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Nephrology and kidney transplantation

Our research group is accredited by the Agency for Management of University and Research Grants (AGAUR) in Catalonia, and focuses on two main areas of interest which are related to Solid Organ Transplantation and especially Kidney, and in clinical Nephrology. We tackle these areas from an innovative perspective, both basic-experimental and mechanistic, always with a translational goal. On the one hand, we investigate, develop, and use novel diagnostic and therapeutic technologies to decipher and target main molecular and immune mechanisms of transplant rejection as well as the immune susceptibility to opportunistic infections and malignancies. Also, a main task force of the group is devoted to better understand the main mechanisms involved in certain autoimmune glomerular diseases and idiopathic nephrotic syndrome as well as in diabetic kidney disease, having a specific interest in the role of the renin-angiotensin system. Our ultimate goal is to improve the management and care of patients suffering from kidney diseases as well as their quality of life, reducing associated morbidity and mortality.

Publications

Association of renin-angiotensin system blockers with COVID-19 diagnosis and prognosis in patients with hypertension: a population-based study.

PMID: 35035939
Journal: Clinical Kidney Journal
Year: 2022
Reference: Clin Kidney J. 2021 Sep 3;15(1):79-94. doi: 10.1093/ckj/sfab161. eCollection 2022 Jan.
Impact factor: 4.452
Publication type: Paper in international publication
Authors: Soler, Maria Jose, Ribera, Aida, Marsal, Josep R, Mendez, Ana Belen, Andres, Mireia, Azancot, Maria Antonia, Oristrell, Gerard, Mendez-Boo, Leonardo, Cohen, Jordana, Barrabes, Jose A et al.
DOI: 10.1093/ckj/sfab161

Loss of humoral response 3 months after SARS-CoV-2 vaccination in the CKD spectrum: the multicentric SENCOVAC study.

PMID: 35022757
Journal: NEPHROLOGY DIALYSIS TRANSPLANTATION
Year: 2022
Reference: Nephrol Dial Transplant. 2022 Apr 25;37(5):994-999. doi: 10.1093/ndt/gfac007.
Impact factor: 5.992
Publication type: Paper in international publication
Authors: Carmona, Nicolas Macias, Ortiz, Alberto, Bernat, Amparo, Diaz, Ana Beatriz Munoz, Mantecon, Carlos Jesus Jarava, Perez, Virginia Olinda Gomez, Gonzalez, Carmen Calderon, Cervienka, Michal, Mazuecos, Auxiliadora, Cazorla, Juan Manuel et al.
DOI: 10.1093/ndt/gfac007

Evaluation of SARS-CoV-2 entry, inflammation and new therapeutics in human lung tissue cells.

PMID: 35025963
Journal: PLoS Pathogens
Year: 2022
Reference: PLoS Pathog. 2022 Jan 13;18(1):e1010171. doi: 10.1371/journal.ppat.1010171. eCollection 2022 Jan.
Impact factor: 6.823
Publication type: Paper in international publication
Authors: Grau-Exposito, Judith, Perea, David, Suppi, Marina, Massana, Nuria, Vergara, Ander, Soler, Maria Jose, Trinite, Benjamin, Blanco, Julia, Garcia-Perez, Javier, Alcami, Jose et al.
DOI: 10.1371/journal.ppat.1010171

A multicenter blinded preclinical randomized controlled trial on Jak1/2 inhibition in MRL/MpJ-Fas(lpr) mice with proliferative lupus nephritis predicts low effect size.

PMID: 33607177
Journal: KIDNEY INTERNATIONAL
Year: 2021
Reference: Kidney Int. 2021 Jun;99(6):1331-1341. doi: 10.1016/j.kint.2021.01.024. Epub 2021 Feb 16.
Impact factor: 10.612
Publication type: Paper in international publication
Authors: Lei, Yutian, Sehnert, Bettina, Voll, Reinhard E, Jacobs-Cacha, Conxita, Soler, Maria Jose, Sanchez-Nino, Maria D, Ortiz, Alberto, Bulow, Roman D, Boor, Peter, Anders, Hans-Joachim et al.
DOI: 10.1016/j.kint.2021.01.024

Progression of Interstitial Fibrosis and Tubular Atrophy in Low Immunological Risk Renal Transplants Monitored by Sequential Surveillance Biopsies: The Influence of TAC Exposure and Metabolism.

PMID: 33406589
Journal: Journal of Clinical Medicine
Year: 2021
Reference: J Clin Med. 2021 Jan 4;10(1). pii: jcm10010141. doi: 10.3390/jcm10010141.
Impact factor: 4.242
Publication type: Paper in international publication
Authors: Chamoun, Betty, Torres, Irina B, Gabaldon, Alejandra, Sellares, Joana, Perello, Manel, Castella, Eva, Guri, Xavier, Salcedo, Maite, Toapanta, Nestor G, Cidraque, Ignacio et al.
DOI: 10.3390/jcm10010141

Results from the IRoc-GN international registry of patients with COVID-19 and glomerular disease suggest close monitoring.

PMID: 33181156
Journal: KIDNEY INTERNATIONAL
Year: 2021
Reference: Kidney Int. 2021 Jan;99(1):227-237. doi: 10.1016/j.kint.2020.10.032. Epub 2020 Nov 9.
Impact factor: 10.612
Publication type: Paper in international publication
Authors: Agraz, Irene, Sinaii, Ninet, Cravedi, Paolo, Manrique, Joaquin, Slon, Maria F, Bini, Claudia, Waldman, Meryl, Soler, Maria J, Garcia-Carro, Clara, Lightstone, Liz et al.
DOI: 10.1016/j.kint.2020.10.032

Blog

News

The Department of Health of the Generalitat de Catalunya grants subsidies for carrying out validation tests on innovative projects in the field of health that are in the early stages of development.

Hypertension, a key risk factor for heart disease that contributes significantly to cardiovascular mortality and morbidity and damage to vital organs, was the focus of this multi-centre study.

The new findings were presented at the American Society of Nephrology's Kidney Week 2024 meeting in San Diego and simultaneously published in the prestigious journal Nature Medicine.