.
DOI: 10.1016/j.anpedi.2020.10.018

The Role of Molecular Techniques for the Detection of Mycobacterium Tuberculosis Complex in Paraffin-embedded Biopsies.

PMID: 28549036
Journal: APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
Year: 2019
Reference: Appl Immunohistochem Mol Morphol. 2019 Jan;27(1):77-80. doi: 10.1097/PAI.0000000000000533.
Impact factor:
Publication type: Paper in international publication
Authors: Castellvi, Josep; Moure, Zaira; Pumarola, Tomas; Sanchez-Montalva, Adrian; Tortola, M Teresa et al.
DOI: 10.1097/PAI.0000000000000533

Is antibody-mediated rejection in kidney transplant recipients a risk factor for developing cytomegalovirus or BK virus infection? Results from a case-control study.

PMID: 30537648
Journal: JOURNAL OF CLINICAL VIROLOGY
Year: 2019
Reference: J Clin Virol. 2019 Jan;110:45-50. doi: 10.1016/j.jcv.2018.11.010. Epub 2018 Dec 1.
Impact factor:
Publication type: Paper in international publication
Authors: Codina, Gemma; Esperalba, Juliana; Gavalda, Joan; Len, Oscar; Los-Arcos, Ibai; Moreso, Francesc; Perello, Manel; Sellares, Joana; Seron, Daniel; Torres, Irina B et al.
DOI: 10.1016/j.jcv.2018.11.010

Surveillance of enteroviruses from paediatric patients attended at a tertiary hospital in Catalonia from 2014 to 2017.

PMID: 30530096
Journal: JOURNAL OF CLINICAL VIROLOGY
Year: 2019
Reference: J Clin Virol. 2019 Jan;110:29-35. doi: 10.1016/j.jcv.2018.11.004. Epub 2018 Nov 30.
Impact factor:
Publication type: Paper in international publication
Authors: Alcubilla, Pilar; Andres, Cristina; Anton, Andres; Barnes, Meritxell; Codina, Maria Gema; Esperalba, Juliana; Fuentes, Francisco; Gimferrer, Laura; Martin, Maria Carmen; Pinana, Maria et al.
DOI: 10.1016/j.jcv.2018.11.004

High-dose benznidazole in a 62-year-old Bolivian kidney transplant recipient with Chagas central nervous system involvement.

PMID: 30391324
Journal: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
Year: 2019
Reference: Int J Infect Dis. 2019 Jan;78:103-106. doi: 10.1016/j.ijid.2018.10.014. Epub 2018 Oct 25.
Impact factor:
Publication type: Paper in international publication
Authors: Avalos Esquivel, J L; Crespo, M; Garcia Lopez, E; Grau, S; Horcajada, J P; Lopez Montesinos, I; Mir, M; Molina-Morant, D; Monge, I; Montero, M et al.
DOI: 10.1016/j.ijid.2018.10.014

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