About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The group of Physiology and Pathophysiology of the Digestive Tract focuses its research activity on the functioning of the digestive tract as a whole, including the functions of secretion, motility, absorption and barrier both in healthy individuals and in the presence of disease. The application of knowledge to clinical practice is a priority for the group.
Research in digestive motility encompasses disorders of visceral sensitivity, the brain-gut axis and intestinal allergy. Research on inflammation also includes the pancreas.
We have also launched a cross-sectional research program that focuses on the role of the gut microbiota in inflammation and gut function.
PMID: 38012160 Journal: Nature Communications Year: 2023 Reference: Nat Commun. 2023 Nov 27;14(1):7770. doi: 10.1038/s41467-023-43652-x. Impact factor: Publication type: Paper in international publication Authors: Alonso, Fabiola; Arpa, Berta; Aunon, Pilar; Corral-Pujol, Marta; Cosovanu, Catalina; Egia-Mendikute, Leire; Garcia, Patricia; Garcia-Carro, Clara; Gutierrez, Eduardo; Manichanh, Chaysavanh et al. DOI: 10.1038/s41467-023-43652-x
PMID: 38023553 Journal: Open Forum Infectious Diseases Year: 2023 Reference: Open Forum Infect Dis. 2023 Oct 31;10(11):ofad542. doi: 10.1093/ofid/ofad542. eCollection 2023 Nov. Impact factor: Publication type: Paper in international publication Authors: Arpa, Berta; Bernal, Enrique; Clotet, Bonaventura; Corral-Pujol, Marta; Cosovanu, Catalina; Curran, Adria; Domingo, Pere; Egia-Mendikute, Leire; Gutierrez, Felix; Imaz, Arkaitz et al. DOI: 10.1093/ofid/ofad542
PMID: 38030035 Journal: JOURNAL OF HEPATOLOGY Year: 2023 Reference: J Hepatol. 2023 Nov 27:S0168-8278(23)05285-6. doi: 10.1016/j.jhep.2023.10.043. Impact factor: Publication type: Paper in international publication Authors: Arijs, Ingrid; Borruel, Natalia; Carney, Nicholas; Casellas, Francesc; Charlafti, Ilias; Ferrante, Marc; Fierens, Liselotte; Fiorino, Gionata; Gerold, Nathalie; Gross, Evelyn et al. DOI: 10.1016/j.jhep.2023.10.043
PMID: 38075176 Journal: Advances in Laboratory Medicine Year: 2023 Reference: Adv Lab Med. 2023 Sep 13;4(3):203-204. doi: 10.1515/almed-2023-0116. eCollection 2023 Sep. Impact factor: Publication type: Editorail in international publication Authors: Arribas, Ignacio; Azpiroz, Fernando; Fernandez-Calle, Pilar; Ferrer-Costa, Roser; Gonzalez, Alvaro; Jimenez, Wladimiro; Livovsky, Dan M; Nieto, Adoracion et al. DOI: 10.1515/almed-2023-0116
PMID: 35163449 Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Year: 2022 Reference: Int J Mol Sci. 2022 Jan 28;23(3). pii: ijms23031527. doi: 10.3390/ijms23031527. Impact factor: 5.924 Publication type: Paper in international publication Authors: Notararigo, Sara; Varela, Encarnacion; Otal, Anna; Antolin, Maria; Guarner, Francisco; Lopez, Paloma et al. DOI: 10.3390/ijms23031527
