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Microbiology

The Microbiology research group of the Vall d'Hebron Research Institute (VHIR) focuses on the study of microbiological aspects —in basic, translational and clinical research— that could improve the outcome of patients with infectious diseases.

Our priority research areas are:

  • Microbiological surveillance of emerging and re-emerging infectious diseases.
    • Diseases due to viral infections of the respiratory tract
    • Microorganisms that cause vaccine-preventable diseases
    • Infectious diseases of sexual transmission
  • Antimicrobial resistance
  • Sepsis
  • Development and validation of rapid microbiological diagnostic devices.
  • International Health
  • Hepatitis 

We actively collaborate with other microbiology laboratories, health services, national and international centres and organizations, as well as with the different research networks of the Carlos III Health Institute in Spain.

In addition, we carry out an important activity in the surveillance of the genotypic and phenotypic evolution of microorganisms present in the community in terms of their virulence, transmissibility, antigenic escape and antimicrobial resistance, in collaboration with public administrations, both at the national and international level.
 

Publications

Safety of Rifampicin at High Dose for Difficult-to-Treat Tuberculosis: Protocol for RIAlta Phase 2b/c Trial.

PMID: 36678638
Journal: Pharmaceutics
Year: 2022
Reference: Pharmaceutics. 2022 Dec 20;15(1):9. doi: 10.3390/pharmaceutics15010009.
Impact factor:
Publication type: Paper in international publication
Authors: Aguirre, Sarita; Akkerman, Onno W; Alffenaar, Jan-Willem C; Battaglia, Arturo; Espinosa-Pereiro, Juan; Ghimire, Samiksha; Magis-Escurra, Cecile; Molinas, Gladys; Sanchez-Montalva, Adrian; Sturkenboom, Marieke G G et al.
DOI: 10.3390/pharmaceutics15010009

Corrigendum: Transmissibility, hospitalization, and intensive care admissions due to omicron compared to delta variants of SARS-CoV-2 in Catalonia: A cohort study and ecological analysis.

PMID: 36743167
Journal: Frontiers in Public Health
Year: 2022
Reference: Front Public Health. 2022 Nov 3;10:1060328. doi: 10.3389/fpubh.2022.1060328. eCollection 2022.
Impact factor:
Publication type: Letter or abstract
Authors: Alonso, Sergio; Alvarez-Lacalle, Enrique; Andres, Cristina; Anton, Andres; Blanco, Ignacio; Bordoy, Antoni E; Cardona, Pere-Joan; Catala, Marti; Coma, Ermengol; Fina, Francesc et al.
DOI: 10.3389/fpubh.2022.1060328

Pulmonary Cryptococcosis Mimicking Lung Cancer

PMID: NOPMID0099
Journal: Open Respiratory Archives
Year: 2022
Reference: Open Respir Arch. 2022;4(2):100154. doi:10.1016/j.opresp.2021.100154
Impact factor:
Publication type: Letter whit IF
Authors: Eremiev, Simeon; Espejo, David; Martín-Gómez, Maria Teresa; Ojanguren, Iñigo; Pilia, Maria Florencia; Ruiz, Isabel; Sempere, Abiu et al.
DOI: 10.1016/j.opresp.2021.100154

Clinical evaluation of the Procleix SARS-CoV-2 assay, a sensitive, high-throughput test that runs on an automated system.

PMID: 34688036
Journal: DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
Year: 2022
Reference: Diagn Microbiol Infect Dis. 2022 Jan;102(1):115560. doi: 10.1016/j.diagmicrobio.2021.115560. Epub 2021 Sep 25.
Impact factor: 2.803
Publication type: Paper in international publication
Authors: Sauleda, Silvia; Palacios, Lourdes; Bres, Vanessa; Pinana, Maria; Alonso-Hernandez, Lorena; Bes, Marta; Piron, Maria; Entrena, Edurne; Gurrola, Adrian; Soria, Gloria et al.
DOI: 10.1016/j.diagmicrobio.2021.115560

Polyresistant Mycobacterium bovis Infection in Human and Sympatric Sheep, Spain, 2017-2018.