PMID: 35764931 Journal: BMC GASTROENTEROLOGY Year: 2022 Reference: BMC Gastroenterol. 2022 Jun 28;22(1):320. doi: 10.1186/s12876-022-02392-w. Impact factor: 3.067 Publication type: Paper in international publication Authors: Batista, Lissette; Robles, Virginia; Manichanh, Chaysavanh; Ruiz, Laura; Pinsach, Ferran; Guarner, Francisco; Fernandez-Banares, Fernando; Guagnozzi, Danila et al. DOI: 10.1186/s12876-022-02392-w
PMID: 35838300 Journal: CURRENT OPINION IN CLINICAL NUTRITION AND METABOLI Year: 2022 Reference: Curr Opin Clin Nutr Metab Care. 2022 Jul 16. pii: 00075197-990000000-00020. doi: 10.1097/MCO.0000000000000856. Impact factor: 4.294 Publication type: Paper in international publication Authors: Aguilar, Ariadna, Serra, Jordi, Malagelada, Carolina et al. DOI: 10.1097/MCO.0000000000000856
PMID: 35805133 Journal: Cells Year: 2022 Reference: Cells. 2022 Jun 28;11(13). pii: cells11132046. doi: 10.3390/cells11132046. Impact factor: 6.6 Publication type: Paper in international publication Authors: Rodriguez-Urrutia, Amanda, Torres, Ines de, Santos-Briones, Ignacio, Azpiroz, Fernando, Lobo, Beatriz, Alonso-Cotoner, Carmen, Santos, Javier, Gonzalez-Castro, Ana M, Vicario, Maria, Guagnozzi, Danila et al. DOI: 10.3390/cells11132046
PMID: 32941879 Journal: GASTROENTEROLOGY Year: 2021 Reference: Gastroenterology. 2021 Jan;160(1):206-218.e13. doi: 10.1053/j.gastro.2020.08.054. Epub 2020 Sep 14. Impact factor: Publication type: Paper in international publication Authors: Berland, Magali; Borruel, Natalia; Carol, Marta; Casellas, Francesc; Da Silva, Kevin; De Prada, Gloria; Dore, Joel; Ehrlich, Stanislav Dusko; Fabrellas, Nuria; Gines, Pere et al. DOI: 10.1053/j.gastro.2020.08.054
PMID: 32294476 Journal: GASTROENTEROLOGY Year: 2021 Reference: Gastroenterology. 2021 Jan;160(1):99-114.e3. doi: 10.1053/j.gastro.2020.04.014. Epub 2020 Apr 12. Impact factor: Publication type: Paper in international publication Authors: Adibi, Payman; Andresen, Viola; Archampong, Timothy; Bangdiwala, Shrikant I; Benninga, Marc A; Bonaz, Bruno; Bor, Serhat; Choi, Suck Chei; Corazziari, Enrico S; Costa, Valeria et al. DOI: 10.1053/j.gastro.2020.04.014
PMID: 35099124 Journal: United European Gastroenterology Journal Year: 2021 Reference: United European Gastroenterol J. 2021 Sep;9(7):883-884. doi: 10.1002/ueg2.12090. Epub 2021 Jul 14. Impact factor: 4.623 Publication type: Letter or abstract Authors: Pohl, Daniel, Mulak, A, Serra, J, Enck, P, Tack, J, Accarino, Anna, Barbara, Giovanni, Bor, Serhat, Coffin, Benoit, Corsetti, Maura et al. DOI: 10.1002/ueg2.12090
PMID: 34960094 Journal: Nutrients Year: 2021 Reference: Nutrients. 2021 Dec 18;13(12). pii: nu13124542. doi: 10.3390/nu13124542. Impact factor: 5.719 Publication type: Paper in international publication Authors: Neve, Boris Le, Martinez-De la Torre, Adrian, Tap, Julien, Ruiz, Adoracion Nieto, Derrien, Muriel, Cotillard, Aurelie, Faurie, Jean-Michel, Barba, Elizabeth, Mego, Marianela, Dornic, Quentin et al. DOI: 10.3390/nu13124542
PMID: 32722760 Journal: Journal of Crohns & Colitis Year: 2020 Reference: J Crohns Colitis. 2020 Jul 29. pii: 5877457. doi: 10.1093/ecco-jcc/jjaa159. Impact factor: 8.658 Publication type: Paper in international publication Authors: Ghosh, Subrata, Sensky, Tom, Casellas, Francesc, Rioux, Louis-Charles, Ahmad, Tariq, Marquez, Juan R, Vanasek, Tomas, Gubonina, Irina, Sezgin, Orhan, Ardizzone, Sandro et al. DOI: 10.1093/ecco-jcc/jjaa159
PMID: 32680731 Journal: Gastroenterologia y Hepatologia Year: 2020 Reference: Gastroenterol Hepatol. 2020 Oct;43(8):485-496. doi: 10.1016/j.gastrohep.2020.05.011. Epub 2020 Jun 18. Impact factor: 1.581 Publication type: Paper in national publication Authors: Mas, Pilar, Barba, Elizabeth, Suarez, Jose Francisco, Accarino, Anna, Perez de la Serna, Julio, Serra, Jordi, Alcedo, Javier et al. DOI: 10.1016/j.gastrohep.2020.05.011
PMID: 32600917 Journal: Gastroenterologia y Hepatologia Year: 2020 Reference: Gastroenterol Hepatol. 2020 Dec;43(10):649-658. doi: 10.1016/j.gastrohep.2020.04.004. Epub 2020 Jun 27. Impact factor: 1.581 Publication type: Paper in national publication Authors: Barreiro-de Acosta, Manuel, Marin-Jimenez, Ignacio, Rodriguez-Lago, Iago, Guarner, Francisco, Espin, Eloy, Ferrer Bradley, Isabel, Gutierrez, Ana, Chaparro, Maria, Gisbert, Javier P, Nos, Pilar et al. DOI: 10.1016/j.gastrohep.2020.04.004
PMID: 32525249 Journal: NEUROGASTROENTEROLOGY AND MOTILITY Year: 2020 Reference: Neurogastroenterol Motil. 2020 Jul;32(7):e13930. doi: 10.1111/nmo.13930. Impact factor: 2.946 Publication type: Paper in international publication Authors: Farmer, Adam, Hauser, Goran, Mulak, Agata, Novais, Luis, Edoardo Savarino, Daniel Pohl, Storonova, Olga, Zerbib, Frank, Carbone, Florencia, Geeraerts, Annelies, Enck, Paul et al. DOI: 10.1111/nmo.13930
PMID: 30794765 Journal: GASTROENTEROLOGY Year: 2019 Reference: Gastroenterology. 2019 Mar;156(4):1223. doi: 10.1053/j.gastro.2019.02.026. Impact factor: 19.233 Publication type: Letter or abstract Authors: Azpiroz, Fernando, Gibson, Glenn, Guarner, Francisco et al. DOI: 10.1053/j.gastro.2019.02.026
PMID: 30782268 Journal: Eurosurveillance Year: 2019 Reference: Euro Surveill. 2019 Feb;24(7). doi: 10.2807/1560-7917.ES.2019.24.7.1700857. Impact factor: 7.421 Publication type: Review in international publication Authors: Martinez-Gomez, Xavier, Curran, Adrian, Campins, Magda, Alemany, Laia, Rodrigo-Pendas, Jose Angel, Borruel, Natalia, Castellsague, Xavier, Diaz-de-Heredia, Cristina, Moraga-Llop, Fernando A, Del Pino, Marta et al. DOI: 10.2807/1560-7917.ES.2019.24.7.1700857
PMID: 30744042 Journal: Cells Year: 2019 Reference: Cells. 2019 Feb 8;8(2). pii: cells8020135. doi: 10.3390/cells8020135. Impact factor: 5.656 Publication type: Review in national publication Authors: Albert-Bayo, Merce, Paracuellos, Irene, Gonzalez-Castro, Ana M, Rodriguez-Urrutia, Amanda, Rodriguez-Lagunas, Maria J, Alonso-Cotoner, Carmen, Santos, Javier, Vicario, Maria et al. DOI: 10.3390/cells8020135