PMID: 33755008
Journal: EMERGING INFECTIOUS DISEASES
Year: 2021
Reference: Emerg Infect Dis. 2021 Apr;27(4):1241-1243. doi: 10.3201/eid2704.204467.
Impact factor: 6.883
Publication type: Letter whit IF
Authors: de Val, Bernat Perez, Romero, Beatriz, Tortola, Maria Teresa, Leon, Laura Herrera, Pozo, Pilar, Mercader, Irene, Saez, Jose Luis, Domingo, Mariano, Vidal, Enric et al.
DOI: 10.3201/eid2704.204467

[Screening for strongyloidiasis in Spain in the context of the SARS-CoV-2 pandemic: results of a survey on diagnosis and treatment].

PMID: 34931102
Journal: ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
Year: 2021
Reference: Enferm Infecc Microbiol Clin. 2021 Dec 15. pii: S0213-005X(21)00386-4. doi: 10.1016/j.eimc.2021.11.010.
Impact factor: 1.731
Publication type: Paper in national publication
Authors: Rodriguez-Guardado, Azucena, Alvarez-Martinez, Miriam J, Flores, Maria Delmans, Sulleiro, Elena, Torrus-Tendero, Diego, Velasco, Maria, Membrillo, Francisco Javier et al.
DOI: 10.1016/j.eimc.2021.11.010

Cross-sectional evaluation of circulating hepatitis B virus RNA and DNA: Different quasispecies?

PMID: 34887634
Journal: WORLD JOURNAL OF GASTROENTEROLOGY
Year: 2021
Reference: World J Gastroenterol. 2021 Nov 7;27(41):7144-7158. doi: 10.3748/wjg.v27.i41.7144.
Impact factor: 5.742
Publication type: Paper in international publication
Authors: Garcia-Garcia, Selene, Cortese, Maria Francesca, Tabernero, David, Gregori, Josep, Vila, Marta, Pacin, Beatriz, Quer, Josep, Casillas, Rosario, Castillo-Ribelles, Laura, Ferrer-Costa, Roser et al.
DOI: 10.3748/wjg.v27.i41.7144

Performance of QuantiFERON-TB Gold Plus assays in children and adolescents at risk of tuberculosis: a cross-sectional multicentre study.

PMID: 34876500
Journal: THORAX
Year: 2021
Reference: Thorax. 2021 Dec 7. pii: thoraxjnl-2021-217592. doi: 10.1136/thoraxjnl-2021-217592.
Impact factor: 9.25
Publication type: Paper in international publication
Authors: Soriano-Arandes, Antonio, Santiago, Begona, Tortola, Teresa, Ruiz-Serrano, Maria Jesus, Korta Murua, Jose Javier, Bustillo-Alonso, Matilde, Garrote-Llanos, Maria Isabel, Rodriguez-Molino, Paula, Piqueras, Ana Isabel, Tagarro, Alfredo et al.
DOI: 10.1136/thoraxjnl-2021-217592

Prevalence of asymptomatic SARS-CoV-2 infection in children undergoing hospital screening.

PMID: 33160709
Journal: ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
Year: 2020
Reference: Enferm Infecc Microbiol Clin. 2020 Oct 13. pii: S0213-005X(20)30316-5. doi: 10.1016/j.eimc.2020.10.004.
Impact factor: 1.654
Publication type: Letter whit IF
Authors: Soler-Palacin, Pere, Borras-Bermejo, Blanca, Anton, Andres, Soriano-Arandes, Antoni et al.
DOI: 10.1016/j.eimc.2020.10.004

Pneumococcal serotypes in children, clinical presentation and antimicrobial susceptibility in the PCV13 era.

PMID: 33148361
Journal: EPIDEMIOLOGY AND INFECTION
Year: 2020
Reference: Epidemiol Infect. 2020 Nov 5;148:e279. doi: 10.1017/S0950268820002708.
Impact factor: 2.152
Publication type: Paper in international publication
Authors: Uriona, S, Campins, M, Munoz-Almagro, C, Salleras, L, Dominguez, A, Planes, A M, Codina, G, Gonzalez-Peris, S, Fernandez de Sevilla, M, Izquierdo, C et al.
DOI: 10.1017/S0950268820002708

The Importance of Rapid Influenza Testing in Pediatric Primary Care: Experience During Three Consecutive Influenza Seasons (2016-2019) in Barcelona (Catalonia, Spain).