PMID: 30721954 Journal: Journal of Crohns & Colitis Year: 2019 Reference: J Crohns Colitis. 2019 Aug 14;13(8):996-1002. doi: 10.1093/ecco-jcc/jjz024. Impact factor: 7.827 Publication type: Paper in international publication Authors: Castro-Laria, L, Martin-Arranz, M D, Martinez-Montiel, M P, Valls, M, Ferreiro-Iglesias, R, Llao, J, Moraleja-Yudego, I, Casellas, F, Antolin-Melero, B, Cortes, X et al. DOI: 10.1093/ecco-jcc/jjz024
PMID: 29622808 Journal: Nature Reviews Gastroenterology & Hepatology Year: 2018 Reference: Nat Rev Gastroenterol Hepatol. 2018 May;15(5):291-308. doi: 10.1038/nrgastro.2018.7. Epub 2018 Apr 6. Impact factor: 16.99 Publication type: Review in national publication Authors: Grover, Madhusudan, Hellstrom, Per M, Ke, Meiyun, Layer, Peter, Malagelada, Carolina, Parkman, Henry P, Scott, S Mark, Tack, Jan, Simren, Magnus, Tornblom, Hans et al. DOI: 10.1038/nrgastro.2018.7
PMID: 29575437 Journal: NEUROGASTROENTEROLOGY AND MOTILITY Year: 2018 Reference: Neurogastroenterology & Motility. 2018 Aug;30(8):e13337. doi: 10.1111/nmo.13337. Impact factor: 3.842 Publication type: Paper in international publication Authors: Pribic, T, Vilaseca, H, Nieto, A, Hernandez, L, Monrroy, H, Malagelada, C, Accarino, A, Roca, J, Azpiroz, F et al. DOI: 10.1111/nmo.13337
PMID: 29113028 Journal: HEPATOLOGY Year: 2018 Reference: Hepatology. 2018 Apr;67(4):1485-1498. doi: 10.1002/hep.29646. Epub 2018 Feb 19. Impact factor: 14.079 Publication type: Paper in international publication Authors: Garcia-Lezana, Teresa, Raurell, Imma, Bravo, Miren, Torres-Arauz, Manuel, Salcedo, Maria Teresa, Santiago, Alba, Schoenenberger, Andreu, Manichanh, Chaysavanh, Genesca, Joan, Martell, Maria et al. DOI: 10.1002/hep.29646
PMID: 29498019 Journal: ADVANCES IN THERAPY Year: 2018 Reference: Adv Ther. 2018 Mar;35(3):289-310. doi: 10.1007/s12325-018-0673-5. Epub 2018 Mar 1. Impact factor: 3.085 Publication type: Review in international publication Authors: Rodino-Janeiro, Bruno K, Vicario, Maria, Alonso-Cotoner, Carmen, Pascua-Garcia, Roberto, Santos, Javier et al. DOI: 10.1007/s12325-018-0673-5
PMID: 29026603 Journal: United European Gastroenterology Journal Year: 2017 Reference: United European Gastroenterol J. 2017 Oct;5(6):887-897. doi: 10.1177/2050640617691690. Epub 2017 Jan 29. Impact factor: 3.673 Publication type: Paper in international publication Authors: Azpiroz, Fernando, Santos, Javier, Vicario, Maria, Guagnozzi, Danila, Pardo-Camacho, Cristina, Salvo-Romero, Eloisa, Lobo, Beatriz, Ramos, Laura, Martinez, Cristina, Guilarte, Mar et al. DOI: 10.1177/2050640617691690
PMID: 28967887 Journal: NATURE BIOTECHNOLOGY Year: 2017 Reference: Nat Biotechnol. 2017 Nov;35(11):1069-1076. doi: 10.1038/nbt.3960. Epub 2017 Oct 2. Impact factor: 41.667 Publication type: Paper in international publication Authors: Costea, Paul I, Zeller, Georg, Sunagawa, Shinichi, Pelletier, Eric, Alberti, Adriana, Levenez, Florence, Tramontano, Melanie, Driessen, Marja, Hercog, Rajna, Jung, Ferris-Elias et al. DOI: 10.1038/nbt.3960
PMID: 28966116 Journal: Stem Cell Reports Year: 2017 Reference: Stem Cell Reports. 2017 Oct 10;9(4):1109-1123. doi: 10.1016/j.stemcr.2017.07.014. Epub 2017 Sep 28. Impact factor: 7.338 Publication type: Paper in international publication Authors: Serena, Carolina, Keiran, Noelia, Madeira, Ana, Maymo-Masip, Elsa, Ejarque, Miriam, Terron-Puig, Margarida, Espin, Eloy, Marti, Marc, Borruel, Natalia, Guarner, Francisco et al. DOI: 10.1016/j.stemcr.2017.07.014
PMID: 28882888 Journal: CLINICAL CHEMISTRY Year: 2017 Reference: Clin Chem. 2017 Nov;63(11):1674-1679. doi: 10.1373/clinchem.2016.264473. Epub 2017 Sep 7. Impact factor: 8.008 Publication type: Paper in international publication Authors: Versalovic, James, Dore, Joel, Guarner, Francisco, Luna, Ruth Ann, Ringel, Yehuda et al. DOI: 10.1373/clinchem.2016.264473
PMID: 27147122 Journal: GASTROENTEROLOGY Year: 2016 Reference: Gastroenterology. 2016 May;150(6):1380-92. doi: 10.1053/j.gastro.2016.02.011. Impact factor: 18.187 Publication type: Review in international publication Authors: Stanghellini, Vincenzo, Chan, Francis K L, Hasler, William L, Malagelada, Juan R, Suzuki, Hidekazu, Tack, Jan, Talley, Nicholas J et al. DOI: 10.1053/j.gastro.2016.02.011
PMID: 26556786 Journal: NEUROGASTROENTEROLOGY AND MOTILITY Year: 2016 Reference: Neurogastroenterol Motil. 2016 Apr;28(4):463-86. doi: 10.1111/nmo.12717. Epub 2015 Nov 11. Impact factor: 3.587 Publication type: Paper in international publication Authors: Santos, J, Pigrau, M, Rodino-Janeiro, B K, Casado-Bedmar, M, Lobo, B, Vicario, M, Alonso-Cotoner, C et al. DOI: 10.1111/nmo.12717
PMID: 26481311 Journal: FASEB JOURNAL Year: 2016 Reference: FASEB J. 2016 Feb;30(2):544-54. doi: 10.1096/fj.15-272773. Epub 2015 Oct 19. Impact factor: 5.043 Publication type: Paper in international publication Authors: Fernandez-Calotti, Paula, Casulleras, Olga, Antolin, Maria, Guarner, Francisco, Pastor-Anglada, Marcal et al. DOI: 10.1096/fj.15-272773
PMID: 25921480 Journal: Journal of health psychology Year: 2016 Reference: J Health Psychol. 2016 Nov;21(11):2590-2599. doi: 10.1177/1359105315581069. Epub 2016 Jul 9. Impact factor: Publication type: Letter or abstract Authors: Azpiroz, Fernando, Parramon, Gemma, Santamarina-Perez, Pilar, Accarino, Anna, Rodriguez-Urrutia, Amanda, Eiroa-Orosa, Francisco Jose et al. DOI: 10.1177/1359105315581069
PMID: 26362981 Journal: APPLIED AND ENVIRONMENTAL MICROBIOLOGY Year: 2015 Reference: Appl Environ Microbiol. 2015 Dec 1;81(23):7960-8. doi: 10.1128/AEM.02095-15. Epub 2015 Sep 11. Impact factor: 3.668 Publication type: Paper in international publication Authors: Hidalgo-Cantabrana, Claudio, Sanchez, Borja, Alvarez-Martin, Pablo, Lopez, Patricia, Martinez-Alvarez, Noelia, Delley, Michele, Varela, Encarna, Suarez, Ana, Antolin, Maria, Guarner, Francisco et al. DOI: 10.1128/AEM.02095-15
PMID: 25809217 Journal: Beneficial Microbes Year: 2015 Reference: Benef Microbes. 2015 Oct 15;6(5):615-30. doi: 10.3920/BM2014.0157. Epub 2015 Apr 22. Impact factor: 2.614 Publication type: Paper in international publication Authors: van den Nieuwboer, M, Brummer, R J, Guarner, F, Morelli, L, Cabana, M, Claassen, E et al. DOI: 10.3920/BM2014.0157