PMID: 33163462
Journal: Frontiers in Pediatrics
Year: 2020
Reference: Front Pediatr. 2020 Oct 8;8:565. doi: 10.3389/fped.2020.00565. eCollection 2020.
Impact factor: 2.634
Publication type: Paper in international publication
Authors: Andres, Cristina, Iglesias, Sheila, Ferrer, Josep, Losada, Lucia, Ricos, Gemma, Sanchez, Lorena, Morera, Patricia, Perez, Mar, Ferrandez, M feminine Angeles, Hernando, Esther et al.
DOI: 10.3389/fped.2020.00565

Consensus Multilocus Sequence Typing Scheme for Pneumocystis jirovecii.

PMID: 33143112
Journal: Journal of Fungi
Year: 2020
Reference: J Fungi (Basel). 2020 Oct 30;6(4). pii: jof6040259. doi: 10.3390/jof6040259.
Impact factor: 4.621
Publication type: Review in international publication
Authors: Martin-Gomez, M Teresa, Meyer, Wieland, Vargas, Sergio L, Ponce, Carolina A, Kan, Alex, Irinyi, Laszlo, Pasic, Lana, Goterris, Lidia, Guerrero-Murillo, Mercedes et al.
DOI: 10.3390/jof6040259

Author Correction: Combined quantification of procalcitonin and HLA-DR improves sepsis detection in surgical patients.

PMID: 30808978
Journal: Scientific Reports
Year: 2019
Reference: Sci Rep. 2019 Feb 27;9(1):3426. doi: 10.1038/s41598-019-39976-8.
Impact factor:
Publication type: Other (letters to the editor, abstracts, corrigendum, etc.)
Authors: Aldecoa, Cesar; Almansa, Raquel; Andres, Cristina; Aragon, Marta; Benavides, Diana; Bermejo-Martin, Jesus F; Calvo, Dolores; Calvo-Vecino, Jose Maria; de Cenarruzabeitia, Inigo Lopez; de Heredia, Juan Beltran et al.
DOI: 10.1038/s41598-019-39976-8

Twenty-nine Cases of Enterovirus-D68-associated Acute Flaccid Myelitis in Europe 2016: A Case Series and Epidemiologic Overview.

PMID: 30234793
Journal: PEDIATRIC INFECTIOUS DISEASE JOURNAL
Year: 2019
Reference: Pediatr Infect Dis J. 2019 Jan;38(1):16-21. doi: 10.1097/INF.0000000000002188.
Impact factor: 2.317
Publication type: Paper in international publication
Authors: Valli, Maria Beatrice, Rainetova, Petra, Midgley, Sofie, Fischer, Thea Kolsen, Simonlatser, Grethel, Savolainen-Kopra, Carita, Lina, Bruno, Schuffenecker, Isabelle, Kossorotoff, Manoelle, Antona, Denise et al.
DOI: 10.1097/INF.0000000000002188

Association between Pseudomonas aeruginosa O-antigen serotypes, resistance profiles and high-risk clones: results from a Spanish nationwide survey.

PMID: 31430372
Journal: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Year: 2019
Reference: J Antimicrob Chemother. 2019 Nov 1;74(11):3217-3220. doi: 10.1093/jac/dkz346.
Impact factor: 5.113
Publication type: Paper in international publication
Authors: Aspiroz, Carmen, de la Iglesia, Pedro, Ramon, Susana, Riera, Elena, Perez, Maria Cruz, Gallegos, Carmen, Calvo, Jorge, Quesada, Maria Dolores, Marco, Francesc, Hoyos, Yannick et al.
DOI: 10.1093/jac/dkz346

Spanish nationwide survey on Pseudomonas aeruginosa antimicrobial resistance mechanisms and epidemiology.

PMID: 30989186
Journal: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Year: 2019
Reference: J Antimicrob Chemother. 2019 Jul 1;74(7):1825-1835. doi: 10.1093/jac/dkz147.
Impact factor: 5.113
Publication type: Paper in international publication
Authors: Martin, Lina, Del Barrio-Tofino, Ester, Zamorano, Laura, Cortes-Lara, Sara, Lopez-Causape, Carla, Sanchez-Diener, Irina, Cabot, Gabriel, Bou, German, Martinez-Martinez, Luis, Oliver, Antonio et al.
DOI: 10.1093/jac/dkz147

Blog

News

The collaboration will focus on several key areas of mutual interest in microbiology in particular antimicrobial resistance and stewardship.

On European Antibiotic Awareness Day, we highlight the importance of using these medications responsibly and finding innovative solutions to combat this issue.

The new diagnostic method, designed for use in endemic regions, combines a mobile application with a low-cost robotic microscope.