PMID: 26303858 Journal: NEUROGASTROENTEROLOGY AND MOTILITY Year: 2015 Reference: Neurogastroenterol Motil. 2015 Nov;27(11):1621-8. doi: 10.1111/nmo.12662. Epub 2015 Aug 25. Impact factor: 3.587 Publication type: Paper in international publication Authors: Mego, M, Accarino, A, Malagelada, J-R, Guarner, F, Azpiroz, F et al. DOI: 10.1111/nmo.12662
PMID: 25912458 Journal: COMPUTERS IN BIOLOGY AND MEDICINE Year: 2015 Reference: Comput Biol Med. 2015 Oct 1;65:320-30. doi: 10.1016/j.compbiomed.2015.04.006. Epub 2015 Apr 14. Impact factor: 1.24 Publication type: Paper in international publication Authors: Drozdzal, Michal, Segui, Santi, Radeva, Petia, Malagelada, Carolina, Vitria, Jordi, Azpiroz, Fernando et al. DOI: 10.1016/j.compbiomed.2015.04.006
PMID: 23138131 Journal: Journal of Crohns & Colitis Year: 2013 Reference: J Crohns Colitis. 2013 Aug 1;7(7):e249-55. doi: 10.1016/j.crohns.2012.10.003. Epub 2012 Nov 6. Impact factor: 3.385 Publication type: Paper in international publication Authors: Casellas, Francesc, Ginard, Daniel, Vera, Isabel, Torrejon, Antonio et al. DOI: 10.1016/j.crohns.2012.10.003
PMID: 23639273 Journal: Gastroenterologia y Hepatologia Year: 2013 Reference: Gastroenterol Hepatol. 2013 Jun-Jul;36(6):422-36. doi: 10.1016/j.gastrohep.2012.12.003. Epub 2013 Apr 30. Impact factor: 0.567 Publication type: Paper in national publication Authors: Moreno-Perez, Oscar, Navarro, Salvador, Palazon, Jose Maria, Perez-Mateo, Miguel, Sabater, Luis, Sastre, Yolanda, Vaquero, Eva C, Martinez, Juan, Molero, Xavier, Lopez, Antonio et al. DOI: 10.1016/j.gastrohep.2012.12.003
PMID: 23474420 Journal: GUT Year: 2013 Reference: Gut. 2013 May;62(5):787-96. doi: 10.1136/gutjnl-2012-302504. Epub 2013 Mar 8. Impact factor: 10.732 Publication type: Review in international publication Authors: Quigley, Eamonn Mm, Sartor, R Balfour, Sherman, Philip M, Mayer, Emeran A, Holt, Peter R, Guerrant, Richard, Sanders, Mary Ellen, Guarner, Francisco et al. DOI: 10.1136/gutjnl-2012-302504
PMID: 23429448 Journal: INFLAMMATORY BOWEL DISEASES Year: 2013 Reference: Inflamm Bowel Dis. 2013 Mar;19(3):559-68. doi: 10.1097/MIB.0b013e31827febd1. Impact factor: 5.119 Publication type: Paper in international publication Authors: Fernandez, R, Garrido, J, Taxonera, C, Canas, M M, Fernandez, F, Moreno, A, Ruiz, M C, Perez, J L, Lopez, P, Gonzalez, M et al. DOI: 10.1097/MIB.0b013e31827febd1
A new diagnostic algorithm has been created to guide professionals in cases of persistent vomiting for more than four weeks.
Among the genes described, there are some related to digestive system functions, which reinforces the biological entity of irritable bowel syndrome as a digestive disease.
The international study, in which Vall d'Hebron participated, monitored patients who were hospitalized for COVID-19 for 12 months and compared their gastrointestinal symptoms with another group of patients diagnosed with other medical pathologies.